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The map label for this gene is tktA [C]

Identifier: 167039620

GI number: 167039620

Start: 988299

End: 989120

Strand: Direct

Name: tktA [C]

Synonym: Teth514_0968

Alternate gene names: 167039620

Gene position: 988299-989120 (Clockwise)

Preceding gene: 167039619

Following gene: 167039621

Centisome position: 40.22

GC content: 39.54

Gene sequence:

>822_bases
ATGGACAAAGAATTTTTAAAGCAAAAGGCAAAAGAAGTGAGAATAGACATCATAAACATGTTGGCAGAAGCAGGATCTGG
CCATCCTGGGGGGTCATTATCCTGTGCAGATATTTTAACCCTGCTCTATTTTGACAAAATGAATGTAAAGCCTGACAATC
CCAAATGGGAAGATAGGGACAGACTTGTGCTTTCAAAAGGTCATGCAGCTCCTGCCCTGTATGCTGTATTAGCTGAAAAA
GGGTTTTTCCCGAAAGAAGAGTTAAAAACTTTAAGAAAGCTTGGCTCAATACTTCAAGGGCATCCCGATATGAAATCCAC
ACCGGGACTTGATATGACCACAGGGTCATTAGGGCAAGGACTTTCTGCTGCAAATGGAATGGCATTAGCAGGTAAATTAG
ATAAAAAGGGCTATAGAGTCTATGTAATATTAGGAGATGGAGAATTACAAGAAGGGCAAATATGGGAAGCAGCTATGACA
GCAGCCCATTACAAATTGGACAACTTAACAGCAATACTTGACTTTAACGGCTTACAAATAGATGGCCCAAACAGAGAAGT
AAAAAACATAGAACCAGTAAATGAAAAATTCAATGCTTTTGGATGGCACGTAATAGAAATAGACGGTCACGACTTTGACC
AAATAGACAAAGCCATAGAAGAAGCAAAAGCTACAAAAGGAAAACCCACTTTGATAATAGCTCATACAATAAAAGGAAAA
GGCGTATCCTTCATGGAAAATCAAGTAGGATGGCATGGCAGTGCGCCTAACGAAGAACAAAGACAAAAAGCTATACAAGA
ACTTGAAGGGAGTGGAGTATAA

Upstream 100 bases:

>100_bases
CCTTGTGAAAAGAATAGACCCCAACGCTTTCATGATATTATCAACAGCCCATGAAGTTTTAGGAGAAGGATTTAAAAACA
TGTGAAATGGAGGTATTGGT

Downstream 100 bases:

>100_bases
ATGGCTATGGCGACAAGAGAAGCCTATGGGAAAGCCTTAGTAGAATTAGGCGCAAAAAACAAAGATGTAGTGGTATTAGA
CGCTGACCTATCAAAATCCA

Product: transketolase domain-containing protein

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MDKEFLKQKAKEVRIDIINMLAEAGSGHPGGSLSCADILTLLYFDKMNVKPDNPKWEDRDRLVLSKGHAAPALYAVLAEK
GFFPKEELKTLRKLGSILQGHPDMKSTPGLDMTTGSLGQGLSAANGMALAGKLDKKGYRVYVILGDGELQEGQIWEAAMT
AAHYKLDNLTAILDFNGLQIDGPNREVKNIEPVNEKFNAFGWHVIEIDGHDFDQIDKAIEEAKATKGKPTLIIAHTIKGK
GVSFMENQVGWHGSAPNEEQRQKAIQELEGSGV

Sequences:

>Translated_273_residues
MDKEFLKQKAKEVRIDIINMLAEAGSGHPGGSLSCADILTLLYFDKMNVKPDNPKWEDRDRLVLSKGHAAPALYAVLAEK
GFFPKEELKTLRKLGSILQGHPDMKSTPGLDMTTGSLGQGLSAANGMALAGKLDKKGYRVYVILGDGELQEGQIWEAAMT
AAHYKLDNLTAILDFNGLQIDGPNREVKNIEPVNEKFNAFGWHVIEIDGHDFDQIDKAIEEAKATKGKPTLIIAHTIKGK
GVSFMENQVGWHGSAPNEEQRQKAIQELEGSGV
>Mature_273_residues
MDKEFLKQKAKEVRIDIINMLAEAGSGHPGGSLSCADILTLLYFDKMNVKPDNPKWEDRDRLVLSKGHAAPALYAVLAEK
GFFPKEELKTLRKLGSILQGHPDMKSTPGLDMTTGSLGQGLSAANGMALAGKLDKKGYRVYVILGDGELQEGQIWEAAMT
AAHYKLDNLTAILDFNGLQIDGPNREVKNIEPVNEKFNAFGWHVIEIDGHDFDQIDKAIEEAKATKGKPTLIIAHTIKGK
GVSFMENQVGWHGSAPNEEQRQKAIQELEGSGV

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=264, Percent_Identity=47.7272727272727, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI4507521, Length=264, Percent_Identity=47.7272727272727, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI133778974, Length=266, Percent_Identity=42.1052631578947, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI225637459, Length=268, Percent_Identity=33.2089552238806, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI225637461, Length=235, Percent_Identity=33.6170212765957, Blast_Score=128, Evalue=5e-30,
Organism=Homo sapiens, GI225637463, Length=231, Percent_Identity=32.9004329004329, Blast_Score=125, Evalue=3e-29,
Organism=Escherichia coli, GI48994911, Length=260, Percent_Identity=40.3846153846154, Blast_Score=176, Evalue=1e-45,
Organism=Escherichia coli, GI1788808, Length=274, Percent_Identity=39.4160583941606, Blast_Score=174, Evalue=6e-45,
Organism=Escherichia coli, GI1786304, Length=230, Percent_Identity=27.8260869565217, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17539652, Length=265, Percent_Identity=46.4150943396226, Blast_Score=226, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6325331, Length=248, Percent_Identity=42.3387096774194, Blast_Score=167, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6319593, Length=262, Percent_Identity=36.2595419847328, Blast_Score=153, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24666278, Length=268, Percent_Identity=46.6417910447761, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI45551847, Length=269, Percent_Identity=43.1226765799257, Blast_Score=214, Evalue=5e-56,
Organism=Drosophila melanogaster, GI45550715, Length=269, Percent_Identity=43.1226765799257, Blast_Score=214, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24645119, Length=236, Percent_Identity=43.2203389830509, Blast_Score=191, Evalue=5e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 29891; Mature: 29891

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKEFLKQKAKEVRIDIINMLAEAGSGHPGGSLSCADILTLLYFDKMNVKPDNPKWEDRD
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
RLVLSKGHAAPALYAVLAEKGFFPKEELKTLRKLGSILQGHPDMKSTPGLDMTTGSLGQG
CEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
LSAANGMALAGKLDKKGYRVYVILGDGELQEGQIWEAAMTAAHYKLDNLTAILDFNGLQI
CCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCEEE
DGPNREVKNIEPVNEKFNAFGWHVIEIDGHDFDQIDKAIEEAKATKGKPTLIIAHTIKGK
CCCCCCCCCCCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCC
GVSFMENQVGWHGSAPNEEQRQKAIQELEGSGV
CCHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDKEFLKQKAKEVRIDIINMLAEAGSGHPGGSLSCADILTLLYFDKMNVKPDNPKWEDRD
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
RLVLSKGHAAPALYAVLAEKGFFPKEELKTLRKLGSILQGHPDMKSTPGLDMTTGSLGQG
CEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
LSAANGMALAGKLDKKGYRVYVILGDGELQEGQIWEAAMTAAHYKLDNLTAILDFNGLQI
CCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCEEE
DGPNREVKNIEPVNEKFNAFGWHVIEIDGHDFDQIDKAIEEAKATKGKPTLIIAHTIKGK
CCCCCCCCCCCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCC
GVSFMENQVGWHGSAPNEEQRQKAIQELEGSGV
CCHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]