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The map label for this gene is hisC [H]

Identifier: 167039652

GI number: 167039652

Start: 1033028

End: 1034083

Strand: Direct

Name: hisC [H]

Synonym: Teth514_1002

Alternate gene names: 167039652

Gene position: 1033028-1034083 (Clockwise)

Preceding gene: 167039651

Following gene: 167039653

Centisome position: 42.04

GC content: 32.39

Gene sequence:

>1056_bases
ATGATTGAGAATTTGGTGAGAGAAGAAATTAAGGGATTTAAAAATTATGAAGTGCACAGTATTCCCTACAGATATAAGAT
GGATGCAAATGAAACGCCTTTTGAACTTCCTGAAGAAGTGATAAAAAATATTCAAGAGATTGTAAAATCTTCTCAAGTAA
ATGTATATCCAGACCCTACTGCAGAAAAGTTAAAAGAAGAATTGGCACGATATTGTGGAGTAGTGCCTACAAACATATTT
GTGGGAAATGGCTCGGATGAGATAATCCACCTTATTATGCTGGCTTTCATAAACAAAGGTGATGTGGTAGCATATCCTCA
TCCTTCTTTTGCTATGTACAGTGTATATAGCAAAATTGCAGGAGCAGTCGAAATACCTGTAAGGTTGAGAGAAGATTATA
ATTACGATGTTGATAGTTTTATTAAAGTTATAGAAAAATATCAGCCTAAATTAGTGTTTTTGTGCAACCCTAATAATCCA
ACAGGAAGTGTTATAGAAAGAGAAGATATAATTAAAATAATACAAAAGAGCAATGGAATTGTAGTTGTTGACGAAGCTTA
TTTTGAGTTTTATGGTAATACAATTGTAGATGCTATAAATGAATTTGAAAACTTGATTGTTTTAAGGACCTTATCTAAGG
CTTTTGGACTTGCCGGTTTGAGAGTAGGATATGCTGTAGCTAACGAGAATATTTTAAAGTATTTAAACCTTGTGAAATCA
CCTTATAACATTAACTCTTTATCTCAGATAATAGCTTTGAAGGTTTTAAGGACAGATGTTTTAAAAGAAAGAATTAACTA
CATTTTAGAAGAAAGAAAGCGTCTTATAAAAGAGCTAGGCAAAATTCCTGGCGTTAAAGTTTATCCCTCAAAAACGAATT
TTATATTGGTAAAATTTAAAGATGCAGATTATGTGTACCAGGGGCTTTTAGAAAGAGGAATTTTGGTGAGAGATTTTTCA
AAGGTAGAAGGGCTTGAAGGAGCTTTAAGGATAACAGTGAGTAGTTGCGAGGCTAATGATTATTTAATAAATGGGTTAAA
GGAGTTATTGCTATGA

Upstream 100 bases:

>100_bases
TCTAAGGATTCTTTGAGAGAGGTAAAAGAGGATGTAATAACTTTAGCAAATTCAGAAGGGCTTACCGCTCATGCTAATTC
TATAAAAGTGAGGTTTTAAA

Downstream 100 bases:

>100_bases
GGAAGGCGGAAGTTAAAAGAAAAACTAAAGAGACGGATATATACGCTGAACTTAATATTGACGGAAAAGGAAATTATGAC
ATAGCTACAGGAATAGGTTT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MIENLVREEIKGFKNYEVHSIPYRYKMDANETPFELPEEVIKNIQEIVKSSQVNVYPDPTAEKLKEELARYCGVVPTNIF
VGNGSDEIIHLIMLAFINKGDVVAYPHPSFAMYSVYSKIAGAVEIPVRLREDYNYDVDSFIKVIEKYQPKLVFLCNPNNP
TGSVIEREDIIKIIQKSNGIVVVDEAYFEFYGNTIVDAINEFENLIVLRTLSKAFGLAGLRVGYAVANENILKYLNLVKS
PYNINSLSQIIALKVLRTDVLKERINYILEERKRLIKELGKIPGVKVYPSKTNFILVKFKDADYVYQGLLERGILVRDFS
KVEGLEGALRITVSSCEANDYLINGLKELLL

Sequences:

>Translated_351_residues
MIENLVREEIKGFKNYEVHSIPYRYKMDANETPFELPEEVIKNIQEIVKSSQVNVYPDPTAEKLKEELARYCGVVPTNIF
VGNGSDEIIHLIMLAFINKGDVVAYPHPSFAMYSVYSKIAGAVEIPVRLREDYNYDVDSFIKVIEKYQPKLVFLCNPNNP
TGSVIEREDIIKIIQKSNGIVVVDEAYFEFYGNTIVDAINEFENLIVLRTLSKAFGLAGLRVGYAVANENILKYLNLVKS
PYNINSLSQIIALKVLRTDVLKERINYILEERKRLIKELGKIPGVKVYPSKTNFILVKFKDADYVYQGLLERGILVRDFS
KVEGLEGALRITVSSCEANDYLINGLKELLL
>Mature_351_residues
MIENLVREEIKGFKNYEVHSIPYRYKMDANETPFELPEEVIKNIQEIVKSSQVNVYPDPTAEKLKEELARYCGVVPTNIF
VGNGSDEIIHLIMLAFINKGDVVAYPHPSFAMYSVYSKIAGAVEIPVRLREDYNYDVDSFIKVIEKYQPKLVFLCNPNNP
TGSVIEREDIIKIIQKSNGIVVVDEAYFEFYGNTIVDAINEFENLIVLRTLSKAFGLAGLRVGYAVANENILKYLNLVKS
PYNINSLSQIIALKVLRTDVLKERINYILEERKRLIKELGKIPGVKVYPSKTNFILVKFKDADYVYQGLLERGILVRDFS
KVEGLEGALRITVSSCEANDYLINGLKELLL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=354, Percent_Identity=33.3333333333333, Blast_Score=194, Evalue=5e-51,
Organism=Escherichia coli, GI1788722, Length=243, Percent_Identity=27.1604938271605, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788627, Length=230, Percent_Identity=25.6521739130435, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=210, Percent_Identity=28.0952380952381, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71994472, Length=210, Percent_Identity=28.0952380952381, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17567369, Length=178, Percent_Identity=28.0898876404494, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71981209, Length=334, Percent_Identity=24.251497005988, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=361, Percent_Identity=33.5180055401662, Blast_Score=160, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 39964; Mature: 39964

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIENLVREEIKGFKNYEVHSIPYRYKMDANETPFELPEEVIKNIQEIVKSSQVNVYPDPT
CCHHHHHHHHCCCCCCCEEECCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCC
AEKLKEELARYCGVVPTNIFVGNGSDEIIHLIMLAFINKGDVVAYPHPSFAMYSVYSKIA
HHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHC
GAVEIPVRLREDYNYDVDSFIKVIEKYQPKLVFLCNPNNPTGSVIEREDIIKIIQKSNGI
CCEEECEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCE
VVVDEAYFEFYGNTIVDAINEFENLIVLRTLSKAFGLAGLRVGYAVANENILKYLNLVKS
EEEEHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
PYNINSLSQIIALKVLRTDVLKERINYILEERKRLIKELGKIPGVKVYPSKTNFILVKFK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEC
DADYVYQGLLERGILVRDFSKVEGLEGALRITVSSCEANDYLINGLKELLL
CHHHHHHHHHHCCCEEEHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MIENLVREEIKGFKNYEVHSIPYRYKMDANETPFELPEEVIKNIQEIVKSSQVNVYPDPT
CCHHHHHHHHCCCCCCCEEECCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCC
AEKLKEELARYCGVVPTNIFVGNGSDEIIHLIMLAFINKGDVVAYPHPSFAMYSVYSKIA
HHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHC
GAVEIPVRLREDYNYDVDSFIKVIEKYQPKLVFLCNPNNPTGSVIEREDIIKIIQKSNGI
CCEEECEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCE
VVVDEAYFEFYGNTIVDAINEFENLIVLRTLSKAFGLAGLRVGYAVANENILKYLNLVKS
EEEEHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
PYNINSLSQIIALKVLRTDVLKERINYILEERKRLIKELGKIPGVKVYPSKTNFILVKFK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEC
DADYVYQGLLERGILVRDFSKVEGLEGALRITVSSCEANDYLINGLKELLL
CHHHHHHHHHHCCCEEEHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA