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The map label for this gene is copA [H]

Identifier: 167039429

GI number: 167039429

Start: 802001

End: 804394

Strand: Direct

Name: copA [H]

Synonym: Teth514_0774

Alternate gene names: 167039429

Gene position: 802001-804394 (Clockwise)

Preceding gene: 167039428

Following gene: 167039431

Centisome position: 32.64

GC content: 37.01

Gene sequence:

>2394_bases
ATGGCCGAAAAAGCTAATTTAAAAATAACAGGGATGTCTTGTGCAGCTTGCGCAACAAAAATAGAAAAAGGGCTTAAAAG
CTTAGATGGAGTTTTAGATGCAAATGTAAATCTTGCGATTGAAAAAGCAACAGTTATATATGATCCAGATAAAATTAATA
TATGCGATATGGAGAAAAAAATAGAAGATATAGGATATGGTGTAATAAAAGATAAAGTAGAGCTTGCACTTATGGGTATG
TCCTGCGCATCCTGCGCTGCTAAAATCGAAAAAACCTTAAAAAACCTTCCTGGTGTAAGCAACGCATCAGTCAACTTTGC
GACGGAAACGGCAACTGTTGAATATGATTCAAATGAAATTGATACAGAAAAAATGATTAAAGCGATAAAAGATATAGGAT
ATGATGCAAAAGAGAAGACTGGAGTAGGTATTGACACTGAAAAAGAGATAAAGGAGAGGGAAATAAATACATTAAGAAAA
TTGGTAATATATTCAGCGATTTTAACTGTCCCACTGGTATTATCAATGTTTTTGGTAATGTTTAAAGTTCCAGGAGGGAT
ACTTGAGAATCCGTGGTTGCAGGTGTTTTTATCTTCACCTGTTCAGTTTATTGTGGGTCTTAGATATTATAAAGGGGCGT
GGAACAATTTAAAAAATATGACGGCAAATATGGATACTTTGGTAGCTATGGGAACATCTGCAGCATATTTTTATAGTTTG
TACAATGTATTTACAAAACCCTCTCATGAGATACACAATTACTTGTATTTTGAGGCATCAGCAGTTATTATAACGCTTGT
AACATTGGGTAAGCTGCTTGAAGCTACAGCCAAAGGGAAAACATCTGAAGCAATAAAAAACCTCATGGGACTACAAGCAA
AGACCGCAAGAGTGATAAGGGATGGACAAGAATTAGATATACCTATTGAAGAAGTCAAAGTCGGGGACATCGTTGTTGTA
AGACCGGGCGAAAAAATACCAGTGGACGGTAAAATAGTTGAAGGTAGTTCCACAATAGATGAATCTATGATAACTGGAGA
ATCTATTCCTGTAGAAAAAGGAGTTGGTGATGAAGTAATTGGTGCTACGATAAATAAAACAGGAACGTTTAAATTTGAAG
CGACAAAAGTGGGTAAAGATACGGTACTATCGCAAATTATTAAAATGGTGGAAGACGCCCAAGGTTCCAAAGCACCAATT
CAACAAATTGCTGATAAAATCTCTGGTATTTTTGTACCCACAGTTATGGGTATAGCTGCTACCACATTTTTAATCTGGTA
TTTTGGGTATGGAGATTTTAATGCGGGCATAATAAATGCAGTATCTGTGCTTGTAATTGCGTGCCCGTGTGCGCTTGGAC
TTGCAGTTCCCACTTCTGTGATGGTAGGGACAGGAAAAGGAGCAGAAAATGGTATACTCATAAAGGGAGGAGAACATCTG
CAGAGGGCAGGAAAAATAACGACAATAGTGCTTGATAAGACTGGGACGATAACAAAAGGAGAACCGGAAGTTACAGACAT
AGAAGCTTTTGGAAATTTCACCGAAGAGGAGATACTAAAAATAGCGGGAATTGCGGAAAAAAATTCTGAGCATCCATTGG
GACAAGCAATTGTCAATAAAGCAAAAGAAAAATTCAAAATATTGGAAGTTCCTGAGAAATTTGAGGCTATACCAGGCTAC
GGTATATGCATTACGATAAATGAAAAAGAATTTTATATTGGCAATAGAAGGCTTATGGATAGACAAAATATTGATATAAC
GCCAATTGAAGACAAACTTGTAAATTTAGAAATACAAGGTAAAACATCAATGATTTTGGCTTCCAAAGATTGTGTTTATG
GCATTATAGCAGTTGCAGATACAGTAAAGAGTGACTCGGCAAAAGCTATTAAAGAGTTACAGGCTATGGGTATTGAAGTG
TACATGATTACGGGAGATAATAAAAGGACTGCTGAGGCAATAGCAAAACAAGTTGGTATAAAAAATGTGTTGGCAGAAGT
ATTGCCAGAAGATAAAGCTGAAGAGGTTGCCAAGCTTCAAAAAATGGGAAAGGTAGTTGCAATGGTGGGAGATGGTATTA
ATGATGCTCCTGCTTTAGCTACTGCGGATGTTGGCATAGCGATAGGTACAGGTACAGATGTGGCGATAGAAACCTCAGAT
ATAACGTTGATAAGTGGAAATCTTATGGGTATTGTGACCGCCATAAAATTAAGCAAAGCTACCATGAGAAATATATATCA
AAATTTATTCTGGGCTTTTATATACAACACAATCGGTATACCATTTGCTGCAATGGGATTTTTAACTCCAGCTATAGCGG
GAGGGGCGATGGCGTTTAGCTCAGTATCAGTTGTTTTAAATGCTCTGAGATTAAGAAGGTTTAGGGAGGGATAA

Upstream 100 bases:

>100_bases
GGGGGAACAATAGAAAGAAAAGTTAGATAAAATTTCTGAATCTCCTTTTATGTGGAAGAATTTCCTATAAGAAACTAAAA
GATGAAGAGGAGATGAAAAT

Downstream 100 bases:

>100_bases
ATATTTAAAATGAGTTTGGAATTGTCCAAACTCATTCTTTTAATGCAGGAAGCCACACTACAAAAGTTGCTTCTTTTCTC
TTTTTACTGTAGATTTTGAT

Product: copper-translocating P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: Protein CopA [H]

Number of amino acids: Translated: 797; Mature: 796

Protein sequence:

>797_residues
MAEKANLKITGMSCAACATKIEKGLKSLDGVLDANVNLAIEKATVIYDPDKINICDMEKKIEDIGYGVIKDKVELALMGM
SCASCAAKIEKTLKNLPGVSNASVNFATETATVEYDSNEIDTEKMIKAIKDIGYDAKEKTGVGIDTEKEIKEREINTLRK
LVIYSAILTVPLVLSMFLVMFKVPGGILENPWLQVFLSSPVQFIVGLRYYKGAWNNLKNMTANMDTLVAMGTSAAYFYSL
YNVFTKPSHEIHNYLYFEASAVIITLVTLGKLLEATAKGKTSEAIKNLMGLQAKTARVIRDGQELDIPIEEVKVGDIVVV
RPGEKIPVDGKIVEGSSTIDESMITGESIPVEKGVGDEVIGATINKTGTFKFEATKVGKDTVLSQIIKMVEDAQGSKAPI
QQIADKISGIFVPTVMGIAATTFLIWYFGYGDFNAGIINAVSVLVIACPCALGLAVPTSVMVGTGKGAENGILIKGGEHL
QRAGKITTIVLDKTGTITKGEPEVTDIEAFGNFTEEEILKIAGIAEKNSEHPLGQAIVNKAKEKFKILEVPEKFEAIPGY
GICITINEKEFYIGNRRLMDRQNIDITPIEDKLVNLEIQGKTSMILASKDCVYGIIAVADTVKSDSAKAIKELQAMGIEV
YMITGDNKRTAEAIAKQVGIKNVLAEVLPEDKAEEVAKLQKMGKVVAMVGDGINDAPALATADVGIAIGTGTDVAIETSD
ITLISGNLMGIVTAIKLSKATMRNIYQNLFWAFIYNTIGIPFAAMGFLTPAIAGGAMAFSSVSVVLNALRLRRFREG

Sequences:

>Translated_797_residues
MAEKANLKITGMSCAACATKIEKGLKSLDGVLDANVNLAIEKATVIYDPDKINICDMEKKIEDIGYGVIKDKVELALMGM
SCASCAAKIEKTLKNLPGVSNASVNFATETATVEYDSNEIDTEKMIKAIKDIGYDAKEKTGVGIDTEKEIKEREINTLRK
LVIYSAILTVPLVLSMFLVMFKVPGGILENPWLQVFLSSPVQFIVGLRYYKGAWNNLKNMTANMDTLVAMGTSAAYFYSL
YNVFTKPSHEIHNYLYFEASAVIITLVTLGKLLEATAKGKTSEAIKNLMGLQAKTARVIRDGQELDIPIEEVKVGDIVVV
RPGEKIPVDGKIVEGSSTIDESMITGESIPVEKGVGDEVIGATINKTGTFKFEATKVGKDTVLSQIIKMVEDAQGSKAPI
QQIADKISGIFVPTVMGIAATTFLIWYFGYGDFNAGIINAVSVLVIACPCALGLAVPTSVMVGTGKGAENGILIKGGEHL
QRAGKITTIVLDKTGTITKGEPEVTDIEAFGNFTEEEILKIAGIAEKNSEHPLGQAIVNKAKEKFKILEVPEKFEAIPGY
GICITINEKEFYIGNRRLMDRQNIDITPIEDKLVNLEIQGKTSMILASKDCVYGIIAVADTVKSDSAKAIKELQAMGIEV
YMITGDNKRTAEAIAKQVGIKNVLAEVLPEDKAEEVAKLQKMGKVVAMVGDGINDAPALATADVGIAIGTGTDVAIETSD
ITLISGNLMGIVTAIKLSKATMRNIYQNLFWAFIYNTIGIPFAAMGFLTPAIAGGAMAFSSVSVVLNALRLRRFREG
>Mature_796_residues
AEKANLKITGMSCAACATKIEKGLKSLDGVLDANVNLAIEKATVIYDPDKINICDMEKKIEDIGYGVIKDKVELALMGMS
CASCAAKIEKTLKNLPGVSNASVNFATETATVEYDSNEIDTEKMIKAIKDIGYDAKEKTGVGIDTEKEIKEREINTLRKL
VIYSAILTVPLVLSMFLVMFKVPGGILENPWLQVFLSSPVQFIVGLRYYKGAWNNLKNMTANMDTLVAMGTSAAYFYSLY
NVFTKPSHEIHNYLYFEASAVIITLVTLGKLLEATAKGKTSEAIKNLMGLQAKTARVIRDGQELDIPIEEVKVGDIVVVR
PGEKIPVDGKIVEGSSTIDESMITGESIPVEKGVGDEVIGATINKTGTFKFEATKVGKDTVLSQIIKMVEDAQGSKAPIQ
QIADKISGIFVPTVMGIAATTFLIWYFGYGDFNAGIINAVSVLVIACPCALGLAVPTSVMVGTGKGAENGILIKGGEHLQ
RAGKITTIVLDKTGTITKGEPEVTDIEAFGNFTEEEILKIAGIAEKNSEHPLGQAIVNKAKEKFKILEVPEKFEAIPGYG
ICITINEKEFYIGNRRLMDRQNIDITPIEDKLVNLEIQGKTSMILASKDCVYGIIAVADTVKSDSAKAIKELQAMGIEVY
MITGDNKRTAEAIAKQVGIKNVLAEVLPEDKAEEVAKLQKMGKVVAMVGDGINDAPALATADVGIAIGTGTDVAIETSDI
TLISGNLMGIVTAIKLSKATMRNIYQNLFWAFIYNTIGIPFAAMGFLTPAIAGGAMAFSSVSVVLNALRLRRFREG

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=860, Percent_Identity=40.3488372093023, Blast_Score=575, Evalue=1e-164,
Organism=Homo sapiens, GI115529486, Length=897, Percent_Identity=38.907469342252, Blast_Score=558, Evalue=1e-159,
Organism=Homo sapiens, GI55743073, Length=538, Percent_Identity=43.8661710037175, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI209413709, Length=165, Percent_Identity=33.9393939393939, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI24638454, Length=165, Percent_Identity=33.9393939393939, Blast_Score=90, Evalue=8e-18,
Organism=Homo sapiens, GI4502285, Length=165, Percent_Identity=33.9393939393939, Blast_Score=90, Evalue=1e-17,
Organism=Homo sapiens, GI28373109, Length=185, Percent_Identity=30.8108108108108, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI28373105, Length=185, Percent_Identity=30.8108108108108, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI28373107, Length=185, Percent_Identity=30.8108108108108, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI28373113, Length=185, Percent_Identity=30.8108108108108, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI28373103, Length=185, Percent_Identity=30.8108108108108, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI28373115, Length=185, Percent_Identity=30.8108108108108, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI28373111, Length=185, Percent_Identity=30.8108108108108, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI48762689, Length=160, Percent_Identity=34.375, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI48762685, Length=160, Percent_Identity=34.375, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI48762687, Length=160, Percent_Identity=34.375, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI48762691, Length=160, Percent_Identity=34.375, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI27886529, Length=165, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI10835220, Length=165, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI310128958, Length=159, Percent_Identity=33.9622641509434, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI118498343, Length=184, Percent_Identity=29.8913043478261, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI4502271, Length=209, Percent_Identity=28.7081339712919, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI153946397, Length=207, Percent_Identity=27.536231884058, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI237681111, Length=207, Percent_Identity=27.0531400966184, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI237681109, Length=207, Percent_Identity=27.0531400966184, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI21361181, Length=207, Percent_Identity=27.0531400966184, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI22748667, Length=207, Percent_Identity=26.5700483091787, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI51944966, Length=217, Percent_Identity=25.3456221198157, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI83700225, Length=363, Percent_Identity=23.9669421487603, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI297374799, Length=366, Percent_Identity=23.224043715847, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1786691, Length=847, Percent_Identity=37.8984651711924, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI1789879, Length=726, Percent_Identity=32.6446280991736, Blast_Score=343, Evalue=2e-95,
Organism=Escherichia coli, GI1786914, Length=514, Percent_Identity=30.5447470817121, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI2367363, Length=606, Percent_Identity=24.9174917491749, Blast_Score=150, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17556548, Length=877, Percent_Identity=37.1721778791334, Blast_Score=472, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17554158, Length=193, Percent_Identity=31.6062176165803, Blast_Score=102, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71988506, Length=193, Percent_Identity=31.6062176165803, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193210130, Length=203, Percent_Identity=31.5270935960591, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17557486, Length=184, Percent_Identity=33.695652173913, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17557770, Length=184, Percent_Identity=32.6086956521739, Blast_Score=95, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32566766, Length=190, Percent_Identity=31.5789473684211, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI193203356, Length=188, Percent_Identity=31.9148936170213, Blast_Score=92, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193203354, Length=188, Percent_Identity=31.9148936170213, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71997262, Length=280, Percent_Identity=27.5, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71997275, Length=280, Percent_Identity=27.5, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17541776, Length=198, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71997269, Length=280, Percent_Identity=27.5, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17559224, Length=226, Percent_Identity=26.5486725663717, Blast_Score=79, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71995286, Length=198, Percent_Identity=31.8181818181818, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71995291, Length=198, Percent_Identity=31.8181818181818, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71995298, Length=198, Percent_Identity=31.8181818181818, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17531459, Length=104, Percent_Identity=37.5, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320475, Length=872, Percent_Identity=36.697247706422, Blast_Score=452, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6319772, Length=660, Percent_Identity=30, Blast_Score=286, Evalue=9e-78,
Organism=Saccharomyces cerevisiae, GI6321430, Length=523, Percent_Identity=26.5774378585086, Blast_Score=158, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6325221, Length=552, Percent_Identity=26.4492753623188, Blast_Score=158, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6321271, Length=180, Percent_Identity=37.7777777777778, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321432, Length=180, Percent_Identity=35, Blast_Score=95, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320245, Length=298, Percent_Identity=25.8389261744966, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320244, Length=284, Percent_Identity=25.7042253521127, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320243, Length=284, Percent_Identity=25.7042253521127, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221329854, Length=628, Percent_Identity=37.4203821656051, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI281366676, Length=733, Percent_Identity=22.237380627558, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17136664, Length=165, Percent_Identity=32.7272727272727, Blast_Score=94, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24762455, Length=165, Percent_Identity=32.7272727272727, Blast_Score=94, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24762453, Length=165, Percent_Identity=32.7272727272727, Blast_Score=94, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24762447, Length=165, Percent_Identity=32.7272727272727, Blast_Score=94, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24762457, Length=165, Percent_Identity=32.7272727272727, Blast_Score=94, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24762449, Length=165, Percent_Identity=32.7272727272727, Blast_Score=94, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24762445, Length=165, Percent_Identity=32.7272727272727, Blast_Score=94, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24762451, Length=165, Percent_Identity=32.7272727272727, Blast_Score=94, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24668704, Length=166, Percent_Identity=33.1325301204819, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24668708, Length=166, Percent_Identity=33.1325301204819, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI161085803, Length=166, Percent_Identity=33.1325301204819, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281366617, Length=166, Percent_Identity=33.1325301204819, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24668696, Length=166, Percent_Identity=33.1325301204819, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281362164, Length=301, Percent_Identity=26.578073089701, Blast_Score=79, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45553437, Length=301, Percent_Identity=26.578073089701, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45553435, Length=301, Percent_Identity=26.578073089701, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45553439, Length=301, Percent_Identity=26.578073089701, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24648576, Length=301, Percent_Identity=26.578073089701, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45553441, Length=297, Percent_Identity=25.2525252525253, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24648580, Length=297, Percent_Identity=25.2525252525253, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24648578, Length=297, Percent_Identity=25.2525252525253, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24648582, Length=301, Percent_Identity=26.578073089701, Blast_Score=78, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR006122
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 85758; Mature: 85627

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKANLKITGMSCAACATKIEKGLKSLDGVLDANVNLAIEKATVIYDPDKINICDMEKK
CCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCEECHHHH
IEDIGYGVIKDKVELALMGMSCASCAAKIEKTLKNLPGVSNASVNFATETATVEYDSNEI
HHHCCCCHHHHHHHHEEECCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEECCCCC
DTEKMIKAIKDIGYDAKEKTGVGIDTEKEIKEREINTLRKLVIYSAILTVPLVLSMFLVM
CHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKVPGGILENPWLQVFLSSPVQFIVGLRYYKGAWNNLKNMTANMDTLVAMGTSAAYFYSL
HHCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEECCHHHHHHHH
YNVFTKPSHEIHNYLYFEASAVIITLVTLGKLLEATAKGKTSEAIKNLMGLQAKTARVIR
HHHHCCCCHHHHHEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHC
DGQELDIPIEEVKVGDIVVVRPGEKIPVDGKIVEGSSTIDESMITGESIPVEKGVGDEVI
CCCCCCCCHHHEEECCEEEECCCCCCCCCCEEECCCCCHHHHHHCCCCCCCCCCCCCHHH
GATINKTGTFKFEATKVGKDTVLSQIIKMVEDAQGSKAPIQQIADKISGIFVPTVMGIAA
CCEECCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHH
TTFLIWYFGYGDFNAGIINAVSVLVIACPCALGLAVPTSVMVGTGKGAENGILIKGGEHL
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEECCHHH
QRAGKITTIVLDKTGTITKGEPEVTDIEAFGNFTEEEILKIAGIAEKNSEHPLGQAIVNK
HHCCCEEEEEEECCCCCCCCCCCCEEHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHH
AKEKFKILEVPEKFEAIPGYGICITINEKEFYIGNRRLMDRQNIDITPIEDKLVNLEIQG
HHHHEEEECCCHHHHCCCCCEEEEEECCCEEEECCCEECCCCCCCCCCCCCEEEEEEECC
KTSMILASKDCVYGIIAVADTVKSDSAKAIKELQAMGIEVYMITGDNKRTAEAIAKQVGI
CCEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCH
KNVLAEVLPEDKAEEVAKLQKMGKVVAMVGDGINDAPALATADVGIAIGTGTDVAIETSD
HHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCEEECCCCEEEECCCCEEEEECC
ITLISGNLMGIVTAIKLSKATMRNIYQNLFWAFIYNTIGIPFAAMGFLTPAIAGGAMAFS
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHH
SVSVVLNALRLRRFREG
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AEKANLKITGMSCAACATKIEKGLKSLDGVLDANVNLAIEKATVIYDPDKINICDMEKK
CCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCEECHHHH
IEDIGYGVIKDKVELALMGMSCASCAAKIEKTLKNLPGVSNASVNFATETATVEYDSNEI
HHHCCCCHHHHHHHHEEECCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEECCCCC
DTEKMIKAIKDIGYDAKEKTGVGIDTEKEIKEREINTLRKLVIYSAILTVPLVLSMFLVM
CHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKVPGGILENPWLQVFLSSPVQFIVGLRYYKGAWNNLKNMTANMDTLVAMGTSAAYFYSL
HHCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEECCHHHHHHHH
YNVFTKPSHEIHNYLYFEASAVIITLVTLGKLLEATAKGKTSEAIKNLMGLQAKTARVIR
HHHHCCCCHHHHHEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHC
DGQELDIPIEEVKVGDIVVVRPGEKIPVDGKIVEGSSTIDESMITGESIPVEKGVGDEVI
CCCCCCCCHHHEEECCEEEECCCCCCCCCCEEECCCCCHHHHHHCCCCCCCCCCCCCHHH
GATINKTGTFKFEATKVGKDTVLSQIIKMVEDAQGSKAPIQQIADKISGIFVPTVMGIAA
CCEECCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHH
TTFLIWYFGYGDFNAGIINAVSVLVIACPCALGLAVPTSVMVGTGKGAENGILIKGGEHL
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEECCHHH
QRAGKITTIVLDKTGTITKGEPEVTDIEAFGNFTEEEILKIAGIAEKNSEHPLGQAIVNK
HHCCCEEEEEEECCCCCCCCCCCCEEHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHH
AKEKFKILEVPEKFEAIPGYGICITINEKEFYIGNRRLMDRQNIDITPIEDKLVNLEIQG
HHHHEEEECCCHHHHCCCCCEEEEEECCCEEEECCCEECCCCCCCCCCCCCEEEEEEECC
KTSMILASKDCVYGIIAVADTVKSDSAKAIKELQAMGIEVYMITGDNKRTAEAIAKQVGI
CCEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCH
KNVLAEVLPEDKAEEVAKLQKMGKVVAMVGDGINDAPALATADVGIAIGTGTDVAIETSD
HHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCEEECCCCEEEECCCCEEEEECC
ITLISGNLMGIVTAIKLSKATMRNIYQNLFWAFIYNTIGIPFAAMGFLTPAIAGGAMAFS
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHH
SVSVVLNALRLRRFREG
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 12644235; 11922674; 12590580 [H]