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The map label for this gene is folE

Identifier: 167039465

GI number: 167039465

Start: 844432

End: 844998

Strand: Direct

Name: folE

Synonym: Teth514_0811

Alternate gene names: 167039465

Gene position: 844432-844998 (Clockwise)

Preceding gene: 167039464

Following gene: 167039466

Centisome position: 34.36

GC content: 38.27

Gene sequence:

>567_bases
ATGATAGATAAAGAAAAGATTAAAAAAGCGGTAAGAGACATACTTGAAGCCATAGGAGAAGACCCGGATAGGGAGGGGCT
CCTTGAGACTCCTGATAGGGTTGCAAGGATGTATGAGGAAATTTTTGCTGGCCTTCATACGGATGTAAAAGACGTTATAA
AGATTTTTCAGGAGGATGAACATCAAGAAATAATACTTGTAAAAGATATTCCGCTTTATTCTATGTGCGAACATCATCTC
TTGCCTTTTATAGGAGTTGCCCATGTAGCGTATTTGCCTAGAAAAGGTAGAATTTTAGGCCTTTCAAAATTAGCTCGCAT
AGTAGATATTTTAGCAAAAAGGCCACAGCTTCAAGAGAGGTTGACAAGTGAAATTGCAGATACCATAATGGAAGCAGTGA
ATCCCTTAGGTGTTGCCGTTGTCATTGAGGCAGAACATTTGTGTATGACAATGAGAGGTATCAAAAAGCCGGGGGCCAAG
ACTGTTACTTCTGCTTTGAGAGGAATATTTAGAACAGATGAAAAATCAAGGGCAGAGGTAATGTCTTTAATAAATTCTAA
AAAATAA

Upstream 100 bases:

>100_bases
GTCGAAAGACTGCTTTTTAACTTTTTTGTAAGGACTGGCTTTTTAGAGATAAAAATAATATAATAAAGTTGTCAACTTTT
TAAACAAAGGGGTATCGTAC

Downstream 100 bases:

>100_bases
GGGAGGTAAATTATGCTATTTAGGTGCAGAGATAAAAGTCTGGAGATTGGAAAAAAAACTTACATAATGGGAATTTTAAA
TATGACTCCTGATTCTTTTT

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MIDKEKIKKAVRDILEAIGEDPDREGLLETPDRVARMYEEIFAGLHTDVKDVIKIFQEDEHQEIILVKDIPLYSMCEHHL
LPFIGVAHVAYLPRKGRILGLSKLARIVDILAKRPQLQERLTSEIADTIMEAVNPLGVAVVIEAEHLCMTMRGIKKPGAK
TVTSALRGIFRTDEKSRAEVMSLINSKK

Sequences:

>Translated_188_residues
MIDKEKIKKAVRDILEAIGEDPDREGLLETPDRVARMYEEIFAGLHTDVKDVIKIFQEDEHQEIILVKDIPLYSMCEHHL
LPFIGVAHVAYLPRKGRILGLSKLARIVDILAKRPQLQERLTSEIADTIMEAVNPLGVAVVIEAEHLCMTMRGIKKPGAK
TVTSALRGIFRTDEKSRAEVMSLINSKK
>Mature_188_residues
MIDKEKIKKAVRDILEAIGEDPDREGLLETPDRVARMYEEIFAGLHTDVKDVIKIFQEDEHQEIILVKDIPLYSMCEHHL
LPFIGVAHVAYLPRKGRILGLSKLARIVDILAKRPQLQERLTSEIADTIMEAVNPLGVAVVIEAEHLCMTMRGIKKPGAK
TVTSALRGIFRTDEKSRAEVMSLINSKK

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family

Homologues:

Organism=Homo sapiens, GI66932968, Length=183, Percent_Identity=51.3661202185792, Blast_Score=192, Evalue=2e-49,
Organism=Homo sapiens, GI4503949, Length=183, Percent_Identity=51.3661202185792, Blast_Score=192, Evalue=2e-49,
Organism=Homo sapiens, GI66932970, Length=151, Percent_Identity=48.3443708609272, Blast_Score=143, Evalue=7e-35,
Organism=Homo sapiens, GI66932972, Length=141, Percent_Identity=51.063829787234, Blast_Score=142, Evalue=1e-34,
Organism=Escherichia coli, GI1788476, Length=180, Percent_Identity=38.3333333333333, Blast_Score=119, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17560486, Length=181, Percent_Identity=48.0662983425414, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321706, Length=186, Percent_Identity=47.8494623655914, Blast_Score=178, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24656782, Length=183, Percent_Identity=49.7267759562842, Blast_Score=176, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24656796, Length=183, Percent_Identity=49.7267759562842, Blast_Score=175, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24656791, Length=183, Percent_Identity=49.7267759562842, Blast_Score=175, Evalue=2e-44,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): GCH1_THEP3 (B0KCE5)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001664324.1
- ProteinModelPortal:   B0KCE5
- SMR:   B0KCE5
- GeneID:   5874234
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_0319
- HOGENOM:   HBG370191
- OMA:   ARIVEMF
- ProtClustDB:   PRK09347
- BioCyc:   TPSE340099:TETH39_0319-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00223
- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234
- TIGRFAMs:   TIGR00063

Pfam domain/function: PF01227 GTP_cyclohydroI

EC number: =3.5.4.16

Molecular weight: Translated: 21204; Mature: 21204

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDKEKIKKAVRDILEAIGEDPDREGLLETPDRVARMYEEIFAGLHTDVKDVIKIFQEDE
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
HQEIILVKDIPLYSMCEHHLLPFIGVAHVAYLPRKGRILGLSKLARIVDILAKRPQLQER
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHCCHHHHHH
LTSEIADTIMEAVNPLGVAVVIEAEHLCMTMRGIKKPGAKTVTSALRGIFRTDEKSRAEV
HHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHH
MSLINSKK
HHHHHCCC
>Mature Secondary Structure
MIDKEKIKKAVRDILEAIGEDPDREGLLETPDRVARMYEEIFAGLHTDVKDVIKIFQEDE
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
HQEIILVKDIPLYSMCEHHLLPFIGVAHVAYLPRKGRILGLSKLARIVDILAKRPQLQER
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHCCHHHHHH
LTSEIADTIMEAVNPLGVAVVIEAEHLCMTMRGIKKPGAKTVTSALRGIFRTDEKSRAEV
HHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHH
MSLINSKK
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA