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The map label for this gene is hisH [H]

Identifier: 167039654

GI number: 167039654

Start: 1034726

End: 1035337

Strand: Direct

Name: hisH [H]

Synonym: Teth514_1004

Alternate gene names: 167039654

Gene position: 1034726-1035337 (Clockwise)

Preceding gene: 167039653

Following gene: 167039655

Centisome position: 42.11

GC content: 34.31

Gene sequence:

>612_bases
TTGATAGGGATTATTGACTATGGAATGGGAAATTTAAGGAGTGTAGAAAAGGCATTTGAATACGTAGGCTATGAAGCAAA
AATTATAAAAGATGTAGATTCGGTAAAAGAGGCTCATGCATTAGTTCTTCCTGGAGTGGGCGCTTTTCCTGATGCGATGG
ATACTCTCATTAAAACAAGCATGTTAGAAGAGATAAAAAGACAAATTGATAAAGGTAAGTTGTTTCTTGGGATATGTTTA
GGGATGCAGCTTTTATTTGAAAAGGGTTTTGAGATAGAAGAAACTGAGGGCTTTAAGATTTTTAAAGGGCAAGTAATAGA
ACTTCCAAAGCATAATAAAATTCCTCACATGGGATGGAATAGTCTTGAAATAAAAAAGGAAACTCCACTTCTTAAAGGAG
TGGAGAATGGAGATTATGCGTATTTTGTTCATTCTTATTATGTAGCCAACAATGAAGAGAAATATGTGTATGCAGTGACT
GATTATGGTGTTCAGATTCCTGCAGTTATAATTAAAGACAATGTTTTTTCTTGTCAATTCCATCCTGAGAAGAGCGGAAA
AGTGGGGCTTAAAATTTTAAAGAATTTTGGAGAGATGGCAAAATGGTTTTAA

Upstream 100 bases:

>100_bases
AGGGCAGAGGGTATACCTTCTACTAAAGGGATTTTATAAAGATACAGTTTAAGGGAGATTGCATATACTTTACACGTAAC
TTAAGTGAGGCGGTGAAAAA

Downstream 100 bases:

>100_bases
TACCTGCAATTGATATTATGGAAGAAAAATGTGTAAGGCTTACAAAAGGAGATTTTAATACCAAAGAGGTTTATTATGAA
AATCCCGTTGACGTAGCTAA

Product: imidazole glycerol phosphate synthase subunit HisH

Products: NA

Alternate protein names: IGP synthase glutamine amidotransferase subunit; IGP synthase subunit hisH; ImGP synthase subunit hisH; IGPS subunit hisH [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MIGIIDYGMGNLRSVEKAFEYVGYEAKIIKDVDSVKEAHALVLPGVGAFPDAMDTLIKTSMLEEIKRQIDKGKLFLGICL
GMQLLFEKGFEIEETEGFKIFKGQVIELPKHNKIPHMGWNSLEIKKETPLLKGVENGDYAYFVHSYYVANNEEKYVYAVT
DYGVQIPAVIIKDNVFSCQFHPEKSGKVGLKILKNFGEMAKWF

Sequences:

>Translated_203_residues
MIGIIDYGMGNLRSVEKAFEYVGYEAKIIKDVDSVKEAHALVLPGVGAFPDAMDTLIKTSMLEEIKRQIDKGKLFLGICL
GMQLLFEKGFEIEETEGFKIFKGQVIELPKHNKIPHMGWNSLEIKKETPLLKGVENGDYAYFVHSYYVANNEEKYVYAVT
DYGVQIPAVIIKDNVFSCQFHPEKSGKVGLKILKNFGEMAKWF
>Mature_203_residues
MIGIIDYGMGNLRSVEKAFEYVGYEAKIIKDVDSVKEAHALVLPGVGAFPDAMDTLIKTSMLEEIKRQIDKGKLFLGICL
GMQLLFEKGFEIEETEGFKIFKGQVIELPKHNKIPHMGWNSLEIKKETPLLKGVENGDYAYFVHSYYVANNEEKYVYAVT
DYGVQIPAVIIKDNVFSCQFHPEKSGKVGLKILKNFGEMAKWF

Specific function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to hisF for the synthesis of IGP and AICAR [H]

COG id: COG0118

COG function: function code E; Glutamine amidotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788334, Length=200, Percent_Identity=41.5, Blast_Score=137, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6319725, Length=208, Percent_Identity=34.1346153846154, Blast_Score=113, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR010139
- InterPro:   IPR016226 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 22996; Mature: 22996

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGIIDYGMGNLRSVEKAFEYVGYEAKIIKDVDSVKEAHALVLPGVGAFPDAMDTLIKTS
CEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHH
MLEEIKRQIDKGKLFLGICLGMQLLFEKGFEIEETEGFKIFKGQVIELPKHNKIPHMGWN
HHHHHHHHHHCCCEEHHHHHHHHHHHHCCCCEECCCCEEEECCEEEECCCCCCCCCCCCC
SLEIKKETPLLKGVENGDYAYFVHSYYVANNEEKYVYAVTDYGVQIPAVIIKDNVFSCQF
CEEEECCCCHHCCCCCCCEEEEEEEEEEECCCCEEEEEEECCCEEECEEEEECCEEEEEE
HPEKSGKVGLKILKNFGEMAKWF
CCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIGIIDYGMGNLRSVEKAFEYVGYEAKIIKDVDSVKEAHALVLPGVGAFPDAMDTLIKTS
CEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHH
MLEEIKRQIDKGKLFLGICLGMQLLFEKGFEIEETEGFKIFKGQVIELPKHNKIPHMGWN
HHHHHHHHHHCCCEEHHHHHHHHHHHHCCCCEECCCCEEEECCEEEECCCCCCCCCCCCC
SLEIKKETPLLKGVENGDYAYFVHSYYVANNEEKYVYAVTDYGVQIPAVIIKDNVFSCQF
CEEEECCCCHHCCCCCCCEEEEEEEEEEECCCCEEEEEEECCCEEECEEEEECCEEEEEE
HPEKSGKVGLKILKNFGEMAKWF
CCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Glycosyltransferases; Pentosyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]