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The map label for this gene is serS

Identifier: 167038703

GI number: 167038703

Start: 31701

End: 32972

Strand: Direct

Name: serS

Synonym: Teth514_0028

Alternate gene names: 167038703

Gene position: 31701-32972 (Clockwise)

Preceding gene: 167038702

Following gene: 167038704

Centisome position: 1.29

GC content: 37.11

Gene sequence:

>1272_bases
GTGTTAGACGTAAAGAGGATAAGAAATAATCCAGAGGCTGTAAGAATAGCTATAGAGCTTAAAGGAGAAAAAGCAGATAT
AGATAGGTTTTTAGAATTAGACGAAAAAAGAAGACAAATGCTAGTGGAGTTGGAAACATTAAAAAATCGTAGAAATGTGG
AATCAGACAATATTGCAAAACTAAAAAGAGAAGGCAAAGATGCTAGCGATTTGATTGCTGAAATGAAAGAATTATCGGAT
AAGATTAAAGAAATGGAACAAGAGGTAAAAGAAGTAGAAGAAGAATTAGAGCGAATTTTATGGACAATCCCTAATATACC
TCATGAGAGTGTTCCAATTGGCGATAGTGATGAAGATAATGTTGAAATAAGGAGATGGGGAGAACCGAGAAAATTTGACT
TTGAACCAAAACCTCATTGGGAAATAGGACAAGAGTTGGATATTTTAGACTTTGAAGCTGCAGCGAGAGTAACAGGCTCA
AGGTTTACTTTTTACAAGGGACTTGGAGCTCGTTTGGAAAGAGCGCTTATAAACTTCATGCTGGACTTACACATTGAAAA
ACATGGCTATACTGAAGTGTTTCCTCCCTTTATGGTACATAGAAGAAGCATGTTTGGCACAGGTCAACTTCCTAAGTTTG
AAGAGGATGCTTTTAAAGTTTACGGCACAGACTATTTTTTGATACCTACAGCAGAAGTGCCTGTAACCAATATGTACAGA
GATACAATAATAGATGGAGACAAGCTTCCAATATACCACTGTGCTTATAGCGCTTGTTTTAGACAAGAGGCAGGTTCTGC
AGGGAGAGATACGAGAGGGCTTATAAGGCAGCACCAGTTTAATAAAGTTGAGCTTGTCAAATTTACAGAGCCAGACAAAT
CCTATGAAGAGTTAGAAAAAATGACTAGAGATGCTGAAGAAGTATTGCAGGCGTTAGGACTTCCTTACAGAGTAGTGGTC
ATATGCACAGGAGATTTAGGCTTTACTGCTTCTAAAAAATACGATATAGAAGTGTGGATGCCAAGCTATGGACGATATGT
AGAGATATCTTCTTGTAGCAATTGTGAAGACTTTCAAGCAAGAAGAGCTAATATAAAGTATAGGCCTAAAGATGGTGGGA
AGGCACAATATGTCCATACTTTAAATGGCTCTGGAGTTGCTGTAGGAAGAACTTTTGCTGCAATATTAGAAAATTATCAA
CAAGAAGATGGATCTGTTGTAATACCAGAAGTTTTAAGGCCCTACATGAAAGTAGATGTGATAAAGAAATAA

Upstream 100 bases:

>100_bases
TAAATCATGTGGAGGGCTTATTTAAGCCAAAAGAGGGTGGCAACACGGCATTCCCGTCCCTTTATGGGACGGGAATTATT
TTTAAGGGAGGTGTGGTAAA

Downstream 100 bases:

>100_bases
ATATATTGTTTTCCAATATTATACTATATAAGCATATTGACAATAAAGCTGGGGTATGATATACTTTATATCGTCCCAGC
GGGGAGAGGTGTCCGAGTGG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MLDVKRIRNNPEAVRIAIELKGEKADIDRFLELDEKRRQMLVELETLKNRRNVESDNIAKLKREGKDASDLIAEMKELSD
KIKEMEQEVKEVEEELERILWTIPNIPHESVPIGDSDEDNVEIRRWGEPRKFDFEPKPHWEIGQELDILDFEAAARVTGS
RFTFYKGLGARLERALINFMLDLHIEKHGYTEVFPPFMVHRRSMFGTGQLPKFEEDAFKVYGTDYFLIPTAEVPVTNMYR
DTIIDGDKLPIYHCAYSACFRQEAGSAGRDTRGLIRQHQFNKVELVKFTEPDKSYEELEKMTRDAEEVLQALGLPYRVVV
ICTGDLGFTASKKYDIEVWMPSYGRYVEISSCSNCEDFQARRANIKYRPKDGGKAQYVHTLNGSGVAVGRTFAAILENYQ
QEDGSVVIPEVLRPYMKVDVIKK

Sequences:

>Translated_423_residues
MLDVKRIRNNPEAVRIAIELKGEKADIDRFLELDEKRRQMLVELETLKNRRNVESDNIAKLKREGKDASDLIAEMKELSD
KIKEMEQEVKEVEEELERILWTIPNIPHESVPIGDSDEDNVEIRRWGEPRKFDFEPKPHWEIGQELDILDFEAAARVTGS
RFTFYKGLGARLERALINFMLDLHIEKHGYTEVFPPFMVHRRSMFGTGQLPKFEEDAFKVYGTDYFLIPTAEVPVTNMYR
DTIIDGDKLPIYHCAYSACFRQEAGSAGRDTRGLIRQHQFNKVELVKFTEPDKSYEELEKMTRDAEEVLQALGLPYRVVV
ICTGDLGFTASKKYDIEVWMPSYGRYVEISSCSNCEDFQARRANIKYRPKDGGKAQYVHTLNGSGVAVGRTFAAILENYQ
QEDGSVVIPEVLRPYMKVDVIKK
>Mature_423_residues
MLDVKRIRNNPEAVRIAIELKGEKADIDRFLELDEKRRQMLVELETLKNRRNVESDNIAKLKREGKDASDLIAEMKELSD
KIKEMEQEVKEVEEELERILWTIPNIPHESVPIGDSDEDNVEIRRWGEPRKFDFEPKPHWEIGQELDILDFEAAARVTGS
RFTFYKGLGARLERALINFMLDLHIEKHGYTEVFPPFMVHRRSMFGTGQLPKFEEDAFKVYGTDYFLIPTAEVPVTNMYR
DTIIDGDKLPIYHCAYSACFRQEAGSAGRDTRGLIRQHQFNKVELVKFTEPDKSYEELEKMTRDAEEVLQALGLPYRVVV
ICTGDLGFTASKKYDIEVWMPSYGRYVEISSCSNCEDFQARRANIKYRPKDGGKAQYVHTLNGSGVAVGRTFAAILENYQ
QEDGSVVIPEVLRPYMKVDVIKK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=388, Percent_Identity=37.8865979381443, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI8923421, Length=439, Percent_Identity=32.1184510250569, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI225579074, Length=443, Percent_Identity=31.1512415349887, Blast_Score=214, Evalue=8e-56,
Organism=Escherichia coli, GI1787120, Length=424, Percent_Identity=50.4716981132076, Blast_Score=442, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17539260, Length=469, Percent_Identity=32.8358208955224, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17542084, Length=336, Percent_Identity=31.547619047619, Blast_Score=152, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6320226, Length=442, Percent_Identity=35.2941176470588, Blast_Score=252, Evalue=6e-68,
Organism=Saccharomyces cerevisiae, GI6321799, Length=406, Percent_Identity=32.7586206896552, Blast_Score=226, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24581334, Length=354, Percent_Identity=37.0056497175141, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI17737985, Length=333, Percent_Identity=31.8318318318318, Blast_Score=163, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_THEP3 (B0KAI8)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001664038.1
- ProteinModelPortal:   B0KAI8
- SMR:   B0KAI8
- GeneID:   5873499
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_0029
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   PRK05431
- BioCyc:   TPSE340099:TETH39_0029-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48878; Mature: 48878

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 284-284 BINDING 384-384

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDVKRIRNNPEAVRIAIELKGEKADIDRFLELDEKRRQMLVELETLKNRRNVESDNIAK
CCCHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LKREGKDASDLIAEMKELSDKIKEMEQEVKEVEEELERILWTIPNIPHESVPIGDSDEDN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEIRRWGEPRKFDFEPKPHWEIGQELDILDFEAAARVTGSRFTFYKGLGARLERALINFM
EEEEECCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
LDLHIEKHGYTEVFPPFMVHRRSMFGTGQLPKFEEDAFKVYGTDYFLIPTAEVPVTNMYR
HHEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCEEEEEECCCCCCHHHHH
DTIIDGDKLPIYHCAYSACFRQEAGSAGRDTRGLIRQHQFNKVELVKFTEPDKSYEELEK
HHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHH
MTRDAEEVLQALGLPYRVVVICTGDLGFTASKKYDIEVWMPSYGRYVEISSCSNCEDFQA
HHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEECCCCCCEEEECCCCCCHHHHH
RRANIKYRPKDGGKAQYVHTLNGSGVAVGRTFAAILENYQQEDGSVVIPEVLRPYMKVDV
HHCCCEECCCCCCCEEEEEEECCCCEEHHHHHHHHHHHHHHCCCCEECHHHHCHHHHHHC
IKK
CCC
>Mature Secondary Structure
MLDVKRIRNNPEAVRIAIELKGEKADIDRFLELDEKRRQMLVELETLKNRRNVESDNIAK
CCCHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LKREGKDASDLIAEMKELSDKIKEMEQEVKEVEEELERILWTIPNIPHESVPIGDSDEDN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEIRRWGEPRKFDFEPKPHWEIGQELDILDFEAAARVTGSRFTFYKGLGARLERALINFM
EEEEECCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
LDLHIEKHGYTEVFPPFMVHRRSMFGTGQLPKFEEDAFKVYGTDYFLIPTAEVPVTNMYR
HHEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCEEEEEECCCCCCHHHHH
DTIIDGDKLPIYHCAYSACFRQEAGSAGRDTRGLIRQHQFNKVELVKFTEPDKSYEELEK
HHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHH
MTRDAEEVLQALGLPYRVVVICTGDLGFTASKKYDIEVWMPSYGRYVEISSCSNCEDFQA
HHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEECCCCCCEEEECCCCCCHHHHH
RRANIKYRPKDGGKAQYVHTLNGSGVAVGRTFAAILENYQQEDGSVVIPEVLRPYMKVDV
HHCCCEECCCCCCCEEEEEEECCCCEEHHHHHHHHHHHHHHCCCCEECHHHHCHHHHHHC
IKK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA