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The map label for this gene is rnhA

Identifier: 167040253

GI number: 167040253

Start: 1633378

End: 1633845

Strand: Direct

Name: rnhA

Synonym: Teth514_1616

Alternate gene names: 167040253

Gene position: 1633378-1633845 (Clockwise)

Preceding gene: 167040252

Following gene: 167040254

Centisome position: 66.47

GC content: 33.55

Gene sequence:

>468_bases
ATGTCAAATAATATCGATGTTGTTGAAATATACACAGATGGAGCTTGTAGTGGTAATCCTGGTCCAGGTGGCTGGGCAGC
AGTTTTACTGTACAAAGGAACAAAAAAAGAAATATCAGGATTTGAAGAAAATACTACAAACAATAGAATGGAATTAAAAG
CAGTAATAGAAGGTTTGAAAGCCTTAAAAAGGCCTTGTAAAGTTAATTTATATAGTGATAGTAGTTATGTAATAAATGCC
TTTAAAGAAGGCTGGCTTGAAAAGTGGCAGAAAAACAATTGGCTAAAATCAGATAAAACTCCAGTAGAAAATCAGGACTT
GTGGAAGGAGCTTTTAGAGATTTCAAAAAATCATCAAGTCAATTGGATTAAAGTAAAGGGCCATGCAGATAATGAATACA
ATAATTTATGTGATAGACTGGCTACAGAGCAAATAAAAAGAAATACCAGACAAAACCCCAAGGAGTGA

Upstream 100 bases:

>100_bases
CTATTGAAGGTATAAGGATTTTGGAAAAAAATGCAATGAGAAGTGCAGTGATTGAAGCAGTGGCTGCAGCATATCAAAAA
ACAAAGGGATTGAAGTAAAA

Downstream 100 bases:

>100_bases
ATTTACAAATTTCCTTTGGGGTTTTGTTTATATGGTGTAAAATAATTAAGGCAAGGATGCCGAAGTTATACCAAAAAATA
CTTGATTTTGGCTCAGAAAT

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H

Number of amino acids: Translated: 155; Mature: 154

Protein sequence:

>155_residues
MSNNIDVVEIYTDGACSGNPGPGGWAAVLLYKGTKKEISGFEENTTNNRMELKAVIEGLKALKRPCKVNLYSDSSYVINA
FKEGWLEKWQKNNWLKSDKTPVENQDLWKELLEISKNHQVNWIKVKGHADNEYNNLCDRLATEQIKRNTRQNPKE

Sequences:

>Translated_155_residues
MSNNIDVVEIYTDGACSGNPGPGGWAAVLLYKGTKKEISGFEENTTNNRMELKAVIEGLKALKRPCKVNLYSDSSYVINA
FKEGWLEKWQKNNWLKSDKTPVENQDLWKELLEISKNHQVNWIKVKGHADNEYNNLCDRLATEQIKRNTRQNPKE
>Mature_154_residues
SNNIDVVEIYTDGACSGNPGPGGWAAVLLYKGTKKEISGFEENTTNNRMELKAVIEGLKALKRPCKVNLYSDSSYVINAF
KEGWLEKWQKNNWLKSDKTPVENQDLWKELLEISKNHQVNWIKVKGHADNEYNNLCDRLATEQIKRNTRQNPKE

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain

Homologues:

Organism=Homo sapiens, GI21359816, Length=148, Percent_Identity=30.4054054054054, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1786408, Length=146, Percent_Identity=47.945205479452, Blast_Score=135, Evalue=9e-34,
Organism=Drosophila melanogaster, GI17137476, Length=146, Percent_Identity=30.8219178082192, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45552509, Length=146, Percent_Identity=30.8219178082192, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNH_THEP3 (B0K9M0)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001665169.1
- ProteinModelPortal:   B0K9M0
- SMR:   B0K9M0
- GeneID:   5875244
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_1179
- HOGENOM:   HBG742437
- OMA:   NGWRTAD
- ProtClustDB:   PRK00203
- BioCyc:   TPSE340099:TETH39_1179-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00042
- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156

Pfam domain/function: PF00075 RnaseH; SSF53098 RNaseH_fold

EC number: =3.1.26.4

Molecular weight: Translated: 17785; Mature: 17654

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNIDVVEIYTDGACSGNPGPGGWAAVLLYKGTKKEISGFEENTTNNRMELKAVIEGLK
CCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCHHHHCCCCCCCCCCHHHHHHHHHHHH
ALKRPCKVNLYSDSSYVINAFKEGWLEKWQKNNWLKSDKTPVENQDLWKELLEISKNHQV
HHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCE
NWIKVKGHADNEYNNLCDRLATEQIKRNTRQNPKE
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SNNIDVVEIYTDGACSGNPGPGGWAAVLLYKGTKKEISGFEENTTNNRMELKAVIEGLK
CCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCHHHHCCCCCCCCCCHHHHHHHHHHHH
ALKRPCKVNLYSDSSYVINAFKEGWLEKWQKNNWLKSDKTPVENQDLWKELLEISKNHQV
HHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCE
NWIKVKGHADNEYNNLCDRLATEQIKRNTRQNPKE
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA