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The map label for this gene is ach1 [H]

Identifier: 162447368

GI number: 162447368

Start: 529919

End: 531253

Strand: Direct

Name: ach1 [H]

Synonym: ACL_0506

Alternate gene names: 162447368

Gene position: 529919-531253 (Clockwise)

Preceding gene: 162447367

Following gene: 162447369

Centisome position: 35.4

GC content: 34.91

Gene sequence:

>1335_bases
ATGTATACTATGTACAAAGACAAGTTAATCACTGCAAAAGAAGCTGTGAAACTTATCAAATCTAATGATCATATTGTAGT
TGGGATGACGGCAGCTGAGCCTCAACTATTTATGAATGAGTTACACACAATCGCGGATAATATTTCAAAGGTAACAGTGT
CAAACTGTCTACCTATTTTAGAAGCAGAATTTTTTATAAATGTTCAATATAAAGACAAATTTGATGTTGCGGGTTGGTTT
TATACCAATACGTTAAGACGTGTTCAAAAAAACGGTAATATTTCATTTATACCAAATCACTTACACTTAGCAGGTAAAAA
AAGATTTCAACACTTAAAACCTAACGTGTTTGTTATGACAACATCAATGCCAGATGAGCATGGATTTGTATCGTTATCTG
TTGGTAACGTTTATGAACGTGATGCAATCGATCAAGCTGATCTTGTCATTATTGAAGTGAACCCGAATTTTCCAAGAACA
TTTGGTGATAATAACGTTCACTTAAGAGAAGTAGATTATGTGATTGAATCTAGTTACCCAATTCCTTCTATTCCAGATTT
AGAACCAAATGATAAGGATAGAGTCATTGGTAACTTAATTGCTGAAAAAATTAATGATGGAGACACCATTCAAATTGGTA
TTGGTGGTATTCCAAACGCTGTAGCAAGCGCACTTATGGGTAAAAAGGATTTAGGTATCCATACTGAAATGTTTACTACA
GGTATCATGAAACTTATTAAAGCCGGTGTTGCAAACGGTGCTAGAAAAAACTACATGCCTCATAAACATGTGGCCGCCTT
TGCATATGGCACACAAGAATTATATGACTTTTTAAATAACAACCCAAGTATTTACTTTATGCGTGGTGTTCATGCAAATG
ACCCATACATTATCGGTAAGAATGATAACCAAGTAAGTATCAACACAACATTAGAAGTTGATTTAACCGGACAATGTGCA
TCTGAATCCATTGGACCTGTTCAATTTTCAGGTACAGGTGGTCAATCAGACACAGCTGTAGGGGCTCAAAACTCTAAAAA
TGGTCGTTCATTTATCGCTTTATACTCAACTGCAATGGTTAAAAATCCAGTAACTGGTGAGCGTGAAGAAATATCAAAAA
TTGTACCGATGCTTAAACAAGGTGCAGCTGTATCCTTATCAAGAAATGATGTGGATTATGTTGTAACTGAATATGGTATG
GTTTCTCTTCGTGGCACAACCATTCAAGAAAGAACCAAACTACTTATCTCCATCGCGCATCCTAAATTTAGAGAACAATT
ACTAAAAGAAGCTAAAGAATTAATGTACATTGGTCAAGATTATGAGCTACTTTAA

Upstream 100 bases:

>100_bases
AAAGATGGTACAGTTATGGCTATGATTGCAGCTGGTATTGGTTATGTATGGGCAGCAAATATTATTCAATGGGGACCAAT
GAAATCCTAATAAAAAGGAG

Downstream 100 bases:

>100_bases
TTATTTAGGTAAAAAAATATATTACGATGTTGCTGGAAGTGGTCAACCGGTTGTTATTTTAAATGGCATCATGATGTCTA
CTAAAAGTTGGGAACCTTTT

Product: acetyl-CoA hydrolase

Products: propionate; succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MYTMYKDKLITAKEAVKLIKSNDHIVVGMTAAEPQLFMNELHTIADNISKVTVSNCLPILEAEFFINVQYKDKFDVAGWF
YTNTLRRVQKNGNISFIPNHLHLAGKKRFQHLKPNVFVMTTSMPDEHGFVSLSVGNVYERDAIDQADLVIIEVNPNFPRT
FGDNNVHLREVDYVIESSYPIPSIPDLEPNDKDRVIGNLIAEKINDGDTIQIGIGGIPNAVASALMGKKDLGIHTEMFTT
GIMKLIKAGVANGARKNYMPHKHVAAFAYGTQELYDFLNNNPSIYFMRGVHANDPYIIGKNDNQVSINTTLEVDLTGQCA
SESIGPVQFSGTGGQSDTAVGAQNSKNGRSFIALYSTAMVKNPVTGEREEISKIVPMLKQGAAVSLSRNDVDYVVTEYGM
VSLRGTTIQERTKLLISIAHPKFREQLLKEAKELMYIGQDYELL

Sequences:

>Translated_444_residues
MYTMYKDKLITAKEAVKLIKSNDHIVVGMTAAEPQLFMNELHTIADNISKVTVSNCLPILEAEFFINVQYKDKFDVAGWF
YTNTLRRVQKNGNISFIPNHLHLAGKKRFQHLKPNVFVMTTSMPDEHGFVSLSVGNVYERDAIDQADLVIIEVNPNFPRT
FGDNNVHLREVDYVIESSYPIPSIPDLEPNDKDRVIGNLIAEKINDGDTIQIGIGGIPNAVASALMGKKDLGIHTEMFTT
GIMKLIKAGVANGARKNYMPHKHVAAFAYGTQELYDFLNNNPSIYFMRGVHANDPYIIGKNDNQVSINTTLEVDLTGQCA
SESIGPVQFSGTGGQSDTAVGAQNSKNGRSFIALYSTAMVKNPVTGEREEISKIVPMLKQGAAVSLSRNDVDYVVTEYGM
VSLRGTTIQERTKLLISIAHPKFREQLLKEAKELMYIGQDYELL
>Mature_444_residues
MYTMYKDKLITAKEAVKLIKSNDHIVVGMTAAEPQLFMNELHTIADNISKVTVSNCLPILEAEFFINVQYKDKFDVAGWF
YTNTLRRVQKNGNISFIPNHLHLAGKKRFQHLKPNVFVMTTSMPDEHGFVSLSVGNVYERDAIDQADLVIIEVNPNFPRT
FGDNNVHLREVDYVIESSYPIPSIPDLEPNDKDRVIGNLIAEKINDGDTIQIGIGGIPNAVASALMGKKDLGIHTEMFTT
GIMKLIKAGVANGARKNYMPHKHVAAFAYGTQELYDFLNNNPSIYFMRGVHANDPYIIGKNDNQVSINTTLEVDLTGQCA
SESIGPVQFSGTGGQSDTAVGAQNSKNGRSFIALYSTAMVKNPVTGEREEISKIVPMLKQGAAVSLSRNDVDYVVTEYGM
VSLRGTTIQERTKLLISIAHPKFREQLLKEAKELMYIGQDYELL

Specific function: Unknown

COG id: COG0427

COG function: function code C; Acetyl-CoA hydrolase

Gene ontology:
GO:0003824: Acetyl-CoA hydrolase
GO:0003986: Acetyl-CoA hydrolase
GO:0006084: Acetyl-CoA hydrolase
GO:0016787: Acetyl-CoA hydrolase

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetyl-CoA hydrolase/transferase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI32563853, Length=438, Percent_Identity=36.7579908675799, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17538151, Length=446, Percent_Identity=33.6322869955157, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI21358615, Length=433, Percent_Identity=36.7205542725173, Blast_Score=260, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003702 [H]

Pfam domain/function: PF02550 AcetylCoA_hydro [H]

EC number: NA

Molecular weight: Translated: 49314; Mature: 49314

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTMYKDKLITAKEAVKLIKSNDHIVVGMTAAEPQLFMNELHTIADNISKVTVSNCLPIL
CCCEECCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHEEEHHHCCHHE
EAEFFINVQYKDKFDVAGWFYTNTLRRVQKNGNISFIPNHLHLAGKKRFQHLKPNVFVMT
EEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCEEEEE
TSMPDEHGFVSLSVGNVYERDAIDQADLVIIEVNPNFPRTFGDNNVHLREVDYVIESSYP
ECCCCCCCEEEEEECCEEHHCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEEEEECCCC
IPSIPDLEPNDKDRVIGNLIAEKINDGDTIQIGIGGIPNAVASALMGKKDLGIHTEMFTT
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCCCCHHHHHHH
GIMKLIKAGVANGARKNYMPHKHVAAFAYGTQELYDFLNNNPSIYFMRGVHANDPYIIGK
HHHHHHHHHHCCCHHHCCCCCHHHEEEECCHHHHHHHHCCCCCEEEEECCCCCCCEEEEC
NDNQVSINTTLEVDLTGQCASESIGPVQFSGTGGQSDTAVGAQNSKNGRSFIALYSTAMV
CCCEEEEEEEEEEEECCCCCCCCCCCEEEECCCCCCCCEECCCCCCCCCEEEEEEEHHHH
KNPVTGEREEISKIVPMLKQGAAVSLSRNDVDYVVTEYGMVSLRGTTIQERTKLLISIAH
CCCCCCCHHHHHHHHHHHHCCCEEEEECCCCEEEEECCCEEEEECCCHHHHHEEEEEECC
PKFREQLLKEAKELMYIGQDYELL
HHHHHHHHHHHHHHEEECCCCCCC
>Mature Secondary Structure
MYTMYKDKLITAKEAVKLIKSNDHIVVGMTAAEPQLFMNELHTIADNISKVTVSNCLPIL
CCCEECCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHEEEHHHCCHHE
EAEFFINVQYKDKFDVAGWFYTNTLRRVQKNGNISFIPNHLHLAGKKRFQHLKPNVFVMT
EEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCEEEEE
TSMPDEHGFVSLSVGNVYERDAIDQADLVIIEVNPNFPRTFGDNNVHLREVDYVIESSYP
ECCCCCCCEEEEEECCEEHHCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEEEEECCCC
IPSIPDLEPNDKDRVIGNLIAEKINDGDTIQIGIGGIPNAVASALMGKKDLGIHTEMFTT
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCCCCHHHHHHH
GIMKLIKAGVANGARKNYMPHKHVAAFAYGTQELYDFLNNNPSIYFMRGVHANDPYIIGK
HHHHHHHHHHCCCHHHCCCCCHHHEEEECCHHHHHHHHCCCCCEEEEECCCCCCCEEEEC
NDNQVSINTTLEVDLTGQCASESIGPVQFSGTGGQSDTAVGAQNSKNGRSFIALYSTAMV
CCCEEEEEEEEEEEECCCCCCCCCCCEEEECCCCCCCCEECCCCCCCCCEEEEEEEHHHH
KNPVTGEREEISKIVPMLKQGAAVSLSRNDVDYVVTEYGMVSLRGTTIQERTKLLISIAH
CCCCCCCHHHHHHHHHHHHCCCEEEEECCCCEEEEECCCEEEEECCCHHHHHEEEEEECC
PKFREQLLKEAKELMYIGQDYELL
HHHHHHHHHHHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: propionyl-CoA; succinate [C]

Specific reaction: propionyl-CoA + succinate = propionate + succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]