Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 167039153

GI number: 167039153

Start: 506174

End: 507124

Strand: Direct

Name: serA [H]

Synonym: Teth514_0492

Alternate gene names: 167039153

Gene position: 506174-507124 (Clockwise)

Preceding gene: 167039152

Following gene: 167039155

Centisome position: 20.6

GC content: 33.12

Gene sequence:

>951_bases
ATGAGAAATATTTTGCTTTTCACAAAATTAAATGACAATTACATAAAAGAAATTAAAGAGCAAATGGAGGGATATGACGT
TCTTTACGTTCAAAATGAGGAAGAGGCTGAAAAGTATGTAAAAGATACAGAGATTATCATAAGCTTTGACTTTGAATTTT
ATTCCAATATTGTGGACAAGGCTTCAAACCTTAAATGGATTCATCTTTTGAGTGCGGGAGCAGATACTCTTCCCTTTGAA
AAACTCAAAGAAATGAAGGTATTAGTTACTAATTCTAGAGATGTCCACAAATATCAAATTTCACAACAGGTTATAGGTTA
TATGCTTATGTTTGAAAGAAGTTTAAATACCTTTTTAAGAAATCAGATAAAAAAGGTGTGGGATAGGTCTGTTAGGGTTT
CAGAACTTACAGGTAAGACTGCTTTGATAATAGGAGTAGGAAGCATAGGTGAAGAAATTGCAAGGCTTTTGAGAGAGTTT
GGCATGAAGGTCTACGGTATAAGAAGTTCGGGCAAGCCTTCTTTATATGTTGAAAAAATGTATACCTCTATTGAAGATTG
TGATATATTGCCACTTGCCGATTATGTAATATCTATACTTCCTTTGACTAAAGATACTTATCATTTGATAGGAGAAAATG
TGTTTAATAAAATGAAAAATAATAGCTATTTTATAAATGTGGGAAGAGGCAAAGTAGTAGATGAATCAGCTCTTATAAAT
GCCCTCAAGAATAAAGCTATAAAGGGAGCTGCGTTGGATGTGTTTGAAGAAGAGCCTTTAAGTGAGGACAGCCCTTTGTG
GGATATGGAAAATGTGATAATCACTCCTCACATTGCAGGGGTCACGCCTTTATACATGAAAAGAGCGATGGAAATTTTAA
GAGAAAATTTGATAGCTTATAAAGAAGGAAGACCTTTGAGAAATATTGTAAATTTAGATAAAGGATACTAA

Upstream 100 bases:

>100_bases
GGATATTGTGCTTAAATATATTTCATTGTATTTACTGTAATAAAATAGAATGAAAATATATTAAAAATAAATCAAAATTT
TAAAGCTTAGGGGGGTTATT

Downstream 100 bases:

>100_bases
AGCGGGTTTTTACCCGCTTAAATTTTCCCATTCTTCATACATTTGTTCTAATTTGCTTTTAAGGGCGTTGTATTCTTTTT
GTATTTCTACAATTTCTCCT

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MRNILLFTKLNDNYIKEIKEQMEGYDVLYVQNEEEAEKYVKDTEIIISFDFEFYSNIVDKASNLKWIHLLSAGADTLPFE
KLKEMKVLVTNSRDVHKYQISQQVIGYMLMFERSLNTFLRNQIKKVWDRSVRVSELTGKTALIIGVGSIGEEIARLLREF
GMKVYGIRSSGKPSLYVEKMYTSIEDCDILPLADYVISILPLTKDTYHLIGENVFNKMKNNSYFINVGRGKVVDESALIN
ALKNKAIKGAALDVFEEEPLSEDSPLWDMENVIITPHIAGVTPLYMKRAMEILRENLIAYKEGRPLRNIVNLDKGY

Sequences:

>Translated_316_residues
MRNILLFTKLNDNYIKEIKEQMEGYDVLYVQNEEEAEKYVKDTEIIISFDFEFYSNIVDKASNLKWIHLLSAGADTLPFE
KLKEMKVLVTNSRDVHKYQISQQVIGYMLMFERSLNTFLRNQIKKVWDRSVRVSELTGKTALIIGVGSIGEEIARLLREF
GMKVYGIRSSGKPSLYVEKMYTSIEDCDILPLADYVISILPLTKDTYHLIGENVFNKMKNNSYFINVGRGKVVDESALIN
ALKNKAIKGAALDVFEEEPLSEDSPLWDMENVIITPHIAGVTPLYMKRAMEILRENLIAYKEGRPLRNIVNLDKGY
>Mature_316_residues
MRNILLFTKLNDNYIKEIKEQMEGYDVLYVQNEEEAEKYVKDTEIIISFDFEFYSNIVDKASNLKWIHLLSAGADTLPFE
KLKEMKVLVTNSRDVHKYQISQQVIGYMLMFERSLNTFLRNQIKKVWDRSVRVSELTGKTALIIGVGSIGEEIARLLREF
GMKVYGIRSSGKPSLYVEKMYTSIEDCDILPLADYVISILPLTKDTYHLIGENVFNKMKNNSYFINVGRGKVVDESALIN
ALKNKAIKGAALDVFEEEPLSEDSPLWDMENVIITPHIAGVTPLYMKRAMEILRENLIAYKEGRPLRNIVNLDKGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=315, Percent_Identity=28.5714285714286, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI6912396, Length=261, Percent_Identity=31.0344827586207, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI145580578, Length=278, Percent_Identity=30.2158273381295, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4557499, Length=278, Percent_Identity=30.2158273381295, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI145580575, Length=274, Percent_Identity=29.9270072992701, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI61743967, Length=281, Percent_Identity=29.8932384341637, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI4557497, Length=281, Percent_Identity=29.8932384341637, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI87082289, Length=318, Percent_Identity=31.1320754716981, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789279, Length=257, Percent_Identity=28.7937743190661, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787645, Length=268, Percent_Identity=28.7313432835821, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081824, Length=267, Percent_Identity=25.8426966292135, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17532191, Length=250, Percent_Identity=30.8, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=296, Percent_Identity=29.7297297297297, Blast_Score=108, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=297, Percent_Identity=29.96632996633, Blast_Score=108, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=235, Percent_Identity=29.3617021276596, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=290, Percent_Identity=24.4827586206897, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=179, Percent_Identity=29.608938547486, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=166, Percent_Identity=30.1204819277108, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28574286, Length=313, Percent_Identity=25.5591054313099, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI19921140, Length=316, Percent_Identity=26.2658227848101, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585514, Length=253, Percent_Identity=27.6679841897233, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI28574282, Length=253, Percent_Identity=27.6679841897233, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI45552429, Length=251, Percent_Identity=27.8884462151394, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI28574284, Length=253, Percent_Identity=27.6679841897233, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI45551003, Length=250, Percent_Identity=28, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24585516, Length=263, Percent_Identity=27.3764258555133, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI28571528, Length=294, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24646446, Length=276, Percent_Identity=28.6231884057971, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646448, Length=276, Percent_Identity=28.6231884057971, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646452, Length=276, Percent_Identity=28.6231884057971, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646450, Length=276, Percent_Identity=28.6231884057971, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI62472511, Length=276, Percent_Identity=28.6231884057971, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 36359; Mature: 36359

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNILLFTKLNDNYIKEIKEQMEGYDVLYVQNEEEAEKYVKDTEIIISFDFEFYSNIVDK
CCCEEEEEECCHHHHHHHHHHHCCCEEEEEECHHHHHHHHCCCEEEEEECHHHHHHHHHH
ASNLKWIHLLSAGADTLPFEKLKEMKVLVTNSRDVHKYQISQQVIGYMLMFERSLNTFLR
CCCCEEEEEEECCCCCCCHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NQIKKVWDRSVRVSELTGKTALIIGVGSIGEEIARLLREFGMKVYGIRSSGKPSLYVEKM
HHHHHHHHCCCEEEHHCCCEEEEEEECHHHHHHHHHHHHHCCEEEEECCCCCCCEEHHHH
YTSIEDCDILPLADYVISILPLTKDTYHLIGENVFNKMKNNSYFINVGRGKVVDESALIN
HCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEECHHHHHH
ALKNKAIKGAALDVFEEEPLSEDSPLWDMENVIITPHIAGVTPLYMKRAMEILRENLIAY
HHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KEGRPLRNIVNLDKGY
CCCCCHHHHHCCCCCC
>Mature Secondary Structure
MRNILLFTKLNDNYIKEIKEQMEGYDVLYVQNEEEAEKYVKDTEIIISFDFEFYSNIVDK
CCCEEEEEECCHHHHHHHHHHHCCCEEEEEECHHHHHHHHCCCEEEEEECHHHHHHHHHH
ASNLKWIHLLSAGADTLPFEKLKEMKVLVTNSRDVHKYQISQQVIGYMLMFERSLNTFLR
CCCCEEEEEEECCCCCCCHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NQIKKVWDRSVRVSELTGKTALIIGVGSIGEEIARLLREFGMKVYGIRSSGKPSLYVEKM
HHHHHHHHCCCEEEHHCCCEEEEEEECHHHHHHHHHHHHHCCEEEEECCCCCCCEEHHHH
YTSIEDCDILPLADYVISILPLTKDTYHLIGENVFNKMKNNSYFINVGRGKVVDESALIN
HCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEECHHHHHH
ALKNKAIKGAALDVFEEEPLSEDSPLWDMENVIITPHIAGVTPLYMKRAMEILRENLIAY
HHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KEGRPLRNIVNLDKGY
CCCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]