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The map label for this gene is serA [H]

Identifier: 167038809

GI number: 167038809

Start: 133361

End: 134323

Strand: Direct

Name: serA [H]

Synonym: Teth514_0136

Alternate gene names: 167038809

Gene position: 133361-134323 (Clockwise)

Preceding gene: 167038808

Following gene: 167038810

Centisome position: 5.43

GC content: 31.05

Gene sequence:

>963_bases
ATGAGGAAAAAAATATTGATTACGCCAAGATCTTTTGGGAAAAGTAGTAATCTCCCATTTGAGATGCTAAAAAAGTATGA
TTATGAAATTATAAAAAATGAATCCGGACAACCATATGAAGAATCACAATTGATTGATCTCATTAAGGATGTGGATGGTA
TAATTGTTGGTTTAGATAAGATAACAAGCAATGTGTTGAGAAATGCAAAAAAATTAAAAGTTATAACAAAATATGGAGTT
GGCGTAGATAATATAGATGTTGATGAAGCAGAAAGAATGGGGATAAAGATTACTTATACGCCTGATGCAAATAAAGAATC
TGTAGCAGATTTAGTTTTTGCTCTAATGTTGGGTTTAAGCAGAGAAATCATAAAGTTAGATAATATAGTTAGAAACAACC
GATGGGAAAAAATAATTGGTAACGAAATTTATAAGAAAACAATTGGAATTATTGGGACGGGAGCCATTGGTAGATGTGTT
GCCAAAAGAGCTACGGGTTTTGATATGAAAATATTAGCATATGACAAGTACCCTAATTATGAGTTTGCAAATAGCATAGG
CATGAAATACGTTGATAAAAAAGCATTATTAGAAGAGTCTGATTTTATAACATTACATTTACCATTGACAGAAGAAACCT
ATCATTTTATAGATGAGGAAGAATTAAAAATTATGAAAGATACAGCTTATATAATTAATACTTCGCGTGGTGGAATTATA
AACGAGAATGCTCTATATAACGCGTTAAAAAATAAAAAAATTGCAGGAGCGGCATTAGATGTTTTTGAAATAGAACCACC
GATAGATAGTAAATTATTGAAATTAGACAATATAATTTTAACACCTCATTGTGGAGCATCTACCAAAGATGCGACAGATA
GGATGGGAATTATGGCAGTGGAAGGACTTATCAGCGTATTAGAAGGCATGGAACCAAAATATCTTTATAAAAGGCAGAAA
TAA

Upstream 100 bases:

>100_bases
TAGACATGAACAAAATGTTAAACCAAGGTCATTAAAAATAAAATTCATAGAACACATAGATAGGTTTCTTTCTTTAAAAA
TAAAGGGAGGTTTAATAAGA

Downstream 100 bases:

>100_bases
AATAATTTTAAAAAATAGGAGGTAGGAAGATGGAAAAACAACAAATAATTGAAAAACTTAAACAACTTAAAATTACAGCT
GTAATTAGAAATAGTGATAT

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MRKKILITPRSFGKSSNLPFEMLKKYDYEIIKNESGQPYEESQLIDLIKDVDGIIVGLDKITSNVLRNAKKLKVITKYGV
GVDNIDVDEAERMGIKITYTPDANKESVADLVFALMLGLSREIIKLDNIVRNNRWEKIIGNEIYKKTIGIIGTGAIGRCV
AKRATGFDMKILAYDKYPNYEFANSIGMKYVDKKALLEESDFITLHLPLTEETYHFIDEEELKIMKDTAYIINTSRGGII
NENALYNALKNKKIAGAALDVFEIEPPIDSKLLKLDNIILTPHCGASTKDATDRMGIMAVEGLISVLEGMEPKYLYKRQK

Sequences:

>Translated_320_residues
MRKKILITPRSFGKSSNLPFEMLKKYDYEIIKNESGQPYEESQLIDLIKDVDGIIVGLDKITSNVLRNAKKLKVITKYGV
GVDNIDVDEAERMGIKITYTPDANKESVADLVFALMLGLSREIIKLDNIVRNNRWEKIIGNEIYKKTIGIIGTGAIGRCV
AKRATGFDMKILAYDKYPNYEFANSIGMKYVDKKALLEESDFITLHLPLTEETYHFIDEEELKIMKDTAYIINTSRGGII
NENALYNALKNKKIAGAALDVFEIEPPIDSKLLKLDNIILTPHCGASTKDATDRMGIMAVEGLISVLEGMEPKYLYKRQK
>Mature_320_residues
MRKKILITPRSFGKSSNLPFEMLKKYDYEIIKNESGQPYEESQLIDLIKDVDGIIVGLDKITSNVLRNAKKLKVITKYGV
GVDNIDVDEAERMGIKITYTPDANKESVADLVFALMLGLSREIIKLDNIVRNNRWEKIIGNEIYKKTIGIIGTGAIGRCV
AKRATGFDMKILAYDKYPNYEFANSIGMKYVDKKALLEESDFITLHLPLTEETYHFIDEEELKIMKDTAYIINTSRGGII
NENALYNALKNKKIAGAALDVFEIEPPIDSKLLKLDNIILTPHCGASTKDATDRMGIMAVEGLISVLEGMEPKYLYKRQK

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=263, Percent_Identity=38.7832699619772, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI6912396, Length=300, Percent_Identity=32.3333333333333, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI61743967, Length=267, Percent_Identity=34.0823970037453, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI4557497, Length=267, Percent_Identity=34.0823970037453, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI145580578, Length=267, Percent_Identity=32.5842696629214, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4557499, Length=267, Percent_Identity=32.5842696629214, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI145580575, Length=267, Percent_Identity=32.5842696629214, Blast_Score=131, Evalue=6e-31,
Organism=Escherichia coli, GI87082289, Length=303, Percent_Identity=34.983498349835, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1787645, Length=263, Percent_Identity=34.2205323193916, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789279, Length=295, Percent_Identity=32.2033898305085, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI87081824, Length=166, Percent_Identity=30.1204819277108, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788660, Length=244, Percent_Identity=27.0491803278689, Blast_Score=74, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=249, Percent_Identity=38.1526104417671, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI25147481, Length=267, Percent_Identity=32.5842696629214, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320925, Length=298, Percent_Identity=36.241610738255, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322116, Length=299, Percent_Identity=34.1137123745819, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324055, Length=240, Percent_Identity=31.25, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324964, Length=327, Percent_Identity=26.605504587156, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6325144, Length=177, Percent_Identity=29.3785310734463, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=170, Percent_Identity=30, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921140, Length=284, Percent_Identity=35.9154929577465, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI45551003, Length=306, Percent_Identity=34.3137254901961, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI28574284, Length=306, Percent_Identity=34.3137254901961, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI45552429, Length=306, Percent_Identity=34.3137254901961, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24585514, Length=306, Percent_Identity=34.3137254901961, Blast_Score=165, Evalue=3e-41,
Organism=Drosophila melanogaster, GI28574282, Length=306, Percent_Identity=34.3137254901961, Blast_Score=165, Evalue=3e-41,
Organism=Drosophila melanogaster, GI28574286, Length=307, Percent_Identity=32.5732899022801, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24585516, Length=312, Percent_Identity=30.1282051282051, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI28571528, Length=299, Percent_Identity=32.1070234113712, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24646446, Length=269, Percent_Identity=34.2007434944238, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24646448, Length=269, Percent_Identity=34.2007434944238, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24646452, Length=269, Percent_Identity=34.2007434944238, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24646450, Length=269, Percent_Identity=34.2007434944238, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI62472511, Length=256, Percent_Identity=35.9375, Blast_Score=137, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 36098; Mature: 36098

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKKILITPRSFGKSSNLPFEMLKKYDYEIIKNESGQPYEESQLIDLIKDVDGIIVGLDK
CCCEEEECCCCCCCCCCCCHHHHHHCCHHEEECCCCCCHHHHHHHHHHHCCCCEEEEHHH
ITSNVLRNAKKLKVITKYGVGVDNIDVDEAERMGIKITYTPDANKESVADLVFALMLGLS
HHHHHHCCHHHEEEEEECCCCCCCCCCCHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCC
REIIKLDNIVRNNRWEKIIGNEIYKKTIGIIGTGAIGRCVAKRATGFDMKILAYDKYPNY
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCEEECCHHHHHHHHHCCCCCEEEEEEECCCCC
EFANSIGMKYVDKKALLEESDFITLHLPLTEETYHFIDEEELKIMKDTAYIINTSRGGII
HHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCHHHHHEEECCEEEEECCCCCEE
NENALYNALKNKKIAGAALDVFEIEPPIDSKLLKLDNIILTPHCGASTKDATDRMGIMAV
CCHHHHHHHHCCCCCCCEEEEEECCCCCCHHHEEECCEEECCCCCCCCCCHHHHHHHHHH
EGLISVLEGMEPKYLYKRQK
HHHHHHHHCCCCHHHHCCCC
>Mature Secondary Structure
MRKKILITPRSFGKSSNLPFEMLKKYDYEIIKNESGQPYEESQLIDLIKDVDGIIVGLDK
CCCEEEECCCCCCCCCCCCHHHHHHCCHHEEECCCCCCHHHHHHHHHHHCCCCEEEEHHH
ITSNVLRNAKKLKVITKYGVGVDNIDVDEAERMGIKITYTPDANKESVADLVFALMLGLS
HHHHHHCCHHHEEEEEECCCCCCCCCCCHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCC
REIIKLDNIVRNNRWEKIIGNEIYKKTIGIIGTGAIGRCVAKRATGFDMKILAYDKYPNY
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCEEECCHHHHHHHHHCCCCCEEEEEEECCCCC
EFANSIGMKYVDKKALLEESDFITLHLPLTEETYHFIDEEELKIMKDTAYIINTSRGGII
HHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCHHHHHEEECCEEEEECCCCCEE
NENALYNALKNKKIAGAALDVFEIEPPIDSKLLKLDNIILTPHCGASTKDATDRMGIMAV
CCHHHHHHHHCCCCCCCEEEEEECCCCCCHHHEEECCEEECCCCCCCCCCHHHHHHHHHH
EGLISVLEGMEPKYLYKRQK
HHHHHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]