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The map label for this gene is ilvC [H]

Identifier: 167038688

GI number: 167038688

Start: 15630

End: 16625

Strand: Direct

Name: ilvC [H]

Synonym: Teth514_0013

Alternate gene names: 167038688

Gene position: 15630-16625 (Clockwise)

Preceding gene: 167038687

Following gene: 167038689

Centisome position: 0.64

GC content: 36.85

Gene sequence:

>996_bases
ATGGCAAAGATGTATTATGACAAGGATGCAGATTTGAATTTGCTTAAAAACAAGAAAATCGCAATAATAGGTTTTGGAAG
TCAAGGTCATGCTCATGCACTAAATTTAAGAGATTCTGGACTTGATGTAATAGTTGGTCTTTACGAGGGAAGTAAATCAA
AAGAAAGAGCAGAAAAAGAAGGGCTGCGAGTTTATACAGTTGAGGAAGCAGCTAAAGTAGCAGATATCATAATGATGCTG
ATACCGGATGAAAAGCAGGCAAAAGTCTATAAAGAAAGCATAGAAAAAAATCTTACAGAAGGTAAAGCTCTTGCCTTTGC
TCATGGGTTTAATATTCACTTTAAACAGATTGTTCCTCCAAAAAATGTGGATGTGTTTATGGTAGCTCCAAAAGGACCAG
GACACCTTGTAAGAAGGGTATACCAAGAAGGAAAGGGAGTTCCAAATCTTGTAGCAGTGTATCAAGATTACACAGGGAAA
GCTTTTGAAATAGCTTTAGCCTATGCAAAGGGAATAGGAGGTACAAGAGCAGGTGTCATTGAGACTACTTTTAAAGAGGA
GACAGAAACAGACCTCTTTGGGGAGCAGGCTGTCCTTTGTGGTGGAGTTACTGAACTCATGAAAGCAGGATTTGAAACAT
TGGTAGAAGCTGGTTATCAGCCAGAAATAGCTTATTTCGAATGTGTGCATGAAATGAAACTTATAGTTGACCTCATATAC
GAAGGCGGTTTTAGTTATATGAGATATTCTATTTCGGATACTGCAGAATTTGGAGACTATATGACAGGTAAGAGGATAAT
AACAGAAGAGACTCGAAAAGAGATGAAAAAAGTTTTATCAGAAATACAATCAGGAAAATTTGCAAAAGAGTGGCTTTTAG
AAAATCAGGTAGGAAGACCACAGTACAATGCTATAAAAGATAAAGAGGCAAATCATCTTATTGAAAAAGTCGGCAAAGGT
TTGAGAGAAATGATGGCTTGGATTAAAAAAGAATGA

Upstream 100 bases:

>100_bases
ATTTAATTAATAAGTTTGAGGTAAAAGAACTTGTCAGGACAGGACTTGTATCTTTAGAGAGAGGCAATAAAACACTAAAA
GAATATGAGGGGGAATTATA

Downstream 100 bases:

>100_bases
ATAAGGAGGTAGAAGACAATGGGGGTCAAAAGAGTCATTGTTTTTGACACTACGTTAAGGGATGGTGAGCAGACTCCTGG
TGTGAATTTTAACAGCAATG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MAKMYYDKDADLNLLKNKKIAIIGFGSQGHAHALNLRDSGLDVIVGLYEGSKSKERAEKEGLRVYTVEEAAKVADIIMML
IPDEKQAKVYKESIEKNLTEGKALAFAHGFNIHFKQIVPPKNVDVFMVAPKGPGHLVRRVYQEGKGVPNLVAVYQDYTGK
AFEIALAYAKGIGGTRAGVIETTFKEETETDLFGEQAVLCGGVTELMKAGFETLVEAGYQPEIAYFECVHEMKLIVDLIY
EGGFSYMRYSISDTAEFGDYMTGKRIITEETRKEMKKVLSEIQSGKFAKEWLLENQVGRPQYNAIKDKEANHLIEKVGKG
LREMMAWIKKE

Sequences:

>Translated_331_residues
MAKMYYDKDADLNLLKNKKIAIIGFGSQGHAHALNLRDSGLDVIVGLYEGSKSKERAEKEGLRVYTVEEAAKVADIIMML
IPDEKQAKVYKESIEKNLTEGKALAFAHGFNIHFKQIVPPKNVDVFMVAPKGPGHLVRRVYQEGKGVPNLVAVYQDYTGK
AFEIALAYAKGIGGTRAGVIETTFKEETETDLFGEQAVLCGGVTELMKAGFETLVEAGYQPEIAYFECVHEMKLIVDLIY
EGGFSYMRYSISDTAEFGDYMTGKRIITEETRKEMKKVLSEIQSGKFAKEWLLENQVGRPQYNAIKDKEANHLIEKVGKG
LREMMAWIKKE
>Mature_330_residues
AKMYYDKDADLNLLKNKKIAIIGFGSQGHAHALNLRDSGLDVIVGLYEGSKSKERAEKEGLRVYTVEEAAKVADIIMMLI
PDEKQAKVYKESIEKNLTEGKALAFAHGFNIHFKQIVPPKNVDVFMVAPKGPGHLVRRVYQEGKGVPNLVAVYQDYTGKA
FEIALAYAKGIGGTRAGVIETTFKEETETDLFGEQAVLCGGVTELMKAGFETLVEAGYQPEIAYFECVHEMKLIVDLIYE
GGFSYMRYSISDTAEFGDYMTGKRIITEETRKEMKKVLSEIQSGKFAKEWLLENQVGRPQYNAIKDKEANHLIEKVGKGL
REMMAWIKKE

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=292, Percent_Identity=36.6438356164384, Blast_Score=153, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323387, Length=331, Percent_Identity=35.6495468277946, Blast_Score=163, Evalue=4e-41,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 37116; Mature: 36985

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKMYYDKDADLNLLKNKKIAIIGFGSQGHAHALNLRDSGLDVIVGLYEGSKSKERAEKE
CCCCCCCCCCCCEEECCCEEEEEEECCCCCEEEEECCCCCCEEEEEEECCCCHHHHHHHC
GLRVYTVEEAAKVADIIMMLIPDEKQAKVYKESIEKNLTEGKALAFAHGFNIHFKQIVPP
CCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCC
KNVDVFMVAPKGPGHLVRRVYQEGKGVPNLVAVYQDYTGKAFEIALAYAKGIGGTRAGVI
CCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHEEHHHHHHCCCCCCCCEE
ETTFKEETETDLFGEQAVLCGGVTELMKAGFETLVEAGYQPEIAYFECVHEMKLIVDLIY
EHHHHHCHHHHHCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGFSYMRYSISDTAEFGDYMTGKRIITEETRKEMKKVLSEIQSGKFAKEWLLENQVGRP
HCCHHHEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCC
QYNAIKDKEANHLIEKVGKGLREMMAWIKKE
CCHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKMYYDKDADLNLLKNKKIAIIGFGSQGHAHALNLRDSGLDVIVGLYEGSKSKERAEKE
CCCCCCCCCCCEEECCCEEEEEEECCCCCEEEEECCCCCCEEEEEEECCCCHHHHHHHC
GLRVYTVEEAAKVADIIMMLIPDEKQAKVYKESIEKNLTEGKALAFAHGFNIHFKQIVPP
CCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCC
KNVDVFMVAPKGPGHLVRRVYQEGKGVPNLVAVYQDYTGKAFEIALAYAKGIGGTRAGVI
CCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHEEHHHHHHCCCCCCCCEE
ETTFKEETETDLFGEQAVLCGGVTELMKAGFETLVEAGYQPEIAYFECVHEMKLIVDLIY
EHHHHHCHHHHHCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGFSYMRYSISDTAEFGDYMTGKRIITEETRKEMKKVLSEIQSGKFAKEWLLENQVGRP
HCCHHHEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCC
QYNAIKDKEANHLIEKVGKGLREMMAWIKKE
CCHHHCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA