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The map label for this gene is mdh [H]

Identifier: 167038817

GI number: 167038817

Start: 141920

End: 143074

Strand: Reverse

Name: mdh [H]

Synonym: Teth514_0145

Alternate gene names: 167038817

Gene position: 143074-141920 (Counterclockwise)

Preceding gene: 167038818

Following gene: 167038774

Centisome position: 5.82

GC content: 43.55

Gene sequence:

>1155_bases
ATGTTGTTATCCTATTCGAGATACGCCCAATTGTGTCCAATTATTTACGGAAGAGGAACTGTAAGTCTTATGGGCGACGA
AGTCAAAAAACTAGGATGTTCGAAGGTGCTCCTGGTATCAGATAAAACTGTGTCAAATCTTGATATTTACCAAAAGTGCA
AAAAAAGTCTAAGTGATGCTGGCATAAGCTTTGTAGAATTTGATGAAATATTACCTGATCCTCCGGATTATATAGTCAAT
AAAGGCGGAGAAGTGGCAAGAGAGCAAAAAGTTGACGGGATAGTGGCTGTAGGTGGAGGAAGCGTAATGGATGCGGCTAA
AGGCATAAATATACTTATAAATAATCCGCCGCCCATAAACCGGTATTTTGGGAATCCCTTTTTTAAGCCCGGCGTTCCCG
TTGTGATGGTGGTGACAACAGCCGGTACCGGAAGCGAAAGCACGGGAGTCGCTGTAATAACAGATACTGTAAATAATGCT
AAAAACTCTGTCTTTGGAGTAGCTTCCCTTGGAATATTAGATCCCGAAGCTACTGTAAGCTTGCCAAAGGATGCCACTGT
CCATACAGGGATGGACGCATTCGCCCATGCGGCTGAAGCTATTACGGCAAAACTGCCTAATCCTAAATCGCAGCTTCTTG
CCTTTGATGCGATTAATAAAATAATTAAGTATCTGCCGGTTGCTGCCGAAGATGGTGCCAACATCGAAGCAAGAGCAAAT
ATGCTTCTCGCTAGCAATTTTGCAGGTATAGCCTTTAACGATGCCTTAGTACACTTAGGACATGCCATAGCTCACACCAT
AGGTGCGAAGTTCCATGTAGTCCATGGCGAAGCATGTGCTCTGGCGCTACCCGAAGTGATGAAATACGCCGCTACGGTGG
ATGCATCTAGGGTAAAGATTGTGGGCAAAGCGATGGGCCTTGATTTTTCAGGCAGGGAAAGTGGCGAAGAAATTGGCGAA
AAGGTTGCTCAAGCCATAAGAAGGTTCATGAAGGGGTTGGGAATAAGGCCGCTTAGAGAGCTTGGGATATCTAAAGAAGA
TTTATTGGGTACGGTTGATATGGTGTTTAAAGATCCTTGCTACAGTTTTGTTCCGCGGCAATTGGAAAGAGAAGAAATTT
TGAAGATATTGGAAGATATGTACGAAAATTATTAA

Upstream 100 bases:

>100_bases
GCAGAAAAAGCAGGGAAAATAAGAAATGCTATAGAGGCTGGCTTTTTGGCAGCGTATAATTTGTAAAATATCAATGAAGC
TAAAAAGGGGGAAATCTGAG

Downstream 100 bases:

>100_bases
GCAAAAAATCCACCCTCAAACTGTCAAAGTTTGGGGGTGGATTTTTTATCACTTTATGTAATTTACTACATCCTTTTTCC
TTTCTATGGGACGCGGTGGT

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MLLSYSRYAQLCPIIYGRGTVSLMGDEVKKLGCSKVLLVSDKTVSNLDIYQKCKKSLSDAGISFVEFDEILPDPPDYIVN
KGGEVAREQKVDGIVAVGGGSVMDAAKGINILINNPPPINRYFGNPFFKPGVPVVMVVTTAGTGSESTGVAVITDTVNNA
KNSVFGVASLGILDPEATVSLPKDATVHTGMDAFAHAAEAITAKLPNPKSQLLAFDAINKIIKYLPVAAEDGANIEARAN
MLLASNFAGIAFNDALVHLGHAIAHTIGAKFHVVHGEACALALPEVMKYAATVDASRVKIVGKAMGLDFSGRESGEEIGE
KVAQAIRRFMKGLGIRPLRELGISKEDLLGTVDMVFKDPCYSFVPRQLEREEILKILEDMYENY

Sequences:

>Translated_384_residues
MLLSYSRYAQLCPIIYGRGTVSLMGDEVKKLGCSKVLLVSDKTVSNLDIYQKCKKSLSDAGISFVEFDEILPDPPDYIVN
KGGEVAREQKVDGIVAVGGGSVMDAAKGINILINNPPPINRYFGNPFFKPGVPVVMVVTTAGTGSESTGVAVITDTVNNA
KNSVFGVASLGILDPEATVSLPKDATVHTGMDAFAHAAEAITAKLPNPKSQLLAFDAINKIIKYLPVAAEDGANIEARAN
MLLASNFAGIAFNDALVHLGHAIAHTIGAKFHVVHGEACALALPEVMKYAATVDASRVKIVGKAMGLDFSGRESGEEIGE
KVAQAIRRFMKGLGIRPLRELGISKEDLLGTVDMVFKDPCYSFVPRQLEREEILKILEDMYENY
>Mature_384_residues
MLLSYSRYAQLCPIIYGRGTVSLMGDEVKKLGCSKVLLVSDKTVSNLDIYQKCKKSLSDAGISFVEFDEILPDPPDYIVN
KGGEVAREQKVDGIVAVGGGSVMDAAKGINILINNPPPINRYFGNPFFKPGVPVVMVVTTAGTGSESTGVAVITDTVNNA
KNSVFGVASLGILDPEATVSLPKDATVHTGMDAFAHAAEAITAKLPNPKSQLLAFDAINKIIKYLPVAAEDGANIEARAN
MLLASNFAGIAFNDALVHLGHAIAHTIGAKFHVVHGEACALALPEVMKYAATVDASRVKIVGKAMGLDFSGRESGEEIGE
KVAQAIRRFMKGLGIRPLRELGISKEDLLGTVDMVFKDPCYSFVPRQLEREEILKILEDMYENY

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=381, Percent_Identity=31.2335958005249, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI48994951, Length=350, Percent_Identity=33.7142857142857, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI87082107, Length=368, Percent_Identity=33.695652173913, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789163, Length=375, Percent_Identity=30.9333333333333, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI1787493, Length=404, Percent_Identity=30.9405940594059, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1789386, Length=334, Percent_Identity=26.6467065868263, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17537053, Length=421, Percent_Identity=27.5534441805226, Blast_Score=152, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6321181, Length=376, Percent_Identity=30.0531914893617, Blast_Score=167, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24657991, Length=417, Percent_Identity=29.7362110311751, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 41116; Mature: 41116

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSYSRYAQLCPIIYGRGTVSLMGDEVKKLGCSKVLLVSDKTVSNLDIYQKCKKSLSDA
CCCCHHHHHHHCCEEECCCEEEECHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHC
GISFVEFDEILPDPPDYIVNKGGEVAREQKVDGIVAVGGGSVMDAAKGINILINNPPPIN
CCCEEEHHHHCCCCCHHHHCCCCHHHHHHCCCEEEEECCCHHHHHCCCCEEEECCCCCCH
RYFGNPFFKPGVPVVMVVTTAGTGSESTGVAVITDTVNNAKNSVFGVASLGILDPEATVS
HHCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCEEEEHEECCCCCCCCEE
LPKDATVHTGMDAFAHAAEAITAKLPNPKSQLLAFDAINKIIKYLPVAAEDGANIEARAN
CCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHC
MLLASNFAGIAFNDALVHLGHAIAHTIGAKFHVVHGEACALALPEVMKYAATVDASRVKI
EEEECCCCCEEHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHCCCHHEEE
VGKAMGLDFSGRESGEEIGEKVAQAIRRFMKGLGIRPLRELGISKEDLLGTVDMVFKDPC
EHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHCCCH
YSFVPRQLEREEILKILEDMYENY
HHHHHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLSYSRYAQLCPIIYGRGTVSLMGDEVKKLGCSKVLLVSDKTVSNLDIYQKCKKSLSDA
CCCCHHHHHHHCCEEECCCEEEECHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHC
GISFVEFDEILPDPPDYIVNKGGEVAREQKVDGIVAVGGGSVMDAAKGINILINNPPPIN
CCCEEEHHHHCCCCCHHHHCCCCHHHHHHCCCEEEEECCCHHHHHCCCCEEEECCCCCCH
RYFGNPFFKPGVPVVMVVTTAGTGSESTGVAVITDTVNNAKNSVFGVASLGILDPEATVS
HHCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCEEEEHEECCCCCCCCEE
LPKDATVHTGMDAFAHAAEAITAKLPNPKSQLLAFDAINKIIKYLPVAAEDGANIEARAN
CCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHC
MLLASNFAGIAFNDALVHLGHAIAHTIGAKFHVVHGEACALALPEVMKYAATVDASRVKI
EEEECCCCCEEHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHCCCHHEEE
VGKAMGLDFSGRESGEEIGEKVAQAIRRFMKGLGIRPLRELGISKEDLLGTVDMVFKDPC
EHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHCCCH
YSFVPRQLEREEILKILEDMYENY
HHHHHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]