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The map label for this gene is lon [H]

Identifier: 162447398

GI number: 162447398

Start: 570427

End: 572739

Strand: Direct

Name: lon [H]

Synonym: ACL_0536

Alternate gene names: 162447398

Gene position: 570427-572739 (Clockwise)

Preceding gene: 162447397

Following gene: 162447399

Centisome position: 38.1

GC content: 32.38

Gene sequence:

>2313_bases
ATGGAATTACAGACAAGTTTACCCGCGATTGTTGTACGTGGTATCGTACCGATTCCTAATAATGATTTTAGAATTGAAGT
TGGCCGTAAAGTATCCCTTAAAGCGATTGAAGAGTCTGAAAAGAGTTTTTCATCTTACGTACTTATATTGGTTCAAAAAA
ATCCATTAATAGAAAACCCAACAGTTGCTGATATTGAAACTCATGGTGTCTTAGCTAAGATTGCTATGAAGATTAAATTA
CCTAATAACAACTATAAAATTAAGTTTAATTTAATGTCTAGAATTAAAGTCAATGAGTACTTTTTAACAGATCCTTACTT
TGTAGCAGACTATGAAGAATTAGAATCAAAAGTAGGGGAAATTGAAGAAGAAACTACATTACTTAAATTAATTACTGATG
AAGCTGTTGTAAATGCAAATCAGTTGTTTAATAATGCCCAAGTGATTACATCACAAATTCAATCTGGTTTATCATCAGAT
AAAATGGCGGACATTTTAGCATATAATTTAAGAACTCAAGATACTGAAAAATATAAGTATCTAGCTGAATTAAATGTAAA
TTCAAGACTAAAATTAATTTTAGAAGATATTAACCGTCTAAAGATGATTGCTGATTTAGAACAGCGTATTAATGAAGATG
TTAAAAAGGCAATTGATGAAAATCAAAAAGAATATTATTTAAGAGAAAAAATGCGTGCAATTCAAAATGAATTAGGTGAT
AAAGCTAAAAAAGAAGATGAAATTGATAAATTAAGAGAAGATATTAAGAAGGCTAAAATGCCGCTTCATATCGAAGAAAA
GGCCCTACAAGAGCTATCTCGTTATCAATCAACACCTTCAGCAATGGCTGAATCTCAAATTATTAAAACTTACCTAGATT
TTCTAGTTGCATTACCTTGGAATGAATCATCAACAGATTTAAATGATTTACAAAAGGTACAAGATAACTTAGATAAGAAT
CATTATGGTCTGGAAAATGTTAAAGAACGTATTATTGAATATCTAGCAGTTAAGATGATGACTGGTAGAAATCCACAGAC
TATTTTATGTTTAGCAGGTCCTCCAGGGGTTGGTAAAACATCACTTGCAACATCTATTGCAGAAGCTTTAGGTCGTAAGT
TTGTTAAACAATCACTAGGTGGCGTTAAAGATGAATCAGAAATACGTGGTCATAGAAGAACTTACGTAGGCGCTATGCCT
GGTCGTATCCTTAAGGGTATGAAGGATGCTGGTACAGTAAATCCTGTCTTCTTATTAGATGAAATTGATAAAATGGCATC
TGATTATAGAGGGGACCCTGCATCTGCAATGCTTGAAGTATTAGACCCAGAGCAAAATGCTAAATTTAGTGATCACTACT
TGGAAGAAAATTATGACTTATCTCAAGTATTATTCATTACAACAGCAAACTATCTTGAAAATGTGCCTGCACCTTTAAGA
GATCGTATGGAAATTGTAGAACTATCTAGCTATACTGAGTATGAAAAAATTCAGATTGCTCAAAAACACTTAGTTAACAA
ACAATTATCAGCACACGGTTTAGATAGTGATAAATTTACAATTGATGAAGAAACACTTTACTTTATTGTAAGACATTACA
CTAGAGAAGCTGGTGTTCGTGAGTTAAACCGTTATATTGGTTCTTTAGTACGTAAAGCAATTAAAGAAATTCTTATGAAA
AAAGCAGATAAAATTCATATCACTAAAGAAAATGTAGAAACATATATAGGTAAACCTAAGTTTGTACATAATTTAGTGGA
TGAAAAACAACAAATTGGTGTTGTGACTGGTCTAGCATATACTGCATTTGGTGGAGACACACTTCCGGTTGAAGTTACTT
ACTATAAAGGTAAGGGACAACTTGTTTTAACAGGTAAACTAGGGGATGTCATGAAAGAATCAGCAATTACTGCACTTTCA
TATGTAAAATCACATGCACTAGAATTTAATTTAGACCCAACGATATTTGAAAACAACGACTTCCACGTCCACGTACCAGA
AGGAGCAATTCCTAAAGATGGTCCTTCAGCGGGTATTACCATGGCAACTGCGATTATGTCAGCTGCAAGTAAACTCTATG
TTAGAAAAGACCTTGGTATGACCGGTGAAATTACATTACGCGGTTATGTACTACCAATTGGTGGATTAAAAGAAAAAGCA
ATTGCTGCTTTAAGAAGTGGTTTAACTACTATTTTAATTCCAAAACAAAACGTTAAAGATGTTGATGATATTCCAAAAGA
AGTTAGAGACAAATTAACAATTATTCCTGTTGAAAATGTATCTGATGTTTTTGCACAAGCATTGATTAGATAA

Upstream 100 bases:

>100_bases
AGATGGGATAACGATTGGCACTCATGCATTATGATTGCTAATTGACAATTTTATATTATAATATATAATAAGAATATAAC
CCAGAAAGGGGATCAAAGAT

Downstream 100 bases:

>100_bases
TCTTAAACAATCACTAAAGATAAGAGTGTTATGAACGTCATAACACTCTTATTTTATGGGGTTTAGTAAAATGTGACATT
CAATGATTGTAAATATATGA

Product: serine protease Lon, ATP-dependent

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 770; Mature: 770

Protein sequence:

>770_residues
MELQTSLPAIVVRGIVPIPNNDFRIEVGRKVSLKAIEESEKSFSSYVLILVQKNPLIENPTVADIETHGVLAKIAMKIKL
PNNNYKIKFNLMSRIKVNEYFLTDPYFVADYEELESKVGEIEEETTLLKLITDEAVVNANQLFNNAQVITSQIQSGLSSD
KMADILAYNLRTQDTEKYKYLAELNVNSRLKLILEDINRLKMIADLEQRINEDVKKAIDENQKEYYLREKMRAIQNELGD
KAKKEDEIDKLREDIKKAKMPLHIEEKALQELSRYQSTPSAMAESQIIKTYLDFLVALPWNESSTDLNDLQKVQDNLDKN
HYGLENVKERIIEYLAVKMMTGRNPQTILCLAGPPGVGKTSLATSIAEALGRKFVKQSLGGVKDESEIRGHRRTYVGAMP
GRILKGMKDAGTVNPVFLLDEIDKMASDYRGDPASAMLEVLDPEQNAKFSDHYLEENYDLSQVLFITTANYLENVPAPLR
DRMEIVELSSYTEYEKIQIAQKHLVNKQLSAHGLDSDKFTIDEETLYFIVRHYTREAGVRELNRYIGSLVRKAIKEILMK
KADKIHITKENVETYIGKPKFVHNLVDEKQQIGVVTGLAYTAFGGDTLPVEVTYYKGKGQLVLTGKLGDVMKESAITALS
YVKSHALEFNLDPTIFENNDFHVHVPEGAIPKDGPSAGITMATAIMSAASKLYVRKDLGMTGEITLRGYVLPIGGLKEKA
IAALRSGLTTILIPKQNVKDVDDIPKEVRDKLTIIPVENVSDVFAQALIR

Sequences:

>Translated_770_residues
MELQTSLPAIVVRGIVPIPNNDFRIEVGRKVSLKAIEESEKSFSSYVLILVQKNPLIENPTVADIETHGVLAKIAMKIKL
PNNNYKIKFNLMSRIKVNEYFLTDPYFVADYEELESKVGEIEEETTLLKLITDEAVVNANQLFNNAQVITSQIQSGLSSD
KMADILAYNLRTQDTEKYKYLAELNVNSRLKLILEDINRLKMIADLEQRINEDVKKAIDENQKEYYLREKMRAIQNELGD
KAKKEDEIDKLREDIKKAKMPLHIEEKALQELSRYQSTPSAMAESQIIKTYLDFLVALPWNESSTDLNDLQKVQDNLDKN
HYGLENVKERIIEYLAVKMMTGRNPQTILCLAGPPGVGKTSLATSIAEALGRKFVKQSLGGVKDESEIRGHRRTYVGAMP
GRILKGMKDAGTVNPVFLLDEIDKMASDYRGDPASAMLEVLDPEQNAKFSDHYLEENYDLSQVLFITTANYLENVPAPLR
DRMEIVELSSYTEYEKIQIAQKHLVNKQLSAHGLDSDKFTIDEETLYFIVRHYTREAGVRELNRYIGSLVRKAIKEILMK
KADKIHITKENVETYIGKPKFVHNLVDEKQQIGVVTGLAYTAFGGDTLPVEVTYYKGKGQLVLTGKLGDVMKESAITALS
YVKSHALEFNLDPTIFENNDFHVHVPEGAIPKDGPSAGITMATAIMSAASKLYVRKDLGMTGEITLRGYVLPIGGLKEKA
IAALRSGLTTILIPKQNVKDVDDIPKEVRDKLTIIPVENVSDVFAQALIR
>Mature_770_residues
MELQTSLPAIVVRGIVPIPNNDFRIEVGRKVSLKAIEESEKSFSSYVLILVQKNPLIENPTVADIETHGVLAKIAMKIKL
PNNNYKIKFNLMSRIKVNEYFLTDPYFVADYEELESKVGEIEEETTLLKLITDEAVVNANQLFNNAQVITSQIQSGLSSD
KMADILAYNLRTQDTEKYKYLAELNVNSRLKLILEDINRLKMIADLEQRINEDVKKAIDENQKEYYLREKMRAIQNELGD
KAKKEDEIDKLREDIKKAKMPLHIEEKALQELSRYQSTPSAMAESQIIKTYLDFLVALPWNESSTDLNDLQKVQDNLDKN
HYGLENVKERIIEYLAVKMMTGRNPQTILCLAGPPGVGKTSLATSIAEALGRKFVKQSLGGVKDESEIRGHRRTYVGAMP
GRILKGMKDAGTVNPVFLLDEIDKMASDYRGDPASAMLEVLDPEQNAKFSDHYLEENYDLSQVLFITTANYLENVPAPLR
DRMEIVELSSYTEYEKIQIAQKHLVNKQLSAHGLDSDKFTIDEETLYFIVRHYTREAGVRELNRYIGSLVRKAIKEILMK
KADKIHITKENVETYIGKPKFVHNLVDEKQQIGVVTGLAYTAFGGDTLPVEVTYYKGKGQLVLTGKLGDVMKESAITALS
YVKSHALEFNLDPTIFENNDFHVHVPEGAIPKDGPSAGITMATAIMSAASKLYVRKDLGMTGEITLRGYVLPIGGLKEKA
IAALRSGLTTILIPKQNVKDVDDIPKEVRDKLTIIPVENVSDVFAQALIR

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=849, Percent_Identity=35.1001177856302, Blast_Score=504, Evalue=1e-143,
Organism=Homo sapiens, GI21396489, Length=613, Percent_Identity=40.9461663947798, Blast_Score=497, Evalue=1e-140,
Organism=Escherichia coli, GI1786643, Length=765, Percent_Identity=44.7058823529412, Blast_Score=639, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=692, Percent_Identity=38.0057803468208, Blast_Score=469, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17556486, Length=797, Percent_Identity=32.7478042659975, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6319449, Length=666, Percent_Identity=37.3873873873874, Blast_Score=462, Evalue=1e-131,
Organism=Drosophila melanogaster, GI221513036, Length=619, Percent_Identity=40.7108239095315, Blast_Score=492, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24666867, Length=619, Percent_Identity=40.7108239095315, Blast_Score=491, Evalue=1e-139,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 86694; Mature: 86694

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELQTSLPAIVVRGIVPIPNNDFRIEVGRKVSLKAIEESEKSFSSYVLILVQKNPLIENP
CCCCHHCCHHHHHCCCCCCCCCEEEEECCEEEHHHHHHHHHCCCEEEEEEEECCCCCCCC
TVADIETHGVLAKIAMKIKLPNNNYKIKFNLMSRIKVNEYFLTDPYFVADYEELESKVGE
CEECCHHHHHEEEEEEEEEECCCCEEEEEEEEEEEEECEEEECCCEEECCHHHHHHHHCC
IEEETTLLKLITDEAVVNANQLFNNAQVITSQIQSGLSSDKMADILAYNLRTQDTEKYKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHE
LAELNVNSRLKLILEDINRLKMIADLEQRINEDVKKAIDENQKEYYLREKMRAIQNELGD
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
KAKKEDEIDKLREDIKKAKMPLHIEEKALQELSRYQSTPSAMAESQIIKTYLDFLVALPW
HHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEECCC
NESSTDLNDLQKVQDNLDKNHYGLENVKERIIEYLAVKMMTGRNPQTILCLAGPPGVGKT
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHH
SLATSIAEALGRKFVKQSLGGVKDESEIRGHRRTYVGAMPGRILKGMKDAGTVNPVFLLD
HHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHEECCCCHHHHHCCCCCCCCCHHHHHH
EIDKMASDYRGDPASAMLEVLDPEQNAKFSDHYLEENYDLSQVLFITTANYLENVPAPLR
HHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCHHHEEEEEEHHHHHCCCCCHH
DRMEIVELSSYTEYEKIQIAQKHLVNKQLSAHGLDSDKFTIDEETLYFIVRHYTREAGVR
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHH
ELNRYIGSLVRKAIKEILMKKADKIHITKENVETYIGKPKFVHNLVDEKQQIGVVTGLAY
HHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHEE
TAFGGDTLPVEVTYYKGKGQLVLTGKLGDVMKESAITALSYVKSHALEFNLDPTIFENND
EECCCCCCEEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCEEECCCCCEEECCC
FHVHVPEGAIPKDGPSAGITMATAIMSAASKLYVRKDLGMTGEITLRGYVLPIGGLKEKA
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCHHHH
IAALRSGLTTILIPKQNVKDVDDIPKEVRDKLTIIPVENVSDVFAQALIR
HHHHHCCCEEEEECCCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHCC
>Mature Secondary Structure
MELQTSLPAIVVRGIVPIPNNDFRIEVGRKVSLKAIEESEKSFSSYVLILVQKNPLIENP
CCCCHHCCHHHHHCCCCCCCCCEEEEECCEEEHHHHHHHHHCCCEEEEEEEECCCCCCCC
TVADIETHGVLAKIAMKIKLPNNNYKIKFNLMSRIKVNEYFLTDPYFVADYEELESKVGE
CEECCHHHHHEEEEEEEEEECCCCEEEEEEEEEEEEECEEEECCCEEECCHHHHHHHHCC
IEEETTLLKLITDEAVVNANQLFNNAQVITSQIQSGLSSDKMADILAYNLRTQDTEKYKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHE
LAELNVNSRLKLILEDINRLKMIADLEQRINEDVKKAIDENQKEYYLREKMRAIQNELGD
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
KAKKEDEIDKLREDIKKAKMPLHIEEKALQELSRYQSTPSAMAESQIIKTYLDFLVALPW
HHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEECCC
NESSTDLNDLQKVQDNLDKNHYGLENVKERIIEYLAVKMMTGRNPQTILCLAGPPGVGKT
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHH
SLATSIAEALGRKFVKQSLGGVKDESEIRGHRRTYVGAMPGRILKGMKDAGTVNPVFLLD
HHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHEECCCCHHHHHCCCCCCCCCHHHHHH
EIDKMASDYRGDPASAMLEVLDPEQNAKFSDHYLEENYDLSQVLFITTANYLENVPAPLR
HHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCHHHEEEEEEHHHHHCCCCCHH
DRMEIVELSSYTEYEKIQIAQKHLVNKQLSAHGLDSDKFTIDEETLYFIVRHYTREAGVR
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHH
ELNRYIGSLVRKAIKEILMKKADKIHITKENVETYIGKPKFVHNLVDEKQQIGVVTGLAY
HHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHEE
TAFGGDTLPVEVTYYKGKGQLVLTGKLGDVMKESAITALSYVKSHALEFNLDPTIFENND
EECCCCCCEEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCEEECCCCCEEECCC
FHVHVPEGAIPKDGPSAGITMATAIMSAASKLYVRKDLGMTGEITLRGYVLPIGGLKEKA
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCHHHH
IAALRSGLTTILIPKQNVKDVDDIPKEVRDKLTIIPVENVSDVFAQALIR
HHHHHCCCEEEEECCCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA