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The map label for this gene is map [H]

Identifier: 167039541

GI number: 167039541

Start: 915658

End: 916404

Strand: Direct

Name: map [H]

Synonym: Teth514_0888

Alternate gene names: 167039541

Gene position: 915658-916404 (Clockwise)

Preceding gene: 167039540

Following gene: 167039542

Centisome position: 37.26

GC content: 35.88

Gene sequence:

>747_bases
ATGATATATATTAAGTCTAAGAATGAAATTGATTTGATGAGAACAGCTGGCAAGGTAATAGCAAATCTCTTTGAGGTTTT
AGAAAGGGCAATTAAGCCAGGAGTTACGACATTAGAGCTTGATAGAATTGCAGAAGAGTTTATAATAAAAAATGGTTGTA
AACCTGCTTTCAAAGGTTTATACGGTTTTCCTGCTAGTATTTGCACTTCAATAAATGAAGAAGTAGTTCATGGAATACCA
AGTTTAAGAAAACTTAAAGAAGGCGATATTATAAGTATAGACCTTGGAGCTACCTATAAAGGGTATAATGCAGATGCAGC
AAGAACTTTCCTTGTTGGAGAGATATCAGAGGAAGCACAAAAATTGATTGAGGTCACAAAAAATAGCTTTTTTGAGGGTA
TAAAATATGCAAAAGAAGGGAATAGGTTATCGGATATTTCTTACGCAATACAAACTTATGTAGAAAGTCATGGCTTTTCA
GTAGTAAGAGAATATGTGGGACATGGGATAGGTATAAAAATGCATGAAGATCCACAGATTCCTAATTTCGGTCCCCCTGG
CAGAGGACCTAGATTAAAAAGAGGGATGTGCCTTGCTATAGAACCGATGGTAAATGCGGGACATTATGCCGTAAGAACAT
TAGAAGATAATTGGACAGTAGTCACTGTTGATGGTAGTTTATCTGCCCATTACGAAAATACTATTGTTATTACGGAGGGG
GACCCAGAAATACTGACCATTTTATAA

Upstream 100 bases:

>100_bases
AGTATTATACAAAGAAAAACACTTTAGTGAATATTGATGGAAATAAATCGGTAGAAGAAGTATTTGAAGATATAAAAAAG
GCTTTGGGAGACAGAGGCAA

Downstream 100 bases:

>100_bases
GAGGTGAATTTATTAATGGAAGACTTGCAAATTGGTCAGGTAGTGCGGAGCAAAGCAGGTCGCGACAAAGGCAGAGTTTT
TGTAGTTGTAGGAAAGTTTG

Product: type I methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MIYIKSKNEIDLMRTAGKVIANLFEVLERAIKPGVTTLELDRIAEEFIIKNGCKPAFKGLYGFPASICTSINEEVVHGIP
SLRKLKEGDIISIDLGATYKGYNADAARTFLVGEISEEAQKLIEVTKNSFFEGIKYAKEGNRLSDISYAIQTYVESHGFS
VVREYVGHGIGIKMHEDPQIPNFGPPGRGPRLKRGMCLAIEPMVNAGHYAVRTLEDNWTVVTVDGSLSAHYENTIVITEG
DPEILTIL

Sequences:

>Translated_248_residues
MIYIKSKNEIDLMRTAGKVIANLFEVLERAIKPGVTTLELDRIAEEFIIKNGCKPAFKGLYGFPASICTSINEEVVHGIP
SLRKLKEGDIISIDLGATYKGYNADAARTFLVGEISEEAQKLIEVTKNSFFEGIKYAKEGNRLSDISYAIQTYVESHGFS
VVREYVGHGIGIKMHEDPQIPNFGPPGRGPRLKRGMCLAIEPMVNAGHYAVRTLEDNWTVVTVDGSLSAHYENTIVITEG
DPEILTIL
>Mature_248_residues
MIYIKSKNEIDLMRTAGKVIANLFEVLERAIKPGVTTLELDRIAEEFIIKNGCKPAFKGLYGFPASICTSINEEVVHGIP
SLRKLKEGDIISIDLGATYKGYNADAARTFLVGEISEEAQKLIEVTKNSFFEGIKYAKEGNRLSDISYAIQTYVESHGFS
VVREYVGHGIGIKMHEDPQIPNFGPPGRGPRLKRGMCLAIEPMVNAGHYAVRTLEDNWTVVTVDGSLSAHYENTIVITEG
DPEILTIL

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=246, Percent_Identity=38.2113821138211, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI40385867, Length=247, Percent_Identity=36.4372469635627, Blast_Score=169, Evalue=2e-42,
Organism=Escherichia coli, GI1786364, Length=248, Percent_Identity=45.5645161290323, Blast_Score=218, Evalue=3e-58,
Organism=Escherichia coli, GI1788728, Length=205, Percent_Identity=27.8048780487805, Blast_Score=73, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71996291, Length=247, Percent_Identity=38.4615384615385, Blast_Score=187, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6323273, Length=246, Percent_Identity=39.0243902439024, Blast_Score=181, Evalue=1e-46,
Organism=Drosophila melanogaster, GI21355531, Length=245, Percent_Identity=39.5918367346939, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24583427, Length=245, Percent_Identity=37.1428571428571, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI19920384, Length=232, Percent_Identity=23.2758620689655, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27392; Mature: 27392

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYIKSKNEIDLMRTAGKVIANLFEVLERAIKPGVTTLELDRIAEEFIIKNGCKPAFKGL
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCHHHHHH
YGFPASICTSINEEVVHGIPSLRKLKEGDIISIDLGATYKGYNADAARTFLVGEISEEAQ
CCCHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEECCCCCCCCCCCHHHEEEEEHHHHHHH
KLIEVTKNSFFEGIKYAKEGNRLSDISYAIQTYVESHGFSVVREYVGHGIGIKMHEDPQI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEECCCCCC
PNFGPPGRGPRLKRGMCLAIEPMVNAGHYAVRTLEDNWTVVTVDGSLSAHYENTIVITEG
CCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCEEEEEECCCEEECCCCEEEEECC
DPEILTIL
CCCEEEEC
>Mature Secondary Structure
MIYIKSKNEIDLMRTAGKVIANLFEVLERAIKPGVTTLELDRIAEEFIIKNGCKPAFKGL
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCHHHHHH
YGFPASICTSINEEVVHGIPSLRKLKEGDIISIDLGATYKGYNADAARTFLVGEISEEAQ
CCCHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEECCCCCCCCCCCHHHEEEEEHHHHHHH
KLIEVTKNSFFEGIKYAKEGNRLSDISYAIQTYVESHGFSVVREYVGHGIGIKMHEDPQI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEECCCCCC
PNFGPPGRGPRLKRGMCLAIEPMVNAGHYAVRTLEDNWTVVTVDGSLSAHYENTIVITEG
CCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCEEEEEECCCEEECCCCEEEEECC
DPEILTIL
CCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842; 7559358 [H]