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The map label for this gene is hisA

Identifier: 167039655

GI number: 167039655

Start: 1035328

End: 1036035

Strand: Direct

Name: hisA

Synonym: Teth514_1005

Alternate gene names: 167039655

Gene position: 1035328-1036035 (Clockwise)

Preceding gene: 167039654

Following gene: 167039656

Centisome position: 42.13

GC content: 32.34

Gene sequence:

>708_bases
ATGGTTTTAATACCTGCAATTGATATTATGGAAGAAAAATGTGTAAGGCTTACAAAAGGAGATTTTAATACCAAAGAGGT
TTATTATGAAAATCCCGTTGACGTAGCTAAAATGTGGGAGGAATTAGGAGCAAAGAGAATTCATGTGGTAGATTTAGATG
GTGCAAAACAAGGTCATTTGGTAAATGGTAATATCATTGAACAGATTATAAAAAGTTGTAAAGCCGAGATAGAAGTAGGT
GGAGGAATAAGGAATAGAGAAACTATCGATTATCTTTTTTCTGTAGGTGTTAAGTATGTAATTTTAGGTTCGGCGGCAAT
ATATGACAAAGACCTTCTTCTTTATTCCCTTTCCAATTACGGAGAAAGGACGATAGTGGGTATAGATTCAAAGAATGGAG
AAGTTGCCGTAAGTGGATGGCTTGAAAAGACTAAAATAAAAGATATGGAGTTAGCTAAAAAAATGAAAGAAATAGGAGTA
AAAACGATAATTTTCACTGATATTTCTAAAGATGGAACTCTTAATGGACCAAATTTTAAAGCTTTAGAAAATATTTTAAA
AACAGGTGTTCAAGTGATAGCATCAGGAGGAATATCCTCAATTGAGGATTTAAAAAAGCTTAAAGAGATGGGAGCATATG
GTGCGATAATTGGAAAAGCCTTATATATTGGAAAAATAAACTTTAAAAGTGCTTTGGAGGTAATATAA

Upstream 100 bases:

>100_bases
CAGTTATAATTAAAGACAATGTTTTTTCTTGTCAATTCCATCCTGAGAAGAGCGGAAAAGTGGGGCTTAAAATTTTAAAG
AATTTTGGAGAGATGGCAAA

Downstream 100 bases:

>100_bases
ATGCTTGCAAAAAGAATAATTCCTTGTTTAGATGTGAAAGACGGCAGGGTAGTAAAAGGAGTTAACTTTTTAAATTTAAA
AGATGCGGGAGACCCTGTCC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MVLIPAIDIMEEKCVRLTKGDFNTKEVYYENPVDVAKMWEELGAKRIHVVDLDGAKQGHLVNGNIIEQIIKSCKAEIEVG
GGIRNRETIDYLFSVGVKYVILGSAAIYDKDLLLYSLSNYGERTIVGIDSKNGEVAVSGWLEKTKIKDMELAKKMKEIGV
KTIIFTDISKDGTLNGPNFKALENILKTGVQVIASGGISSIEDLKKLKEMGAYGAIIGKALYIGKINFKSALEVI

Sequences:

>Translated_235_residues
MVLIPAIDIMEEKCVRLTKGDFNTKEVYYENPVDVAKMWEELGAKRIHVVDLDGAKQGHLVNGNIIEQIIKSCKAEIEVG
GGIRNRETIDYLFSVGVKYVILGSAAIYDKDLLLYSLSNYGERTIVGIDSKNGEVAVSGWLEKTKIKDMELAKKMKEIGV
KTIIFTDISKDGTLNGPNFKALENILKTGVQVIASGGISSIEDLKKLKEMGAYGAIIGKALYIGKINFKSALEVI
>Mature_235_residues
MVLIPAIDIMEEKCVRLTKGDFNTKEVYYENPVDVAKMWEELGAKRIHVVDLDGAKQGHLVNGNIIEQIIKSCKAEIEVG
GGIRNRETIDYLFSVGVKYVILGSAAIYDKDLLLYSLSNYGERTIVGIDSKNGEVAVSGWLEKTKIKDMELAKKMKEIGV
KTIIFTDISKDGTLNGPNFKALENILKTGVQVIASGGISSIEDLKKLKEMGAYGAIIGKALYIGKINFKSALEVI

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=239, Percent_Identity=33.4728033472803, Blast_Score=137, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_THEPX (B0K628)

Other databases:

- EMBL:   CP000923
- RefSeq:   YP_001662640.1
- ProteinModelPortal:   B0K628
- SMR:   B0K628
- GeneID:   5877714
- GenomeReviews:   CP000923_GR
- KEGG:   tex:Teth514_1005
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   PRK00748
- BioCyc:   TSP1755:TETH514_1005-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 25804; Mature: 25804

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLIPAIDIMEEKCVRLTKGDFNTKEVYYENPVDVAKMWEELGAKRIHVVDLDGAKQGHL
CEEECCHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHCCCEEEEEECCCCCCCEE
VNGNIIEQIIKSCKAEIEVGGGIRNRETIDYLFSVGVKYVILGSAAIYDKDLLLYSLSNY
ECCHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHEEECCCC
GERTIVGIDSKNGEVAVSGWLEKTKIKDMELAKKMKEIGVKTIIFTDISKDGTLNGPNFK
CCEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHH
ALENILKTGVQVIASGGISSIEDLKKLKEMGAYGAIIGKALYIGKINFKSALEVI
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHEEECCCHHHHHHCC
>Mature Secondary Structure
MVLIPAIDIMEEKCVRLTKGDFNTKEVYYENPVDVAKMWEELGAKRIHVVDLDGAKQGHL
CEEECCHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHCCCEEEEEECCCCCCCEE
VNGNIIEQIIKSCKAEIEVGGGIRNRETIDYLFSVGVKYVILGSAAIYDKDLLLYSLSNY
ECCHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHEEECCCC
GERTIVGIDSKNGEVAVSGWLEKTKIKDMELAKKMKEIGVKTIIFTDISKDGTLNGPNFK
CCEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHH
ALENILKTGVQVIASGGISSIEDLKKLKEMGAYGAIIGKALYIGKINFKSALEVI
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHEEECCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA