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The map label for this gene is accC [H]

Identifier: 162447321

GI number: 162447321

Start: 483540

End: 484919

Strand: Direct

Name: accC [H]

Synonym: ACL_0458

Alternate gene names: 162447321

Gene position: 483540-484919 (Clockwise)

Preceding gene: 162447320

Following gene: 162447322

Centisome position: 32.3

GC content: 34.71

Gene sequence:

>1380_bases
ATGGCACAAAACAAGGTATTAGTAGCAAACCGTGGTGAAATTGCTGTTCGTATTATTAGAGCATGTAAAGAATTAGGTAT
ACCTGTTGTAGCGGTCTATTCAACTGCTGATAAATCTTCACTTCATACAAAATTAGCAGATGAAGCAGTTTGTATTGGGT
CTGCAAGATCCAAAGATAGTTATTTAAATATGCAGGCTGTATTAAGTGCAGCAATCGCAACAGGATGTAATGCCATTCAC
CCAGGTTATGGCTTTTTAGCAGAGAATGCTAAATTTATCGAGATGGTTGAAGCAACAGGTATTAAGTTTATCGGCCCATC
ATCTAACGTTGTTAGTAAATTAGGCGATAAAGCGACTGCTAGAGCGATTGCTAAAGCAGTAGGTGTTCCAGTCGTTGAAG
GTTCTGATGGTGTTGTTGAAAACAAGGAGATCGGATTAAAGATTGCTAAACAGATTGGTTATCCTATTATGATTAAAGCA
AGTTCTGGTGGTGGTGGACGTGGTATTAGCGTATGTCACAATGATACAGAATTCAAAAAGGCTTTTGACATGACATCGAT
GGAGGCAGAATCAGCATTTGGCGATAAATCTGTCTATATTGAAAAATTTGTAGAAAATCCAAGACATATTGAAATCCAAA
TTATTGCAGATAGTAAAGGCAATGTCGTGCATTTATATGAACGTGATTGTTCAATGCAAAGACGTAATCAAAAATTAATT
GAAGAAGCACCGTCTTCTATTTTAAATGAGGACTTAAGACGCAAAATGGGTCAATCTGCAGTTAAGTTAGCTAAACATGT
AGGCTATGAAAATGCTGGAACCATTGAATTTTTAGTTGACTCTAGAAAAAATTACTATTTTATTGAAATGAATACACGTA
TTCAAGTAGAACATCCAGTTACTGAGATGATTACAGGTATTGATCTTGTTAAAGAACAAATTAAAATAGCATATGGTAAA
CCTCTAAGCTTTAAACAACGTGATGTCAAGATTACAGGGCATGCGATTGAATGTAGAATCAATGCTGAGGATCCAATGAA
TAACTTTATGCCGGCTCCTGGTAAAATCGGTAAGATTTTACTTCCAGGTGGTTTTAATGTACGCTTTGATTCTCATATAT
ATCCAGATTACGAGGTACCACCTTTCTATGATTCAATGTTGGGTAAATTAATTGTATTTGCACCTACTAGAAAAGAAGCG
ATGCGTAAAATGCGCATTGCATTAGAACAATTAGTTATTGAAGGTATTACTACAAATATTGAATATCATTATGCAATATT
ACATGCTACTGATTTTATTAAAGGTACATATGATACAGGATTTGTAGCTAAATTTAATGGATTAATCCAAGGTGAATATA
ATGAATCACTTATTGGATGA

Upstream 100 bases:

>100_bases
AGATTACATCGTCAGTAGATGGCAAGGTGACTAAAATCAACTTTAAAAATGGTGATGTTGTAGGGTTTGATGATGTCTTA
TTTGCAGTGGTGCAAGCGTA

Downstream 100 bases:

>100_bases
ACGTAAAAGAAGATTATCTCAGTTTCATGAGATTATTAAAAAAAGACCTATAGAAACTAGGCCAGTAGATATTCCTGATG
GTGTATTTAGTCAGTGTGAA

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MAQNKVLVANRGEIAVRIIRACKELGIPVVAVYSTADKSSLHTKLADEAVCIGSARSKDSYLNMQAVLSAAIATGCNAIH
PGYGFLAENAKFIEMVEATGIKFIGPSSNVVSKLGDKATARAIAKAVGVPVVEGSDGVVENKEIGLKIAKQIGYPIMIKA
SSGGGGRGISVCHNDTEFKKAFDMTSMEAESAFGDKSVYIEKFVENPRHIEIQIIADSKGNVVHLYERDCSMQRRNQKLI
EEAPSSILNEDLRRKMGQSAVKLAKHVGYENAGTIEFLVDSRKNYYFIEMNTRIQVEHPVTEMITGIDLVKEQIKIAYGK
PLSFKQRDVKITGHAIECRINAEDPMNNFMPAPGKIGKILLPGGFNVRFDSHIYPDYEVPPFYDSMLGKLIVFAPTRKEA
MRKMRIALEQLVIEGITTNIEYHYAILHATDFIKGTYDTGFVAKFNGLIQGEYNESLIG

Sequences:

>Translated_459_residues
MAQNKVLVANRGEIAVRIIRACKELGIPVVAVYSTADKSSLHTKLADEAVCIGSARSKDSYLNMQAVLSAAIATGCNAIH
PGYGFLAENAKFIEMVEATGIKFIGPSSNVVSKLGDKATARAIAKAVGVPVVEGSDGVVENKEIGLKIAKQIGYPIMIKA
SSGGGGRGISVCHNDTEFKKAFDMTSMEAESAFGDKSVYIEKFVENPRHIEIQIIADSKGNVVHLYERDCSMQRRNQKLI
EEAPSSILNEDLRRKMGQSAVKLAKHVGYENAGTIEFLVDSRKNYYFIEMNTRIQVEHPVTEMITGIDLVKEQIKIAYGK
PLSFKQRDVKITGHAIECRINAEDPMNNFMPAPGKIGKILLPGGFNVRFDSHIYPDYEVPPFYDSMLGKLIVFAPTRKEA
MRKMRIALEQLVIEGITTNIEYHYAILHATDFIKGTYDTGFVAKFNGLIQGEYNESLIG
>Mature_458_residues
AQNKVLVANRGEIAVRIIRACKELGIPVVAVYSTADKSSLHTKLADEAVCIGSARSKDSYLNMQAVLSAAIATGCNAIHP
GYGFLAENAKFIEMVEATGIKFIGPSSNVVSKLGDKATARAIAKAVGVPVVEGSDGVVENKEIGLKIAKQIGYPIMIKAS
SGGGGRGISVCHNDTEFKKAFDMTSMEAESAFGDKSVYIEKFVENPRHIEIQIIADSKGNVVHLYERDCSMQRRNQKLIE
EAPSSILNEDLRRKMGQSAVKLAKHVGYENAGTIEFLVDSRKNYYFIEMNTRIQVEHPVTEMITGIDLVKEQIKIAYGKP
LSFKQRDVKITGHAIECRINAEDPMNNFMPAPGKIGKILLPGGFNVRFDSHIYPDYEVPPFYDSMLGKLIVFAPTRKEAM
RKMRIALEQLVIEGITTNIEYHYAILHATDFIKGTYDTGFVAKFNGLIQGEYNESLIG

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:
GO:0003824: Acetyl-CoA carboxylase, biotin carboxylase
GO:0004075: Acetyl-CoA carboxylase, biotin carboxylase
GO:0005524: Acetyl-CoA carboxylase, biotin carboxylase
GO:0008152: Acetyl-CoA carboxylase, biotin carboxylase
GO:0016874: Acetyl-CoA carboxylase, biotin carboxylase
GO:0046872: Acetyl-CoA carboxylase, biotin carboxylase

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=466, Percent_Identity=49.1416309012876, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI295821183, Length=466, Percent_Identity=49.1416309012876, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI65506442, Length=466, Percent_Identity=49.1416309012876, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI116805327, Length=444, Percent_Identity=45.7207207207207, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI106049528, Length=451, Percent_Identity=45.2328159645233, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI106049295, Length=451, Percent_Identity=45.2328159645233, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI106049292, Length=451, Percent_Identity=45.2328159645233, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI38679960, Length=523, Percent_Identity=31.3575525812619, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI38679971, Length=523, Percent_Identity=31.3575525812619, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI38679974, Length=523, Percent_Identity=31.3575525812619, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI38679977, Length=523, Percent_Identity=31.3575525812619, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI38679967, Length=523, Percent_Identity=31.3575525812619, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI134142062, Length=506, Percent_Identity=31.0276679841897, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI18105007, Length=181, Percent_Identity=25.414364640884, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI21361331, Length=195, Percent_Identity=27.6923076923077, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI170295797, Length=195, Percent_Identity=27.6923076923077, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI169790915, Length=195, Percent_Identity=27.6923076923077, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789654, Length=446, Percent_Identity=54.7085201793722, Blast_Score=487, Evalue=1e-139,
Organism=Escherichia coli, GI1786216, Length=245, Percent_Identity=22.4489795918367, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17567343, Length=441, Percent_Identity=47.1655328798186, Blast_Score=431, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17562816, Length=452, Percent_Identity=46.0176991150442, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71987519, Length=440, Percent_Identity=44.3181818181818, Blast_Score=386, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71997163, Length=504, Percent_Identity=32.5396825396825, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71997168, Length=504, Percent_Identity=32.5396825396825, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI133931226, Length=489, Percent_Identity=31.0838445807771, Blast_Score=240, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6319695, Length=455, Percent_Identity=44.1758241758242, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=41.3092550790068, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6321376, Length=455, Percent_Identity=45.0549450549451, Blast_Score=354, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6324343, Length=513, Percent_Identity=30.4093567251462, Blast_Score=246, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6323863, Length=469, Percent_Identity=31.5565031982942, Blast_Score=241, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24651757, Length=441, Percent_Identity=44.8979591836735, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652212, Length=450, Percent_Identity=46.6666666666667, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652210, Length=450, Percent_Identity=46.6666666666667, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652214, Length=450, Percent_Identity=46.6666666666667, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI19921944, Length=450, Percent_Identity=46.6666666666667, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652216, Length=450, Percent_Identity=46.6666666666667, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI281363050, Length=450, Percent_Identity=46.6666666666667, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652224, Length=450, Percent_Identity=46.6666666666667, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652222, Length=450, Percent_Identity=46.6666666666667, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652220, Length=450, Percent_Identity=46.6666666666667, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652218, Length=450, Percent_Identity=46.6666666666667, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24651759, Length=404, Percent_Identity=44.3069306930693, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI161076407, Length=519, Percent_Identity=31.2138728323699, Blast_Score=268, Evalue=4e-72,
Organism=Drosophila melanogaster, GI24586460, Length=519, Percent_Identity=31.2138728323699, Blast_Score=268, Evalue=4e-72,
Organism=Drosophila melanogaster, GI161076409, Length=519, Percent_Identity=31.2138728323699, Blast_Score=268, Evalue=5e-72,
Organism=Drosophila melanogaster, GI24586458, Length=519, Percent_Identity=31.2138728323699, Blast_Score=268, Evalue=5e-72,
Organism=Drosophila melanogaster, GI45555749, Length=203, Percent_Identity=24.1379310344828, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24642586, Length=203, Percent_Identity=24.1379310344828, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50508; Mature: 50377

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQNKVLVANRGEIAVRIIRACKELGIPVVAVYSTADKSSLHTKLADEAVCIGSARSKDS
CCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCEEEECCCCCCCH
YLNMQAVLSAAIATGCNAIHPGYGFLAENAKFIEMVEATGIKFIGPSSNVVSKLGDKATA
HHHHHHHHHHHHHHCCCCCCCCCCCHHCCCHHEEHHHHCCEEEECCCHHHHHHHCCHHHH
RAIAKAVGVPVVEGSDGVVENKEIGLKIAKQIGYPIMIKASSGGGGRGISVCHNDTEFKK
HHHHHHHCCCEEECCCCCEECHHHHHHHHHHCCCEEEEEECCCCCCCCEEEECCCHHHHH
AFDMTSMEAESAFGDKSVYIEKFVENPRHIEIQIIADSKGNVVHLYERDCSMQRRNQKLI
HHCCCHHHHHHCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCHHHHHHHHHH
EEAPSSILNEDLRRKMGQSAVKLAKHVGYENAGTIEFLVDSRKNYYFIEMNTRIQVEHPV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCH
TEMITGIDLVKEQIKIAYGKPLSFKQRDVKITGHAIECRINAEDPMNNFMPAPGKIGKIL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECEEEEEEECCCCCHHHCCCCCCCCCEEE
LPGGFNVRFDSHIYPDYEVPPFYDSMLGKLIVFAPTRKEAMRKMRIALEQLVIEGITTNI
ECCCCEEEECCCCCCCCCCCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCE
EYHYAILHATDFIKGTYDTGFVAKFNGLIQGEYNESLIG
EEEEEEEEEHHHHCCCCCCCEEEEECCEEECCCCCCCCC
>Mature Secondary Structure 
AQNKVLVANRGEIAVRIIRACKELGIPVVAVYSTADKSSLHTKLADEAVCIGSARSKDS
CCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCEEEECCCCCCCH
YLNMQAVLSAAIATGCNAIHPGYGFLAENAKFIEMVEATGIKFIGPSSNVVSKLGDKATA
HHHHHHHHHHHHHHCCCCCCCCCCCHHCCCHHEEHHHHCCEEEECCCHHHHHHHCCHHHH
RAIAKAVGVPVVEGSDGVVENKEIGLKIAKQIGYPIMIKASSGGGGRGISVCHNDTEFKK
HHHHHHHCCCEEECCCCCEECHHHHHHHHHHCCCEEEEEECCCCCCCCEEEECCCHHHHH
AFDMTSMEAESAFGDKSVYIEKFVENPRHIEIQIIADSKGNVVHLYERDCSMQRRNQKLI
HHCCCHHHHHHCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCHHHHHHHHHH
EEAPSSILNEDLRRKMGQSAVKLAKHVGYENAGTIEFLVDSRKNYYFIEMNTRIQVEHPV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCH
TEMITGIDLVKEQIKIAYGKPLSFKQRDVKITGHAIECRINAEDPMNNFMPAPGKIGKIL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECEEEEEEECCCCCHHHCCCCCCCCCEEE
LPGGFNVRFDSHIYPDYEVPPFYDSMLGKLIVFAPTRKEAMRKMRIALEQLVIEGITTNI
ECCCCEEEECCCCCCCCCCCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCE
EYHYAILHATDFIKGTYDTGFVAKFNGLIQGEYNESLIG
EEEEEEEEEHHHHCCCCCCCEEEEECCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]