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The map label for this gene is moeA [C]

Identifier: 167040031

GI number: 167040031

Start: 1431578

End: 1433485

Strand: Direct

Name: moeA [C]

Synonym: Teth514_1391

Alternate gene names: 167040031

Gene position: 1431578-1433485 (Clockwise)

Preceding gene: 167040030

Following gene: 167040032

Centisome position: 58.26

GC content: 34.7

Gene sequence:

>1908_bases
ATGAGGCAAAATATCTATCTTTCAAATATAAGCTTGAATGAGGCAATAAATATTTTTCTTGAAAAAATAAAAGATTTTAA
GGTTGAAACAGAATATGTAAAAACTTATGAAGCAAATGGTAGAATTACAGCAAAACCTATATTTGCCAAAATTTCATCGC
CCTTTTACAACAGTTCTGCTGTTGACGGGATTGCAACAGTAGCAAAAAAGACATTTACTGCAACAGACAAAAATCCTGTA
AGGCTTAAAGAAGGAGTTGATTATGTAGTTATTGATACAGGTGATCCTATTCCAGATGAATATGATTGCGTAATTATGGT
TGAAGATTTAATTTGGGTATCTCAAGATGAGGTTGAGATAATAAAGCCTGCTATTCCATGGCAAAATATACGACAAATTG
GTGAGGATATAGTAGAAGGACAACTTATACTTCCTCAAAGCCATAGAATAAGACCTGTTGATATTGGTGCTTTGATTGCA
GGAGGAGTATTTGAAGTTGAAGTTTATAAAAAGCCTAAAGTTGCAATCATTCCAACAGGAACAGAGCTAGTAGAACCAGG
GGAAGAACTTAAAGTTGGAGATATAATAGAATTTAACTCGAGAGTTTTTGCCGCGCAGGTTGAAGAATACGGCGGAATTC
CAACAAGATTTGATATTGCAAAAGATGATTTTGAGAAATTGAAAGCTGCTGTTGATAAAGCTTCAAAGGAATACGACATT
ATCCTATTAAATGCTGGTTCATCTGCAGGACGTGAGGATTATTCTAAAAAGGTTATTGAAACCTTAGGTGAAGTCTATAT
TCATGGAATTGCTATAAAACCTGGAAAGCCAGTTATACTAGGAAAGGTAAACAATAAGCCTATTGTTGGAATACCAGGTT
TTCCTGTTTCAGCTTATTTTATAATGGAAAACATAGTTAAGAAGCTTATCAACTTTGTTCAAGGATATGATATAAAGGAT
AAGAGATATATAGAAGCAACTCTTTCAAAAAGAATTATGTCATCTTCAAAATATCTTGAGTTTGTAAGAGTAAAACTTGG
TTTTATAGACGGTAAATACATCGCAGCGCCAATTGAACGGGGAGCAGGTACTACAATGAGCCTTGTAAGGGCTGATGGGG
TTTTGGAAATACCTGAGGAGCTTGAGGGTTATGAAAAAGGGACAAGGGTTAATGTAAACATATTAAAAAGCGAAGACGAG
ATTAAAAATACAATTCTTTGTATAGGAAGCCACGATTTGATACTTGATATTGCAGCAGATCTTCTTGCCAAAAGAGGAAA
ATTCACGCTATCTTCAGCCCATGTCGGAAGCATTGGGGGAATACTCTCATTGAAGGATAGGGAAACACATTTTGCAACAA
TTCACCTTCTTGATGTGGAAACGGGTGAGTATAATAAATCTTATGTGAAAAGATATATTCCAAACAGAAAAATTGCCCTT
ATAAAATTTGTAAAAAGAATTCAGGGGCTTATGGTTAAAAAAGGTAATCCACTAGAGATTAATTCTTTGGAGGATATTGT
AAAAAAAGGTGCAAGGTTTGTGAACAGGCAAAAGGGATCTGGTACAAGGATTTTGCTTGATTATGAATTAAAAAGATTGG
GTATAAATCCCAAAGACATCATAGGTTATGATAGGGAAGAATATACTCATATTTCGGTTGCAGCACAAATAGCTAAAGGA
AATGCAGATGCTGGACTTGGGGTATTTTCTGCTGCTAAGATTATGGACCTTGATTTTATTCCGATAGCAAATGAAGAGTA
TGACATTGCAATTCCCGTTGAGTACTTAGAACTTGAAGGGGTAAAGCAGTTTTTGGAGGTTATAAATTCAGAAGAATTTA
AAAATGAGCTTGATAAGCTTGGAGGGTATGACTATAGCAATTTAGGAGAAATTATCATTATCGAGTAA

Upstream 100 bases:

>100_bases
TCGTTTTGCAAAATCCTTTGGATATGTTTACATCGAAAAAGAATTAGAGGGCATATCTGAAGGACAAATAGTTAAAGTTT
ATAAATTTTAGGAGGGTGCT

Downstream 100 bases:

>100_bases
AGGAGAATTTTTATGAGAGATAGGTTAGGAAGAAATGTTGATTATTTAAGAGTTTCTGTTACGGATAGATGTAACTTAAG
GTGCATTTATTGTATGCCGG

Product: putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MRQNIYLSNISLNEAINIFLEKIKDFKVETEYVKTYEANGRITAKPIFAKISSPFYNSSAVDGIATVAKKTFTATDKNPV
RLKEGVDYVVIDTGDPIPDEYDCVIMVEDLIWVSQDEVEIIKPAIPWQNIRQIGEDIVEGQLILPQSHRIRPVDIGALIA
GGVFEVEVYKKPKVAIIPTGTELVEPGEELKVGDIIEFNSRVFAAQVEEYGGIPTRFDIAKDDFEKLKAAVDKASKEYDI
ILLNAGSSAGREDYSKKVIETLGEVYIHGIAIKPGKPVILGKVNNKPIVGIPGFPVSAYFIMENIVKKLINFVQGYDIKD
KRYIEATLSKRIMSSSKYLEFVRVKLGFIDGKYIAAPIERGAGTTMSLVRADGVLEIPEELEGYEKGTRVNVNILKSEDE
IKNTILCIGSHDLILDIAADLLAKRGKFTLSSAHVGSIGGILSLKDRETHFATIHLLDVETGEYNKSYVKRYIPNRKIAL
IKFVKRIQGLMVKKGNPLEINSLEDIVKKGARFVNRQKGSGTRILLDYELKRLGINPKDIIGYDREEYTHISVAAQIAKG
NADAGLGVFSAAKIMDLDFIPIANEEYDIAIPVEYLELEGVKQFLEVINSEEFKNELDKLGGYDYSNLGEIIIIE

Sequences:

>Translated_635_residues
MRQNIYLSNISLNEAINIFLEKIKDFKVETEYVKTYEANGRITAKPIFAKISSPFYNSSAVDGIATVAKKTFTATDKNPV
RLKEGVDYVVIDTGDPIPDEYDCVIMVEDLIWVSQDEVEIIKPAIPWQNIRQIGEDIVEGQLILPQSHRIRPVDIGALIA
GGVFEVEVYKKPKVAIIPTGTELVEPGEELKVGDIIEFNSRVFAAQVEEYGGIPTRFDIAKDDFEKLKAAVDKASKEYDI
ILLNAGSSAGREDYSKKVIETLGEVYIHGIAIKPGKPVILGKVNNKPIVGIPGFPVSAYFIMENIVKKLINFVQGYDIKD
KRYIEATLSKRIMSSSKYLEFVRVKLGFIDGKYIAAPIERGAGTTMSLVRADGVLEIPEELEGYEKGTRVNVNILKSEDE
IKNTILCIGSHDLILDIAADLLAKRGKFTLSSAHVGSIGGILSLKDRETHFATIHLLDVETGEYNKSYVKRYIPNRKIAL
IKFVKRIQGLMVKKGNPLEINSLEDIVKKGARFVNRQKGSGTRILLDYELKRLGINPKDIIGYDREEYTHISVAAQIAKG
NADAGLGVFSAAKIMDLDFIPIANEEYDIAIPVEYLELEGVKQFLEVINSEEFKNELDKLGGYDYSNLGEIIIIE
>Mature_635_residues
MRQNIYLSNISLNEAINIFLEKIKDFKVETEYVKTYEANGRITAKPIFAKISSPFYNSSAVDGIATVAKKTFTATDKNPV
RLKEGVDYVVIDTGDPIPDEYDCVIMVEDLIWVSQDEVEIIKPAIPWQNIRQIGEDIVEGQLILPQSHRIRPVDIGALIA
GGVFEVEVYKKPKVAIIPTGTELVEPGEELKVGDIIEFNSRVFAAQVEEYGGIPTRFDIAKDDFEKLKAAVDKASKEYDI
ILLNAGSSAGREDYSKKVIETLGEVYIHGIAIKPGKPVILGKVNNKPIVGIPGFPVSAYFIMENIVKKLINFVQGYDIKD
KRYIEATLSKRIMSSSKYLEFVRVKLGFIDGKYIAAPIERGAGTTMSLVRADGVLEIPEELEGYEKGTRVNVNILKSEDE
IKNTILCIGSHDLILDIAADLLAKRGKFTLSSAHVGSIGGILSLKDRETHFATIHLLDVETGEYNKSYVKRYIPNRKIAL
IKFVKRIQGLMVKKGNPLEINSLEDIVKKGARFVNRQKGSGTRILLDYELKRLGINPKDIIGYDREEYTHISVAAQIAKG
NADAGLGVFSAAKIMDLDFIPIANEEYDIAIPVEYLELEGVKQFLEVINSEEFKNELDKLGGYDYSNLGEIIIIE

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=393, Percent_Identity=29.7709923664122, Blast_Score=136, Evalue=7e-32,
Organism=Homo sapiens, GI10880983, Length=393, Percent_Identity=29.7709923664122, Blast_Score=136, Evalue=8e-32,
Organism=Escherichia coli, GI1787049, Length=319, Percent_Identity=30.7210031347962, Blast_Score=149, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI25147659, Length=335, Percent_Identity=29.2537313432836, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17562606, Length=335, Percent_Identity=22.9850746268657, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI17136978, Length=289, Percent_Identity=28.719723183391, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24638841, Length=289, Percent_Identity=28.719723183391, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 70719; Mature: 70719

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQNIYLSNISLNEAINIFLEKIKDFKVETEYVKTYEANGRITAKPIFAKISSPFYNSSA
CCCCEEEECCCHHHHHHHHHHHHHCCCEEEHEEEEEECCCEEEECCHHEECCCCCCCCCH
VDGIATVAKKTFTATDKNPVRLKEGVDYVVIDTGDPIPDEYDCVIMVEDLIWVSQDEVEI
HHHHHHHHHHHEECCCCCCEECCCCCCEEEEECCCCCCCCCCEEEEEEEEEECCCCCCEE
IKPAIPWQNIRQIGEDIVEGQLILPQSHRIRPVDIGALIAGGVFEVEVYKKPKVAIIPTG
EECCCCHHHHHHHHHHHHCCEEECCCCCCCEEEEHHHEEECCEEEEEEECCCCEEEEECC
TELVEPGEELKVGDIIEFNSRVFAAQVEEYGGIPTRFDIAKDDFEKLKAAVDKASKEYDI
HHHHCCCCCCCCCCEEEECCEEEEEEHHHHCCCCCEECCCHHHHHHHHHHHHHCCCCEEE
ILLNAGSSAGREDYSKKVIETLGEVYIHGIAIKPGKPVILGKVNNKPIVGIPGFPVSAYF
EEEECCCCCCHHHHHHHHHHHHHHHEEEEEEECCCCCEEEEECCCCCEEECCCCCHHHHH
IMENIVKKLINFVQGYDIKDKRYIEATLSKRIMSSSKYLEFVRVKLGFIDGKYIAAPIER
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCEEEECCCC
GAGTTMSLVRADGVLEIPEELEGYEKGTRVNVNILKSEDEIKNTILCIGSHDLILDIAAD
CCCCEEEEEECCCCEECCHHHCCCCCCCEEEEEEECCCCCCCCEEEEECCCCHHHHHHHH
LLAKRGKFTLSSAHVGSIGGILSLKDRETHFATIHLLDVETGEYNKSYVKRYIPNRKIAL
HHHCCCCEEEECCCCCCCCCEEEECCCCCEEEEEEEEEECCCCCCHHHHHHHCCCCCHHH
IKFVKRIQGLMVKKGNPLEINSLEDIVKKGARFVNRQKGSGTRILLDYELKRLGINPKDI
HHHHHHHHCEEECCCCCEEECHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCCCHHHH
IGYDREEYTHISVAAQIAKGNADAGLGVFSAAKIMDLDFIPIANEEYDIAIPVEYLELEG
CCCCCHHCEEEEEEEEECCCCCCCCCCHHHHHHEEEEEEEECCCCCCEEEEEHHHHHHHH
VKQFLEVINSEEFKNELDKLGGYDYSNLGEIIIIE
HHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEC
>Mature Secondary Structure
MRQNIYLSNISLNEAINIFLEKIKDFKVETEYVKTYEANGRITAKPIFAKISSPFYNSSA
CCCCEEEECCCHHHHHHHHHHHHHCCCEEEHEEEEEECCCEEEECCHHEECCCCCCCCCH
VDGIATVAKKTFTATDKNPVRLKEGVDYVVIDTGDPIPDEYDCVIMVEDLIWVSQDEVEI
HHHHHHHHHHHEECCCCCCEECCCCCCEEEEECCCCCCCCCCEEEEEEEEEECCCCCCEE
IKPAIPWQNIRQIGEDIVEGQLILPQSHRIRPVDIGALIAGGVFEVEVYKKPKVAIIPTG
EECCCCHHHHHHHHHHHHCCEEECCCCCCCEEEEHHHEEECCEEEEEEECCCCEEEEECC
TELVEPGEELKVGDIIEFNSRVFAAQVEEYGGIPTRFDIAKDDFEKLKAAVDKASKEYDI
HHHHCCCCCCCCCCEEEECCEEEEEEHHHHCCCCCEECCCHHHHHHHHHHHHHCCCCEEE
ILLNAGSSAGREDYSKKVIETLGEVYIHGIAIKPGKPVILGKVNNKPIVGIPGFPVSAYF
EEEECCCCCCHHHHHHHHHHHHHHHEEEEEEECCCCCEEEEECCCCCEEECCCCCHHHHH
IMENIVKKLINFVQGYDIKDKRYIEATLSKRIMSSSKYLEFVRVKLGFIDGKYIAAPIER
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCEEEECCCC
GAGTTMSLVRADGVLEIPEELEGYEKGTRVNVNILKSEDEIKNTILCIGSHDLILDIAAD
CCCCEEEEEECCCCEECCHHHCCCCCCCEEEEEEECCCCCCCCEEEEECCCCHHHHHHHH
LLAKRGKFTLSSAHVGSIGGILSLKDRETHFATIHLLDVETGEYNKSYVKRYIPNRKIAL
HHHCCCCEEEECCCCCCCCCEEEECCCCCEEEEEEEEEECCCCCCHHHHHHHCCCCCHHH
IKFVKRIQGLMVKKGNPLEINSLEDIVKKGARFVNRQKGSGTRILLDYELKRLGINPKDI
HHHHHHHHCEEECCCCCEEECHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCCCHHHH
IGYDREEYTHISVAAQIAKGNADAGLGVFSAAKIMDLDFIPIANEEYDIAIPVEYLELEG
CCCCCHHCEEEEEEEEECCCCCCCCCCHHHHHHEEEEEEEECCCCCCEEEEEHHHHHHHH
VKQFLEVINSEEFKNELDKLGGYDYSNLGEIIIIE
HHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]