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The map label for this gene is dxs [C]

Identifier: 167039621

GI number: 167039621

Start: 989121

End: 990041

Strand: Direct

Name: dxs [C]

Synonym: Teth514_0969

Alternate gene names: 167039621

Gene position: 989121-990041 (Clockwise)

Preceding gene: 167039620

Following gene: 167039623

Centisome position: 40.25

GC content: 41.15

Gene sequence:

>921_bases
ATGGCTATGGCGACAAGAGAAGCCTATGGGAAAGCCTTAGTAGAATTAGGCGCAAAAAACAAAGATGTAGTGGTATTAGA
CGCTGACCTATCAAAATCCACAAAGACGGCAGATTTTCAAAAAGTATATCCAGATAGATTTTTTAACATGGGAATATCAG
AGCAAGATATGATGGTAACAGCAGCAGGACTCGCTACCTGTGGGAAAATTCCTTTTGCCAGCACTTTTGCCATATTTGCA
ACAGGAAGAGCTTATGAGCAAGTGAGAAACTCCATAGGTTATCCACACTTAAACGTAAAAATAGCAGCTACCCATGCTGG
CATAACAGTAGGAGAAGACGGAGCGACACACCAATCAATAGAGGATATATCCCTTATGAGAGGAATACCTGGGATGGTGG
TAATAAACCCAGCCGATGCAGAAGAGACGAGACAAGCCATATTTGCGGCTGCAGAACACTATGGACCAGTATACATAAGA
TTGGGGAGGATGGCAGTACCAGATATACACGATCAAAACTACAAATTTGAATTAGGAAAAGGTGAAGTAATAAGAGAAGG
GAAAGACGTAGCGATAATAGCGACAGGGATAATGGTAGCCATAGCGATTGAAGCAGCAGATAAACTAAAAGAAGAGGGAA
TAGAAGCGACAGTGGTGAACATCCACACAATAAAGCCGATAGACAAAGATTTAATAGTAGAAGTAGCTAAAAAGACGGGC
AAAGTTATAACAGCAGAAGAGCACAGCATAATAGGTGGGCTTGGTTCGGCGGTAGCAGAGGTTCTTTCAGAGGAATATCC
AGTGAAGATAAAGAGAATTGGAATAAGAGATGAGTTTGGACAATCCGGTTCACCTAAAGAGCTTTTAAAACATTATGGTT
TGACAGCGGAGGATATTGTAAAAGCAGCTAAGTCATTTTAA

Upstream 100 bases:

>100_bases
CGTATCCTTCATGGAAAATCAAGTAGGATGGCATGGCAGTGCGCCTAACGAAGAACAAAGACAAAAAGCTATACAAGAAC
TTGAAGGGAGTGGAGTATAA

Downstream 100 bases:

>100_bases
AAAATGCCAGGATTTAACCTGGCATTTTTTATCTATCAAAGTATATGTTTTTGCCTGTAGCAGAAAGAGGAATGCCTATA
ACAATTTCTCCTTCAATTAA

Product: transketolase, central region

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MAMATREAYGKALVELGAKNKDVVVLDADLSKSTKTADFQKVYPDRFFNMGISEQDMMVTAAGLATCGKIPFASTFAIFA
TGRAYEQVRNSIGYPHLNVKIAATHAGITVGEDGATHQSIEDISLMRGIPGMVVINPADAEETRQAIFAAAEHYGPVYIR
LGRMAVPDIHDQNYKFELGKGEVIREGKDVAIIATGIMVAIAIEAADKLKEEGIEATVVNIHTIKPIDKDLIVEVAKKTG
KVITAEEHSIIGGLGSAVAEVLSEEYPVKIKRIGIRDEFGQSGSPKELLKHYGLTAEDIVKAAKSF

Sequences:

>Translated_306_residues
MAMATREAYGKALVELGAKNKDVVVLDADLSKSTKTADFQKVYPDRFFNMGISEQDMMVTAAGLATCGKIPFASTFAIFA
TGRAYEQVRNSIGYPHLNVKIAATHAGITVGEDGATHQSIEDISLMRGIPGMVVINPADAEETRQAIFAAAEHYGPVYIR
LGRMAVPDIHDQNYKFELGKGEVIREGKDVAIIATGIMVAIAIEAADKLKEEGIEATVVNIHTIKPIDKDLIVEVAKKTG
KVITAEEHSIIGGLGSAVAEVLSEEYPVKIKRIGIRDEFGQSGSPKELLKHYGLTAEDIVKAAKSF
>Mature_305_residues
AMATREAYGKALVELGAKNKDVVVLDADLSKSTKTADFQKVYPDRFFNMGISEQDMMVTAAGLATCGKIPFASTFAIFAT
GRAYEQVRNSIGYPHLNVKIAATHAGITVGEDGATHQSIEDISLMRGIPGMVVINPADAEETRQAIFAAAEHYGPVYIRL
GRMAVPDIHDQNYKFELGKGEVIREGKDVAIIATGIMVAIAIEAADKLKEEGIEATVVNIHTIKPIDKDLIVEVAKKTGK
VITAEEHSIIGGLGSAVAEVLSEEYPVKIKRIGIRDEFGQSGSPKELLKHYGLTAEDIVKAAKSF

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=306, Percent_Identity=35.9477124183007, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI4507521, Length=306, Percent_Identity=35.9477124183007, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI225637463, Length=307, Percent_Identity=39.413680781759, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI225637459, Length=307, Percent_Identity=39.413680781759, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI225637461, Length=307, Percent_Identity=39.413680781759, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI133778974, Length=303, Percent_Identity=34.983498349835, Blast_Score=178, Evalue=4e-45,
Organism=Homo sapiens, GI4557353, Length=235, Percent_Identity=27.2340425531915, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI34101272, Length=235, Percent_Identity=27.2340425531915, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI291084858, Length=276, Percent_Identity=22.463768115942, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI156564403, Length=281, Percent_Identity=22.0640569395018, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786622, Length=302, Percent_Identity=34.4370860927152, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI48994911, Length=314, Percent_Identity=26.1146496815287, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1788808, Length=310, Percent_Identity=26.4516129032258, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17539652, Length=309, Percent_Identity=37.5404530744337, Blast_Score=202, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17506935, Length=157, Percent_Identity=28.6624203821656, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319593, Length=327, Percent_Identity=29.9694189602446, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325331, Length=324, Percent_Identity=29.0123456790123, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319698, Length=281, Percent_Identity=27.4021352313167, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI45551847, Length=306, Percent_Identity=35.6209150326797, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI45550715, Length=306, Percent_Identity=35.6209150326797, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24645119, Length=306, Percent_Identity=35.6209150326797, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24666278, Length=307, Percent_Identity=34.8534201954397, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI160714832, Length=201, Percent_Identity=31.3432835820896, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI160714828, Length=201, Percent_Identity=31.3432835820896, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21358145, Length=280, Percent_Identity=25, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24650940, Length=280, Percent_Identity=25, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 32945; Mature: 32814

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMATREAYGKALVELGAKNKDVVVLDADLSKSTKTADFQKVYPDRFFNMGISEQDMMVT
CCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHCCHHHHCCCCCCCHHEEE
AAGLATCGKIPFASTFAIFATGRAYEQVRNSIGYPHLNVKIAATHAGITVGEDGATHQSI
EHHHHHHCCCCCCCEEEEEECCHHHHHHHHHCCCCEEEEEEEEEECCEEECCCCCCHHHH
EDISLMRGIPGMVVINPADAEETRQAIFAAAEHYGPVYIRLGRMAVPDIHDQNYKFELGK
HHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCEECCCCCCCCEEEECCC
GEVIREGKDVAIIATGIMVAIAIEAADKLKEEGIEATVVNIHTIKPIDKDLIVEVAKKTG
CCEEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHCC
KVITAEEHSIIGGLGSAVAEVLSEEYPVKIKRIGIRDEFGQSGSPKELLKHYGLTAEDIV
CEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHCCCCCCHHHHHHHCCCCHHHHH
KAAKSF
HHHHCC
>Mature Secondary Structure 
AMATREAYGKALVELGAKNKDVVVLDADLSKSTKTADFQKVYPDRFFNMGISEQDMMVT
CCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHCCHHHHCCCCCCCHHEEE
AAGLATCGKIPFASTFAIFATGRAYEQVRNSIGYPHLNVKIAATHAGITVGEDGATHQSI
EHHHHHHCCCCCCCEEEEEECCHHHHHHHHHCCCCEEEEEEEEEECCEEECCCCCCHHHH
EDISLMRGIPGMVVINPADAEETRQAIFAAAEHYGPVYIRLGRMAVPDIHDQNYKFELGK
HHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCEECCCCCCCCEEEECCC
GEVIREGKDVAIIATGIMVAIAIEAADKLKEEGIEATVVNIHTIKPIDKDLIVEVAKKTG
CCEEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHCC
KVITAEEHSIIGGLGSAVAEVLSEEYPVKIKRIGIRDEFGQSGSPKELLKHYGLTAEDIV
CEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHCCCCCCHHHHHHHCCCCHHHHH
KAAKSF
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]