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The map label for this gene is fadH [C]

Identifier: 167038818

GI number: 167038818

Start: 143109

End: 145073

Strand: Reverse

Name: fadH [C]

Synonym: Teth514_0146

Alternate gene names: 167038818

Gene position: 145073-143109 (Counterclockwise)

Preceding gene: 167038820

Following gene: 167038817

Centisome position: 5.9

GC content: 42.54

Gene sequence:

>1965_bases
ATGTTTAAAAACTTGTTTTCTCACGGCAGAATAGGGACTATGGAAACAAAAAGCAGGGTCGTCTTTACAGCTATGGGAAA
CGCCCTCGCAAATTCCGATGGAACTGTTTCGGAAAGGGACATCCAATTTTACGCGGCTAGGGCAAAAGGTGGAGTAGGGC
TCATTATCACCGAATGTATGGTTGTAGACGAGAGGGGCAAAGGTAACACCAGGCAGATGTGTGCGTATGACGATAAATTT
ATACCCGGTCTCAGAGCTCTGGCCGATGAGGTGCACAAATACGGTGCGAAGATTGTGGCTCAGATTTATCATCCGGGAAG
GCAAGGAATTTCTGCGATAAACGGAAATATGCCGATGGCGGCACCGAGCGAGGTGGAATGCAAAGTCGTGCATCAACCCG
TGAGGGCAATGAGTACGGAAGAAGTCGAGGAAATGGTAAAAAAATTTGTAGATGCTGCAGTTCGAATAAAGAAAGCCGGA
TTCGACGGAGTTGAAGTCCATGGAGCGCACGGATATTTAATAAACCAGTTTTTGAGTCCATATACAAATAAAAGGACTGA
CAAGTACGGCGGGAGTTTTGAAAACAGGATGAGGTTTTTAGAAGAAATAGTAGTTGGCATTAGAGAAAAGTGCGGAAAAG
ATTTTCCACTTCTTGTAAGATTGACGGTCGATGAATTTTTGGAGAAGGTGGGGCTTCCAAATGAAGGGCTTCATCTAGAA
GATGGGGTAAAAATAGCAAAGAGGCTTGAGGAGCTTGGCGTGGATGCACTGGATATAAGTTGCGGTATCTATGAAACAAT
GAATGTGTCCTGGGAACCGACCTCTTACGAGCAGGGATGGAAGATATATCTTGCTGAAACGATAAAGAAAGCCGTGGACA
TCCCAGTAATAGGAGTTTCAGTAATAAGGGACCCCGAATTTGCAGACAGAATGATAAGGGAAGGTAAGATCGACTTTGCG
GGTTCCGCAAGACAGCATTTTGCTGATCCGGAATGGGCGAATAAGGCAATGGAAGGTAAAGTAAATGAAATAAGAAAGTG
CATATCTTGCCTTTATTGTATGGAAACCTTAATTGGTGCCGATATAACAGGAATGCCTTGCCAGTGCAGCATAAACATCC
AAAGTGGCCGCGAATGGGAGTTAAATCAACTTAAGGAGGATGGGGAAGGTAGGATTGTAGCTATAATAGGCGCAGGGCCT
GCGGGGCTTGAGGCAGCAAGAATACTGGCGAAACGGAAGTTTAGGCCGGTGATTTTTGAAAGGACCGATAAAATAGGCGG
ACAGTTGAACCTTGCAAGCAAGCCTCCCAAAAAGGAGAAGATAAATTGGCTCATTGATTATTTTAACTCTCAGATTGAAA
AGGAAAATATAGAGGTAAGATTTAATGCGATGCCGACGATTGATGAATTAAAGGCACTTAACCCCTACGCGGTGTTTGTA
ACTCAAGGTTCAGAGCCCATAATACCTAAATCGATTCCCGGCATCGAAAGCGAAAACGTATTTACAGCAGAAGATATATT
AGGTGAGAAAGTATATATATCCGGTAAAAAAGTAGCAGTAGTTGGATCTGGAATGACGGGGCTTGAAACCGCTCATTACC
TCGCGGAAAAAGGAAATGAGGTCAGTGTATTTGAAATGCTAGATGAAATCGGACCCGGATTATTTTTCCAGAATTTAATA
GATGTTTTAGGTCATTTGAAAGCATATAATGTAGAGCTAAATCCAAACCACAAACTTGTTGCGATAAATGGAAATGAAGT
GATTTTTGAGAACACGAAAACTCAAGAAAAAGTCGTTTGCAAATTCGATTACGTGGTGCTGTCTCTTGGGAGGATACCGA
ATAAAAACTTGGTTGAAGAGATAAAAAGCAGCTTTGAAAAGGTCTTTATATTGGGAGATGCAGAAAAAGCAGGGAAAATA
AGAAATGCTATAGAGGCTGGCTTTTTGGCAGCGTATAATTTGTAA

Upstream 100 bases:

>100_bases
GCTAATACAACTACTTTATGTTAGGCAAGAGGTTTTATGTTGGCTAAAATATATATTGAAATGGGATAGTTATAACATTA
ACAAAGTAGGAGGGAAGGGT

Downstream 100 bases:

>100_bases
AATATCAATGAAGCTAAAAAGGGGGAAATCTGAGATGTTGTTATCCTATTCGAGATACGCCCAATTGTGTCCAATTATTT
ACGGAAGAGGAACTGTAAGT

Product: NADH:flavin oxidoreductase/NADH oxidase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 654; Mature: 654

Protein sequence:

>654_residues
MFKNLFSHGRIGTMETKSRVVFTAMGNALANSDGTVSERDIQFYAARAKGGVGLIITECMVVDERGKGNTRQMCAYDDKF
IPGLRALADEVHKYGAKIVAQIYHPGRQGISAINGNMPMAAPSEVECKVVHQPVRAMSTEEVEEMVKKFVDAAVRIKKAG
FDGVEVHGAHGYLINQFLSPYTNKRTDKYGGSFENRMRFLEEIVVGIREKCGKDFPLLVRLTVDEFLEKVGLPNEGLHLE
DGVKIAKRLEELGVDALDISCGIYETMNVSWEPTSYEQGWKIYLAETIKKAVDIPVIGVSVIRDPEFADRMIREGKIDFA
GSARQHFADPEWANKAMEGKVNEIRKCISCLYCMETLIGADITGMPCQCSINIQSGREWELNQLKEDGEGRIVAIIGAGP
AGLEAARILAKRKFRPVIFERTDKIGGQLNLASKPPKKEKINWLIDYFNSQIEKENIEVRFNAMPTIDELKALNPYAVFV
TQGSEPIIPKSIPGIESENVFTAEDILGEKVYISGKKVAVVGSGMTGLETAHYLAEKGNEVSVFEMLDEIGPGLFFQNLI
DVLGHLKAYNVELNPNHKLVAINGNEVIFENTKTQEKVVCKFDYVVLSLGRIPNKNLVEEIKSSFEKVFILGDAEKAGKI
RNAIEAGFLAAYNL

Sequences:

>Translated_654_residues
MFKNLFSHGRIGTMETKSRVVFTAMGNALANSDGTVSERDIQFYAARAKGGVGLIITECMVVDERGKGNTRQMCAYDDKF
IPGLRALADEVHKYGAKIVAQIYHPGRQGISAINGNMPMAAPSEVECKVVHQPVRAMSTEEVEEMVKKFVDAAVRIKKAG
FDGVEVHGAHGYLINQFLSPYTNKRTDKYGGSFENRMRFLEEIVVGIREKCGKDFPLLVRLTVDEFLEKVGLPNEGLHLE
DGVKIAKRLEELGVDALDISCGIYETMNVSWEPTSYEQGWKIYLAETIKKAVDIPVIGVSVIRDPEFADRMIREGKIDFA
GSARQHFADPEWANKAMEGKVNEIRKCISCLYCMETLIGADITGMPCQCSINIQSGREWELNQLKEDGEGRIVAIIGAGP
AGLEAARILAKRKFRPVIFERTDKIGGQLNLASKPPKKEKINWLIDYFNSQIEKENIEVRFNAMPTIDELKALNPYAVFV
TQGSEPIIPKSIPGIESENVFTAEDILGEKVYISGKKVAVVGSGMTGLETAHYLAEKGNEVSVFEMLDEIGPGLFFQNLI
DVLGHLKAYNVELNPNHKLVAINGNEVIFENTKTQEKVVCKFDYVVLSLGRIPNKNLVEEIKSSFEKVFILGDAEKAGKI
RNAIEAGFLAAYNL
>Mature_654_residues
MFKNLFSHGRIGTMETKSRVVFTAMGNALANSDGTVSERDIQFYAARAKGGVGLIITECMVVDERGKGNTRQMCAYDDKF
IPGLRALADEVHKYGAKIVAQIYHPGRQGISAINGNMPMAAPSEVECKVVHQPVRAMSTEEVEEMVKKFVDAAVRIKKAG
FDGVEVHGAHGYLINQFLSPYTNKRTDKYGGSFENRMRFLEEIVVGIREKCGKDFPLLVRLTVDEFLEKVGLPNEGLHLE
DGVKIAKRLEELGVDALDISCGIYETMNVSWEPTSYEQGWKIYLAETIKKAVDIPVIGVSVIRDPEFADRMIREGKIDFA
GSARQHFADPEWANKAMEGKVNEIRKCISCLYCMETLIGADITGMPCQCSINIQSGREWELNQLKEDGEGRIVAIIGAGP
AGLEAARILAKRKFRPVIFERTDKIGGQLNLASKPPKKEKINWLIDYFNSQIEKENIEVRFNAMPTIDELKALNPYAVFV
TQGSEPIIPKSIPGIESENVFTAEDILGEKVYISGKKVAVVGSGMTGLETAHYLAEKGNEVSVFEMLDEIGPGLFFQNLI
DVLGHLKAYNVELNPNHKLVAINGNEVIFENTKTQEKVVCKFDYVVLSLGRIPNKNLVEEIKSSFEKVFILGDAEKAGKI
RNAIEAGFLAAYNL

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=695, Percent_Identity=29.2086330935252, Blast_Score=268, Evalue=1e-72,
Organism=Escherichia coli, GI1787939, Length=344, Percent_Identity=27.0348837209302, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17564188, Length=321, Percent_Identity=31.7757009345794, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17559804, Length=355, Percent_Identity=30.1408450704225, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI72001454, Length=323, Percent_Identity=31.8885448916409, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17565138, Length=322, Percent_Identity=28.8819875776398, Blast_Score=115, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17559802, Length=314, Percent_Identity=30.2547770700637, Blast_Score=115, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17566914, Length=240, Percent_Identity=31.6666666666667, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17540738, Length=348, Percent_Identity=28.448275862069, Blast_Score=106, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6321973, Length=224, Percent_Identity=32.1428571428571, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6325086, Length=224, Percent_Identity=27.6785714285714, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 72534; Mature: 72534

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKNLFSHGRIGTMETKSRVVFTAMGNALANSDGTVSERDIQFYAARAKGGVGLIITECM
CCCCHHCCCCCCCCCCCCEEEEEECCCHHCCCCCCCCCCCEEEEEEECCCCEEEEEEEEE
VVDERGKGNTRQMCAYDDKFIPGLRALADEVHKYGAKIVAQIYHPGRQGISAINGNMPMA
EEECCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
APSEVECKVVHQPVRAMSTEEVEEMVKKFVDAAVRIKKAGFDGVEVHGAHGYLINQFLSP
CCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCC
YTNKRTDKYGGSFENRMRFLEEIVVGIREKCGKDFPLLVRLTVDEFLEKVGLPNEGLHLE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHCCCCCCCCCH
DGVKIAKRLEELGVDALDISCGIYETMNVSWEPTSYEQGWKIYLAETIKKAVDIPVIGVS
HHHHHHHHHHHHCCCEEEECCCCEEECCCCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEE
VIRDPEFADRMIREGKIDFAGSARQHFADPEWANKAMEGKVNEIRKCISCLYCMETLIGA
EECCCHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
DITGMPCQCSINIQSGREWELNQLKEDGEGRIVAIIGAGPAGLEAARILAKRKFRPVIFE
CCCCCCCEEEEECCCCCCCCHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCHHHH
RTDKIGGQLNLASKPPKKEKINWLIDYFNSQIEKENIEVRFNAMPTIDELKALNPYAVFV
HHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHCCCCEEEEE
TQGSEPIIPKSIPGIESENVFTAEDILGEKVYISGKKVAVVGSGMTGLETAHYLAEKGNE
ECCCCCCCCCCCCCCCCCCEEEHHHHCCCEEEECCCEEEEEECCCCHHHHHHHHHHCCCC
VSVFEMLDEIGPGLFFQNLIDVLGHLKAYNVELNPNHKLVAINGNEVIFENTKTQEKVVC
CHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEEECCCEEEEEECCCEEEEECCCCCHHEEE
KFDYVVLSLGRIPNKNLVEEIKSSFEKVFILGDAEKAGKIRNAIEAGFLAAYNL
EEHHHHHHHCCCCCHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHCCEEEECC
>Mature Secondary Structure
MFKNLFSHGRIGTMETKSRVVFTAMGNALANSDGTVSERDIQFYAARAKGGVGLIITECM
CCCCHHCCCCCCCCCCCCEEEEEECCCHHCCCCCCCCCCCEEEEEEECCCCEEEEEEEEE
VVDERGKGNTRQMCAYDDKFIPGLRALADEVHKYGAKIVAQIYHPGRQGISAINGNMPMA
EEECCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
APSEVECKVVHQPVRAMSTEEVEEMVKKFVDAAVRIKKAGFDGVEVHGAHGYLINQFLSP
CCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCC
YTNKRTDKYGGSFENRMRFLEEIVVGIREKCGKDFPLLVRLTVDEFLEKVGLPNEGLHLE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHCCCCCCCCCH
DGVKIAKRLEELGVDALDISCGIYETMNVSWEPTSYEQGWKIYLAETIKKAVDIPVIGVS
HHHHHHHHHHHHCCCEEEECCCCEEECCCCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEE
VIRDPEFADRMIREGKIDFAGSARQHFADPEWANKAMEGKVNEIRKCISCLYCMETLIGA
EECCCHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
DITGMPCQCSINIQSGREWELNQLKEDGEGRIVAIIGAGPAGLEAARILAKRKFRPVIFE
CCCCCCCEEEEECCCCCCCCHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCHHHH
RTDKIGGQLNLASKPPKKEKINWLIDYFNSQIEKENIEVRFNAMPTIDELKALNPYAVFV
HHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHCCCCEEEEE
TQGSEPIIPKSIPGIESENVFTAEDILGEKVYISGKKVAVVGSGMTGLETAHYLAEKGNE
ECCCCCCCCCCCCCCCCCCEEEHHHHCCCEEEECCCEEEEEECCCCHHHHHHHHHHCCCC
VSVFEMLDEIGPGLFFQNLIDVLGHLKAYNVELNPNHKLVAINGNEVIFENTKTQEKVVC
CHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEEECCCEEEEEECCCEEEEECCCCCHHEEE
KFDYVVLSLGRIPNKNLVEEIKSSFEKVFILGDAEKAGKIRNAIEAGFLAAYNL
EEHHHHHHHCCCCCHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]