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The map label for this gene is xseA

Identifier: 162447339

GI number: 162447339

Start: 499664

End: 501004

Strand: Direct

Name: xseA

Synonym: ACL_0476

Alternate gene names: 162447339

Gene position: 499664-501004 (Clockwise)

Preceding gene: 162447338

Following gene: 162447340

Centisome position: 33.38

GC content: 32.07

Gene sequence:

>1341_bases
ATGAACGAACAAAAGTATTTAAGCGTTTCGGCACTAACTGAATATATTAAAGTCAAATTAGAAAATGATAACCATCTTAA
ACGCGTATTTTTAAAAGGTGAAATTTCAAATTTTACGCATCATGGTTCAGGACATCTGTATTTTTCATTAAAAGATGAAG
ATGCAGCAATCTCTGCAATGATGTTTAAAACGTATGCATCTACATTAAGTTTTAAACCTAAAGCAGGGGATAAAGTATTA
GTAGAAGGTTATATTTCTTTATATAAAGCACGTGGTACGTATAGTATCTCGATTTTTTCTATGACACTCGATGGTATTGG
TGAGCTCTTCTTAAAATATGAACAAAATAGAAAGATGTTTCAAGAATTAGGCTATTTTGATGAATCACTAAAAAAACCTA
TTCCTAAGTTTCCTAAGATTATTGCAGTCATTACATCTGAAACTGGTGCAGTGATTCAAGATATAAAAACAACCATTTCA
AGACGTTACTTACTCGCGAAAATTGAACTCTATCCTATTTTAGTTCAAGGTGAAGGTTCTAAAGACGATATTGTTAAAAC
ACTAGCAAGAGTCAACAGAGAAAGTCAAGCAGATGTCATTATCTTAGGACGCGGTGGTGGGTCGATTGAAGACTTATGGA
GTTTTAATGAGGCTGAAGTCGTTGTTGCAATTCATCAGTCTAAAATACCTGTTATTACAGCAATAGGACATGAAACAGAT
ACAACCCTATCTGATTATGTTTCAGACTTACGTGCACCAACACCAACAGCTGCAGCAGAACTTGCTACACCGAATATGGC
GGACTTAATTAAAGAAATAAAAGACAAAGTTCAATTAAGTCAGTACTATATGAATGAGCGTATAAAAAACTATACTGCAT
TAATACTTAATTTAGATGAAAGACTTGAACTAGCCAGTCCTAAATCCAAGTTAGAGTTAGAACATAAACAAATTGATAAC
TTAACATCTAAATTAACGTACTTTTATAAGTCAAAACTAACAGATAACTTAAATCAGGTCAGACTTTTAAGTCAAAGACT
TACGTCGCCTGATGAAAAAATAGAACGTTATAAAGAACGTATAGAAACATTAACATCCAGAATAAACCTTTTATATAAGA
AGCAAGTAGACTTGAAAACTTACGAATATCAATCAAGTCTAAAGCAACTACAAGGACTAGATCCATTACGTATTATGCAA
AGAGGTTTCTCATTAACAACCAAAAATCAAAAAGTGATTACAAGTATAGAACAAATCAATACGAATGATGAATTAGATAT
TCAATATAAAGATGGTACAGCCAAGGTTAAAGTATTAAGCAAGGAAGGTAAACACATATGA

Upstream 100 bases:

>100_bases
TTGAATTATCCAAGGAATATACAGATTTAGATGATGAAAAGCAACACAAATTTAACAATAGTTTAATTGATAATATATAT
AAAAAAATTAAGTAGGGCAT

Downstream 100 bases:

>100_bases
GTGAAAAACTTACATTTGAAGAAACAATTAAAAAGTTAGAAGAAGTTGTTAAGCAACTTGAAAGTAAAGATATTTCTTTA
GAACAATCTATTGAAAAATA

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MNEQKYLSVSALTEYIKVKLENDNHLKRVFLKGEISNFTHHGSGHLYFSLKDEDAAISAMMFKTYASTLSFKPKAGDKVL
VEGYISLYKARGTYSISIFSMTLDGIGELFLKYEQNRKMFQELGYFDESLKKPIPKFPKIIAVITSETGAVIQDIKTTIS
RRYLLAKIELYPILVQGEGSKDDIVKTLARVNRESQADVIILGRGGGSIEDLWSFNEAEVVVAIHQSKIPVITAIGHETD
TTLSDYVSDLRAPTPTAAAELATPNMADLIKEIKDKVQLSQYYMNERIKNYTALILNLDERLELASPKSKLELEHKQIDN
LTSKLTYFYKSKLTDNLNQVRLLSQRLTSPDEKIERYKERIETLTSRINLLYKKQVDLKTYEYQSSLKQLQGLDPLRIMQ
RGFSLTTKNQKVITSIEQINTNDELDIQYKDGTAKVKVLSKEGKHI

Sequences:

>Translated_446_residues
MNEQKYLSVSALTEYIKVKLENDNHLKRVFLKGEISNFTHHGSGHLYFSLKDEDAAISAMMFKTYASTLSFKPKAGDKVL
VEGYISLYKARGTYSISIFSMTLDGIGELFLKYEQNRKMFQELGYFDESLKKPIPKFPKIIAVITSETGAVIQDIKTTIS
RRYLLAKIELYPILVQGEGSKDDIVKTLARVNRESQADVIILGRGGGSIEDLWSFNEAEVVVAIHQSKIPVITAIGHETD
TTLSDYVSDLRAPTPTAAAELATPNMADLIKEIKDKVQLSQYYMNERIKNYTALILNLDERLELASPKSKLELEHKQIDN
LTSKLTYFYKSKLTDNLNQVRLLSQRLTSPDEKIERYKERIETLTSRINLLYKKQVDLKTYEYQSSLKQLQGLDPLRIMQ
RGFSLTTKNQKVITSIEQINTNDELDIQYKDGTAKVKVLSKEGKHI
>Mature_446_residues
MNEQKYLSVSALTEYIKVKLENDNHLKRVFLKGEISNFTHHGSGHLYFSLKDEDAAISAMMFKTYASTLSFKPKAGDKVL
VEGYISLYKARGTYSISIFSMTLDGIGELFLKYEQNRKMFQELGYFDESLKKPIPKFPKIIAVITSETGAVIQDIKTTIS
RRYLLAKIELYPILVQGEGSKDDIVKTLARVNRESQADVIILGRGGGSIEDLWSFNEAEVVVAIHQSKIPVITAIGHETD
TTLSDYVSDLRAPTPTAAAELATPNMADLIKEIKDKVQLSQYYMNERIKNYTALILNLDERLELASPKSKLELEHKQIDN
LTSKLTYFYKSKLTDNLNQVRLLSQRLTSPDEKIERYKERIETLTSRINLLYKKQVDLKTYEYQSSLKQLQGLDPLRIMQ
RGFSLTTKNQKVITSIEQINTNDELDIQYKDGTAKVKVLSKEGKHI

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:
GO:0003676: Exodeoxyribonuclease 7 large subunit
GO:0004518: Exodeoxyribonuclease 7 large subunit
GO:0004527: Exodeoxyribonuclease 7 large subunit
GO:0005737: Exodeoxyribonuclease 7 large subunit
GO:0006308: Exodeoxyribonuclease 7 large subunit
GO:0008855: Exodeoxyribonuclease 7 large subunit
GO:0009318: Exodeoxyribonuclease 7 large subunit
GO:0016787: Exodeoxyribonuclease 7 large subunit

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=429, Percent_Identity=36.1305361305361, Blast_Score=295, Evalue=3e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_ACHLI (A9NFG5)

Other databases:

- EMBL:   CP000896
- RefSeq:   YP_001620471.1
- GeneID:   5803528
- GenomeReviews:   CP000896_GR
- KEGG:   acl:ACL_0476
- HOGENOM:   HBG634411
- OMA:   SAVGHER
- BioCyc:   ALAI441768:ACL_0476-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 50805; Mature: 50805

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEQKYLSVSALTEYIKVKLENDNHLKRVFLKGEISNFTHHGSGHLYFSLKDEDAAISAM
CCCCCEEEHHHHHHHHEEEECCCCCEEEEEEEECCCCCEECCCCEEEEEECCCCHHHHHH
MFKTYASTLSFKPKAGDKVLVEGYISLYKARGTYSISIFSMTLDGIGELFLKYEQNRKMF
HHHHHHHHCCCCCCCCCEEHHHHHHHHHHCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHH
QELGYFDESLKKPIPKFPKIIAVITSETGAVIQDIKTTISRRYLLAKIELYPILVQGEGS
HHHCCHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHEEEEEEEEEEEEECCCC
KDDIVKTLARVNRESQADVIILGRGGGSIEDLWSFNEAEVVVAIHQSKIPVITAIGHETD
HHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHCCCCCEEEEEEECCCCCEEEEECCCCC
TTLSDYVSDLRAPTPTAAAELATPNMADLIKEIKDKVQLSQYYMNERIKNYTALILNLDE
CCHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECHH
RLELASPKSKLELEHKQIDNLTSKLTYFYKSKLTDNLNQVRLLSQRLTSPDEKIERYKER
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHH
IETLTSRINLLYKKQVDLKTYEYQSSLKQLQGLDPLRIMQRGFSLTTKNQKVITSIEQIN
HHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCHHHHHHCCCCEECCCHHHHHHHHHCC
TNDELDIQYKDGTAKVKVLSKEGKHI
CCCCEEEEECCCCEEEEEEECCCCCC
>Mature Secondary Structure
MNEQKYLSVSALTEYIKVKLENDNHLKRVFLKGEISNFTHHGSGHLYFSLKDEDAAISAM
CCCCCEEEHHHHHHHHEEEECCCCCEEEEEEEECCCCCEECCCCEEEEEECCCCHHHHHH
MFKTYASTLSFKPKAGDKVLVEGYISLYKARGTYSISIFSMTLDGIGELFLKYEQNRKMF
HHHHHHHHCCCCCCCCCEEHHHHHHHHHHCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHH
QELGYFDESLKKPIPKFPKIIAVITSETGAVIQDIKTTISRRYLLAKIELYPILVQGEGS
HHHCCHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHEEEEEEEEEEEEECCCC
KDDIVKTLARVNRESQADVIILGRGGGSIEDLWSFNEAEVVVAIHQSKIPVITAIGHETD
HHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHCCCCCEEEEEEECCCCCEEEEECCCCC
TTLSDYVSDLRAPTPTAAAELATPNMADLIKEIKDKVQLSQYYMNERIKNYTALILNLDE
CCHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECHH
RLELASPKSKLELEHKQIDNLTSKLTYFYKSKLTDNLNQVRLLSQRLTSPDEKIERYKER
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHH
IETLTSRINLLYKKQVDLKTYEYQSSLKQLQGLDPLRIMQRGFSLTTKNQKVITSIEQIN
HHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCHHHHHHCCCCEECCCHHHHHHHHHCC
TNDELDIQYKDGTAKVKVLSKEGKHI
CCCCEEEEECCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA