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The map label for this gene is purD [H]

Identifier: 167039185

GI number: 167039185

Start: 542270

End: 543529

Strand: Direct

Name: purD [H]

Synonym: Teth514_0526

Alternate gene names: 167039185

Gene position: 542270-543529 (Clockwise)

Preceding gene: 167039184

Following gene: 167039186

Centisome position: 22.07

GC content: 36.11

Gene sequence:

>1260_bases
ATGAAGGTTTTAGTCATAGGGGGAGGGGGAAGAGAACATGCAATTGTTCACAAACTTTCACAAAGTCCTAAAGTGGATAA
AATCTACTGTGCTCCTGGTAATGCTGGCATAGGGCTTTTAGCAGAATGTGTTGACATAAAAATTGGAGATATTGAAAAGC
TTAAAGAATTTGCCATAAAAAATAACATTGATTTAACAGTTGTAGGACCTGAGATGCCATTGGTACAAGGTATTGTGGAT
GAATTTGAAAAAGCAGGGCTTAAAATCTTTGGGCCTAATAAAAATGCTGCGGCTATTGAGGGAAGCAAATATTTTACTAA
ACATCTTCTTTCTAAATACAATATTCCTACTGGAAGGTTTAAAGCCTTTGACAAGTATCAGGAGGCTATGAAGTTTTTAA
AAGAGACATGGTATCCTGTTGTGATGAAAGCAGATGGACTGGCACAAGGTAAAGGAGTGTTTATTGTAAAAGACTTTATA
GAGGCAAAAGAAGCTCTTGATTTAATGATGAAAAAAAGGATTTTTGGTGCATCAGGAGATATCGTAATAATAGAAGAGAT
GCTTTTTGGAAAAGAAGCGTCAGTATTCGCATTTACAGATGGAGAAAATATTTTACCTATGGTTTCTGCTATGGATTACA
AAAAGGTCTATGAAGGAGACAAAGGTCCTAACACTGGAGGTATGGGAAGCATTGCACCAAATCCTTATCTTGAAAAAGAA
ACTTTAAAAGAAGTGATGGAAAGTATTTTAAAACCAGTGGTAAAGGCACTTCAAAAAGAAGGCATTGTATATAAAGGAGT
GTTATACGCAGGTTTAATGCTTACAAAAGAAGGGCCTAAGGTTTTAGAATTTAATGCAAGATTTGGAGACCCTGAAACAC
AAGTTGTACTGCCCCTTTTAAAAACAGACCTTATTAATATAATAGAAGCTACCATAGAAGGAAAACTTGATAAAATACAA
ATTGAATGGGAAGACAAAAAGGCTGTATGTGCCGTTGCGGTATCAAACGGTTACCCAGGGGAATATCAGACTGGTTTTGA
GATAACAGGGTTAGAGAAAGTAAAAGAAGCCTTTGTATACCACGCAGGAACGGCATTAAAAGATGGTAAAATTGTCACAT
CAGGAGGAAGAGTGCTTGCTGTTACCACAATAGGGGATTCATATGAAGAAGCGAGAGAGAAAGTTTATAGAGAAATTGAA
AAAATAAGCTTTGAAGGGATGTACTATAGAAAAGATATTGCTTTGGTAAGCCAGGTGTAA

Upstream 100 bases:

>100_bases
CTCACAAAACGATGCTTTATCAATTGAAGCTGCAGATAAAGGCGGCGTATCAATGATATTCACAGGCATAAGGCATTTTA
AACATTGAGGAGGAATTTGT

Downstream 100 bases:

>100_bases
ACCTGGCATTTTTAATTGGCTAAAATTATGGTATAATATCTTCTAACGTGTGTCTTATAATTTTTAAAATGAGGGGAGTA
TGTGTACAATCAAGACAAAA

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MKVLVIGGGGREHAIVHKLSQSPKVDKIYCAPGNAGIGLLAECVDIKIGDIEKLKEFAIKNNIDLTVVGPEMPLVQGIVD
EFEKAGLKIFGPNKNAAAIEGSKYFTKHLLSKYNIPTGRFKAFDKYQEAMKFLKETWYPVVMKADGLAQGKGVFIVKDFI
EAKEALDLMMKKRIFGASGDIVIIEEMLFGKEASVFAFTDGENILPMVSAMDYKKVYEGDKGPNTGGMGSIAPNPYLEKE
TLKEVMESILKPVVKALQKEGIVYKGVLYAGLMLTKEGPKVLEFNARFGDPETQVVLPLLKTDLINIIEATIEGKLDKIQ
IEWEDKKAVCAVAVSNGYPGEYQTGFEITGLEKVKEAFVYHAGTALKDGKIVTSGGRVLAVTTIGDSYEEAREKVYREIE
KISFEGMYYRKDIALVSQV

Sequences:

>Translated_419_residues
MKVLVIGGGGREHAIVHKLSQSPKVDKIYCAPGNAGIGLLAECVDIKIGDIEKLKEFAIKNNIDLTVVGPEMPLVQGIVD
EFEKAGLKIFGPNKNAAAIEGSKYFTKHLLSKYNIPTGRFKAFDKYQEAMKFLKETWYPVVMKADGLAQGKGVFIVKDFI
EAKEALDLMMKKRIFGASGDIVIIEEMLFGKEASVFAFTDGENILPMVSAMDYKKVYEGDKGPNTGGMGSIAPNPYLEKE
TLKEVMESILKPVVKALQKEGIVYKGVLYAGLMLTKEGPKVLEFNARFGDPETQVVLPLLKTDLINIIEATIEGKLDKIQ
IEWEDKKAVCAVAVSNGYPGEYQTGFEITGLEKVKEAFVYHAGTALKDGKIVTSGGRVLAVTTIGDSYEEAREKVYREIE
KISFEGMYYRKDIALVSQV
>Mature_419_residues
MKVLVIGGGGREHAIVHKLSQSPKVDKIYCAPGNAGIGLLAECVDIKIGDIEKLKEFAIKNNIDLTVVGPEMPLVQGIVD
EFEKAGLKIFGPNKNAAAIEGSKYFTKHLLSKYNIPTGRFKAFDKYQEAMKFLKETWYPVVMKADGLAQGKGVFIVKDFI
EAKEALDLMMKKRIFGASGDIVIIEEMLFGKEASVFAFTDGENILPMVSAMDYKKVYEGDKGPNTGGMGSIAPNPYLEKE
TLKEVMESILKPVVKALQKEGIVYKGVLYAGLMLTKEGPKVLEFNARFGDPETQVVLPLLKTDLINIIEATIEGKLDKIQ
IEWEDKKAVCAVAVSNGYPGEYQTGFEITGLEKVKEAFVYHAGTALKDGKIVTSGGRVLAVTTIGDSYEEAREKVYREIE
KISFEGMYYRKDIALVSQV

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI28416899, Length=418, Percent_Identity=46.88995215311, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI4503915, Length=418, Percent_Identity=46.88995215311, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI209869995, Length=418, Percent_Identity=46.88995215311, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI209869993, Length=418, Percent_Identity=46.88995215311, Blast_Score=386, Evalue=1e-107,
Organism=Escherichia coli, GI1790438, Length=419, Percent_Identity=47.4940334128878, Blast_Score=392, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17567511, Length=425, Percent_Identity=41.4117647058824, Blast_Score=303, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6321203, Length=436, Percent_Identity=39.9082568807339, Blast_Score=312, Evalue=6e-86,
Organism=Drosophila melanogaster, GI62471619, Length=425, Percent_Identity=44.7058823529412, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24582400, Length=425, Percent_Identity=45.1764705882353, Blast_Score=333, Evalue=1e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 46136; Mature: 46136

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS50975 ATP_GRASP ; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVIGGGGREHAIVHKLSQSPKVDKIYCAPGNAGIGLLAECVDIKIGDIEKLKEFAIK
CEEEEEECCCCCHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHC
NNIDLTVVGPEMPLVQGIVDEFEKAGLKIFGPNKNAAAIEGSKYFTKHLLSKYNIPTGRF
CCCEEEEECCCCHHHHHHHHHHHHCCEEEECCCCCCEEECCHHHHHHHHHHHCCCCCCHH
KAFDKYQEAMKFLKETWYPVVMKADGLAQGKGVFIVKDFIEAKEALDLMMKKRIFGASGD
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCC
IVIIEEMLFGKEASVFAFTDGENILPMVSAMDYKKVYEGDKGPNTGGMGSIAPNPYLEKE
EEEEEHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
TLKEVMESILKPVVKALQKEGIVYKGVLYAGLMLTKEGPKVLEFNARFGDPETQVVLPLL
HHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCEEEECCCCCEEEEECCCCCCCHHEEHHHH
KTDLINIIEATIEGKLDKIQIEWEDKKAVCAVAVSNGYPGEYQTGFEITGLEKVKEAFVY
HHHHHHHHHHHHCCCEEEEEEEECCCCEEEEEEECCCCCCCCCCCEEEECHHHHHHHHHH
HAGTALKDGKIVTSGGRVLAVTTIGDSYEEAREKVYREIEKISFEGMYYRKDIALVSQV
HCCCEECCCEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHCCC
>Mature Secondary Structure
MKVLVIGGGGREHAIVHKLSQSPKVDKIYCAPGNAGIGLLAECVDIKIGDIEKLKEFAIK
CEEEEEECCCCCHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHC
NNIDLTVVGPEMPLVQGIVDEFEKAGLKIFGPNKNAAAIEGSKYFTKHLLSKYNIPTGRF
CCCEEEEECCCCHHHHHHHHHHHHCCEEEECCCCCCEEECCHHHHHHHHHHHCCCCCCHH
KAFDKYQEAMKFLKETWYPVVMKADGLAQGKGVFIVKDFIEAKEALDLMMKKRIFGASGD
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCC
IVIIEEMLFGKEASVFAFTDGENILPMVSAMDYKKVYEGDKGPNTGGMGSIAPNPYLEKE
EEEEEHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
TLKEVMESILKPVVKALQKEGIVYKGVLYAGLMLTKEGPKVLEFNARFGDPETQVVLPLL
HHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCEEEECCCCCEEEEECCCCCCCHHEEHHHH
KTDLINIIEATIEGKLDKIQIEWEDKKAVCAVAVSNGYPGEYQTGFEITGLEKVKEAFVY
HHHHHHHHHHHHCCCEEEEEEEECCCCEEEEEEECCCCCCCCCCCEEEECHHHHHHHHHH
HAGTALKDGKIVTSGGRVLAVTTIGDSYEEAREKVYREIEKISFEGMYYRKDIALVSQV
HCCCEECCCEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]