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The map label for this gene is nrdZ [H]

Identifier: 167039475

GI number: 167039475

Start: 852679

End: 854991

Strand: Direct

Name: nrdZ [H]

Synonym: Teth514_0821

Alternate gene names: 167039475

Gene position: 852679-854991 (Clockwise)

Preceding gene: 167039474

Following gene: 167039476

Centisome position: 34.7

GC content: 38.05

Gene sequence:

>2313_bases
GTGAAAATTACTGAGAATGCGAGGAAGGTTCTGGAGAGAAGGTATTTGGCTAAAGATGAAAATGGCAAGCCTATTGAGAC
AGTTGAGGAAATGTTTGAAAGGGTTGCAAAGACTATCGCTGAAGTGGATTTAATCTATGACAAAAATGCTGATGTAGAAG
CAGTAAAGAAGAGATTTTATGATATGATGGTAGCTCTGGATTTTTTACCTAATTCTCCTACGTTAATGAATGCCGGTAGG
CCATTAGGTCAGCTTTCTGCCTGTTTTGTTCTTCCTGTGGGAGATTCTATGGAAGAGATTTTTGACGCGGTAAAGTACGC
GGCAATTATTCACAAAAGTGGTGGGGGTACGGGATTTAGCTTTTCTCGCTTACGACCCAAGGGAGCTACAGTCAGATCCA
CTGGAGGCGTTGCATCAGGACCTGTTAGTTTTATGAAAGTTTTTAATGCAGCGACAGAAGCGGTGAAACAAGGTGGTACC
CGAAGAGGAGCAAATATGGGCATTCTGCGTGTTGACCACCCTGATATATTGGAGTTTATACAGTGTAAAAAAGATAACAA
TGAAATAACAAATTTTAATATAAGCGTGGCTATTACAGAAGAATTTATGAAGGCTGTTGAGGAAGATAGGGAATACGATC
TAATAGATCCTCATACGGGTAAGGTTGTAAATAGATTAAGAGCAAGAGAAGTCTTTGACCTGATTGTAGAAATGGCTTGG
AGAAATGGGGAACCGGGTATTGTATTTTTAGACAGAATAAATGAGAAAAATCCTACCCCTGAAGTTGGAGAGATTGAGTC
TACCAATCCCTGTGGTGAACAGCCACTTCTTCCTTATGAATCTTGTAACTTAGGTTCAATTAATCTTGAAAATATGTTAA
AAAAGGTAGAAGGTAGATACGTAATAGATTATGACAAACTTAGAGAAACGGTCTATGATGCAGTACATTTTTTGGATAAT
GTAATAGATGCCAATAAATATCCTCTTCCACAAATTGAGGAGATGACAAAAGGGACAAGAAAAATAGGTCTTGGCGTAAT
GGGATTTGCTAACATGCTTTTGAGATTAGGCATTCCCTATGATTCTGAAGAGGCTGTAGAGTTAGGCGAAGAATTGATGG
AGTTTATTGATGAAACTTCCAAAGAAGCATCGATTAAATTAGCGGAACAAAGAGGTACCTTTGGTTTCTATGATAAGAGT
ATTTACAAAAAAATGGGTATAAAAATTCGAAACGCTACAACTACTACTATTGCCCCGACTGGCACCATATCTATCATTGC
AGGTACTTCTAGTGGCATAGAACCGGTGTTTGCAATAGCTATGACGCGAAATGTTATGGATAATACAGAACTGGTGGAAG
TAAACCCTGTATTTAAAGAGGTTGCCATTGAAAGAGGATTTTATTCAGAAGAACTGATGCGAGAAATTGCTCGAAGGGGA
AGTCTAAAAGACATAAAGGGTATACCAGAAGATGTTAAAAGAATCTTTGTGATAGCTCATGATATTGACCCTGAGTGGCA
TGTTAAAATGCAAGCAGCTTTTCAAAAACATGTTGACAATGCAGTTTCTAAAACGGTGAACTTTAGAAATGAAGCTACAG
TAGAGGATGTTAGAAGAACTTATCTTCTTGCCTATGAACTTGGTTGCAAAGGGGTTACTATATACAGAGATGGAAGTCGT
GAATCGCAAGTATTGAATTTGGGCATAAAAGAGAAAAAAGAAGAAACAAAACCTAAAGAAGAGCAAACTAAAAATGAACC
TTTAAGACCAAGGCCAAGACCTCCTGTGACAAGAGGAATAACTGAAAAAGTGAGAATAGGTTGTGGAAATCTTTATATAA
CAGTTAATTATGATGACCAAGGCATATGTGAGGTATTTACAAATCTTGGAAGAGCAGGTGGATGTCCTTCACAGTCAGAA
GCTACAAGTAGGCTTATATCTATAGCATTGCGCTCAGGCATTGATGCTAAGACAATTGTAGAGCAATTAAAAGGTATAAG
ATGTCATTCTACTTTAAGGCAAATGGCTACAAACAAAGAAATAAAAGTGTTATCTTGCCCTGATGCTATTGGCAAGGTTA
TTGAAAAAGTGATGAAAATCCGAGTGGAAGAGGAGCAGCAATTTGCACCTATTGATGTACCTATATATGAAAATAATCAT
AATGGCGATGAAGATGACCCTAAAGAAGAAGTTGCATTGAGTGAAGCTGACTTATTAGACGAAGAAAAGTTTTGCCCTGA
ATGTGGCAGTCCGATAGAGCATGAAGGTGGTTGTGTTGTGTGTAAAAACTGTGGCTATTCTAAATGCGGCTGA

Upstream 100 bases:

>100_bases
AATCGGATAGTTTTGGAGGTTGCAGAATCCACAATAAAATGTATAATTTAATAAGTAATACACAAAATATTGTGGTTTTA
CATAAGAGGAGGAATTTCCT

Downstream 100 bases:

>100_bases
TATTTATAAAAAACCTTCTGTAGCAATTGCTACAGAAGGTTTTTTATAAATATTTAAAAGGAAGTACAAGATTCGACATA
TTATGATGGGGATTTGTGGT

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 770; Mature: 770

Protein sequence:

>770_residues
MKITENARKVLERRYLAKDENGKPIETVEEMFERVAKTIAEVDLIYDKNADVEAVKKRFYDMMVALDFLPNSPTLMNAGR
PLGQLSACFVLPVGDSMEEIFDAVKYAAIIHKSGGGTGFSFSRLRPKGATVRSTGGVASGPVSFMKVFNAATEAVKQGGT
RRGANMGILRVDHPDILEFIQCKKDNNEITNFNISVAITEEFMKAVEEDREYDLIDPHTGKVVNRLRAREVFDLIVEMAW
RNGEPGIVFLDRINEKNPTPEVGEIESTNPCGEQPLLPYESCNLGSINLENMLKKVEGRYVIDYDKLRETVYDAVHFLDN
VIDANKYPLPQIEEMTKGTRKIGLGVMGFANMLLRLGIPYDSEEAVELGEELMEFIDETSKEASIKLAEQRGTFGFYDKS
IYKKMGIKIRNATTTTIAPTGTISIIAGTSSGIEPVFAIAMTRNVMDNTELVEVNPVFKEVAIERGFYSEELMREIARRG
SLKDIKGIPEDVKRIFVIAHDIDPEWHVKMQAAFQKHVDNAVSKTVNFRNEATVEDVRRTYLLAYELGCKGVTIYRDGSR
ESQVLNLGIKEKKEETKPKEEQTKNEPLRPRPRPPVTRGITEKVRIGCGNLYITVNYDDQGICEVFTNLGRAGGCPSQSE
ATSRLISIALRSGIDAKTIVEQLKGIRCHSTLRQMATNKEIKVLSCPDAIGKVIEKVMKIRVEEEQQFAPIDVPIYENNH
NGDEDDPKEEVALSEADLLDEEKFCPECGSPIEHEGGCVVCKNCGYSKCG

Sequences:

>Translated_770_residues
MKITENARKVLERRYLAKDENGKPIETVEEMFERVAKTIAEVDLIYDKNADVEAVKKRFYDMMVALDFLPNSPTLMNAGR
PLGQLSACFVLPVGDSMEEIFDAVKYAAIIHKSGGGTGFSFSRLRPKGATVRSTGGVASGPVSFMKVFNAATEAVKQGGT
RRGANMGILRVDHPDILEFIQCKKDNNEITNFNISVAITEEFMKAVEEDREYDLIDPHTGKVVNRLRAREVFDLIVEMAW
RNGEPGIVFLDRINEKNPTPEVGEIESTNPCGEQPLLPYESCNLGSINLENMLKKVEGRYVIDYDKLRETVYDAVHFLDN
VIDANKYPLPQIEEMTKGTRKIGLGVMGFANMLLRLGIPYDSEEAVELGEELMEFIDETSKEASIKLAEQRGTFGFYDKS
IYKKMGIKIRNATTTTIAPTGTISIIAGTSSGIEPVFAIAMTRNVMDNTELVEVNPVFKEVAIERGFYSEELMREIARRG
SLKDIKGIPEDVKRIFVIAHDIDPEWHVKMQAAFQKHVDNAVSKTVNFRNEATVEDVRRTYLLAYELGCKGVTIYRDGSR
ESQVLNLGIKEKKEETKPKEEQTKNEPLRPRPRPPVTRGITEKVRIGCGNLYITVNYDDQGICEVFTNLGRAGGCPSQSE
ATSRLISIALRSGIDAKTIVEQLKGIRCHSTLRQMATNKEIKVLSCPDAIGKVIEKVMKIRVEEEQQFAPIDVPIYENNH
NGDEDDPKEEVALSEADLLDEEKFCPECGSPIEHEGGCVVCKNCGYSKCG
>Mature_770_residues
MKITENARKVLERRYLAKDENGKPIETVEEMFERVAKTIAEVDLIYDKNADVEAVKKRFYDMMVALDFLPNSPTLMNAGR
PLGQLSACFVLPVGDSMEEIFDAVKYAAIIHKSGGGTGFSFSRLRPKGATVRSTGGVASGPVSFMKVFNAATEAVKQGGT
RRGANMGILRVDHPDILEFIQCKKDNNEITNFNISVAITEEFMKAVEEDREYDLIDPHTGKVVNRLRAREVFDLIVEMAW
RNGEPGIVFLDRINEKNPTPEVGEIESTNPCGEQPLLPYESCNLGSINLENMLKKVEGRYVIDYDKLRETVYDAVHFLDN
VIDANKYPLPQIEEMTKGTRKIGLGVMGFANMLLRLGIPYDSEEAVELGEELMEFIDETSKEASIKLAEQRGTFGFYDKS
IYKKMGIKIRNATTTTIAPTGTISIIAGTSSGIEPVFAIAMTRNVMDNTELVEVNPVFKEVAIERGFYSEELMREIARRG
SLKDIKGIPEDVKRIFVIAHDIDPEWHVKMQAAFQKHVDNAVSKTVNFRNEATVEDVRRTYLLAYELGCKGVTIYRDGSR
ESQVLNLGIKEKKEETKPKEEQTKNEPLRPRPRPPVTRGITEKVRIGCGNLYITVNYDDQGICEVFTNLGRAGGCPSQSE
ATSRLISIALRSGIDAKTIVEQLKGIRCHSTLRQMATNKEIKVLSCPDAIGKVIEKVMKIRVEEEQQFAPIDVPIYENNH
NGDEDDPKEEVALSEADLLDEEKFCPECGSPIEHEGGCVVCKNCGYSKCG

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=579, Percent_Identity=30.5699481865285, Blast_Score=226, Evalue=6e-59,
Organism=Escherichia coli, GI1789030, Length=634, Percent_Identity=26.0252365930599, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI2367133, Length=654, Percent_Identity=21.8654434250765, Blast_Score=124, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17555242, Length=585, Percent_Identity=28.7179487179487, Blast_Score=216, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6322123, Length=651, Percent_Identity=27.1889400921659, Blast_Score=223, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6320914, Length=625, Percent_Identity=27.84, Blast_Score=214, Evalue=4e-56,
Organism=Drosophila melanogaster, GI17352481, Length=625, Percent_Identity=28.48, Blast_Score=221, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 86050; Mature: 86050

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITENARKVLERRYLAKDENGKPIETVEEMFERVAKTIAEVDLIYDKNADVEAVKKRFY
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHH
DMMVALDFLPNSPTLMNAGRPLGQLSACFVLPVGDSMEEIFDAVKYAAIIHKSGGGTGFS
HHHHHHHHCCCCCCEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHEEECCCCCCCC
FSRLRPKGATVRSTGGVASGPVSFMKVFNAATEAVKQGGTRRGANMGILRVDHPDILEFI
HHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHH
QCKKDNNEITNFNISVAITEEFMKAVEEDREYDLIDPHTGKVVNRLRAREVFDLIVEMAW
HHCCCCCCEEEEEEEEEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RNGEPGIVFLDRINEKNPTPEVGEIESTNPCGEQPLLPYESCNLGSINLENMLKKVEGRY
CCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCE
VIDYDKLRETVYDAVHFLDNVIDANKYPLPQIEEMTKGTRKIGLGVMGFANMLLRLGIPY
EEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
DSEEAVELGEELMEFIDETSKEASIKLAEQRGTFGFYDKSIYKKMGIKIRNATTTTIAPT
CCHHHHHHHHHHHHHHHHCCCHHHEEEHHHCCCCCCHHHHHHHHHCEEEECCEEEEECCC
GTISIIAGTSSGIEPVFAIAMTRNVMDNTELVEVNPVFKEVAIERGFYSEELMREIARRG
CEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCCHHHHHHHHHHCC
SLKDIKGIPEDVKRIFVIAHDIDPEWHVKMQAAFQKHVDNAVSKTVNFRNEATVEDVRRT
CCHHHCCCCHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
YLLAYELGCKGVTIYRDGSRESQVLNLGIKEKKEETKPKEEQTKNEPLRPRPRPPVTRGI
HHEEEEECCCEEEEEECCCCCCCEEECCCHHHHHHCCCCHHHHCCCCCCCCCCCCCHHCC
TEKVRIGCGNLYITVNYDDQGICEVFTNLGRAGGCPSQSEATSRLISIALRSGIDAKTIV
HHHHEECCCEEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHH
EQLKGIRCHSTLRQMATNKEIKVLSCPDAIGKVIEKVMKIRVEEEQQFAPIDVPIYENNH
HHHHCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCC
NGDEDDPKEEVALSEADLLDEEKFCPECGSPIEHEGGCVVCKNCGYSKCG
CCCCCCCHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MKITENARKVLERRYLAKDENGKPIETVEEMFERVAKTIAEVDLIYDKNADVEAVKKRFY
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHH
DMMVALDFLPNSPTLMNAGRPLGQLSACFVLPVGDSMEEIFDAVKYAAIIHKSGGGTGFS
HHHHHHHHCCCCCCEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHEEECCCCCCCC
FSRLRPKGATVRSTGGVASGPVSFMKVFNAATEAVKQGGTRRGANMGILRVDHPDILEFI
HHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHH
QCKKDNNEITNFNISVAITEEFMKAVEEDREYDLIDPHTGKVVNRLRAREVFDLIVEMAW
HHCCCCCCEEEEEEEEEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RNGEPGIVFLDRINEKNPTPEVGEIESTNPCGEQPLLPYESCNLGSINLENMLKKVEGRY
CCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCE
VIDYDKLRETVYDAVHFLDNVIDANKYPLPQIEEMTKGTRKIGLGVMGFANMLLRLGIPY
EEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
DSEEAVELGEELMEFIDETSKEASIKLAEQRGTFGFYDKSIYKKMGIKIRNATTTTIAPT
CCHHHHHHHHHHHHHHHHCCCHHHEEEHHHCCCCCCHHHHHHHHHCEEEECCEEEEECCC
GTISIIAGTSSGIEPVFAIAMTRNVMDNTELVEVNPVFKEVAIERGFYSEELMREIARRG
CEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCCHHHHHHHHHHCC
SLKDIKGIPEDVKRIFVIAHDIDPEWHVKMQAAFQKHVDNAVSKTVNFRNEATVEDVRRT
CCHHHCCCCHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
YLLAYELGCKGVTIYRDGSRESQVLNLGIKEKKEETKPKEEQTKNEPLRPRPRPPVTRGI
HHEEEEECCCEEEEEECCCCCCCEEECCCHHHHHHCCCCHHHHCCCCCCCCCCCCCHHCC
TEKVRIGCGNLYITVNYDDQGICEVFTNLGRAGGCPSQSEATSRLISIALRSGIDAKTIV
HHHHEECCCEEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHH
EQLKGIRCHSTLRQMATNKEIKVLSCPDAIGKVIEKVMKIRVEEEQQFAPIDVPIYENNH
HHHHCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCC
NGDEDDPKEEVALSEADLLDEEKFCPECGSPIEHEGGCVVCKNCGYSKCG
CCCCCCCHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]