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The map label for this gene is adk

Identifier: 167039540

GI number: 167039540

Start: 915008

End: 915661

Strand: Direct

Name: adk

Synonym: Teth514_0887

Alternate gene names: 167039540

Gene position: 915008-915661 (Clockwise)

Preceding gene: 167039539

Following gene: 167039541

Centisome position: 37.24

GC content: 35.47

Gene sequence:

>654_bases
ATGAGAGTAATACTTTTAGGCCCCCCAGGTGCAGGCAAAGGGACGCAAGCTGTGAAAATTGCTAAGGAGTTTGACATTCC
TCACATATCTACTGGAGATATTTTTAGACAAAATTTAAGAGACAATACTGACTTAGGGAAACTTGCAAAAGAATACATGG
ACAAAGGATTATTGGTCCCCGATGAGGTTACGAATAAAATAGTAGAAGATAGATTAGAAAAAGATGATTGCCAAAAAGGG
TTTTTATTAGATGGTTACCCCAGAAATGTTGCACAGGCTGAGGAATTAGACAGGTTTTTACATGACAAAGGCATTCATCT
AGATTGTGTATTAAATATTGAAGTTGACAGAGAAGCTTTAATTGAAAGAATAACAGGCAGAAGAGTATGTCCTAATTGCG
GTGCGACTTATCACATAAAGACTTCTCCTCCTGCAGTCGACAATGTATGTGATAAATGTGGTGCACAACTTATACAGCGT
TCAGATGATAAATTAGAATCAGTTGTAAAAAGATTAGAGGTTTATGAAAGTCAAACTAAGCCTTTGATTGAGTATTATAC
AAAGAAAAACACTTTAGTGAATATTGATGGAAATAAATCGGTAGAAGAAGTATTTGAAGATATAAAAAAGGCTTTGGGAG
ACAGAGGCAAATGA

Upstream 100 bases:

>100_bases
TAATTGCAGTTGGTGTAGCGCTTGATACTATGAAACAAATTGAAGGACATCTTATCATGAGGAATTATCAAGGATTTTTG
AAATAAAAGGGGGAGGATTT

Downstream 100 bases:

>100_bases
TATATATTAAGTCTAAGAATGAAATTGATTTGATGAGAACAGCTGGCAAGGTAATAGCAAATCTCTTTGAGGTTTTAGAA
AGGGCAATTAAGCCAGGAGT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MRVILLGPPGAGKGTQAVKIAKEFDIPHISTGDIFRQNLRDNTDLGKLAKEYMDKGLLVPDEVTNKIVEDRLEKDDCQKG
FLLDGYPRNVAQAEELDRFLHDKGIHLDCVLNIEVDREALIERITGRRVCPNCGATYHIKTSPPAVDNVCDKCGAQLIQR
SDDKLESVVKRLEVYESQTKPLIEYYTKKNTLVNIDGNKSVEEVFEDIKKALGDRGK

Sequences:

>Translated_217_residues
MRVILLGPPGAGKGTQAVKIAKEFDIPHISTGDIFRQNLRDNTDLGKLAKEYMDKGLLVPDEVTNKIVEDRLEKDDCQKG
FLLDGYPRNVAQAEELDRFLHDKGIHLDCVLNIEVDREALIERITGRRVCPNCGATYHIKTSPPAVDNVCDKCGAQLIQR
SDDKLESVVKRLEVYESQTKPLIEYYTKKNTLVNIDGNKSVEEVFEDIKKALGDRGK
>Mature_217_residues
MRVILLGPPGAGKGTQAVKIAKEFDIPHISTGDIFRQNLRDNTDLGKLAKEYMDKGLLVPDEVTNKIVEDRLEKDDCQKG
FLLDGYPRNVAQAEELDRFLHDKGIHLDCVLNIEVDREALIERITGRRVCPNCGATYHIKTSPPAVDNVCDKCGAQLIQR
SDDKLESVVKRLEVYESQTKPLIEYYTKKNTLVNIDGNKSVEEVFEDIKKALGDRGK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=213, Percent_Identity=43.1924882629108, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI4502013, Length=213, Percent_Identity=43.1924882629108, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI19923437, Length=200, Percent_Identity=41.5, Blast_Score=174, Evalue=4e-44,
Organism=Homo sapiens, GI310110345, Length=200, Percent_Identity=37.5, Blast_Score=155, Evalue=2e-38,
Organism=Homo sapiens, GI53832003, Length=200, Percent_Identity=37.5, Blast_Score=155, Evalue=2e-38,
Organism=Homo sapiens, GI8051579, Length=200, Percent_Identity=37.5, Blast_Score=155, Evalue=2e-38,
Organism=Homo sapiens, GI53832001, Length=200, Percent_Identity=37.5, Blast_Score=155, Evalue=2e-38,
Organism=Homo sapiens, GI22749187, Length=212, Percent_Identity=30.188679245283, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI4502011, Length=207, Percent_Identity=30.9178743961353, Blast_Score=107, Evalue=6e-24,
Organism=Homo sapiens, GI28144899, Length=217, Percent_Identity=28.5714285714286, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI28144897, Length=210, Percent_Identity=29.0476190476191, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI7706497, Length=219, Percent_Identity=29.6803652968037, Blast_Score=96, Evalue=2e-20,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=45.8715596330275, Blast_Score=190, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17552384, Length=204, Percent_Identity=42.156862745098, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17537943, Length=214, Percent_Identity=31.3084112149533, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17567503, Length=204, Percent_Identity=30.8823529411765, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17533833, Length=211, Percent_Identity=28.9099526066351, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17550688, Length=211, Percent_Identity=29.3838862559242, Blast_Score=98, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320432, Length=214, Percent_Identity=40.6542056074766, Blast_Score=184, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=35.8585858585859, Blast_Score=130, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6322828, Length=217, Percent_Identity=31.3364055299539, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI22026816, Length=208, Percent_Identity=42.3076923076923, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI17737899, Length=215, Percent_Identity=38.1395348837209, Blast_Score=145, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24645822, Length=215, Percent_Identity=38.1395348837209, Blast_Score=145, Evalue=1e-35,
Organism=Drosophila melanogaster, GI221459597, Length=209, Percent_Identity=29.6650717703349, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21356893, Length=209, Percent_Identity=29.6650717703349, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24663208, Length=211, Percent_Identity=25.5924170616114, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17647141, Length=211, Percent_Identity=25.5924170616114, Blast_Score=88, Evalue=4e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_THEP3 (B0KCM0)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001664399.1
- ProteinModelPortal:   B0KCM0
- SMR:   B0KCM0
- GeneID:   5874138
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_0394
- HOGENOM:   HBG630208
- OMA:   AKNRIMG
- ProtClustDB:   PRK00279
- BioCyc:   TPSE340099:TETH39_0394-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- InterPro:   IPR001878
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- SMART:   SM00343
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24396; Mature: 24396

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVILLGPPGAGKGTQAVKIAKEFDIPHISTGDIFRQNLRDNTDLGKLAKEYMDKGLLVP
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
DEVTNKIVEDRLEKDDCQKGFLLDGYPRNVAQAEELDRFLHDKGIHLDCVLNIEVDREAL
HHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCHHHH
IERITGRRVCPNCGATYHIKTSPPAVDNVCDKCGAQLIQRSDDKLESVVKRLEVYESQTK
HHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
PLIEYYTKKNTLVNIDGNKSVEEVFEDIKKALGDRGK
HHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRVILLGPPGAGKGTQAVKIAKEFDIPHISTGDIFRQNLRDNTDLGKLAKEYMDKGLLVP
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
DEVTNKIVEDRLEKDDCQKGFLLDGYPRNVAQAEELDRFLHDKGIHLDCVLNIEVDREAL
HHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCHHHH
IERITGRRVCPNCGATYHIKTSPPAVDNVCDKCGAQLIQRSDDKLESVVKRLEVYESQTK
HHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
PLIEYYTKKNTLVNIDGNKSVEEVFEDIKKALGDRGK
HHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA