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The map label for this gene is pncB [H]

Identifier: 162447354

GI number: 162447354

Start: 514790

End: 516226

Strand: Direct

Name: pncB [H]

Synonym: ACL_0492

Alternate gene names: 162447354

Gene position: 514790-516226 (Clockwise)

Preceding gene: 162447353

Following gene: 162447355

Centisome position: 34.39

GC content: 31.59

Gene sequence:

>1437_bases
ATGAAACGAAATTTAGCGTTATTAACAGACTTTTATGAACTGACTATGTCCAATGGATATTTCAAAGATAACCGCCATAA
TCAAGTGGCAGTATTTGATGTATTCTTTAGAAGTATTCCAGATGATGGCGGTTATGCAATATTTGCTGGTCTAGAATCTA
TTATTGAATACATTAAGAATTTAACATTTGATAAAGAATCAATTGAATTTTTAAGAAATAAAAAAATATTTGATGAAGGT
TTTTTAACTTATTTAGAAAACTTTAAATTTACCTCTGATGTTTACGCGATCAAAGAAGGTACTCCAATTTTCCCTAATGA
ACCATTAATGGTTATTAAAGGACCTATCATTGAATGTCAACTCATTGAAACATTTGTACTACTTTCAATTAATCATCAAT
CCTTGATTGCAACAAAGGCATCAAGAATTGTAAGAGAAGCAAAAGGTAGACCAGTCTTTGAATTTGGTGCAAGAAGAGCA
CATTCTTATGATGCAGCAAATCTAGGTGCTAGAAGTGCATATATTAGTGGTGTTACAGGTACGTCAAATACCTTAGCTGA
CTTTATGTATGGCATTCCATCTTCTGGTACAATGGCACATTCCTATGTTCAAAGTTTTCCTAGTGAATATGAAGCATTTA
AGAGCTATGCCCTAAATTACCCAGATAACTGTTTATTATTAGTAGATACCTATGATACTTTACATGAAGGTATTCCAAAT
GCTATAAGAATTCATAATGAAGTTTTAAAGCCAATGGGTAAATACTTAAAAGGTATTCGAATTGATTCGGGTGACTTAGC
TTATTTATCTAAGAAAGTACGTGCTTTATTAGATGAAGCAGGTCTAACTGAAACTAAGATTACTGTATCGAACTCATTGG
ATGAGTTTATTATCAGAGACTTGATCGTACATCAAGAAGCAGAAATCGATGCTTTTGGTGTCGGTGAAAGATTAATCACT
GCAAGAAGTGAGGCGGTCTTTGGTGGTGTATTTAAGTTAAGTGCAATTGAAGAAAACGGTCAAATTGTGCCGAAAATTAA
AATTTCTGATAATGTTGCAAAAACAACTATTCCAGGATTTAAGCAACTTTATCGCTTCTATGATGAAAATGATATGGCCA
TAGCAGATGTCATTACACTTCACAATGAAGAAATAGATCCATCTAAACCATATACATTATTTGATCCAAATCATCCTTGG
AAACAAAAGGTGGTAGAAAAATATAGAGTAGAAAAACTTTTAGTACCTATCTTTGAAAAAGGTAAACTAGTTTATGAACT
ACCTTCAATAGAAGCAATTAGAAAACATAAAGAAATTAATTTTAATAAACTTTGGAAAGAAGTAATACGTTTAAAGTTTC
CACATGAATACTATGTTGATTTATCACAAGATTTATGGGATTTACGACGAGCATTAGTAGTTAAGCATAAACATTAG

Upstream 100 bases:

>100_bases
AGATGCAAATTTATAAGAAAAATCCCTTAATTGGGATTCGTTTTTCTTTCGTCTAGTATTAAAAAAAATACATGATAAAA
TACCTTTAGGAGATGATTTT

Downstream 100 bases:

>100_bases
AAAGTAGAACCTGATAATCATGGAACAAGGCATTTCAAAAAATACACAACGCATGTTAAACGGGAAGCATATATGGCTAT
ATATGCTCCTTTTATCGTTA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MKRNLALLTDFYELTMSNGYFKDNRHNQVAVFDVFFRSIPDDGGYAIFAGLESIIEYIKNLTFDKESIEFLRNKKIFDEG
FLTYLENFKFTSDVYAIKEGTPIFPNEPLMVIKGPIIECQLIETFVLLSINHQSLIATKASRIVREAKGRPVFEFGARRA
HSYDAANLGARSAYISGVTGTSNTLADFMYGIPSSGTMAHSYVQSFPSEYEAFKSYALNYPDNCLLLVDTYDTLHEGIPN
AIRIHNEVLKPMGKYLKGIRIDSGDLAYLSKKVRALLDEAGLTETKITVSNSLDEFIIRDLIVHQEAEIDAFGVGERLIT
ARSEAVFGGVFKLSAIEENGQIVPKIKISDNVAKTTIPGFKQLYRFYDENDMAIADVITLHNEEIDPSKPYTLFDPNHPW
KQKVVEKYRVEKLLVPIFEKGKLVYELPSIEAIRKHKEINFNKLWKEVIRLKFPHEYYVDLSQDLWDLRRALVVKHKH

Sequences:

>Translated_478_residues
MKRNLALLTDFYELTMSNGYFKDNRHNQVAVFDVFFRSIPDDGGYAIFAGLESIIEYIKNLTFDKESIEFLRNKKIFDEG
FLTYLENFKFTSDVYAIKEGTPIFPNEPLMVIKGPIIECQLIETFVLLSINHQSLIATKASRIVREAKGRPVFEFGARRA
HSYDAANLGARSAYISGVTGTSNTLADFMYGIPSSGTMAHSYVQSFPSEYEAFKSYALNYPDNCLLLVDTYDTLHEGIPN
AIRIHNEVLKPMGKYLKGIRIDSGDLAYLSKKVRALLDEAGLTETKITVSNSLDEFIIRDLIVHQEAEIDAFGVGERLIT
ARSEAVFGGVFKLSAIEENGQIVPKIKISDNVAKTTIPGFKQLYRFYDENDMAIADVITLHNEEIDPSKPYTLFDPNHPW
KQKVVEKYRVEKLLVPIFEKGKLVYELPSIEAIRKHKEINFNKLWKEVIRLKFPHEYYVDLSQDLWDLRRALVVKHKH
>Mature_478_residues
MKRNLALLTDFYELTMSNGYFKDNRHNQVAVFDVFFRSIPDDGGYAIFAGLESIIEYIKNLTFDKESIEFLRNKKIFDEG
FLTYLENFKFTSDVYAIKEGTPIFPNEPLMVIKGPIIECQLIETFVLLSINHQSLIATKASRIVREAKGRPVFEFGARRA
HSYDAANLGARSAYISGVTGTSNTLADFMYGIPSSGTMAHSYVQSFPSEYEAFKSYALNYPDNCLLLVDTYDTLHEGIPN
AIRIHNEVLKPMGKYLKGIRIDSGDLAYLSKKVRALLDEAGLTETKITVSNSLDEFIIRDLIVHQEAEIDAFGVGERLIT
ARSEAVFGGVFKLSAIEENGQIVPKIKISDNVAKTTIPGFKQLYRFYDENDMAIADVITLHNEEIDPSKPYTLFDPNHPW
KQKVVEKYRVEKLLVPIFEKGKLVYELPSIEAIRKHKEINFNKLWKEVIRLKFPHEYYVDLSQDLWDLRRALVVKHKH

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:
GO:0004514: Nicotinate phosphoribosyltransferase
GO:0004516: Nicotinate phosphoribosyltransferase
GO:0005737: Nicotinate phosphoribosyltransferase
GO:0009435: Nicotinate phosphoribosyltransferase
GO:0016740: Nicotinate phosphoribosyltransferase
GO:0016757: Nicotinate phosphoribosyltransferase
GO:0019358: Nicotinate phosphoribosyltransferase
GO:0019363: Nicotinate phosphoribosyltransferase

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=529, Percent_Identity=28.7334593572779, Blast_Score=233, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI71997952, Length=537, Percent_Identity=34.4506517690875, Blast_Score=278, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI71997947, Length=537, Percent_Identity=34.4506517690875, Blast_Score=278, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI71997955, Length=226, Percent_Identity=42.9203539823009, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24581587, Length=527, Percent_Identity=34.3453510436433, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI161076680, Length=278, Percent_Identity=35.9712230215827, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24581595, Length=278, Percent_Identity=35.9712230215827, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI28574709, Length=278, Percent_Identity=35.9712230215827, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24581593, Length=278, Percent_Identity=35.9712230215827, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24581591, Length=278, Percent_Identity=35.9712230215827, Blast_Score=148, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 54643; Mature: 54643

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRNLALLTDFYELTMSNGYFKDNRHNQVAVFDVFFRSIPDDGGYAIFAGLESIIEYIKN
CCCCHHHHHHHHHHHHCCCEECCCCCCEEEHHHHHHHHCCCCCCEEHHHHHHHHHHHHHC
LTFDKESIEFLRNKKIFDEGFLTYLENFKFTSDVYAIKEGTPIFPNEPLMVIKGPIIECQ
CCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCEEHH
LIETFVLLSINHQSLIATKASRIVREAKGRPVFEFGARRAHSYDAANLGARSAYISGVTG
HHHEEEHEECCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCHHEEECCCC
TSNTLADFMYGIPSSGTMAHSYVQSFPSEYEAFKSYALNYPDNCLLLVDTYDTLHEGIPN
CCHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEECHHHHHHCCCH
AIRIHNEVLKPMGKYLKGIRIDSGDLAYLSKKVRALLDEAGLTETKITVSNSLDEFIIRD
HHHHHHHHHHHHHHHHHCEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHH
LIVHQEAEIDAFGVGERLITARSEAVFGGVFKLSAIEENGQIVPKIKISDNVAKTTIPGF
HHHHCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEECCCCHHHCCHHH
KQLYRFYDENDMAIADVITLHNEEIDPSKPYTLFDPNHPWKQKVVEKYRVEKLLVPIFEK
HHHHHHHCCCCCEEEHHEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
GKLVYELPSIEAIRKHKEINFNKLWKEVIRLKFPHEYYVDLSQDLWDLRRALVVKHKH
CCEEEECCCHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKRNLALLTDFYELTMSNGYFKDNRHNQVAVFDVFFRSIPDDGGYAIFAGLESIIEYIKN
CCCCHHHHHHHHHHHHCCCEECCCCCCEEEHHHHHHHHCCCCCCEEHHHHHHHHHHHHHC
LTFDKESIEFLRNKKIFDEGFLTYLENFKFTSDVYAIKEGTPIFPNEPLMVIKGPIIECQ
CCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCEEHH
LIETFVLLSINHQSLIATKASRIVREAKGRPVFEFGARRAHSYDAANLGARSAYISGVTG
HHHEEEHEECCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCHHEEECCCC
TSNTLADFMYGIPSSGTMAHSYVQSFPSEYEAFKSYALNYPDNCLLLVDTYDTLHEGIPN
CCHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEECHHHHHHCCCH
AIRIHNEVLKPMGKYLKGIRIDSGDLAYLSKKVRALLDEAGLTETKITVSNSLDEFIIRD
HHHHHHHHHHHHHHHHHCEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHH
LIVHQEAEIDAFGVGERLITARSEAVFGGVFKLSAIEENGQIVPKIKISDNVAKTTIPGF
HHHHCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEECCCCHHHCCHHH
KQLYRFYDENDMAIADVITLHNEEIDPSKPYTLFDPNHPWKQKVVEKYRVEKLLVPIFEK
HHHHHHHCCCCCEEEHHEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
GKLVYELPSIEAIRKHKEINFNKLWKEVIRLKFPHEYYVDLSQDLWDLRRALVVKHKH
CCEEEECCCHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]