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The map label for this gene is moeA [C]

Identifier: 167040030

GI number: 167040030

Start: 1430324

End: 1431568

Strand: Direct

Name: moeA [C]

Synonym: Teth514_1390

Alternate gene names: 167040030

Gene position: 1430324-1431568 (Clockwise)

Preceding gene: 167040029

Following gene: 167040031

Centisome position: 58.21

GC content: 35.82

Gene sequence:

>1245_bases
GTGCAAGAAAGGACGATTAAAATGGAACTTTTAAAACTTGTTACAGTAAAAGAGGCAAAGGAGATAATAGAAAAAAATAT
TAGTTTTAAACCTGGCATAGAGAAAATAAGTATTTTAAATTCGTTAGGAAGAATTTTAGCAGAAGACATATATGCACCGG
AAAATGTTCCCGATTTTAGAAAATCAACCGTTGATGGATATGCTGTGATTTCGAGTGATGTTTTTGGAGCGAGTGAGAGT
TTACCTGCAATTTTAAAGCTTGTTGGAGAAGTCAAGATAGGAACGGAACCAACCCTGGATATAATGCCAGGAGAGTGCAT
GTATGTTCCAACAGGGGGTATGCTTCCTAAAAGTGCCGATACTGTTGTTATGATTGAATACACAGAAAAACTTGATGATG
AAACTATTTTAGTCAATAAACCAGCTGCGCCCTTTCAAAACATAATTGAAATTGGAGAAGATGTAAAAAAAGGTGAACTC
ATTTTAAAAAAAGGCACAAAATTGAGACCCTACGAAATAGGGGTTTTATCAAGTCTTGGAATATTAGAGGTGGAGGTTTA
TAAAAAAGTAAAGGTTGGAATTATTTCCACAGGCGATGAGATAGTGGACCCTAAGGAGAAAATTAATAAAGGACAGGTCA
GGGACATAAATAGCTATCTGTTATACTCTCTGTGTCTTGAAGAAGGAGCAGAGCCTATTCTATACGGCATTGTTAAAGAT
GATTATGAAAAATTAAGAGAGAAATTGCAAGCGGCAATAAGTGAATGCGATTTGGTTTTGATGTCGGGTGGCAGTTCAGC
CGGCAACAAAGATGAAACTCTCAGGGTTATAAGTTCATTTGAAAATTCGAATATTTTTATTCATGGAGTTGCTATACGAC
CTGGGAAACCTACGATTGTTGGAAAAGTAGGTGATAAATTCATATTTGGACTTCCAGGGCATCCACTGGCCTGTGCGGTA
ATATTTAAAACCCTTGTTATTCACTATTTGGACAGGATAAGGAATTTTGAAAGAGAAGAATATCCGGTTGAGTGCAGGTT
TGCCGTAAACTATCATAAGGCTGAGGGTAGAGCAGAATTTTTACCTGTTAGTATAAAAGAAGTGGAAGGAAAATTAATTG
CGTATCCCACTTATTATGAATCAGGACTTATATCTCGTTTTGCAAAATCCTTTGGATATGTTTACATCGAAAAAGAATTA
GAGGGCATATCTGAAGGACAAATAGTTAAAGTTTATAAATTTTAG

Upstream 100 bases:

>100_bases
AATCTTCCAGGAAGCCCTAAGGGGGCTGTTGAAAACTTAAATGTTGTTTTACCTGCTCTTAAGCATGGAATTGAGATTTT
AAAGGGTGAAGCTTCAGAAT

Downstream 100 bases:

>100_bases
GAGGGTGCTATGAGGCAAAATATCTATCTTTCAAATATAAGCTTGAATGAGGCAATAAATATTTTTCTTGAAAAAATAAA
AGATTTTAAGGTTGAAACAG

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MQERTIKMELLKLVTVKEAKEIIEKNISFKPGIEKISILNSLGRILAEDIYAPENVPDFRKSTVDGYAVISSDVFGASES
LPAILKLVGEVKIGTEPTLDIMPGECMYVPTGGMLPKSADTVVMIEYTEKLDDETILVNKPAAPFQNIIEIGEDVKKGEL
ILKKGTKLRPYEIGVLSSLGILEVEVYKKVKVGIISTGDEIVDPKEKINKGQVRDINSYLLYSLCLEEGAEPILYGIVKD
DYEKLREKLQAAISECDLVLMSGGSSAGNKDETLRVISSFENSNIFIHGVAIRPGKPTIVGKVGDKFIFGLPGHPLACAV
IFKTLVIHYLDRIRNFEREEYPVECRFAVNYHKAEGRAEFLPVSIKEVEGKLIAYPTYYESGLISRFAKSFGYVYIEKEL
EGISEGQIVKVYKF

Sequences:

>Translated_414_residues
MQERTIKMELLKLVTVKEAKEIIEKNISFKPGIEKISILNSLGRILAEDIYAPENVPDFRKSTVDGYAVISSDVFGASES
LPAILKLVGEVKIGTEPTLDIMPGECMYVPTGGMLPKSADTVVMIEYTEKLDDETILVNKPAAPFQNIIEIGEDVKKGEL
ILKKGTKLRPYEIGVLSSLGILEVEVYKKVKVGIISTGDEIVDPKEKINKGQVRDINSYLLYSLCLEEGAEPILYGIVKD
DYEKLREKLQAAISECDLVLMSGGSSAGNKDETLRVISSFENSNIFIHGVAIRPGKPTIVGKVGDKFIFGLPGHPLACAV
IFKTLVIHYLDRIRNFEREEYPVECRFAVNYHKAEGRAEFLPVSIKEVEGKLIAYPTYYESGLISRFAKSFGYVYIEKEL
EGISEGQIVKVYKF
>Mature_414_residues
MQERTIKMELLKLVTVKEAKEIIEKNISFKPGIEKISILNSLGRILAEDIYAPENVPDFRKSTVDGYAVISSDVFGASES
LPAILKLVGEVKIGTEPTLDIMPGECMYVPTGGMLPKSADTVVMIEYTEKLDDETILVNKPAAPFQNIIEIGEDVKKGEL
ILKKGTKLRPYEIGVLSSLGILEVEVYKKVKVGIISTGDEIVDPKEKINKGQVRDINSYLLYSLCLEEGAEPILYGIVKD
DYEKLREKLQAAISECDLVLMSGGSSAGNKDETLRVISSFENSNIFIHGVAIRPGKPTIVGKVGDKFIFGLPGHPLACAV
IFKTLVIHYLDRIRNFEREEYPVECRFAVNYHKAEGRAEFLPVSIKEVEGKLIAYPTYYESGLISRFAKSFGYVYIEKEL
EGISEGQIVKVYKF

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=316, Percent_Identity=37.6582278481013, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI66932975, Length=316, Percent_Identity=37.6582278481013, Blast_Score=194, Evalue=2e-49,
Organism=Escherichia coli, GI1787049, Length=371, Percent_Identity=32.8840970350404, Blast_Score=186, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI25147659, Length=380, Percent_Identity=31.3157894736842, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17562606, Length=302, Percent_Identity=32.1192052980132, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17136978, Length=354, Percent_Identity=29.9435028248588, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24638841, Length=354, Percent_Identity=29.9435028248588, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 46048; Mature: 46048

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQERTIKMELLKLVTVKEAKEIIEKNISFKPGIEKISILNSLGRILAEDIYAPENVPDFR
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHH
KSTVDGYAVISSDVFGASESLPAILKLVGEVKIGTEPTLDIMPGECMYVPTGGMLPKSAD
HHCCCCEEEEECCCCCCCCCHHHHHHHHHCEECCCCCCEEECCCCEEEECCCCCCCCCCC
TVVMIEYTEKLDDETILVNKPAAPFQNIIEIGEDVKKGELILKKGTKLRPYEIGVLSSLG
EEEEEEECCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCEEEECCCCCCCEEEEHCCCCC
ILEVEVYKKVKVGIISTGDEIVDPKEKINKGQVRDINSYLLYSLCLEEGAEPILYGIVKD
EEEEEEEEEEEEEEEECCCHHCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEHHH
DYEKLREKLQAAISECDLVLMSGGSSAGNKDETLRVISSFENSNIFIHGVAIRPGKPTIV
HHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCEEE
GKVGDKFIFGLPGHPLACAVIFKTLVIHYLDRIRNFEREEYPVECRFAVNYHKAEGRAEF
ECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCEE
LPVSIKEVEGKLIAYPTYYESGLISRFAKSFGYVYIEKELEGISEGQIVKVYKF
EEEEHHHHCCCEEEECCHHHHHHHHHHHHHHCEEEEEHHHCCCCCCCEEEEEEC
>Mature Secondary Structure
MQERTIKMELLKLVTVKEAKEIIEKNISFKPGIEKISILNSLGRILAEDIYAPENVPDFR
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHH
KSTVDGYAVISSDVFGASESLPAILKLVGEVKIGTEPTLDIMPGECMYVPTGGMLPKSAD
HHCCCCEEEEECCCCCCCCCHHHHHHHHHCEECCCCCCEEECCCCEEEECCCCCCCCCCC
TVVMIEYTEKLDDETILVNKPAAPFQNIIEIGEDVKKGELILKKGTKLRPYEIGVLSSLG
EEEEEEECCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCEEEECCCCCCCEEEEHCCCCC
ILEVEVYKKVKVGIISTGDEIVDPKEKINKGQVRDINSYLLYSLCLEEGAEPILYGIVKD
EEEEEEEEEEEEEEEECCCHHCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEHHH
DYEKLREKLQAAISECDLVLMSGGSSAGNKDETLRVISSFENSNIFIHGVAIRPGKPTIV
HHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCEEE
GKVGDKFIFGLPGHPLACAVIFKTLVIHYLDRIRNFEREEYPVECRFAVNYHKAEGRAEF
ECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCEE
LPVSIKEVEGKLIAYPTYYESGLISRFAKSFGYVYIEKELEGISEGQIVKVYKF
EEEEHHHHCCCEEEECCHHHHHHHHHHHHHHCEEEEEHHHCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]