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The map label for this gene is trmI [H]

Identifier: 167039090

GI number: 167039090

Start: 444345

End: 445109

Strand: Reverse

Name: trmI [H]

Synonym: Teth514_0429

Alternate gene names: 167039090

Gene position: 445109-444345 (Counterclockwise)

Preceding gene: 167039091

Following gene: 167039089

Centisome position: 18.11

GC content: 36.47

Gene sequence:

>765_bases
GTGGAATCACGAATAACTACAAAACGCGTAATAATAGGGCCAGATAATTTTAAAAAAGTAATCGATCTATCCTCTCCCTC
TAAAATAGGACTGCCAAAAGGCCAAATTGATACAGATTTTTTGTCCCAAATAAAACCCGGCAATAGTTTTGAAGTACAAG
GGATAAAATATCACGTGCTTAACTGCGATACTTTTGACTACATAATGCACTCCTTAAAGCGCCAAACACAAATTGTCTAT
CCTAAAGAAGCTTGTTATATAGCAATGCGCCTTGACATTTTTCCAGGCAAAAGAGTAGGTGAAGCAGGAACAGGCTCTGG
AGCTTTCACTGTATACCTCTCTCGCGCTGTGGGACCTTATGGAAGAGTATATACATATGAACAAAGAGAAGAATTTTATA
AGCTTGCACAAAATAATCTCAGCGAATTTTCGGAATTTGACAATGTCATAATGTACAATAAATCTATAAATGATGGAATC
AAAGAAAGAGATTTGGACGCATTTTTCTTAGATGTTAGAAAACCGTGGGAAGTTTTAGAAGAAGTAAGAAAAGCGCTAAA
ACCTGCAGGACACTTAGGAATATTAGTCCCTACCACAAATCAAGTATCTGAAAGTTTGGCTGCACTTGAGGAAAATGGAT
TTTATATTTCAGAAGTAAGTGAAATCCTACTTAGAAAATACAAGTTAAATCCTCAAAGATTAAGGCCAGAAGACCTGATG
GTAGGTCACACAGGTTATCTCATTTTTGCAAGGAAGCTAGAATAG

Upstream 100 bases:

>100_bases
CAGAGCAAATTTAAAACTTACTCATAAATTCTGTAACTTTATGAAACAATGTGTTATAATATAAGCATAAAAACCCTTTT
AAAAGAAAGGGGGAACAATT

Downstream 100 bases:

>100_bases
TAATTGTCTTTATTGACTCTATAAAAACATTGTGCTATTTTAAAAGTGGTGGTATCTTCATAGAACCACACACTTCATAA
AAATTCAATAGGGCTCATTT

Product: tRNA(1-methyladenosine) methyltransferase-like protein

Products: NA

Alternate protein names: tRNA(m1A58)-methyltransferase; tRNA(m1A58)MTase [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MESRITTKRVIIGPDNFKKVIDLSSPSKIGLPKGQIDTDFLSQIKPGNSFEVQGIKYHVLNCDTFDYIMHSLKRQTQIVY
PKEACYIAMRLDIFPGKRVGEAGTGSGAFTVYLSRAVGPYGRVYTYEQREEFYKLAQNNLSEFSEFDNVIMYNKSINDGI
KERDLDAFFLDVRKPWEVLEEVRKALKPAGHLGILVPTTNQVSESLAALEENGFYISEVSEILLRKYKLNPQRLRPEDLM
VGHTGYLIFARKLE

Sequences:

>Translated_254_residues
MESRITTKRVIIGPDNFKKVIDLSSPSKIGLPKGQIDTDFLSQIKPGNSFEVQGIKYHVLNCDTFDYIMHSLKRQTQIVY
PKEACYIAMRLDIFPGKRVGEAGTGSGAFTVYLSRAVGPYGRVYTYEQREEFYKLAQNNLSEFSEFDNVIMYNKSINDGI
KERDLDAFFLDVRKPWEVLEEVRKALKPAGHLGILVPTTNQVSESLAALEENGFYISEVSEILLRKYKLNPQRLRPEDLM
VGHTGYLIFARKLE
>Mature_254_residues
MESRITTKRVIIGPDNFKKVIDLSSPSKIGLPKGQIDTDFLSQIKPGNSFEVQGIKYHVLNCDTFDYIMHSLKRQTQIVY
PKEACYIAMRLDIFPGKRVGEAGTGSGAFTVYLSRAVGPYGRVYTYEQREEFYKLAQNNLSEFSEFDNVIMYNKSINDGI
KERDLDAFFLDVRKPWEVLEEVRKALKPAGHLGILVPTTNQVSESLAALEENGFYISEVSEILLRKYKLNPQRLRPEDLM
VGHTGYLIFARKLE

Specific function: Catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. Is required for cell growth at extreme temperatures [H]

COG id: COG2519

COG function: function code J; tRNA(1-methyladenosine) methyltransferase and related methyltransferases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TrmI family [H]

Homologues:

Organism=Homo sapiens, GI222831587, Length=235, Percent_Identity=33.1914893617021, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI123173772, Length=220, Percent_Identity=29.0909090909091, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17509459, Length=174, Percent_Identity=28.735632183908, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322336, Length=190, Percent_Identity=31.0526315789474, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24650257, Length=186, Percent_Identity=29.0322580645161, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014816 [H]

Pfam domain/function: PF08704 GCD14 [H]

EC number: =2.1.1.36 [H]

Molecular weight: Translated: 29017; Mature: 29017

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESRITTKRVIIGPDNFKKVIDLSSPSKIGLPKGQIDTDFLSQIKPGNSFEVQGIKYHVL
CCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEEEEEEE
NCDTFDYIMHSLKRQTQIVYPKEACYIAMRLDIFPGKRVGEAGTGSGAFTVYLSRAVGPY
CCCHHHHHHHHHHHHHEEECCCHHEEEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCC
GRVYTYEQREEFYKLAQNNLSEFSEFDNVIMYNKSINDGIKERDLDAFFLDVRKPWEVLE
CCEEEHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHCCCCEEEEECCCHHHHHH
EVRKALKPAGHLGILVPTTNQVSESLAALEENGFYISEVSEILLRKYKLNPQRLRPEDLM
HHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCCHHHCCCCCEE
VGHTGYLIFARKLE
ECCCCEEEEEEECC
>Mature Secondary Structure
MESRITTKRVIIGPDNFKKVIDLSSPSKIGLPKGQIDTDFLSQIKPGNSFEVQGIKYHVL
CCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEEEEEEE
NCDTFDYIMHSLKRQTQIVYPKEACYIAMRLDIFPGKRVGEAGTGSGAFTVYLSRAVGPY
CCCHHHHHHHHHHHHHEEECCCHHEEEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCC
GRVYTYEQREEFYKLAQNNLSEFSEFDNVIMYNKSINDGIKERDLDAFFLDVRKPWEVLE
CCEEEHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHCCCCEEEEECCCHHHHHH
EVRKALKPAGHLGILVPTTNQVSESLAALEENGFYISEVSEILLRKYKLNPQRLRPEDLM
HHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCCHHHCCCCCEE
VGHTGYLIFARKLE
ECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA