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The map label for this gene is menA [H]

Identifier: 167039332

GI number: 167039332

Start: 707631

End: 708566

Strand: Direct

Name: menA [H]

Synonym: Teth514_0674

Alternate gene names: 167039332

Gene position: 707631-708566 (Clockwise)

Preceding gene: 167039331

Following gene: 167039333

Centisome position: 28.8

GC content: 30.45

Gene sequence:

>936_bases
ATGAACAAATCAGAATTTTCGAGAGTTTGGAAGGGATTTTGGCAATTAGCAGATCCTAAAATATGGATAGCCTCTACAGT
TCCTATGTTTGTTGCAGCAGCTTATGCTTATGGAAAAACAGGTAAATTTGATTTTTTATGGTTTTTTATATCTGTAATAG
GCATTTACTTTATTGAAATTGGGAAAAATGCTGTTAATGAAGTTATTGATTATAAGTCTGGGGTAGATACATTTGTGACT
CCTGATAAAAGGACTCCTTTTAGTGGGGGAAAAAAGACAATTGTTGAAGGTAAACTTACAGTTAAAGAGACAATAATTAT
CGCAGTTTTAACTATGCTTGCTGCCTGTTTTATAGGTTTAATCATTGTGGTTTTTCGTGAACCTTTAGTGTTAATAATTG
GATTATTAGGAATTTTAATATCAATTTTTTATAGTCTACCTCCTTTTAAATTTAGTTATATAGGTTTTGGAGAAATAGCA
GTTGGAGTAACTTTTGGACCTTTAATTATGACAGGTATGTACTTGGTTTTGACTCATCACATAAGTGGAGATATTTTATT
ACTTTCATTACCGATAGGATTTTTAATAACTAATGTTCTCTGGATAAATCAGTATCCTGATTATGAGGCGGACCTTAGAG
GTCATAAATATAATTTATTGGTGCGAATTGGCAAAGAAAAAGGTGTAATTGTATATGCAGCTCTTTATGGAGCAGCGTAC
CTATCTTTTATTGTAATAGCTATTGTTACTAAGAATTTTCTATGGTTGTTATCTTTTGTTACACTTCCTTTAGCAGTACA
ATCTGTAAAAATTGCTCGCAAATATTATGACAATATACCTAAATTAATAAAAGCAAATGCTAATACTGTGAAGATATATC
AAATAACAGGAATTTCAATGATTATAGCTTCGCTCTTATTAAGAGTAAAATTGTAA

Upstream 100 bases:

>100_bases
TAAAAAAGTATATATAACCTCTGGTCTAAAAGGCAACTTTAAAGTTACTGATCCTGAATATACTTTAATGACTAAATAAT
TTCTTGCAGGAGGAAACATT

Downstream 100 bases:

>100_bases
TATACATAAAAAGGAAAATTTAAAAAGCTTCTTAAAAGAAGTATACGTTTTTTATTTATATTACTTGATATTATTTTAAC
GGAATGGTATAATATTCTTA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MNKSEFSRVWKGFWQLADPKIWIASTVPMFVAAAYAYGKTGKFDFLWFFISVIGIYFIEIGKNAVNEVIDYKSGVDTFVT
PDKRTPFSGGKKTIVEGKLTVKETIIIAVLTMLAACFIGLIIVVFREPLVLIIGLLGILISIFYSLPPFKFSYIGFGEIA
VGVTFGPLIMTGMYLVLTHHISGDILLLSLPIGFLITNVLWINQYPDYEADLRGHKYNLLVRIGKEKGVIVYAALYGAAY
LSFIVIAIVTKNFLWLLSFVTLPLAVQSVKIARKYYDNIPKLIKANANTVKIYQITGISMIIASLLLRVKL

Sequences:

>Translated_311_residues
MNKSEFSRVWKGFWQLADPKIWIASTVPMFVAAAYAYGKTGKFDFLWFFISVIGIYFIEIGKNAVNEVIDYKSGVDTFVT
PDKRTPFSGGKKTIVEGKLTVKETIIIAVLTMLAACFIGLIIVVFREPLVLIIGLLGILISIFYSLPPFKFSYIGFGEIA
VGVTFGPLIMTGMYLVLTHHISGDILLLSLPIGFLITNVLWINQYPDYEADLRGHKYNLLVRIGKEKGVIVYAALYGAAY
LSFIVIAIVTKNFLWLLSFVTLPLAVQSVKIARKYYDNIPKLIKANANTVKIYQITGISMIIASLLLRVKL
>Mature_311_residues
MNKSEFSRVWKGFWQLADPKIWIASTVPMFVAAAYAYGKTGKFDFLWFFISVIGIYFIEIGKNAVNEVIDYKSGVDTFVT
PDKRTPFSGGKKTIVEGKLTVKETIIIAVLTMLAACFIGLIIVVFREPLVLIIGLLGILISIFYSLPPFKFSYIGFGEIA
VGVTFGPLIMTGMYLVLTHHISGDILLLSLPIGFLITNVLWINQYPDYEADLRGHKYNLLVRIGKEKGVIVYAALYGAAY
LSFIVIAIVTKNFLWLLSFVTLPLAVQSVKIARKYYDNIPKLIKANANTVKIYQITGISMIIASLLLRVKL

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Escherichia coli, GI1790365, Length=286, Percent_Identity=26.2237762237762, Blast_Score=82, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17737429, Length=258, Percent_Identity=27.1317829457364, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 34731; Mature: 34731

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKSEFSRVWKGFWQLADPKIWIASTVPMFVAAAYAYGKTGKFDFLWFFISVIGIYFIEI
CCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
GKNAVNEVIDYKSGVDTFVTPDKRTPFSGGKKTIVEGKLTVKETIIIAVLTMLAACFIGL
CHHHHHHHHHHCCCCCCEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
IIVVFREPLVLIIGLLGILISIFYSLPPFKFSYIGFGEIAVGVTFGPLIMTGMYLVLTHH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHEEHHHHHHHHHHHHHHHHHHH
ISGDILLLSLPIGFLITNVLWINQYPDYEADLRGHKYNLLVRIGKEKGVIVYAALYGAAY
CCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEHHHHHHHH
LSFIVIAIVTKNFLWLLSFVTLPLAVQSVKIARKYYDNIPKLIKANANTVKIYQITGISM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEEEEECCHHH
IIASLLLRVKL
HHHHHHHHHCC
>Mature Secondary Structure
MNKSEFSRVWKGFWQLADPKIWIASTVPMFVAAAYAYGKTGKFDFLWFFISVIGIYFIEI
CCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
GKNAVNEVIDYKSGVDTFVTPDKRTPFSGGKKTIVEGKLTVKETIIIAVLTMLAACFIGL
CHHHHHHHHHHCCCCCCEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
IIVVFREPLVLIIGLLGILISIFYSLPPFKFSYIGFGEIAVGVTFGPLIMTGMYLVLTHH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHEEHHHHHHHHHHHHHHHHHHH
ISGDILLLSLPIGFLITNVLWINQYPDYEADLRGHKYNLLVRIGKEKGVIVYAALYGAAY
CCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEHHHHHHHH
LSFIVIAIVTKNFLWLLSFVTLPLAVQSVKIARKYYDNIPKLIKANANTVKIYQITGISM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEEEEECCHHH
IIASLLLRVKL
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]