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The map label for this gene is gltT [H]

Identifier: 167040209

GI number: 167040209

Start: 1589948

End: 1591156

Strand: Direct

Name: gltT [H]

Synonym: Teth514_1571

Alternate gene names: 167040209

Gene position: 1589948-1591156 (Clockwise)

Preceding gene: 167040208

Following gene: 167040210

Centisome position: 64.7

GC content: 51.78

Gene sequence:

>1209_bases
GTGAAAGTGAAGTTTGGCATCGCAACCAAAATCTTTATCGCTCTAATTGTCGGTGTCTTTGTCGGCCTTTTACTTACACC
GGCTCCCGATGTGGCCAGTACTTACATTAAACCCTTTGGAGAGCTGTTCCTCAACCTCATCAGAATGATGGTAGTGCCGC
TGGTCCTTTCCTCGCTGATAGTGGGAACGGCCAGCCTCGGCGATGTTAAGAAATTGGGTAGAATAGGAGCCAAGACTATT
GCATATTACCTCCTCACCACCGCCCTTGCCATAACCATTGGCATCATTCTGGCCAATATCATTAAGCCCGGCACGGGTAT
AACGCTGCCTGTGGAGGAAGTGGAGATCAAAGGAGAGCCTCCTTTGATAACTCCTGCGGATCTCGTCCCGTCAAACCCGG
TAAAGGCAATGGCCGAAGGCAATATGCTCCAGATCATAGTGTTTGCCATCTTCTTGGGAATAGCCATTACCTTAGTCGGT
GAAAAGGGCAAACCGGTCCTAGACTTCTTCAACAGCCTAGCTGAGATCAGTTATAAAATAGTCTGGATAATCATGGAGTA
CTACGCACCCATAGGCGTTTTTGCACTTATTGTACCCGTAGTTGCCGATCACGGTCCATCGCTACTCCTTCCTCTGGGGA
AGCTAATAATAACGGGCTACCTGGGTTTTGCCATCCAACTCTTTATGGTATACTCCGCTCTGGTCTGGATATTTACCAGG
ATGAACCCTGTCAAATTCTTTAAAAGCGCCGCACCGGCGATGCTGACGGCCTACACCACCAGCAGCAGTTCGGGGACCCT
GCCGGTCACCATGGAGGTGACGGAAAAGAAGCTGGGCGTTTCAAAGTCCATCTGCAGTTTTGTGTTGCCGCTGGGTGCCA
CTATTAACATGGACGGTACCGCCCTTCACCTGGGGATCTCCGTTCTGTTCACCGCCCAGCTTTACGGCGTCGAGCTCTCG
CTTTCGCAACAGTTGGCAGTACTACTGACCGCCACTATGTTTTCCATAGGGACTGCCGGAGTCCCCGGCGTGAGCATCTT
TTTCCTCCCAGCGATACTGCAGACGGTGGGTCTGCCTCTGGGGAGCATAGCACTCATAGCGGGAATAGACCGCATCCTGG
ACATGGGCGGGACCTTGGTCAACGTGACGGGTGATATGGCCGGTTCGGTGGTGATAGCCGCTACCGAAAAGGAACTTAAC
CGAACTTAA

Upstream 100 bases:

>100_bases
TATAGTAGTGCCTGGTATAATGTGTAAAAAGGGTTTGGGAGGAGGTAGAATTTTAACTAACTTTATTGTGACGATACAAA
AATGAAATGGGGGTTAACTG

Downstream 100 bases:

>100_bases
CCGGTTCTGTACGGGCAGGTAGATATGCAGTAAATAATGGTAACAGGGAAATTGAAGAAGCTGAAGATGAAGCAGTAATC
AGGAACGTAGATGAATATCC

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MKVKFGIATKIFIALIVGVFVGLLLTPAPDVASTYIKPFGELFLNLIRMMVVPLVLSSLIVGTASLGDVKKLGRIGAKTI
AYYLLTTALAITIGIILANIIKPGTGITLPVEEVEIKGEPPLITPADLVPSNPVKAMAEGNMLQIIVFAIFLGIAITLVG
EKGKPVLDFFNSLAEISYKIVWIIMEYYAPIGVFALIVPVVADHGPSLLLPLGKLIITGYLGFAIQLFMVYSALVWIFTR
MNPVKFFKSAAPAMLTAYTTSSSSGTLPVTMEVTEKKLGVSKSICSFVLPLGATINMDGTALHLGISVLFTAQLYGVELS
LSQQLAVLLTATMFSIGTAGVPGVSIFFLPAILQTVGLPLGSIALIAGIDRILDMGGTLVNVTGDMAGSVVIAATEKELN
RT

Sequences:

>Translated_402_residues
MKVKFGIATKIFIALIVGVFVGLLLTPAPDVASTYIKPFGELFLNLIRMMVVPLVLSSLIVGTASLGDVKKLGRIGAKTI
AYYLLTTALAITIGIILANIIKPGTGITLPVEEVEIKGEPPLITPADLVPSNPVKAMAEGNMLQIIVFAIFLGIAITLVG
EKGKPVLDFFNSLAEISYKIVWIIMEYYAPIGVFALIVPVVADHGPSLLLPLGKLIITGYLGFAIQLFMVYSALVWIFTR
MNPVKFFKSAAPAMLTAYTTSSSSGTLPVTMEVTEKKLGVSKSICSFVLPLGATINMDGTALHLGISVLFTAQLYGVELS
LSQQLAVLLTATMFSIGTAGVPGVSIFFLPAILQTVGLPLGSIALIAGIDRILDMGGTLVNVTGDMAGSVVIAATEKELN
RT
>Mature_402_residues
MKVKFGIATKIFIALIVGVFVGLLLTPAPDVASTYIKPFGELFLNLIRMMVVPLVLSSLIVGTASLGDVKKLGRIGAKTI
AYYLLTTALAITIGIILANIIKPGTGITLPVEEVEIKGEPPLITPADLVPSNPVKAMAEGNMLQIIVFAIFLGIAITLVG
EKGKPVLDFFNSLAEISYKIVWIIMEYYAPIGVFALIVPVVADHGPSLLLPLGKLIITGYLGFAIQLFMVYSALVWIFTR
MNPVKFFKSAAPAMLTAYTTSSSSGTLPVTMEVTEKKLGVSKSICSFVLPLGATINMDGTALHLGISVLFTAQLYGVELS
LSQQLAVLLTATMFSIGTAGVPGVSIFFLPAILQTVGLPLGSIALIAGIDRILDMGGTLVNVTGDMAGSVVIAATEKELN
RT

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=401, Percent_Identity=36.6583541147132, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI66773030, Length=450, Percent_Identity=33.7777777777778, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI5032093, Length=400, Percent_Identity=36.5, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI223468566, Length=260, Percent_Identity=39.6153846153846, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI223468564, Length=251, Percent_Identity=39.4422310756972, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI4827012, Length=272, Percent_Identity=38.2352941176471, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI40254478, Length=263, Percent_Identity=40.3041825095057, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI169790839, Length=274, Percent_Identity=37.956204379562, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI194239697, Length=264, Percent_Identity=34.8484848484849, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI262359914, Length=185, Percent_Identity=37.8378378378378, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI301601644, Length=146, Percent_Identity=41.0958904109589, Blast_Score=112, Evalue=5e-25,
Organism=Escherichia coli, GI1790514, Length=425, Percent_Identity=38.8235294117647, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI1789947, Length=408, Percent_Identity=30.6372549019608, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1788024, Length=384, Percent_Identity=29.6875, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789473, Length=278, Percent_Identity=28.0575539568345, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71996953, Length=450, Percent_Identity=34.6666666666667, Blast_Score=223, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI17537407, Length=415, Percent_Identity=34.6987951807229, Blast_Score=207, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI71983106, Length=426, Percent_Identity=33.8028169014084, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71983099, Length=427, Percent_Identity=33.7236533957845, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI193206505, Length=411, Percent_Identity=35.5231143552311, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI17541374, Length=400, Percent_Identity=30.25, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI193206654, Length=430, Percent_Identity=30.6976744186047, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24583025, Length=437, Percent_Identity=30.4347826086957, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI17137668, Length=437, Percent_Identity=30.4347826086957, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24583023, Length=437, Percent_Identity=30.4347826086957, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI281360483, Length=278, Percent_Identity=33.4532374100719, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI17137666, Length=278, Percent_Identity=33.4532374100719, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI281360481, Length=278, Percent_Identity=33.4532374100719, Blast_Score=118, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 42432; Mature: 42432

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVKFGIATKIFIALIVGVFVGLLLTPAPDVASTYIKPFGELFLNLIRMMVVPLVLSSLI
CEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGTASLGDVKKLGRIGAKTIAYYLLTTALAITIGIILANIIKPGTGITLPVEEVEIKGEP
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHEEECCCC
PLITPADLVPSNPVKAMAEGNMLQIIVFAIFLGIAITLVGEKGKPVLDFFNSLAEISYKI
CCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
VWIIMEYYAPIGVFALIVPVVADHGPSLLLPLGKLIITGYLGFAIQLFMVYSALVWIFTR
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MNPVKFFKSAAPAMLTAYTTSSSSGTLPVTMEVTEKKLGVSKSICSFVLPLGATINMDGT
CCHHHHHHHCCCCEEEEEEECCCCCCEEEEEEEHHHHHCCHHHHHHHHHHCCCEECCCCC
ALHLGISVLFTAQLYGVELSLSQQLAVLLTATMFSIGTAGVPGVSIFFLPAILQTVGLPL
HHHHHHHHHHHHHHHCEEECHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCH
GSIALIAGIDRILDMGGTLVNVTGDMAGSVVIAATEKELNRT
HHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEHHHCCCC
>Mature Secondary Structure
MKVKFGIATKIFIALIVGVFVGLLLTPAPDVASTYIKPFGELFLNLIRMMVVPLVLSSLI
CEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGTASLGDVKKLGRIGAKTIAYYLLTTALAITIGIILANIIKPGTGITLPVEEVEIKGEP
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHEEECCCC
PLITPADLVPSNPVKAMAEGNMLQIIVFAIFLGIAITLVGEKGKPVLDFFNSLAEISYKI
CCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
VWIIMEYYAPIGVFALIVPVVADHGPSLLLPLGKLIITGYLGFAIQLFMVYSALVWIFTR
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MNPVKFFKSAAPAMLTAYTTSSSSGTLPVTMEVTEKKLGVSKSICSFVLPLGATINMDGT
CCHHHHHHHCCCCEEEEEEECCCCCCEEEEEEEHHHHHCCHHHHHHHHHHCCCEECCCCC
ALHLGISVLFTAQLYGVELSLSQQLAVLLTATMFSIGTAGVPGVSIFFLPAILQTVGLPL
HHHHHHHHHHHHHHHCEEECHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCH
GSIALIAGIDRILDMGGTLVNVTGDMAGSVVIAATEKELNRT
HHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]