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The map label for this gene is guaA [H]

Identifier: 167039174

GI number: 167039174

Start: 530006

End: 531544

Strand: Direct

Name: guaA [H]

Synonym: Teth514_0515

Alternate gene names: 167039174

Gene position: 530006-531544 (Clockwise)

Preceding gene: 167039173

Following gene: 167039175

Centisome position: 21.57

GC content: 38.08

Gene sequence:

>1539_bases
ATGGGGATTAAACGGGAAGTAGTGTTAGTTTTAGACTTTGGAGGCCAATACACACAATTAATTGCGAGAAGAATAAGAGA
AGCAAATGTCTTTTGCGAGATTGTTCCTTACAATATTTCTCCAGAGGAGATACGAAAAAAAGAGCCAAAGGGAATTGTGC
TTTCTGGAGGACCTGCCAGTGTATATGCAAAAAATGCTCCTAAATGCGATAAGGAAATTTTTGAGTTAGGCTATCCTGTA
TTAGGTATATGTTATGGTGCACAACTTATGACAGAGCTTTTAGGCGGAAAAGTTGCGCCAGCACCTGTGAAGGAATATGG
CAAGACAGAAATTGTCTTAAATAATACTATTCCTTTGTTTAAAGGGATAGAAAGAGACACTGTTGTTTGGATGAGCCATA
CTGACCACATAGAACTTCCTCCTCCAGATTTTAAGGTAGTAGCCTCTACTGACAATTGTCCTATCGCAGCGATTGCGAAT
GTAGAAAAGAAATTGTATGCGGTTCAATTCCATCCTGAAGTTTCACACACTCATAGAGGAACAGAGATTATAAGAAATTT
CCTTTTTGAAGTATGTGATTGCGCGGCAGATTGGACAATGGATTCTTTGATTGAGCAGACAGTAAAGGAAATAAAAGCGA
AAGTAGGAAAACACAAAGCTGTATGTGCTCTGTCTGGTGGTGTAGATTCTTCAGTGGCTGCTGTTTTAGTAGACAGAGCC
ATTCACGACCAATTGGTGTGCATTTTTGTTGATACAGGGCTTTTAAGGAAAAACGAAGGAGATATGGTTATTGAAACTTT
TAGAAAAAATTATGACATGAACATAATCCGGGTAGATGCAAAGGATAGATTTTTGTCACGACTTAAGGGAGTTACGGATC
CAGAAGAAAAGAGAAAAATTATTGGTAATGTTTTTATAGAAGTTTTTAAAGAAGAAGCTTTAAAGATAGGAGATGTGAAA
TTTTTGGTGCAGGGTACTTTGTATCCTGATGTAATAGAAAGTGGCAATGGCGTGTCTTCTACTATTAAAAGTCACCACAA
TGTTGGAGGTTTGCCTGAAGATATAGGTTTTGAACTTATTGAACCTTTGAGGATGCTTTTTAAAGACGAAGTAAGGCAAG
TAGGTAAAGAATTAGGAATCCCTGAGGAAATATTGTATAGGCAGCCTTTCCCTGGACCAGGCCTTGCAGTCAGAATTCTT
GGAGAAGTTACAGAAGAAAAGTTAGAAATTTTGAGACAAGCTGACAGCATAGTTCTAAGAGAGATGAAAAAATTTGGATG
GTATAATAAAGTGTGGCAGTCATTTGCTGTATTGCCTGGAATAAAGAGCGTTGGTGTTATGGGTGATGAAAGGACATACG
CTTATGCGATAATTTTGAGGGTAGTAGATAGCTACGACGGGATGACGGCGGATTGGACAAAGCTTCCTTATGAAATTTTA
GAAAGTATATCTACTAGCATTACTAATGAAGTTCCAGGAGTAAATCGAGTGCTTTACGACATTACTTCTAAACCTCCTGC
TACCATAGAATGGGAATAA

Upstream 100 bases:

>100_bases
ATAAAAATAACGCAGGCAGGATTAACTGAAAGTCATCCTCATGATATAATTATTACAAAGGAAGCTCCTAATTATAATTT
GAGATAAGAGGAGGATTTTA

Downstream 100 bases:

>100_bases
AAATCCGAACATTATTTTAGTTTTTTATAAAAAAATTCGCAAATAAGGTTGACTAATATTAAAAAAGTTGATAAGATATA
AGTGTGACAATTGAATAAAA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MGIKREVVLVLDFGGQYTQLIARRIREANVFCEIVPYNISPEEIRKKEPKGIVLSGGPASVYAKNAPKCDKEIFELGYPV
LGICYGAQLMTELLGGKVAPAPVKEYGKTEIVLNNTIPLFKGIERDTVVWMSHTDHIELPPPDFKVVASTDNCPIAAIAN
VEKKLYAVQFHPEVSHTHRGTEIIRNFLFEVCDCAADWTMDSLIEQTVKEIKAKVGKHKAVCALSGGVDSSVAAVLVDRA
IHDQLVCIFVDTGLLRKNEGDMVIETFRKNYDMNIIRVDAKDRFLSRLKGVTDPEEKRKIIGNVFIEVFKEEALKIGDVK
FLVQGTLYPDVIESGNGVSSTIKSHHNVGGLPEDIGFELIEPLRMLFKDEVRQVGKELGIPEEILYRQPFPGPGLAVRIL
GEVTEEKLEILRQADSIVLREMKKFGWYNKVWQSFAVLPGIKSVGVMGDERTYAYAIILRVVDSYDGMTADWTKLPYEIL
ESISTSITNEVPGVNRVLYDITSKPPATIEWE

Sequences:

>Translated_512_residues
MGIKREVVLVLDFGGQYTQLIARRIREANVFCEIVPYNISPEEIRKKEPKGIVLSGGPASVYAKNAPKCDKEIFELGYPV
LGICYGAQLMTELLGGKVAPAPVKEYGKTEIVLNNTIPLFKGIERDTVVWMSHTDHIELPPPDFKVVASTDNCPIAAIAN
VEKKLYAVQFHPEVSHTHRGTEIIRNFLFEVCDCAADWTMDSLIEQTVKEIKAKVGKHKAVCALSGGVDSSVAAVLVDRA
IHDQLVCIFVDTGLLRKNEGDMVIETFRKNYDMNIIRVDAKDRFLSRLKGVTDPEEKRKIIGNVFIEVFKEEALKIGDVK
FLVQGTLYPDVIESGNGVSSTIKSHHNVGGLPEDIGFELIEPLRMLFKDEVRQVGKELGIPEEILYRQPFPGPGLAVRIL
GEVTEEKLEILRQADSIVLREMKKFGWYNKVWQSFAVLPGIKSVGVMGDERTYAYAIILRVVDSYDGMTADWTKLPYEIL
ESISTSITNEVPGVNRVLYDITSKPPATIEWE
>Mature_511_residues
GIKREVVLVLDFGGQYTQLIARRIREANVFCEIVPYNISPEEIRKKEPKGIVLSGGPASVYAKNAPKCDKEIFELGYPVL
GICYGAQLMTELLGGKVAPAPVKEYGKTEIVLNNTIPLFKGIERDTVVWMSHTDHIELPPPDFKVVASTDNCPIAAIANV
EKKLYAVQFHPEVSHTHRGTEIIRNFLFEVCDCAADWTMDSLIEQTVKEIKAKVGKHKAVCALSGGVDSSVAAVLVDRAI
HDQLVCIFVDTGLLRKNEGDMVIETFRKNYDMNIIRVDAKDRFLSRLKGVTDPEEKRKIIGNVFIEVFKEEALKIGDVKF
LVQGTLYPDVIESGNGVSSTIKSHHNVGGLPEDIGFELIEPLRMLFKDEVRQVGKELGIPEEILYRQPFPGPGLAVRILG
EVTEEKLEILRQADSIVLREMKKFGWYNKVWQSFAVLPGIKSVGVMGDERTYAYAIILRVVDSYDGMTADWTKLPYEILE
SISTSITNEVPGVNRVLYDITSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=547, Percent_Identity=36.9287020109689, Blast_Score=317, Evalue=2e-86,
Organism=Escherichia coli, GI1788854, Length=521, Percent_Identity=51.2476007677543, Blast_Score=557, Evalue=1e-160,
Organism=Escherichia coli, GI1789760, Length=167, Percent_Identity=29.940119760479, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71992717, Length=570, Percent_Identity=37.5438596491228, Blast_Score=323, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI71992710, Length=570, Percent_Identity=37.5438596491228, Blast_Score=323, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI133901714, Length=570, Percent_Identity=37.5438596491228, Blast_Score=323, Evalue=1e-88,
Organism=Saccharomyces cerevisiae, GI6323873, Length=516, Percent_Identity=50, Blast_Score=519, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6322638, Length=160, Percent_Identity=33.125, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281365319, Length=554, Percent_Identity=35.5595667870036, Blast_Score=310, Evalue=2e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57211; Mature: 57080

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIKREVVLVLDFGGQYTQLIARRIREANVFCEIVPYNISPEEIRKKEPKGIVLSGGPAS
CCCCEEEEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHCCCCCEEEEECCCCE
VYAKNAPKCDKEIFELGYPVLGICYGAQLMTELLGGKVAPAPVKEYGKTEIVLNNTIPLF
EEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEECCCCHHH
KGIERDTVVWMSHTDHIELPPPDFKVVASTDNCPIAAIANVEKKLYAVQFHPEVSHTHRG
CCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCEEEECCCCCEEEEEEECCCCCCCCCH
TEIIRNFLFEVCDCAADWTMDSLIEQTVKEIKAKVGKHKAVCALSGGVDSSVAAVLVDRA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHH
IHDQLVCIFVDTGLLRKNEGDMVIETFRKNYDMNIIRVDAKDRFLSRLKGVTDPEEKRKI
HHHCEEEEEEECCCEECCCCCHHHHHHHCCCCCEEEEECHHHHHHHHHCCCCCHHHHHHH
IGNVFIEVFKEEALKIGDVKFLVQGTLYPDVIESGNGVSSTIKSHHNVGGLPEDIGFELI
HHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHH
EPLRMLFKDEVRQVGKELGIPEEILYRQPFPGPGLAVRILGEVTEEKLEILRQADSIVLR
HHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
EMKKFGWYNKVWQSFAVLPGIKSVGVMGDERTYAYAIILRVVDSYDGMTADWTKLPYEIL
HHHHCCCHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCHHHH
ESISTSITNEVPGVNRVLYDITSKPPATIEWE
HHHHHHHHHCCCCCHHHHEECCCCCCCCEECC
>Mature Secondary Structure 
GIKREVVLVLDFGGQYTQLIARRIREANVFCEIVPYNISPEEIRKKEPKGIVLSGGPAS
CCCEEEEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHCCCCCEEEEECCCCE
VYAKNAPKCDKEIFELGYPVLGICYGAQLMTELLGGKVAPAPVKEYGKTEIVLNNTIPLF
EEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEECCCCHHH
KGIERDTVVWMSHTDHIELPPPDFKVVASTDNCPIAAIANVEKKLYAVQFHPEVSHTHRG
CCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCEEEECCCCCEEEEEEECCCCCCCCCH
TEIIRNFLFEVCDCAADWTMDSLIEQTVKEIKAKVGKHKAVCALSGGVDSSVAAVLVDRA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHH
IHDQLVCIFVDTGLLRKNEGDMVIETFRKNYDMNIIRVDAKDRFLSRLKGVTDPEEKRKI
HHHCEEEEEEECCCEECCCCCHHHHHHHCCCCCEEEEECHHHHHHHHHCCCCCHHHHHHH
IGNVFIEVFKEEALKIGDVKFLVQGTLYPDVIESGNGVSSTIKSHHNVGGLPEDIGFELI
HHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHH
EPLRMLFKDEVRQVGKELGIPEEILYRQPFPGPGLAVRILGEVTEEKLEILRQADSIVLR
HHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
EMKKFGWYNKVWQSFAVLPGIKSVGVMGDERTYAYAIILRVVDSYDGMTADWTKLPYEIL
HHHHCCCHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCHHHH
ESISTSITNEVPGVNRVLYDITSKPPATIEWE
HHHHHHHHHCCCCCHHHHEECCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]