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The map label for this gene is rsmA [H]

Identifier: 167038742

GI number: 167038742

Start: 71777

End: 72598

Strand: Direct

Name: rsmA [H]

Synonym: Teth514_0069

Alternate gene names: 167038742

Gene position: 71777-72598 (Clockwise)

Preceding gene: 167038741

Following gene: 167038743

Centisome position: 2.92

GC content: 31.51

Gene sequence:

>822_bases
ATGAAAGTAAAAGGGGTTAATGTAAAGAAAAAATGGGGACAAAATTTCATATTTGACAAAAATATTTTAGCAAAAATTGT
GATTGCTTCGGGAGTTGCTCTTGAAGATTTTGTATTAGAAATTGGAACAGGATTAGGGACTTTGACAGAAGAACTAGCTA
AAAGGGTTAAAAAGGTAGTTTCTTTTGAAATTGACAGAGAACTTTATGAAGCAACAAAAGAAAAACTTAACATTTATAAC
AATGTGATTATCATGAATGAGGATATAATGAAAGCAGATTTAAATAGAATAGCTAATGAATATTTTGAAGGGAAGCCTTT
TAAAGTGGTTGCTAATCTTCCCTATTACATAACTTCTCCTATAATAATGATGCTTTTAGAGTGTAAATTTGTAAAAGAAA
TAACTGTGCTAGTGCAAAAAGAAGTTGCTGAAAGAATTTGTGCTCTGCCGGGTACTAAGGACTATGGGATACTTACAGTT
TTTATAAATTTTAAAGCAAAGCCTAAGATACTTTTTAATCTTCCACCAAGTGTTTTTGTTCCTCCACCTAAGGTAGATTC
TTCTCTGGTTAAATTAGAGATACTTGATAAACCTTTAGTTGAGGTAAAAGATGAAGCGTTATTTTCTAACGTGGTAAAAG
CTGCTTTTGGACAAAGGAGAAAAGTCTTGTCCAATGCTTTAAAAACTTTAGGGCTTCCAAAAGAAATTATAGATAAAGCT
TTTACTCTTTCAAATTTATCCCATCAAAGGAGAGGAGAAACTCTTAGCATAGAGGAGTTTACTGCTTTGGCAAATGTTAT
TTATGATTTGACAAAGCAGTAA

Upstream 100 bases:

>100_bases
TCCAACCCGTGAAGAAGTAATGAGATGGGGAAGAAGATACGTTAAAGTTTATATTTTAAAGTAGACAGGGTTTCCCTGTC
TTATTTTTTGAGGTGGAGCT

Downstream 100 bases:

>100_bases
TAATAATCCCCCTCTTTTCATAATATATATTGCAAAGTTATATTTAAGATAAATGAGGGGGAAGAATAAATGCCAATAAA
TATATATAAAAGGTTTTATA

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MKVKGVNVKKKWGQNFIFDKNILAKIVIASGVALEDFVLEIGTGLGTLTEELAKRVKKVVSFEIDRELYEATKEKLNIYN
NVIIMNEDIMKADLNRIANEYFEGKPFKVVANLPYYITSPIIMMLLECKFVKEITVLVQKEVAERICALPGTKDYGILTV
FINFKAKPKILFNLPPSVFVPPPKVDSSLVKLEILDKPLVEVKDEALFSNVVKAAFGQRRKVLSNALKTLGLPKEIIDKA
FTLSNLSHQRRGETLSIEEFTALANVIYDLTKQ

Sequences:

>Translated_273_residues
MKVKGVNVKKKWGQNFIFDKNILAKIVIASGVALEDFVLEIGTGLGTLTEELAKRVKKVVSFEIDRELYEATKEKLNIYN
NVIIMNEDIMKADLNRIANEYFEGKPFKVVANLPYYITSPIIMMLLECKFVKEITVLVQKEVAERICALPGTKDYGILTV
FINFKAKPKILFNLPPSVFVPPPKVDSSLVKLEILDKPLVEVKDEALFSNVVKAAFGQRRKVLSNALKTLGLPKEIIDKA
FTLSNLSHQRRGETLSIEEFTALANVIYDLTKQ
>Mature_273_residues
MKVKGVNVKKKWGQNFIFDKNILAKIVIASGVALEDFVLEIGTGLGTLTEELAKRVKKVVSFEIDRELYEATKEKLNIYN
NVIIMNEDIMKADLNRIANEYFEGKPFKVVANLPYYITSPIIMMLLECKFVKEITVLVQKEVAERICALPGTKDYGILTV
FINFKAKPKILFNLPPSVFVPPPKVDSSLVKLEILDKPLVEVKDEALFSNVVKAAFGQRRKVLSNALKTLGLPKEIIDKA
FTLSNLSHQRRGETLSIEEFTALANVIYDLTKQ

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=240, Percent_Identity=29.1666666666667, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI156415992, Length=288, Percent_Identity=28.4722222222222, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1786236, Length=265, Percent_Identity=30.5660377358491, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI25146882, Length=279, Percent_Identity=30.8243727598566, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI25141369, Length=284, Percent_Identity=28.5211267605634, Blast_Score=94, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6324989, Length=222, Percent_Identity=28.8288288288288, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21358017, Length=244, Percent_Identity=28.6885245901639, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21357273, Length=286, Percent_Identity=27.6223776223776, Blast_Score=95, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 30780; Mature: 30780

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVKGVNVKKKWGQNFIFDKNILAKIVIASGVALEDFVLEIGTGLGTLTEELAKRVKKVV
CCCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
SFEIDRELYEATKEKLNIYNNVIIMNEDIMKADLNRIANEYFEGKPFKVVANLPYYITSP
HHHHHHHHHHHHHHHHHHHHCEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHH
IIMMLLECKFVKEITVLVQKEVAERICALPGTKDYGILTVFINFKAKPKILFNLPPSVFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCC
PPPKVDSSLVKLEILDKPLVEVKDEALFSNVVKAAFGQRRKVLSNALKTLGLPKEIIDKA
CCCCCCCHHEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
FTLSNLSHQRRGETLSIEEFTALANVIYDLTKQ
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVKGVNVKKKWGQNFIFDKNILAKIVIASGVALEDFVLEIGTGLGTLTEELAKRVKKVV
CCCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
SFEIDRELYEATKEKLNIYNNVIIMNEDIMKADLNRIANEYFEGKPFKVVANLPYYITSP
HHHHHHHHHHHHHHHHHHHHCEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHH
IIMMLLECKFVKEITVLVQKEVAERICALPGTKDYGILTVFINFKAKPKILFNLPPSVFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCC
PPPKVDSSLVKLEILDKPLVEVKDEALFSNVVKAAFGQRRKVLSNALKTLGLPKEIIDKA
CCCCCCCHHEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
FTLSNLSHQRRGETLSIEEFTALANVIYDLTKQ
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]