Click here to switch to the map view.

The map label for this gene is ilvD [H]

Identifier: 167038693

GI number: 167038693

Start: 20636

End: 22315

Strand: Direct

Name: ilvD [H]

Synonym: Teth514_0018

Alternate gene names: 167038693

Gene position: 20636-22315 (Clockwise)

Preceding gene: 167038692

Following gene: 167038694

Centisome position: 0.84

GC content: 40.12

Gene sequence:

>1680_bases
GTGAGGATATTGATAAGTGATAGCATAAAAAAGGGAGTTGAAAAGGCGCCACATAGGTCACTTTTATATGCTTTAGGCTT
GACTTATGAAGAAATAAAAAGGCCGATTATCGGTGTAGCAAATTCAAAAAACGAAATTATACCAGGTCATATGAATTTAG
ACAAAATAGCTGAAGCTGTAAAAGCAGGCATCAGAATGGCAGGAGGAACTCCTATAGAGTTTTCCACTATTGGTGTTTGT
GATGGCATTGCCATGAACCATAAAGGTATGAAATACTCTTTAGGTAGTAGAGAACTTATTGCAGATAGCATTGAAATCAT
GGCAATGGCCCACGGCTTTGACGGGCTTGTGCTTATACCTAATTGCGACAAAATAGTGCCGGGAATGCTTATGGCAGCAG
CACGACTTAATATTCCTGCAATAGTTGTAAGCGGAGGCCCAATGCTTGCAGGAAATTGTAATGGAGATACCTGTGATTTG
AGCAGTGTTTTTGAGGCGGTAGGGGCTCACAAGGTTGGTAAAATCACTGAGGAAGACCTCTACAGAATAGAGCTTAACGC
TTGCCCTACCTGTGGTTCCTGCTCTGGTATGTTTACCGCAAATACTATGAATTGCTTGACAGAAGCTTTAGGATTAGGAC
TTCCGGGAAATGGCACAATTCCAGCTGTTTATTCTGAAAGGATAAGACTTGCAAAACAAGCTGGAATAAAAATCATGGAG
CTTGTAGAGAGAGGAATTAAGCCTTCTTATATACTCACAAAAGAGGCATTCATAAACGCCTTTAGTTTAGACATGGCTTT
AGGCGGTTCCACAAATACAGTATTGCACTTAAAAGCTATAGCTCATGAGGCAGGGGTAGAAATATCTCTTGATGAAATAA
ACGATATAAGCGGGAGAGTACCTAATTTATGTAAATTAAGTCCTGCAGGTAAATACCACATAGAGGACTTGCATTTTGCA
GGGGGAGTATCGGCTGTTTTAAAAGAACTGACGAAAGCTAATCTTATAAATACTGAAGTGTTAACAGTTACAGGAAAGAC
ATTGGGAGAGAATATAAAAGACGCGAAAGTTTTAAATCATGATGTGATAAGGCCAATAGACAACCCTTACAGCAGTACTG
GAGGTCTTGCGATACTGTACGGGAACATTGCAAGAGAAGGAGCTGTTGTAAAAGCATCTGCTGTAGCAAAAGAGATGTTA
AGACATGAAGGACCAGCAAAGGTATTTAATTCTGAAGAAGAGGCTATTGAAGCAATATATGGTGGGAAAATACAGAAAGG
CGATGTAGTTGTAATAAGGTATGAAGGGCCAAAAGGTGGGCCGGGAATGAGAGAAATGTTAAGTCCTACTTCAGCCCTTG
CAGGTATGGGACTTGACAAAGATGTCGCTCTTATAACAGACGGCAGGTTTTCAGGTGCAACAAGAGGGGCTTCAATAGGA
CATGTATCTCCAGAGGCTATGGAAGGGGGAGAAATAGCGATTATTGAAGATGGGGATATTATTGAAATTGATATTCCCGC
AAGAAAAATTAATGTGAAATTAACTGATGAGGAGATTAAAGAAAGAATGAAAAGATGGGTAAGACCTGAACCAAAGATAA
AAACTGGTTATATGGCAAGATATGCAGAACAAGTGACTTCTGCAAATACAGGTGCAGTTTTTAAGGGGGGAGGTATATGA

Upstream 100 bases:

>100_bases
ATAAAGTTTTAGAGGCAGGTTATAGGACTTTTGATTTAGGAAAAGGAATAATTTTAAATACCCAACAAATGGGAGATAAA
GTGGTGGAGTATATAAAGGG

Downstream 100 bases:

>100_bases
AGTTAAAAGGAGCGCAAGTAATTATAGAAGTTTTAAAAGAGATGGGCGTTGATACTATATTTGGCATACCAGGAGGGGCA
GTTATTCCCATTTATGATGC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MRILISDSIKKGVEKAPHRSLLYALGLTYEEIKRPIIGVANSKNEIIPGHMNLDKIAEAVKAGIRMAGGTPIEFSTIGVC
DGIAMNHKGMKYSLGSRELIADSIEIMAMAHGFDGLVLIPNCDKIVPGMLMAAARLNIPAIVVSGGPMLAGNCNGDTCDL
SSVFEAVGAHKVGKITEEDLYRIELNACPTCGSCSGMFTANTMNCLTEALGLGLPGNGTIPAVYSERIRLAKQAGIKIME
LVERGIKPSYILTKEAFINAFSLDMALGGSTNTVLHLKAIAHEAGVEISLDEINDISGRVPNLCKLSPAGKYHIEDLHFA
GGVSAVLKELTKANLINTEVLTVTGKTLGENIKDAKVLNHDVIRPIDNPYSSTGGLAILYGNIAREGAVVKASAVAKEML
RHEGPAKVFNSEEEAIEAIYGGKIQKGDVVVIRYEGPKGGPGMREMLSPTSALAGMGLDKDVALITDGRFSGATRGASIG
HVSPEAMEGGEIAIIEDGDIIEIDIPARKINVKLTDEEIKERMKRWVRPEPKIKTGYMARYAEQVTSANTGAVFKGGGI

Sequences:

>Translated_559_residues
MRILISDSIKKGVEKAPHRSLLYALGLTYEEIKRPIIGVANSKNEIIPGHMNLDKIAEAVKAGIRMAGGTPIEFSTIGVC
DGIAMNHKGMKYSLGSRELIADSIEIMAMAHGFDGLVLIPNCDKIVPGMLMAAARLNIPAIVVSGGPMLAGNCNGDTCDL
SSVFEAVGAHKVGKITEEDLYRIELNACPTCGSCSGMFTANTMNCLTEALGLGLPGNGTIPAVYSERIRLAKQAGIKIME
LVERGIKPSYILTKEAFINAFSLDMALGGSTNTVLHLKAIAHEAGVEISLDEINDISGRVPNLCKLSPAGKYHIEDLHFA
GGVSAVLKELTKANLINTEVLTVTGKTLGENIKDAKVLNHDVIRPIDNPYSSTGGLAILYGNIAREGAVVKASAVAKEML
RHEGPAKVFNSEEEAIEAIYGGKIQKGDVVVIRYEGPKGGPGMREMLSPTSALAGMGLDKDVALITDGRFSGATRGASIG
HVSPEAMEGGEIAIIEDGDIIEIDIPARKINVKLTDEEIKERMKRWVRPEPKIKTGYMARYAEQVTSANTGAVFKGGGI
>Mature_559_residues
MRILISDSIKKGVEKAPHRSLLYALGLTYEEIKRPIIGVANSKNEIIPGHMNLDKIAEAVKAGIRMAGGTPIEFSTIGVC
DGIAMNHKGMKYSLGSRELIADSIEIMAMAHGFDGLVLIPNCDKIVPGMLMAAARLNIPAIVVSGGPMLAGNCNGDTCDL
SSVFEAVGAHKVGKITEEDLYRIELNACPTCGSCSGMFTANTMNCLTEALGLGLPGNGTIPAVYSERIRLAKQAGIKIME
LVERGIKPSYILTKEAFINAFSLDMALGGSTNTVLHLKAIAHEAGVEISLDEINDISGRVPNLCKLSPAGKYHIEDLHFA
GGVSAVLKELTKANLINTEVLTVTGKTLGENIKDAKVLNHDVIRPIDNPYSSTGGLAILYGNIAREGAVVKASAVAKEML
RHEGPAKVFNSEEEAIEAIYGGKIQKGDVVVIRYEGPKGGPGMREMLSPTSALAGMGLDKDVALITDGRFSGATRGASIG
HVSPEAMEGGEIAIIEDGDIIEIDIPARKINVKLTDEEIKERMKRWVRPEPKIKTGYMARYAEQVTSANTGAVFKGGGI

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=603, Percent_Identity=47.2636815920398, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI1788157, Length=525, Percent_Identity=31.4285714285714, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI2367371, Length=505, Percent_Identity=35.049504950495, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1786464, Length=488, Percent_Identity=34.0163934426229, Blast_Score=216, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6322476, Length=549, Percent_Identity=44.4444444444444, Blast_Score=438, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59387; Mature: 59387

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILISDSIKKGVEKAPHRSLLYALGLTYEEIKRPIIGVANSKNEIIPGHMNLDKIAEAV
CEEEECHHHHHHHHHCCCHHHHHHHCCCHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHH
KAGIRMAGGTPIEFSTIGVCDGIAMNHKGMKYSLGSRELIADSIEIMAMAHGFDGLVLIP
HHHHEECCCCCEEEEEEEEECCEEECCCCCEEECCCHHHHHHHHEEEEEECCCCCEEECC
NCDKIVPGMLMAAARLNIPAIVVSGGPMLAGNCNGDTCDLSSVFEAVGAHKVGKITEEDL
CCCHHHHHHHHHHHHCCCCEEEEECCEEEECCCCCCCCCHHHHHHHHCCHHCCCCCCCCE
YRIELNACPTCGSCSGMFTANTMNCLTEALGLGLPGNGTIPAVYSERIRLAKQAGIKIME
EEEEECCCCCCCCCCCCEECHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHH
LVERGIKPSYILTKEAFINAFSLDMALGGSTNTVLHLKAIAHEAGVEISLDEINDISGRV
HHHHCCCCCEEEEHHHHHHHEEEEEEECCCCCEEEEEEEHHHHCCCEEEHHHCCCCCCCC
PNLCKLSPAGKYHIEDLHFAGGVSAVLKELTKANLINTEVLTVTGKTLGENIKDAKVLNH
CCCEECCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECHHHCCCCCHHHHHCC
DVIRPIDNPYSSTGGLAILYGNIAREGAVVKASAVAKEMLRHEGPAKVFNSEEEAIEAIY
HHCCCCCCCCCCCCCEEEEEECCCCCCCEEEHHHHHHHHHHCCCCHHHCCCHHHHHHHHH
GGKIQKGDVVVIRYEGPKGGPGMREMLSPTSALAGMGLDKDVALITDGRFSGATRGASIG
CCCCCCCCEEEEEECCCCCCCCHHHHHCHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCC
HVSPEAMEGGEIAIIEDGDIIEIDIPARKINVKLTDEEIKERMKRWVRPEPKIKTGYMAR
CCCHHHCCCCCEEEEECCCEEEEECCCEEEEEEECHHHHHHHHHHHCCCCCCCCHHHHHH
YAEQVTSANTGAVFKGGGI
HHHHHHCCCCCCEEECCCC
>Mature Secondary Structure
MRILISDSIKKGVEKAPHRSLLYALGLTYEEIKRPIIGVANSKNEIIPGHMNLDKIAEAV
CEEEECHHHHHHHHHCCCHHHHHHHCCCHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHH
KAGIRMAGGTPIEFSTIGVCDGIAMNHKGMKYSLGSRELIADSIEIMAMAHGFDGLVLIP
HHHHEECCCCCEEEEEEEEECCEEECCCCCEEECCCHHHHHHHHEEEEEECCCCCEEECC
NCDKIVPGMLMAAARLNIPAIVVSGGPMLAGNCNGDTCDLSSVFEAVGAHKVGKITEEDL
CCCHHHHHHHHHHHHCCCCEEEEECCEEEECCCCCCCCCHHHHHHHHCCHHCCCCCCCCE
YRIELNACPTCGSCSGMFTANTMNCLTEALGLGLPGNGTIPAVYSERIRLAKQAGIKIME
EEEEECCCCCCCCCCCCEECHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHH
LVERGIKPSYILTKEAFINAFSLDMALGGSTNTVLHLKAIAHEAGVEISLDEINDISGRV
HHHHCCCCCEEEEHHHHHHHEEEEEEECCCCCEEEEEEEHHHHCCCEEEHHHCCCCCCCC
PNLCKLSPAGKYHIEDLHFAGGVSAVLKELTKANLINTEVLTVTGKTLGENIKDAKVLNH
CCCEECCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECHHHCCCCCHHHHHCC
DVIRPIDNPYSSTGGLAILYGNIAREGAVVKASAVAKEMLRHEGPAKVFNSEEEAIEAIY
HHCCCCCCCCCCCCCEEEEEECCCCCCCEEEHHHHHHHHHHCCCCHHHCCCHHHHHHHHH
GGKIQKGDVVVIRYEGPKGGPGMREMLSPTSALAGMGLDKDVALITDGRFSGATRGASIG
CCCCCCCCEEEEEECCCCCCCCHHHHHCHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCC
HVSPEAMEGGEIAIIEDGDIIEIDIPARKINVKLTDEEIKERMKRWVRPEPKIKTGYMAR
CCCHHHCCCCCEEEEECCCEEEEECCCEEEEEEECHHHHHHHHHHHCCCCCCCCHHHHHH
YAEQVTSANTGAVFKGGGI
HHHHHHCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]