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The map label for this gene is yclK [H]

Identifier: 167039101

GI number: 167039101

Start: 453987

End: 455387

Strand: Direct

Name: yclK [H]

Synonym: Teth514_0440

Alternate gene names: 167039101

Gene position: 453987-455387 (Clockwise)

Preceding gene: 167039100

Following gene: 167039102

Centisome position: 18.48

GC content: 31.62

Gene sequence:

>1401_bases
ATGAGTTTAAGGTGGAAAATCTTTTCTTTATATTTAATAATTTTAATAATTTCATTGGCATTAACTGGGCTTTATCTTTA
CCGTTATATTGAAAGAAGCTATTTAGACAATGTCAGAGTCAATAATTTAATGCAAGCCAATATGGTATCTAATTTTGTAT
CAAGATTTGTAGGTACTACTTCTTCTTATTTGATTGAGCCCACTATAATGGAGTATGCAAAACAAATAAATTCAAGAATA
CTTTTCACTAATATAAATGGAAGAGTATTGGTAGATTCTGCTTCCTCAAAGGAATTTGAAGGAAAAGTAATAAAGGATTA
CAGCGATATAAAAGAGGCTTTAAATGGCAAGGGTTCTACAAGTATTCATGATATAAATGGTGTAGGTTGGGCGATGTATA
CTGCAGTTCCCGTTATAGCAAAAAACAATGTAGTAGGAGCAATACTTATATCTTCTTCTATAGATAATATAATAGATCTT
TTAAACTCTATAAAATATCGCATGATATATACTTTTACAGGTATTGGATTTTTGGTAAGCCTTTTAAGCCTTTTAGTGGC
TTCTTACATTACTAATCCTTTAAAACGATTAACAGAAGCAACAAATATTTTATCTCAAGGGAAATTGGACTACAAAGTTG
AGGTAAAAAGCAATGATGAAATTGGAAAATTGGCTAATGCTTTTAATAAGATGAGTTTCAGTTTAATGAAAATAGATGAA
GAGCGGAAAAGATTTGTTTCAGATGCTTCTCATGAACTAAAAACTCCTCTGGCATCAGTAAAAGCGTTGATAGAATCTCT
CATAAATAGCAAAAATCAAGATATAAAATTTTATAAAGAAATATTAAAGGATGTGGACGGAGAGCTGAATAGGATGACAA
GGTTGGTAAATGACTTGTTAGAATTAGCGAGAATGGATAAGATTAAAGCAGTAAAAGTTAGGAAAAGTGAGATTAGCGAG
ATTATATTAGATGTAATAGAAAGTCTTCTCCCTCTTGCAAAAACGAAAGAGATAAACCTTGAATTTAAAGGGGAAAATAA
TGTTTTTGCAGAAGTTGATCCCGACAGGTTTTATAGGATGGTCTATAACATAGTAGAAAATGGAATAAAATACACTCATG
ATGGAGGGAATGTGATAGTAGGTTTAGAAGAAGATGAAAACAATATTTACCTTACGATAGCGGATAATGGTATGGGTATA
AGTGAAGAAACTCTTCCCAAGATATTTGACCGATTTACAAGGGGAGATACTGCAAGGTCTAAAAAAAGTGGTGGTTTTGG
CTTAGGACTCGCTATTGCTAAGGAGATAATAGATATTCATGAAGGTAAAGTCACAGTGGAAAGTAAAGTGGGAGAAGGAA
CTGTATTTAGAATTACTTTGCCTAAAAAGAAAAAGGATTAA

Upstream 100 bases:

>100_bases
GTGAGAAAACTTAGGGAGAAAATTGAAGATGACCCTGCAAATCCTCAATATATTTTCACCAAATGGGGTGCAGGATACTA
TATGAAGTAAAGGTGATAAA

Downstream 100 bases:

>100_bases
TTTTTTTTAATAATTTTTTTATGCTTATTTAATTATTTGGATATTGAAAAAGTAGTATTATTAAATTAAAGAAAAAATAA
TGAAAGGAGGGGGAAGGGTG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSLRWKIFSLYLIILIISLALTGLYLYRYIERSYLDNVRVNNLMQANMVSNFVSRFVGTTSSYLIEPTIMEYAKQINSRI
LFTNINGRVLVDSASSKEFEGKVIKDYSDIKEALNGKGSTSIHDINGVGWAMYTAVPVIAKNNVVGAILISSSIDNIIDL
LNSIKYRMIYTFTGIGFLVSLLSLLVASYITNPLKRLTEATNILSQGKLDYKVEVKSNDEIGKLANAFNKMSFSLMKIDE
ERKRFVSDASHELKTPLASVKALIESLINSKNQDIKFYKEILKDVDGELNRMTRLVNDLLELARMDKIKAVKVRKSEISE
IILDVIESLLPLAKTKEINLEFKGENNVFAEVDPDRFYRMVYNIVENGIKYTHDGGNVIVGLEEDENNIYLTIADNGMGI
SEETLPKIFDRFTRGDTARSKKSGGFGLGLAIAKEIIDIHEGKVTVESKVGEGTVFRITLPKKKKD

Sequences:

>Translated_466_residues
MSLRWKIFSLYLIILIISLALTGLYLYRYIERSYLDNVRVNNLMQANMVSNFVSRFVGTTSSYLIEPTIMEYAKQINSRI
LFTNINGRVLVDSASSKEFEGKVIKDYSDIKEALNGKGSTSIHDINGVGWAMYTAVPVIAKNNVVGAILISSSIDNIIDL
LNSIKYRMIYTFTGIGFLVSLLSLLVASYITNPLKRLTEATNILSQGKLDYKVEVKSNDEIGKLANAFNKMSFSLMKIDE
ERKRFVSDASHELKTPLASVKALIESLINSKNQDIKFYKEILKDVDGELNRMTRLVNDLLELARMDKIKAVKVRKSEISE
IILDVIESLLPLAKTKEINLEFKGENNVFAEVDPDRFYRMVYNIVENGIKYTHDGGNVIVGLEEDENNIYLTIADNGMGI
SEETLPKIFDRFTRGDTARSKKSGGFGLGLAIAKEIIDIHEGKVTVESKVGEGTVFRITLPKKKKD
>Mature_465_residues
SLRWKIFSLYLIILIISLALTGLYLYRYIERSYLDNVRVNNLMQANMVSNFVSRFVGTTSSYLIEPTIMEYAKQINSRIL
FTNINGRVLVDSASSKEFEGKVIKDYSDIKEALNGKGSTSIHDINGVGWAMYTAVPVIAKNNVVGAILISSSIDNIIDLL
NSIKYRMIYTFTGIGFLVSLLSLLVASYITNPLKRLTEATNILSQGKLDYKVEVKSNDEIGKLANAFNKMSFSLMKIDEE
RKRFVSDASHELKTPLASVKALIESLINSKNQDIKFYKEILKDVDGELNRMTRLVNDLLELARMDKIKAVKVRKSEISEI
ILDVIESLLPLAKTKEINLEFKGENNVFAEVDPDRFYRMVYNIVENGIKYTHDGGNVIVGLEEDENNIYLTIADNGMGIS
EETLPKIFDRFTRGDTARSKKSGGFGLGLAIAKEIIDIHEGKVTVESKVGEGTVFRITLPKKKKD

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=31.3868613138686, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1786783, Length=375, Percent_Identity=27.2, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=28.2608695652174, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790346, Length=278, Percent_Identity=29.8561151079137, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788279, Length=326, Percent_Identity=28.2208588957055, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI87082128, Length=293, Percent_Identity=27.6450511945392, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786912, Length=415, Percent_Identity=25.0602409638554, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1790861, Length=386, Percent_Identity=26.1658031088083, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI145693157, Length=250, Percent_Identity=26, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1788713, Length=255, Percent_Identity=27.0588235294118, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789149, Length=315, Percent_Identity=24.7619047619048, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790551, Length=283, Percent_Identity=25.0883392226148, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=26.3636363636364, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1787894, Length=270, Percent_Identity=25.5555555555556, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789808, Length=269, Percent_Identity=26.3940520446097, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789403, Length=227, Percent_Identity=27.7533039647577, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788549, Length=224, Percent_Identity=26.7857142857143, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI48994928, Length=240, Percent_Identity=24.5833333333333, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87081816, Length=382, Percent_Identity=21.7277486910995, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787374, Length=298, Percent_Identity=24.1610738255034, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52397; Mature: 52266

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLRWKIFSLYLIILIISLALTGLYLYRYIERSYLDNVRVNNLMQANMVSNFVSRFVGTT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
SSYLIEPTIMEYAKQINSRILFTNINGRVLVDSASSKEFEGKVIKDYSDIKEALNGKGST
HHHEECHHHHHHHHHHCCEEEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCC
SIHDINGVGWAMYTAVPVIAKNNVVGAILISSSIDNIIDLLNSIKYRMIYTFTGIGFLVS
CEEECCCCCCHHHHHHHHEECCCEEEEEEEHHHHHHHHHHHHHCHHHHEEEHHHHHHHHH
LLSLLVASYITNPLKRLTEATNILSQGKLDYKVEVKSNDEIGKLANAFNKMSFSLMKIDE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
ERKRFVSDASHELKTPLASVKALIESLINSKNQDIKFYKEILKDVDGELNRMTRLVNDLL
HHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHH
ELARMDKIKAVKVRKSEISEIILDVIESLLPLAKTKEINLEFKGENNVFAEVDPDRFYRM
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEECHHHHHHH
VYNIVENGIKYTHDGGNVIVGLEEDENNIYLTIADNGMGISEETLPKIFDRFTRGDTARS
HHHHHHCCCEEEECCCCEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCC
KKSGGFGLGLAIAKEIIDIHEGKVTVESKVGEGTVFRITLPKKKKD
CCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCC
>Mature Secondary Structure 
SLRWKIFSLYLIILIISLALTGLYLYRYIERSYLDNVRVNNLMQANMVSNFVSRFVGTT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
SSYLIEPTIMEYAKQINSRILFTNINGRVLVDSASSKEFEGKVIKDYSDIKEALNGKGST
HHHEECHHHHHHHHHHCCEEEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCC
SIHDINGVGWAMYTAVPVIAKNNVVGAILISSSIDNIIDLLNSIKYRMIYTFTGIGFLVS
CEEECCCCCCHHHHHHHHEECCCEEEEEEEHHHHHHHHHHHHHCHHHHEEEHHHHHHHHH
LLSLLVASYITNPLKRLTEATNILSQGKLDYKVEVKSNDEIGKLANAFNKMSFSLMKIDE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
ERKRFVSDASHELKTPLASVKALIESLINSKNQDIKFYKEILKDVDGELNRMTRLVNDLL
HHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHH
ELARMDKIKAVKVRKSEISEIILDVIESLLPLAKTKEINLEFKGENNVFAEVDPDRFYRM
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEECHHHHHHH
VYNIVENGIKYTHDGGNVIVGLEEDENNIYLTIADNGMGISEETLPKIFDRFTRGDTARS
HHHHHHCCCEEEECCCCEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCC
KKSGGFGLGLAIAKEIIDIHEGKVTVESKVGEGTVFRITLPKKKKD
CCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]