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The map label for this gene is guaB [H]

Identifier: 167039173

GI number: 167039173

Start: 528538

End: 529992

Strand: Direct

Name: guaB [H]

Synonym: Teth514_0514

Alternate gene names: 167039173

Gene position: 528538-529992 (Clockwise)

Preceding gene: 167039172

Following gene: 167039174

Centisome position: 21.51

GC content: 38.69

Gene sequence:

>1455_bases
ATGGAGGAAAAGTTTGTTAAAGAAGGTTTAACTTTTGACGATGTTCTTTTAATTCCTGCTAAATCCGATGTGCTTCCTAA
GGATGTAGATTTAAAGACAAAGCTTACTAAAAAAATTACTTTAAACATTCCTTTAATGAGTGCTGGAATGGACACTGTTA
CAGAATCCAAACTTGCGATTGCTATAGCAAGGGAAGGCGGCATAGGTGTAATTCACAAAAACATGTCTATTGAAAGACAA
GCTTTAGAAGTTGACAAAGTCAAAAGGTCAGAGCATGGTGTCATAACGGACCCTTTCTCTCTTACTCCTGACCATACTAT
TAAAGATGCAGCTGAACTTATGGCAAGGTATAAAATATCTGGAGTACCTATCACTGTTGATTCGAAACTTGTAGGAATAA
TCACTAATCGCGATATAAGATTTGAAGATGATTTGGATAAACCTATAAGAGAAGTTATGACAAAAGACAATTTGGTAACT
GCTCCTCCTGGAACCACTTTAGAGGAAGCAAGACAGATACTAAAAAAACATAAAATAGAAAAATTGCCGTTAGTAGATGA
AAACAACGTTTTAAAAGGGCTCATAACCATAAAAGATATAGAAAAAGCAGTTGAGTTTCCTAATGCGGCAAAGGACAGCA
AGGGAAGACTTTTAGTGGCTGCTGCTGTCGGTGTTGGGAAAGACATGATGGATAGAGTCAAAGCATTAGTAGAAGCAGGT
GTAGACGCTATCGTGATAGATACAGCTCACGGTCATTCTAAAGGAGTTTTGGAGGCTGTCTCTAAGATAAAAGAAAAATA
TCCAGACCTGCAGCTGATAGCAGGAAATGTAGCTACGGCTGAAGCCACAAGAGACTTAATAGAGAGAGGGGCAGATTGTG
TAAAAGTTGGTATTGGCCCAGGGTCAATCTGTACTACGAGAGTGATCGCTGGAGTAGGAGTTCCTCAAATTACTGCTATT
TACGATTGTGCTCAAGAAGCGGACAAGTATGGGATACCTATAATTGCAGATGGAGGGATTAAGTATTCGGGGGACATCGT
AAAAGCCATTGCGGCGGGAGCTTCTGTAGTTATGCTGGGAAGCCTTTTTGCAGGAACAGAAGAAAGTCCCGGAGAAATAG
AGATATATCAAGGAAGAAGCTATAAGGTCTATAGAGGCATGGGTTCTTTAGGAGCAATGAAAGAAGGAAGCTCAGATAGG
TATTTCCAAGAAGATGTCACAAAGTTTGTACCAGAAGGGGTAGAAGGAAGGGTACCTTATAAAGGACCTTTAAAAGAGAC
AGTGTATCAATTAGTTGGTGGTTTAAGAGCAGGAATGGGATATTGTGGTGTTCGCAATATTGAAGAACTTAGGACAAAAA
CAAAATTTATAAAAATAACGCAGGCAGGATTAACTGAAAGTCATCCTCATGATATAATTATTACAAAGGAAGCTCCTAAT
TATAATTTGAGATAA

Upstream 100 bases:

>100_bases
AATTTATAAAGGACTATAAGTTAATTGTGTAAATTGTATGACGTTCAAAAAGATTTTGCTAATAATATGTTATAATAAAA
CTAAAAAGGGAGATGTAAGT

Downstream 100 bases:

>100_bases
GAGGAGGATTTTAATGGGGATTAAACGGGAAGTAGTGTTAGTTTTAGACTTTGGAGGCCAATACACACAATTAATTGCGA
GAAGAATAAGAGAAGCAAAT

Product: response regulator receiver protein

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MEEKFVKEGLTFDDVLLIPAKSDVLPKDVDLKTKLTKKITLNIPLMSAGMDTVTESKLAIAIAREGGIGVIHKNMSIERQ
ALEVDKVKRSEHGVITDPFSLTPDHTIKDAAELMARYKISGVPITVDSKLVGIITNRDIRFEDDLDKPIREVMTKDNLVT
APPGTTLEEARQILKKHKIEKLPLVDENNVLKGLITIKDIEKAVEFPNAAKDSKGRLLVAAAVGVGKDMMDRVKALVEAG
VDAIVIDTAHGHSKGVLEAVSKIKEKYPDLQLIAGNVATAEATRDLIERGADCVKVGIGPGSICTTRVIAGVGVPQITAI
YDCAQEADKYGIPIIADGGIKYSGDIVKAIAAGASVVMLGSLFAGTEESPGEIEIYQGRSYKVYRGMGSLGAMKEGSSDR
YFQEDVTKFVPEGVEGRVPYKGPLKETVYQLVGGLRAGMGYCGVRNIEELRTKTKFIKITQAGLTESHPHDIIITKEAPN
YNLR

Sequences:

>Translated_484_residues
MEEKFVKEGLTFDDVLLIPAKSDVLPKDVDLKTKLTKKITLNIPLMSAGMDTVTESKLAIAIAREGGIGVIHKNMSIERQ
ALEVDKVKRSEHGVITDPFSLTPDHTIKDAAELMARYKISGVPITVDSKLVGIITNRDIRFEDDLDKPIREVMTKDNLVT
APPGTTLEEARQILKKHKIEKLPLVDENNVLKGLITIKDIEKAVEFPNAAKDSKGRLLVAAAVGVGKDMMDRVKALVEAG
VDAIVIDTAHGHSKGVLEAVSKIKEKYPDLQLIAGNVATAEATRDLIERGADCVKVGIGPGSICTTRVIAGVGVPQITAI
YDCAQEADKYGIPIIADGGIKYSGDIVKAIAAGASVVMLGSLFAGTEESPGEIEIYQGRSYKVYRGMGSLGAMKEGSSDR
YFQEDVTKFVPEGVEGRVPYKGPLKETVYQLVGGLRAGMGYCGVRNIEELRTKTKFIKITQAGLTESHPHDIIITKEAPN
YNLR
>Mature_484_residues
MEEKFVKEGLTFDDVLLIPAKSDVLPKDVDLKTKLTKKITLNIPLMSAGMDTVTESKLAIAIAREGGIGVIHKNMSIERQ
ALEVDKVKRSEHGVITDPFSLTPDHTIKDAAELMARYKISGVPITVDSKLVGIITNRDIRFEDDLDKPIREVMTKDNLVT
APPGTTLEEARQILKKHKIEKLPLVDENNVLKGLITIKDIEKAVEFPNAAKDSKGRLLVAAAVGVGKDMMDRVKALVEAG
VDAIVIDTAHGHSKGVLEAVSKIKEKYPDLQLIAGNVATAEATRDLIERGADCVKVGIGPGSICTTRVIAGVGVPQITAI
YDCAQEADKYGIPIIADGGIKYSGDIVKAIAAGASVVMLGSLFAGTEESPGEIEIYQGRSYKVYRGMGSLGAMKEGSSDR
YFQEDVTKFVPEGVEGRVPYKGPLKETVYQLVGGLRAGMGYCGVRNIEELRTKTKFIKITQAGLTESHPHDIIITKEAPN
YNLR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=479, Percent_Identity=45.9290187891441, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI156616279, Length=479, Percent_Identity=45.9290187891441, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI34328928, Length=479, Percent_Identity=45.9290187891441, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI34328930, Length=479, Percent_Identity=45.9290187891441, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI66933016, Length=479, Percent_Identity=44.258872651357, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI217035152, Length=473, Percent_Identity=45.877378435518, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI217035148, Length=479, Percent_Identity=45.0939457202505, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI217035150, Length=479, Percent_Identity=42.7974947807933, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI156104880, Length=246, Percent_Identity=39.4308943089431, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI50541956, Length=246, Percent_Identity=39.8373983739837, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI50541954, Length=246, Percent_Identity=39.8373983739837, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI50541952, Length=246, Percent_Identity=39.8373983739837, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI50541948, Length=246, Percent_Identity=39.8373983739837, Blast_Score=179, Evalue=6e-45,
Organism=Escherichia coli, GI1788855, Length=484, Percent_Identity=59.504132231405, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI1786293, Length=343, Percent_Identity=33.2361516034985, Blast_Score=179, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI71994385, Length=474, Percent_Identity=40.5063291139241, Blast_Score=310, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI71994389, Length=426, Percent_Identity=42.2535211267606, Blast_Score=294, Evalue=8e-80,
Organism=Caenorhabditis elegans, GI17560440, Length=238, Percent_Identity=39.4957983193277, Blast_Score=179, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6322012, Length=483, Percent_Identity=40.3726708074534, Blast_Score=350, Evalue=3e-97,
Organism=Saccharomyces cerevisiae, GI6323585, Length=454, Percent_Identity=42.2907488986784, Blast_Score=347, Evalue=3e-96,
Organism=Saccharomyces cerevisiae, GI6323464, Length=462, Percent_Identity=42.2077922077922, Blast_Score=340, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6319352, Length=390, Percent_Identity=38.974358974359, Blast_Score=269, Evalue=8e-73,
Organism=Saccharomyces cerevisiae, GI6319353, Length=120, Percent_Identity=39.1666666666667, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24641071, Length=482, Percent_Identity=42.7385892116183, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24641073, Length=482, Percent_Identity=42.7385892116183, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI28571163, Length=440, Percent_Identity=42.5, Blast_Score=325, Evalue=4e-89,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52375; Mature: 52375

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEKFVKEGLTFDDVLLIPAKSDVLPKDVDLKTKLTKKITLNIPLMSAGMDTVTESKLAI
CCCHHHHCCCCCCCEEEEECCCCCCCCCCCCCEEEEEEEEEECCEEECCCCHHCCCEEEE
AIAREGGIGVIHKNMSIERQALEVDKVKRSEHGVITDPFSLTPDHTIKDAAELMARYKIS
EEEECCCEEEEECCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHCCC
GVPITVDSKLVGIITNRDIRFEDDLDKPIREVMTKDNLVTAPPGTTLEEARQILKKHKIE
CCEEEECCEEEEEEECCCEEECCCCHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCCC
KLPLVDENNVLKGLITIKDIEKAVEFPNAAKDSKGRLLVAAAVGVGKDMMDRVKALVEAG
CCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCC
VDAIVIDTAHGHSKGVLEAVSKIKEKYPDLQLIAGNVATAEATRDLIERGADCVKVGIGP
CCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCEEEECCCC
GSICTTRVIAGVGVPQITAIYDCAQEADKYGIPIIADGGIKYSGDIVKAIAAGASVVMLG
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCHHEEHH
SLFAGTEESPGEIEIYQGRSYKVYRGMGSLGAMKEGSSDRYFQEDVTKFVPEGVEGRVPY
HHHCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC
KGPLKETVYQLVGGLRAGMGYCGVRNIEELRTKTKFIKITQAGLTESHPHDIIITKEAPN
CCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEEEEEECCCCCCCCCCEEEEECCCC
YNLR
CCCC
>Mature Secondary Structure
MEEKFVKEGLTFDDVLLIPAKSDVLPKDVDLKTKLTKKITLNIPLMSAGMDTVTESKLAI
CCCHHHHCCCCCCCEEEEECCCCCCCCCCCCCEEEEEEEEEECCEEECCCCHHCCCEEEE
AIAREGGIGVIHKNMSIERQALEVDKVKRSEHGVITDPFSLTPDHTIKDAAELMARYKIS
EEEECCCEEEEECCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHCCC
GVPITVDSKLVGIITNRDIRFEDDLDKPIREVMTKDNLVTAPPGTTLEEARQILKKHKIE
CCEEEECCEEEEEEECCCEEECCCCHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCCC
KLPLVDENNVLKGLITIKDIEKAVEFPNAAKDSKGRLLVAAAVGVGKDMMDRVKALVEAG
CCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCC
VDAIVIDTAHGHSKGVLEAVSKIKEKYPDLQLIAGNVATAEATRDLIERGADCVKVGIGP
CCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCEEEECCCC
GSICTTRVIAGVGVPQITAIYDCAQEADKYGIPIIADGGIKYSGDIVKAIAAGASVVMLG
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCHHEEHH
SLFAGTEESPGEIEIYQGRSYKVYRGMGSLGAMKEGSSDRYFQEDVTKFVPEGVEGRVPY
HHHCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC
KGPLKETVYQLVGGLRAGMGYCGVRNIEELRTKTKFIKITQAGLTESHPHDIIITKEAPN
CCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEEEEEECCCCCCCCCCEEEEECCCC
YNLR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]