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The map label for this gene is hisB [H]

Identifier: 167039653

GI number: 167039653

Start: 1034080

End: 1034664

Strand: Direct

Name: hisB [H]

Synonym: Teth514_1003

Alternate gene names: 167039653

Gene position: 1034080-1034664 (Clockwise)

Preceding gene: 167039652

Following gene: 167039654

Centisome position: 42.08

GC content: 37.26

Gene sequence:

>585_bases
ATGAGGAAGGCGGAAGTTAAAAGAAAAACTAAAGAGACGGATATATACGCTGAACTTAATATTGACGGAAAAGGAAATTA
TGACATAGCTACAGGAATAGGTTTTTTTGACCACATGCTTTCTTTATTTGCCAAGCATGGACTTTTTGATTTAAAAGTAG
TGGCAAAGGGAGATTTAGAGGTAGACACTCATCACACTGTTGAAGACGTAGGTATTGTATTGGGCAATGCTTTTTTAAAG
GCTGCCGGCGATAAAAAATCTATTAAGAGGTTTAGTACATTTTATGTACCCATGGACGAAGCCTTAGTGAGAGTTTCTGT
AGACATAAGTGGAAGGTCTTTTTTATACTGTGATTTGCCTTTAAAAGCTGAAAGAGTTGGAAATTTTGAAACGGAAAATG
TGGAAGAATTTTTAAGAGCCTTTGCTTACAACTTTGGCATTACACTACATGTAGAACTTTTGCACGGCGGTAACAGTCAT
CACATTATAGAGGCAACTTTTAAAGCACTGGGGAGGGCTCTTGATGAGGCATTGAGAATAGATGAAAGGGCAGAGGGTAT
ACCTTCTACTAAAGGGATTTTATAA

Upstream 100 bases:

>100_bases
ATTTTTCAAAGGTAGAAGGGCTTGAAGGAGCTTTAAGGATAACAGTGAGTAGTTGCGAGGCTAATGATTATTTAATAAAT
GGGTTAAAGGAGTTATTGCT

Downstream 100 bases:

>100_bases
AGATACAGTTTAAGGGAGATTGCATATACTTTACACGTAACTTAAGTGAGGCGGTGAAAAATTGATAGGGATTATTGACT
ATGGAATGGGAAATTTAAGG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MRKAEVKRKTKETDIYAELNIDGKGNYDIATGIGFFDHMLSLFAKHGLFDLKVVAKGDLEVDTHHTVEDVGIVLGNAFLK
AAGDKKSIKRFSTFYVPMDEALVRVSVDISGRSFLYCDLPLKAERVGNFETENVEEFLRAFAYNFGITLHVELLHGGNSH
HIIEATFKALGRALDEALRIDERAEGIPSTKGIL

Sequences:

>Translated_194_residues
MRKAEVKRKTKETDIYAELNIDGKGNYDIATGIGFFDHMLSLFAKHGLFDLKVVAKGDLEVDTHHTVEDVGIVLGNAFLK
AAGDKKSIKRFSTFYVPMDEALVRVSVDISGRSFLYCDLPLKAERVGNFETENVEEFLRAFAYNFGITLHVELLHGGNSH
HIIEATFKALGRALDEALRIDERAEGIPSTKGIL
>Mature_194_residues
MRKAEVKRKTKETDIYAELNIDGKGNYDIATGIGFFDHMLSLFAKHGLFDLKVVAKGDLEVDTHHTVEDVGIVLGNAFLK
AAGDKKSIKRFSTFYVPMDEALVRVSVDISGRSFLYCDLPLKAERVGNFETENVEEFLRAFAYNFGITLHVELLHGGNSH
HIIEATFKALGRALDEALRIDERAEGIPSTKGIL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=193, Percent_Identity=47.1502590673575, Blast_Score=177, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6324776, Length=217, Percent_Identity=40.0921658986175, Blast_Score=150, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21601; Mature: 21601

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKAEVKRKTKETDIYAELNIDGKGNYDIATGIGFFDHMLSLFAKHGLFDLKVVAKGDLE
CCCCHHHHHCCCCEEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEE
VDTHHTVEDVGIVLGNAFLKAAGDKKSIKRFSTFYVPMDEALVRVSVDISGRSFLYCDLP
ECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHEEECCHHHEEEEEEEEECCCEEEEECCC
LKAERVGNFETENVEEFLRAFAYNFGITLHVELLHGGNSHHIIEATFKALGRALDEALRI
CCHHHCCCCCCCCHHHHHHHHHHHCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
DERAEGIPSTKGIL
HHHHCCCCCCCCCC
>Mature Secondary Structure
MRKAEVKRKTKETDIYAELNIDGKGNYDIATGIGFFDHMLSLFAKHGLFDLKVVAKGDLE
CCCCHHHHHCCCCEEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEE
VDTHHTVEDVGIVLGNAFLKAAGDKKSIKRFSTFYVPMDEALVRVSVDISGRSFLYCDLP
ECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHEEECCHHHEEEEEEEEECCCEEEEECCC
LKAERVGNFETENVEEFLRAFAYNFGITLHVELLHGGNSHHIIEATFKALGRALDEALRI
CCHHHCCCCCCCCHHHHHHHHHHHCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
DERAEGIPSTKGIL
HHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA