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The map label for this gene is groEL [H]

Identifier: 167039172

GI number: 167039172

Start: 526350

End: 527975

Strand: Direct

Name: groEL [H]

Synonym: Teth514_0513

Alternate gene names: 167039172

Gene position: 526350-527975 (Clockwise)

Preceding gene: 167039171

Following gene: 167039173

Centisome position: 21.42

GC content: 39.61

Gene sequence:

>1626_bases
ATGGCAAAACAAATCAAATATGGAGAGGAAGCAAGAAGAGCATTAGAAAGAGGAGTTAATGCAGTTGCGGATACTGTAAA
AGTTACATTAGGGCCAAGGGGTCGTAATGTAGTATTGGACAAAAAATATGGTTCACCTACGGTTACAAATGACGGTGTTA
CTATTGCAAGAGAGATTGAATTAGAGGATCCATTTGAAAATCAAGGCGCACAACTTTTGAAGGAAGTAGCTACAAAAACT
AATGATGTCGCAGGTGATGGTACAACGACTGCAACGCTTTTAGCTCAAGCAATGGTTCGTGAGGGACTCAAAAACCTCGC
AGCAGGAGCTAACCCAATGCTTTTAAGAAGAGGTATTGCGAAGGCTGTAGATGCTGCAGTTGAGGGGTTAAAGAGGATAT
CTAAACCTATTGATAATAAAGAATCAATTGCCCATGTTGCTTCTATCTCTGCTGCTGATGAAGAAATAGGTAATCTCATT
GCAGAAGCAATGGACAAAGTAGGTAAAGATGGAGTTATAACGGTTGAAGAATCAAAGACTTTAGGTACAACCCTTGAGGT
TGTTGAAGGAATGCAATTTGACAGAGGATATATTTCTCCATACATGGTAACTGATGCTGAAAAAATGGAAGCAGTATTAG
AGGAGCCTGTTATACTCATAACAGATAAGAAACTTTCAAATATCCAAGACTTGTTGCCACTCTTGGAGCAAGTAGTGCAA
CACGGTAAGAAACTTCTTATCATAGCTGATGATGTAGAAGGAGAAGCATTGGCAACATTAGTTGTTAACAAATTAAGAGG
TACATTTACGTGTGTAGCAGTAAAAGCTCCTGGCTTTGGTGACAGAAGAAAAGAAATGTTACAAGATATAGCAATACTGA
CAGGTGGTCAAGTAATTTCAGAAGAGTTAGGTTATGACTTAAAAGATGTGAGATTAGATATGCTTGGCCGCGCAAGACAA
GTAAAAGTTACAAAAGAGAATACCACAATTGTAGGCGGAGCAGGCGATGCTGCAGAAATTAAGAAGAGAGTAAATCAAAT
TAAGGCTCAAATTGAGGAAACTACCTCTGATTATGATAGAGAAAAATTACAAGAAAGACTGGCAAAATTGGCCGGTGGCG
TAGCTGTCATTCAAGCTGGTGCTGCAACTGAGACAGAGCTTAAAGAAAAGAAACACAGAATTGAAGACGCATTGGCGGCT
ACAAAAGCAGCAGTGGAGGAAGGTATAGTACCTGGTGGCGGTATTGCACTTCTCAATGTAATAGAAGATGTGCAAAAAGT
AGTTGATTCCTTAGATGGCGACTTCAAGACAGGTGCGAAGATAGTTTTAAGAGCATTAGAAGAACCCGTAAGACAAATTG
CAGCAAATGCTGGTGTTGACGGTTCTGTAATAGTAGAAAAAATAAAAGCTGCTAAAGATCCAAACTTCGGATATGATGCT
TACAAGGAAGAATTTACAGACATGTTCAAAGCAGGTATCGTAGACCCAACAAAGGTTACAAGGACAGCTTTGCAAAATGC
TGCATCAATTGCTTCAATGATACTTACGACAGAAGCAGTAGTGGTAGATGTACCAGAGAAGAATACAGCAATGCCTAATC
CAGGAGCAGGAATGGATATGATGTGA

Upstream 100 bases:

>100_bases
CCAAATATGCTGGGACAGAAGTTAAGTTAGATGGTGAAGAATATCTACTTTTAAGAGAAAGCGATATTCTAGCAATTATA
GAATAAGGAGGTAGTTGAAA

Downstream 100 bases:

>100_bases
TAAAAAGGGCTGAGCGAAAGCTTAGCCCTTTTTAAGTTTTGGCCTTGACAGCTTTTAAATTGTCTGATAAAATACTCATG
TAACATTTTTAGGCGCCCGT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MAKQIKYGEEARRALERGVNAVADTVKVTLGPRGRNVVLDKKYGSPTVTNDGVTIAREIELEDPFENQGAQLLKEVATKT
NDVAGDGTTTATLLAQAMVREGLKNLAAGANPMLLRRGIAKAVDAAVEGLKRISKPIDNKESIAHVASISAADEEIGNLI
AEAMDKVGKDGVITVEESKTLGTTLEVVEGMQFDRGYISPYMVTDAEKMEAVLEEPVILITDKKLSNIQDLLPLLEQVVQ
HGKKLLIIADDVEGEALATLVVNKLRGTFTCVAVKAPGFGDRRKEMLQDIAILTGGQVISEELGYDLKDVRLDMLGRARQ
VKVTKENTTIVGGAGDAAEIKKRVNQIKAQIEETTSDYDREKLQERLAKLAGGVAVIQAGAATETELKEKKHRIEDALAA
TKAAVEEGIVPGGGIALLNVIEDVQKVVDSLDGDFKTGAKIVLRALEEPVRQIAANAGVDGSVIVEKIKAAKDPNFGYDA
YKEEFTDMFKAGIVDPTKVTRTALQNAASIASMILTTEAVVVDVPEKNTAMPNPGAGMDMM

Sequences:

>Translated_541_residues
MAKQIKYGEEARRALERGVNAVADTVKVTLGPRGRNVVLDKKYGSPTVTNDGVTIAREIELEDPFENQGAQLLKEVATKT
NDVAGDGTTTATLLAQAMVREGLKNLAAGANPMLLRRGIAKAVDAAVEGLKRISKPIDNKESIAHVASISAADEEIGNLI
AEAMDKVGKDGVITVEESKTLGTTLEVVEGMQFDRGYISPYMVTDAEKMEAVLEEPVILITDKKLSNIQDLLPLLEQVVQ
HGKKLLIIADDVEGEALATLVVNKLRGTFTCVAVKAPGFGDRRKEMLQDIAILTGGQVISEELGYDLKDVRLDMLGRARQ
VKVTKENTTIVGGAGDAAEIKKRVNQIKAQIEETTSDYDREKLQERLAKLAGGVAVIQAGAATETELKEKKHRIEDALAA
TKAAVEEGIVPGGGIALLNVIEDVQKVVDSLDGDFKTGAKIVLRALEEPVRQIAANAGVDGSVIVEKIKAAKDPNFGYDA
YKEEFTDMFKAGIVDPTKVTRTALQNAASIASMILTTEAVVVDVPEKNTAMPNPGAGMDMM
>Mature_540_residues
AKQIKYGEEARRALERGVNAVADTVKVTLGPRGRNVVLDKKYGSPTVTNDGVTIAREIELEDPFENQGAQLLKEVATKTN
DVAGDGTTTATLLAQAMVREGLKNLAAGANPMLLRRGIAKAVDAAVEGLKRISKPIDNKESIAHVASISAADEEIGNLIA
EAMDKVGKDGVITVEESKTLGTTLEVVEGMQFDRGYISPYMVTDAEKMEAVLEEPVILITDKKLSNIQDLLPLLEQVVQH
GKKLLIIADDVEGEALATLVVNKLRGTFTCVAVKAPGFGDRRKEMLQDIAILTGGQVISEELGYDLKDVRLDMLGRARQV
KVTKENTTIVGGAGDAAEIKKRVNQIKAQIEETTSDYDREKLQERLAKLAGGVAVIQAGAATETELKEKKHRIEDALAAT
KAAVEEGIVPGGGIALLNVIEDVQKVVDSLDGDFKTGAKIVLRALEEPVRQIAANAGVDGSVIVEKIKAAKDPNFGYDAY
KEEFTDMFKAGIVDPTKVTRTALQNAASIASMILTTEAVVVDVPEKNTAMPNPGAGMDMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=531, Percent_Identity=50.4708097928437, Blast_Score=509, Evalue=1e-144,
Organism=Homo sapiens, GI31542947, Length=531, Percent_Identity=50.4708097928437, Blast_Score=509, Evalue=1e-144,
Organism=Homo sapiens, GI24307939, Length=550, Percent_Identity=23.4545454545455, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI38455427, Length=132, Percent_Identity=30.3030303030303, Blast_Score=73, Evalue=8e-13,
Organism=Escherichia coli, GI1790586, Length=532, Percent_Identity=61.0902255639098, Blast_Score=625, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=48.2954545454545, Blast_Score=506, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=48.5714285714286, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17564182, Length=551, Percent_Identity=21.5970961887477, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25144674, Length=567, Percent_Identity=25.3968253968254, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25147750, Length=135, Percent_Identity=34.0740740740741, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=528, Percent_Identity=51.7045454545455, Blast_Score=514, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6322350, Length=548, Percent_Identity=23.7226277372263, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322524, Length=570, Percent_Identity=23.5087719298246, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322446, Length=171, Percent_Identity=32.1637426900585, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24641193, Length=529, Percent_Identity=49.7164461247637, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24641191, Length=529, Percent_Identity=49.7164461247637, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=47.5285171102662, Blast_Score=498, Evalue=1e-141,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=47.5285171102662, Blast_Score=498, Evalue=1e-141,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=47.5285171102662, Blast_Score=498, Evalue=1e-141,
Organism=Drosophila melanogaster, GI17864606, Length=543, Percent_Identity=40.6998158379374, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24584129, Length=530, Percent_Identity=34.9056603773585, Blast_Score=301, Evalue=6e-82,
Organism=Drosophila melanogaster, GI19921262, Length=530, Percent_Identity=34.9056603773585, Blast_Score=301, Evalue=6e-82,
Organism=Drosophila melanogaster, GI24645179, Length=532, Percent_Identity=21.9924812030075, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24583944, Length=528, Percent_Identity=22.9166666666667, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17647245, Length=172, Percent_Identity=27.3255813953488, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24652903, Length=172, Percent_Identity=27.3255813953488, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI18858175, Length=142, Percent_Identity=33.0985915492958, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI28571140, Length=142, Percent_Identity=33.0985915492958, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57892; Mature: 57761

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQIKYGEEARRALERGVNAVADTVKVTLGPRGRNVVLDKKYGSPTVTNDGVTIAREIE
CCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCEEEEEEE
LEDPFENQGAQLLKEVATKTNDVAGDGTTTATLLAQAMVREGLKNLAAGANPMLLRRGIA
CCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KAVDAAVEGLKRISKPIDNKESIAHVASISAADEEIGNLIAEAMDKVGKDGVITVEESKT
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
LGTTLEVVEGMQFDRGYISPYMVTDAEKMEAVLEEPVILITDKKLSNIQDLLPLLEQVVQ
HHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHH
HGKKLLIIADDVEGEALATLVVNKLRGTFTCVAVKAPGFGDRRKEMLQDIAILTGGQVIS
CCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHH
EELGYDLKDVRLDMLGRARQVKVTKENTTIVGGAGDAAEIKKRVNQIKAQIEETTSDYDR
HHHCCCHHHHHHHHHCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVIQAGAATETELKEKKHRIEDALAATKAAVEEGIVPGGGIALLNV
HHHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
IEDVQKVVDSLDGDFKTGAKIVLRALEEPVRQIAANAGVDGSVIVEKIKAAKDPNFGYDA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHH
YKEEFTDMFKAGIVDPTKVTRTALQNAASIASMILTTEAVVVDVPEKNTAMPNPGAGMDM
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCC
M
C
>Mature Secondary Structure 
AKQIKYGEEARRALERGVNAVADTVKVTLGPRGRNVVLDKKYGSPTVTNDGVTIAREIE
CCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCEEEEEEE
LEDPFENQGAQLLKEVATKTNDVAGDGTTTATLLAQAMVREGLKNLAAGANPMLLRRGIA
CCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KAVDAAVEGLKRISKPIDNKESIAHVASISAADEEIGNLIAEAMDKVGKDGVITVEESKT
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
LGTTLEVVEGMQFDRGYISPYMVTDAEKMEAVLEEPVILITDKKLSNIQDLLPLLEQVVQ
HHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHH
HGKKLLIIADDVEGEALATLVVNKLRGTFTCVAVKAPGFGDRRKEMLQDIAILTGGQVIS
CCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHH
EELGYDLKDVRLDMLGRARQVKVTKENTTIVGGAGDAAEIKKRVNQIKAQIEETTSDYDR
HHHCCCHHHHHHHHHCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVIQAGAATETELKEKKHRIEDALAATKAAVEEGIVPGGGIALLNV
HHHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
IEDVQKVVDSLDGDFKTGAKIVLRALEEPVRQIAANAGVDGSVIVEKIKAAKDPNFGYDA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHH
YKEEFTDMFKAGIVDPTKVTRTALQNAASIASMILTTEAVVVDVPEKNTAMPNPGAGMDM
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCC
M
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9795109; 7912671 [H]