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The map label for this gene is lysS [H]

Identifier: 167039464

GI number: 167039464

Start: 842540

End: 844039

Strand: Direct

Name: lysS [H]

Synonym: Teth514_0810

Alternate gene names: 167039464

Gene position: 842540-844039 (Clockwise)

Preceding gene: 167039463

Following gene: 167039465

Centisome position: 34.29

GC content: 35.87

Gene sequence:

>1500_bases
ATGTCTAATTCAAATGATAACATTTGGAACAACACTGAAGAACTCAATGAACTTTTGCGAATAAGAAGAGAAAAATTAAA
TATTTTAAGAAGCATGGGAATAGAACCTTACGGTATTGACAGGTTTGAAAGGACTAATGTATCCTCTGATATTAAAAACG
ATTACGAGAATTTTGAAGGCAAAGTAGTGACTCTTGCAGGACGAATTATGTCCAAAAGGGCCCATGGCAAAGCTTCTTTT
GCAGATATTCAAGATAGAGATGGCAGGATACAGATTTACGTTAAGTATGATACAGTAGGAGAGAAGAATTATGAAATTTT
TAAAATCCTCGACATTGGAGATATAATAGGGGTTACAGGCGAGGTATTTAAATCTAAAACTGGTGAAATAACTATTCGCG
TAACAGACTTTAAGCTTTTGTCTAAATCTCTTCAAATACTTCCAGAGAAATGGCACGGTTTAAAAGACCCTGATTTGCGT
TATAGACAGAGATATACGGATTTAATAATAAATCCCGAAGTAAAAGAGGTGTTTTTAAAGAGGACGAAAATAATAAAGGC
GATAAGAGAATTTCTTGACAATAGAGGATTTTTAGAAGTGGAGACTCCTATTCTTCATACTATTGCGGGTGGGGCTGCAG
CAAGGCCTTTTATTACTCATCACAATGCTTTAGACATTGATATGTACTTGCGAATTGCTTTAGAGCTTCACTTAAAAAGA
CTTATTGTCGGTGGCCTGGAAAAAGTATATGAAATGGGCAGAGTTTTTAGAAATGAAGGAATGGATATAAGGCACAATCC
GGAATTTACTTTGTTGGAACTTTACGAAGCCTATACGGATTATTACGGTATGATGGAACTTACAGAACAATTATTTGCCT
ATGTGGCCCAAAAGGTTAACGGTACTACGAAAATAGTTTATCAAGGAACAGAAATAGATTTGACACCTCCTTGGAAGAGA
ATTACTATGGTGGATGCAATAAAAGAATATGTAGGTGTAGACTTTAATGAAGTTAAGGCAGATGCAGAAGCAGTAGAGAT
AGCGAAGAGATTAAACCTTGAGACAAAAGAAGGAATGAAAAAGGGAGAAGTAATAGCACTTGTTTTTGATGAGCTGGTAG
AACAACATTTGATACAGCCAACTTTTGTTATGGATTATCCAGTAGAGATTTCTCCTTTAGCTAAGAGAAAACACGACAAT
CCAGCATTTACTTCTAGATTTGAAGCCTTTATTTACGGAAGAGAAGTGGCTAATGCCTTTTCAGAATTAAATGACCCTAT
AGACCAAAAAGAAAGGTTTTTAGAACAATTAAAACAAAGAGAAGCCGGCGACGAAGAAGCTCATATGATGGATGAGGATT
TTATAAATGCTCTTGAGGTTGGTATGCCACCGACTGGAGGACTAGGTATAGGGGTAGACAGACTTGTGATGTTTATGACA
GATGCTTATTCTATAAGAGATGTAATATTATTCCCGACGATGAAGCCTAAAAATGACTAA

Upstream 100 bases:

>100_bases
GGGAAAAAAGTAGGAGATGTTGTCTCTGTTGAAGTTCCTGCTGGAATTATAAAGTTAAAAATATTAGAAATACGCAAATA
AAGGGTGATGGAGGTATAAT

Downstream 100 bases:

>100_bases
AAAAGCAGTCGAAAGACTGCTTTTTAGACTGTAGACAAACTCTTTATTATATGTTGGCATTTTGCATAAGTGAAGCGACT
TGACAGAGCAGCAACTAAAC

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MSNSNDNIWNNTEELNELLRIRREKLNILRSMGIEPYGIDRFERTNVSSDIKNDYENFEGKVVTLAGRIMSKRAHGKASF
ADIQDRDGRIQIYVKYDTVGEKNYEIFKILDIGDIIGVTGEVFKSKTGEITIRVTDFKLLSKSLQILPEKWHGLKDPDLR
YRQRYTDLIINPEVKEVFLKRTKIIKAIREFLDNRGFLEVETPILHTIAGGAAARPFITHHNALDIDMYLRIALELHLKR
LIVGGLEKVYEMGRVFRNEGMDIRHNPEFTLLELYEAYTDYYGMMELTEQLFAYVAQKVNGTTKIVYQGTEIDLTPPWKR
ITMVDAIKEYVGVDFNEVKADAEAVEIAKRLNLETKEGMKKGEVIALVFDELVEQHLIQPTFVMDYPVEISPLAKRKHDN
PAFTSRFEAFIYGREVANAFSELNDPIDQKERFLEQLKQREAGDEEAHMMDEDFINALEVGMPPTGGLGIGVDRLVMFMT
DAYSIRDVILFPTMKPKND

Sequences:

>Translated_499_residues
MSNSNDNIWNNTEELNELLRIRREKLNILRSMGIEPYGIDRFERTNVSSDIKNDYENFEGKVVTLAGRIMSKRAHGKASF
ADIQDRDGRIQIYVKYDTVGEKNYEIFKILDIGDIIGVTGEVFKSKTGEITIRVTDFKLLSKSLQILPEKWHGLKDPDLR
YRQRYTDLIINPEVKEVFLKRTKIIKAIREFLDNRGFLEVETPILHTIAGGAAARPFITHHNALDIDMYLRIALELHLKR
LIVGGLEKVYEMGRVFRNEGMDIRHNPEFTLLELYEAYTDYYGMMELTEQLFAYVAQKVNGTTKIVYQGTEIDLTPPWKR
ITMVDAIKEYVGVDFNEVKADAEAVEIAKRLNLETKEGMKKGEVIALVFDELVEQHLIQPTFVMDYPVEISPLAKRKHDN
PAFTSRFEAFIYGREVANAFSELNDPIDQKERFLEQLKQREAGDEEAHMMDEDFINALEVGMPPTGGLGIGVDRLVMFMT
DAYSIRDVILFPTMKPKND
>Mature_498_residues
SNSNDNIWNNTEELNELLRIRREKLNILRSMGIEPYGIDRFERTNVSSDIKNDYENFEGKVVTLAGRIMSKRAHGKASFA
DIQDRDGRIQIYVKYDTVGEKNYEIFKILDIGDIIGVTGEVFKSKTGEITIRVTDFKLLSKSLQILPEKWHGLKDPDLRY
RQRYTDLIINPEVKEVFLKRTKIIKAIREFLDNRGFLEVETPILHTIAGGAAARPFITHHNALDIDMYLRIALELHLKRL
IVGGLEKVYEMGRVFRNEGMDIRHNPEFTLLELYEAYTDYYGMMELTEQLFAYVAQKVNGTTKIVYQGTEIDLTPPWKRI
TMVDAIKEYVGVDFNEVKADAEAVEIAKRLNLETKEGMKKGEVIALVFDELVEQHLIQPTFVMDYPVEISPLAKRKHDNP
AFTSRFEAFIYGREVANAFSELNDPIDQKERFLEQLKQREAGDEEAHMMDEDFINALEVGMPPTGGLGIGVDRLVMFMTD
AYSIRDVILFPTMKPKND

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=511, Percent_Identity=41.2915851272016, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI194272210, Length=511, Percent_Identity=40.9001956947162, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI40789249, Length=262, Percent_Identity=27.0992366412214, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI45439306, Length=463, Percent_Identity=23.3261339092873, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI226491502, Length=457, Percent_Identity=23.6323851203501, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1790571, Length=516, Percent_Identity=50.5813953488372, Blast_Score=510, Evalue=1e-146,
Organism=Escherichia coli, GI1789256, Length=506, Percent_Identity=49.802371541502, Blast_Score=505, Evalue=1e-144,
Organism=Escherichia coli, GI87082379, Length=326, Percent_Identity=32.8220858895706, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1788173, Length=252, Percent_Identity=26.984126984127, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17535925, Length=505, Percent_Identity=43.1683168316832, Blast_Score=406, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17535927, Length=504, Percent_Identity=43.2539682539683, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71994340, Length=491, Percent_Identity=43.9918533604888, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17551876, Length=351, Percent_Identity=24.2165242165242, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI32566633, Length=304, Percent_Identity=25, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320242, Length=459, Percent_Identity=44.4444444444444, Blast_Score=398, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6324256, Length=481, Percent_Identity=33.8877338877339, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6323011, Length=472, Percent_Identity=23.728813559322, Blast_Score=90, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6325153, Length=300, Percent_Identity=24.3333333333333, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321807, Length=450, Percent_Identity=23.1111111111111, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640851, Length=507, Percent_Identity=41.2228796844181, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24640849, Length=507, Percent_Identity=41.2228796844181, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI17136276, Length=461, Percent_Identity=21.2581344902386, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24584738, Length=262, Percent_Identity=25.5725190839695, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 57512; Mature: 57381

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSNDNIWNNTEELNELLRIRREKLNILRSMGIEPYGIDRFERTNVSSDIKNDYENFEG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHCCC
KVVTLAGRIMSKRAHGKASFADIQDRDGRIQIYVKYDTVGEKNYEIFKILDIGDIIGVTG
EEEEEHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCEEEEEEECHHHHCCCH
EVFKSKTGEITIRVTDFKLLSKSLQILPEKWHGLKDPDLRYRQRYTDLIINPEVKEVFLK
HHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEEECCHHHHHHHH
RTKIIKAIREFLDNRGFLEVETPILHTIAGGAAARPFITHHNALDIDMYLRIALELHLKR
HHHHHHHHHHHHCCCCEEEECCHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHH
LIVGGLEKVYEMGRVFRNEGMDIRHNPEFTLLELYEAYTDYYGMMELTEQLFAYVAQKVN
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GTTKIVYQGTEIDLTPPWKRITMVDAIKEYVGVDFNEVKADAEAVEIAKRLNLETKEGMK
CCEEEEEECCEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCC
KGEVIALVFDELVEQHLIQPTFVMDYPVEISPLAKRKHDNPAFTSRFEAFIYGREVANAF
CCCEEEHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
SELNDPIDQKERFLEQLKQREAGDEEAHMMDEDFINALEVGMPPTGGLGIGVDRLVMFMT
HHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
DAYSIRDVILFPTMKPKND
CCCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
SNSNDNIWNNTEELNELLRIRREKLNILRSMGIEPYGIDRFERTNVSSDIKNDYENFEG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHCCC
KVVTLAGRIMSKRAHGKASFADIQDRDGRIQIYVKYDTVGEKNYEIFKILDIGDIIGVTG
EEEEEHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCEEEEEEECHHHHCCCH
EVFKSKTGEITIRVTDFKLLSKSLQILPEKWHGLKDPDLRYRQRYTDLIINPEVKEVFLK
HHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEEECCHHHHHHHH
RTKIIKAIREFLDNRGFLEVETPILHTIAGGAAARPFITHHNALDIDMYLRIALELHLKR
HHHHHHHHHHHHCCCCEEEECCHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHH
LIVGGLEKVYEMGRVFRNEGMDIRHNPEFTLLELYEAYTDYYGMMELTEQLFAYVAQKVN
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GTTKIVYQGTEIDLTPPWKRITMVDAIKEYVGVDFNEVKADAEAVEIAKRLNLETKEGMK
CCEEEEEECCEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCC
KGEVIALVFDELVEQHLIQPTFVMDYPVEISPLAKRKHDNPAFTSRFEAFIYGREVANAF
CCCEEEHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
SELNDPIDQKERFLEQLKQREAGDEEAHMMDEDFINALEVGMPPTGGLGIGVDRLVMFMT
HHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
DAYSIRDVILFPTMKPKND
CCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA