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The map label for this gene is bioF [H]

Identifier: 163844654

GI number: 163844654

Start: 474150

End: 475286

Strand: Reverse

Name: bioF [H]

Synonym: BSUIS_B0491

Alternate gene names: 163844654

Gene position: 475286-474150 (Counterclockwise)

Preceding gene: 163844655

Following gene: 163844653

Centisome position: 33.93

GC content: 61.13

Gene sequence:

>1137_bases
GTGAAACTCGACACCTACCTGACAAGGCTGGAAAATCTGGAGCGCAAGGGGCGGCGGCGCAATCTTGCGCTGGCCGATGG
GCTTGATTTCAGTTCCAATGATTATCTGGGCCTTGCCACCCACCCCGGCATAAAGGCCGCCGTCGAGGCCGCCCTTCAGC
GTGGCGTTCCACTTGGCGCAACCGGCTCAAGGCTATTGCGCGGCAACCATGCGGAACACGAGGCGCTTGAAGCCGAAGCC
GCAGCACATTTCAGTGCCCCGCGCATGATCTATTTCGGCAGTGGCTACATGACCAATCTGGCAGCACTTTCCACCTTGCC
CCAGCCGGGCGACCTGATCGTGTATGACGAACTCATCCATGCCAGCGCCCATGCGGGCATCCGTGCGGGCCGCGCCGAAG
CGGTTGGCGCCCGGCACAATGATGCACAGGCCTTCGAGGACCGGATAAGGGCCTGGCGCGAAAACGGCGGTCGCGGCACA
CCATGGATCGTGGTTGAAAGCATCTATTCCATGGATGGCGATCAGGCGCCGCTAAAGGCACTTCATGCCATCGCCACCCG
TTATGACGGTGTGCTTTATATCGACGAAGCCCATGCAACCGGGGTTTACGGCGCCAATGGCGGGGGATTTGCCGCTACTC
TTGGCGATGCGGAAAATATTGTCACGTTGCATACCTGCGGCAAGGCGCTTGGCGGCTCCGGTGCCTTGCTGGGCGCACAT
GCCACGCTGTGCGACTATCTCGTCAATCGTGCGAGCGGCTTCATCTTTACCACCGCCCCCTCGCCCTTGCAGGCCGCAGC
CCTGCGCGAGGCACTTCGGATATTGCGTGACCAGCCAGAGAGGCGCGCACGGCTTTTTTCGCGCATCAGCCATGCCAATG
AGCGGATCGCAACCGCTCTCGGCCAGCCGGTGAGCGGAACGCAGATCATTCCCATTATCGTGGGTGACAATGAGCGCGCT
GTTCGCCTTGCTGCACAGATGCAGGCACAAGGGTTCGATATTCGCGCCATCCGCCCGCCGACCGTCCCGCATGGCACGGC
GCGCCTGCGCATTTCCATCACGCTCAATGTCGGTCTCGCCGACATCGACCGCATGGTTGAAACGCTTTCCTACGCGACTT
TTAGAGAAGCAGCATGA

Upstream 100 bases:

>100_bases
TTATGGGCGACACCTTGCTCACAGCCGCCAACCCCGGCGACGACCGCGATTCCAGCCTGCTGCGCCGCCTCGGCATACAG
GCGGAAACGGAGCAGCCTGC

Downstream 100 bases:

>100_bases
ATTCCCGTTTGATCGTTACCGGCACGGATACTGGCATCGGCAAGACCGTGTTCAGCGCGGCGCTCTGCCATGCCTTGGGG
GCCGCCTATTGGAAACCCGT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MKLDTYLTRLENLERKGRRRNLALADGLDFSSNDYLGLATHPGIKAAVEAALQRGVPLGATGSRLLRGNHAEHEALEAEA
AAHFSAPRMIYFGSGYMTNLAALSTLPQPGDLIVYDELIHASAHAGIRAGRAEAVGARHNDAQAFEDRIRAWRENGGRGT
PWIVVESIYSMDGDQAPLKALHAIATRYDGVLYIDEAHATGVYGANGGGFAATLGDAENIVTLHTCGKALGGSGALLGAH
ATLCDYLVNRASGFIFTTAPSPLQAAALREALRILRDQPERRARLFSRISHANERIATALGQPVSGTQIIPIIVGDNERA
VRLAAQMQAQGFDIRAIRPPTVPHGTARLRISITLNVGLADIDRMVETLSYATFREAA

Sequences:

>Translated_378_residues
MKLDTYLTRLENLERKGRRRNLALADGLDFSSNDYLGLATHPGIKAAVEAALQRGVPLGATGSRLLRGNHAEHEALEAEA
AAHFSAPRMIYFGSGYMTNLAALSTLPQPGDLIVYDELIHASAHAGIRAGRAEAVGARHNDAQAFEDRIRAWRENGGRGT
PWIVVESIYSMDGDQAPLKALHAIATRYDGVLYIDEAHATGVYGANGGGFAATLGDAENIVTLHTCGKALGGSGALLGAH
ATLCDYLVNRASGFIFTTAPSPLQAAALREALRILRDQPERRARLFSRISHANERIATALGQPVSGTQIIPIIVGDNERA
VRLAAQMQAQGFDIRAIRPPTVPHGTARLRISITLNVGLADIDRMVETLSYATFREAA
>Mature_378_residues
MKLDTYLTRLENLERKGRRRNLALADGLDFSSNDYLGLATHPGIKAAVEAALQRGVPLGATGSRLLRGNHAEHEALEAEA
AAHFSAPRMIYFGSGYMTNLAALSTLPQPGDLIVYDELIHASAHAGIRAGRAEAVGARHNDAQAFEDRIRAWRENGGRGT
PWIVVESIYSMDGDQAPLKALHAIATRYDGVLYIDEAHATGVYGANGGGFAATLGDAENIVTLHTCGKALGGSGALLGAH
ATLCDYLVNRASGFIFTTAPSPLQAAALREALRILRDQPERRARLFSRISHANERIATALGQPVSGTQIIPIIVGDNERA
VRLAAQMQAQGFDIRAIRPPTVPHGTARLRISITLNVGLADIDRMVETLSYATFREAA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=347, Percent_Identity=31.700288184438, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI284448556, Length=347, Percent_Identity=31.700288184438, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI83977444, Length=350, Percent_Identity=32.8571428571429, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI83977440, Length=350, Percent_Identity=32.8571428571429, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI83977442, Length=350, Percent_Identity=32.8571428571429, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI4502025, Length=337, Percent_Identity=33.5311572700297, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI40316939, Length=337, Percent_Identity=33.5311572700297, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI4758668, Length=393, Percent_Identity=25.4452926208651, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI119220554, Length=387, Percent_Identity=24.031007751938, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI5454084, Length=377, Percent_Identity=23.8726790450928, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1786993, Length=347, Percent_Identity=36.5994236311239, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI1790046, Length=373, Percent_Identity=30.8310991957105, Blast_Score=161, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI71994529, Length=351, Percent_Identity=29.6296296296296, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI32566772, Length=358, Percent_Identity=25.9776536312849, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17560914, Length=377, Percent_Identity=24.9336870026525, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17560912, Length=377, Percent_Identity=24.9336870026525, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71982617, Length=290, Percent_Identity=24.1379310344828, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71982625, Length=290, Percent_Identity=24.1379310344828, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320438, Length=387, Percent_Identity=29.4573643410853, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320267, Length=367, Percent_Identity=24.2506811989101, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323954, Length=268, Percent_Identity=23.5074626865672, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17137420, Length=365, Percent_Identity=32.3287671232877, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24662918, Length=348, Percent_Identity=29.5977011494253, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI17136286, Length=257, Percent_Identity=29.1828793774319, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24653280, Length=289, Percent_Identity=27.681660899654, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24653276, Length=289, Percent_Identity=27.681660899654, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24653278, Length=289, Percent_Identity=27.681660899654, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 40483; Mature: 40483

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDTYLTRLENLERKGRRRNLALADGLDFSSNDYLGLATHPGIKAAVEAALQRGVPLGA
CCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCC
TGSRLLRGNHAEHEALEAEAAAHFSAPRMIYFGSGYMTNLAALSTLPQPGDLIVYDELIH
CCCHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCEEEEHHHHH
ASAHAGIRAGRAEAVGARHNDAQAFEDRIRAWRENGGRGTPWIVVESIYSMDGDQAPLKA
HHHHCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCCCHHHHH
LHAIATRYDGVLYIDEAHATGVYGANGGGFAATLGDAENIVTLHTCGKALGGSGALLGAH
HHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCEEEEEECCHHHCCCCCCHHHH
ATLCDYLVNRASGFIFTTAPSPLQAAALREALRILRDQPERRARLFSRISHANERIATAL
HHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
GQPVSGTQIIPIIVGDNERAVRLAAQMQAQGFDIRAIRPPTVPHGTARLRISITLNVGLA
CCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEEEEECCHH
DIDRMVETLSYATFREAA
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLDTYLTRLENLERKGRRRNLALADGLDFSSNDYLGLATHPGIKAAVEAALQRGVPLGA
CCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCC
TGSRLLRGNHAEHEALEAEAAAHFSAPRMIYFGSGYMTNLAALSTLPQPGDLIVYDELIH
CCCHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCEEEEHHHHH
ASAHAGIRAGRAEAVGARHNDAQAFEDRIRAWRENGGRGTPWIVVESIYSMDGDQAPLKA
HHHHCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCCCHHHHH
LHAIATRYDGVLYIDEAHATGVYGANGGGFAATLGDAENIVTLHTCGKALGGSGALLGAH
HHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCEEEEEECCHHHCCCCCCHHHH
ATLCDYLVNRASGFIFTTAPSPLQAAALREALRILRDQPERRARLFSRISHANERIATAL
HHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
GQPVSGTQIIPIIVGDNERAVRLAAQMQAQGFDIRAIRPPTVPHGTARLRISITLNVGLA
CCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEEEEECCHH
DIDRMVETLSYATFREAA
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA