Click here to switch to the map view.

The map label for this gene is upp

Identifier: 167038772

GI number: 167038772

Start: 96475

End: 97107

Strand: Direct

Name: upp

Synonym: Teth514_0099

Alternate gene names: 167038772

Gene position: 96475-97107 (Clockwise)

Preceding gene: 167038771

Following gene: 167038773

Centisome position: 3.93

GC content: 39.02

Gene sequence:

>633_bases
ATGTATAAAAATGTATTTGTCATTGACCATCCACTTATTCAACATAAAATAAGCCTTATAAGAGATGAAAATACAGGTTC
TAAAGAATTTAGAGAGTTAGTAGAAGAAATTGCAATGCTCATGGCATATGAAGTCACAAGAGATTTGCCTCTTGAGGAGA
TAGAGGTAAAAACTCCAGTGGCAGTGGCAAAGACAAAAGTGATTGCAGGGAAAAAATTAGGAATAATCCCTATATTAAGG
GCAGGATTAGGAATGGTGGATGGAATGTTAAAACTCATTCCAGCTGCTAAAGTAGGACATATAGGAATTTACAGGGACCC
TGAAACTTTAAAACCTGTAGAATATTACTGTAAACTGCCTTCCGACATAGCAGAAAGAGACCTCATTGTGGTAGACCCTA
TGCTTGCGACAGGAGGTTCTGCTTGTGCTGCCATACATTTTCTCAAAGAAAGAGGCGCACAAAATATAAAATTGGTGAAT
TTAATAGCTGCTCCAGAAGGAATTGAGGCAGTTCACAGAGACCATCCAGAGGTTCCAATTTACGTGGCCAGCATAGACCA
AGGTTTAAATGAACATGGTTATATTGTACCGGGTTTAGGAGATGCAGGAGATAGGCTTTTCGGCACAAAGTGA

Upstream 100 bases:

>100_bases
CAGAGAAGGATTGACAAAATAGCGGAAATTGAGAAAAAGTATAGCAAATGATATTAATTTGTTATTAGAAAAGAAATTTT
AAACTTACAGGAGGTAAAAA

Downstream 100 bases:

>100_bases
TGGCGAGGGATGTACAAATGAGACCCTCATGGGATGAATATTTTATGCAAATTGTAGATGTTGTAAAAACTCGCTCTACT
TGTCTTAGAAGACAAGTAGG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MYKNVFVIDHPLIQHKISLIRDENTGSKEFRELVEEIAMLMAYEVTRDLPLEEIEVKTPVAVAKTKVIAGKKLGIIPILR
AGLGMVDGMLKLIPAAKVGHIGIYRDPETLKPVEYYCKLPSDIAERDLIVVDPMLATGGSACAAIHFLKERGAQNIKLVN
LIAAPEGIEAVHRDHPEVPIYVASIDQGLNEHGYIVPGLGDAGDRLFGTK

Sequences:

>Translated_210_residues
MYKNVFVIDHPLIQHKISLIRDENTGSKEFRELVEEIAMLMAYEVTRDLPLEEIEVKTPVAVAKTKVIAGKKLGIIPILR
AGLGMVDGMLKLIPAAKVGHIGIYRDPETLKPVEYYCKLPSDIAERDLIVVDPMLATGGSACAAIHFLKERGAQNIKLVN
LIAAPEGIEAVHRDHPEVPIYVASIDQGLNEHGYIVPGLGDAGDRLFGTK
>Mature_210_residues
MYKNVFVIDHPLIQHKISLIRDENTGSKEFRELVEEIAMLMAYEVTRDLPLEEIEVKTPVAVAKTKVIAGKKLGIIPILR
AGLGMVDGMLKLIPAAKVGHIGIYRDPETLKPVEYYCKLPSDIAERDLIVVDPMLATGGSACAAIHFLKERGAQNIKLVN
LIAAPEGIEAVHRDHPEVPIYVASIDQGLNEHGYIVPGLGDAGDRLFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=30.1980198019802, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=30.1980198019802, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=28.8235294117647, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI87082118, Length=203, Percent_Identity=52.7093596059113, Blast_Score=232, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17539892, Length=213, Percent_Identity=24.8826291079812, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17539894, Length=213, Percent_Identity=24.8826291079812, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321920, Length=211, Percent_Identity=38.8625592417062, Blast_Score=132, Evalue=5e-32,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=31.0344827586207, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=31.0344827586207, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=31.0344827586207, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=31.0344827586207, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21358379, Length=195, Percent_Identity=23.5897435897436, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_THEP3 (B0K7G1)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001666063.1
- ProteinModelPortal:   B0K7G1
- SMR:   B0K7G1
- GeneID:   5874709
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_2104
- HOGENOM:   HBG326432
- OMA:   IQHKLSH
- ProtClustDB:   PRK00129
- BioCyc:   TPSE340099:TETH39_2104-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22995; Mature: 22995

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: BINDING 80-80 BINDING 105-105 BINDING 195-195 BINDING 201-201

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKNVFVIDHPLIQHKISLIRDENTGSKEFRELVEEIAMLMAYEVTRDLPLEEIEVKTPV
CCCCEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCCH
AVAKTKVIAGKKLGIIPILRAGLGMVDGMLKLIPAAKVGHIGIYRDPETLKPVEYYCKLP
HHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHCCC
SDIAERDLIVVDPMLATGGSACAAIHFLKERGAQNIKLVNLIAAPEGIEAVHRDHPEVPI
HHHHHCCEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHCCCCCCCE
YVASIDQGLNEHGYIVPGLGDAGDRLFGTK
EEEECCCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MYKNVFVIDHPLIQHKISLIRDENTGSKEFRELVEEIAMLMAYEVTRDLPLEEIEVKTPV
CCCCEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCCH
AVAKTKVIAGKKLGIIPILRAGLGMVDGMLKLIPAAKVGHIGIYRDPETLKPVEYYCKLP
HHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHCCC
SDIAERDLIVVDPMLATGGSACAAIHFLKERGAQNIKLVNLIAAPEGIEAVHRDHPEVPI
HHHHHCCEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHCCCCCCCE
YVASIDQGLNEHGYIVPGLGDAGDRLFGTK
EEEECCCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA