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The map label for this gene is parC [H]

Identifier: 162447246

GI number: 162447246

Start: 398588

End: 401161

Strand: Direct

Name: parC [H]

Synonym: ACL_0380

Alternate gene names: 162447246

Gene position: 398588-401161 (Clockwise)

Preceding gene: 162447245

Following gene: 162447247

Centisome position: 26.63

GC content: 32.52

Gene sequence:

>2574_bases
ATGAGTAAAATTGACAAAAAACTAGACAAATTCATAGAAGAAAAAATTGAAAAAGTTCTCTTAGAAGATATTATGTCTTC
TAGATTTGGACGATACTCTAAATATATCATTCAAGATCGTGCACTACCAGATGCTAGAGATGGTTTAAAACCAGTTCAAC
GTCGTATTTTATACGCAATGGGACAAATGGGTTTAGCCTTTAACAAATCATATAAAAAATCTGCAAGAATTGCAGGAGAA
GTTATGGGGAAATATCACCCTCATGGGGATTCATCTATTTATGAAGCAATGGTTCGTATGAGCCAGGACTTTAAAATGAG
AGTACCTCTAGTTGATATGCATGGTAACAATGGTTCCATAGATGGTGACTCTGCTGCGGCAATGCGTTATACCGAGGCTA
GACTATCTAAAGAAGCAGAATTTTTACTTAAAGATATCGATAAAAGAACAGTAAACTTTGTACCTAACTTTGATGATGAG
GAACAAGAACCTACCGTATTACCCGCACGTTTTCCAAACTTACTTGTCAATGGTGCAATGGGTATTTCAGCAGGTTATGC
AACAAAAATACCACCACATAACTTAAATGAAGTCATTGATGCAACGATTGCTTTAATTGATAATCCAAATATTACAAATG
ATGAAATATTAAAGTATATAAAAGGACCGGACTTCCCAACAGGTGGTATTGTTCAAGGTAAAGCAGGTATTAAAGAAGCA
CTCACCACAGGTAGTGGGAAAATTATTATCAGGGCTAAGATGAATGTCGAAGAGATGAGTAAATCTCAAGACCGTATTGT
GATTACTGAAATACCTTATGAAGTTAATAAAGCAGATTTAGTGCGTCAAATTGATAATTTACGTATCAATAACAATATCG
AGGATATCTTAGAAATCCGTGATGAAACGGACCAAGAAGGTCTAAGAATTGCCATTGATCTTAAAAAAGGTGCAGATGCA
CAATTTATTCAAAACTACTTATTAAAATCAAGTGATCTTCAAGTAAACTACAACTATAATATGGTTGCTATTTTAAAACA
CCGTCCAGTTTTATCTGGTGCTTTTGAATTATTAAAAGTGTATTTAGAACACCAAAAAGAAGTAGTAACCAATAGATCTA
ATTATGAATTAGAACGTGCAACAAAAAGAAATCATATTGTTGATGGTTTAATTCAAATGACTTCTGTTGTATCAGAAGTT
ATTGAAGAAATTAGAAAATCTAAAAATAAAGCAGACTCAAAAGAAAATATCCAAAAGCGTTTTGGTTTTTCAGAACTACA
AGCTGAAGCGATTGTCATGCTTCAACTATATAGATTATCTACAACCGATATCCAAGCACTACTAGATGAAAAAGATACTT
TATATAAAGAAATTACTAGACTAGAACAAATATTATCGAATGAACGTATTTTACTTAAGACCATCAAATCTGAACTTCAA
GAAGTTCAAACACTACTTCCCTCACCTAGACGTACCGAACTAGAAGCGGAAATTGAAACGATAAAGATTGATGAAAAAGA
TCTCATCTCAGATGAACAAACCTATGTAGCTATCACTAAAGATGGTTACGTAAAACGTGCCTCACTAAGATCTGTTGTAG
CATCTAAAGAAGTAGGTTTAAAAGAAAATGATGCAATGCTTTATGAAGAAGAATTAAACACACTAGATACCTTACTCTTA
TTTACAAATTTAGGTCAATATATTTATTTACCGGTATATAAAATAGAAGAACAAAAATGGCGTGATCTCGGTGTTTATAT
TAATAACATTGTACCTACCTCAAAAGGTGAAACTATTATACGTGTTTTAAAGGTCAGTGATTTTTCAATTGATCAAAAAA
TATTGCTTACAACAAAACAAGGACAAATGAAACAAGTAAATCTAGCAGATTTTGAAGTTTCAAGGTATAATAGACCGTTA
CGCGCAATGAAGTTGTCAAAAGACGATGAATTAGTATCTGTTGACTATAACCAACTAGACAATATAGTAGCTATTTCTAA
ACATGGTTATGTCTTAAGATTCGATACAGAAGAACTGCCAGTATATGGTTTAACCGCTGGTGGGGTTAAATCTATGGCAT
TAGCAGAAGGTGATGAAGTTGCAGTAGCATTTTACGCTAAAGAATCAGATGATTTTTACTTCTTAACATCACGCGGGCAT
ATCATTAAAGATACAGTATTAGAATTACCTAAATACGCTAGAAATAGACGTGGTATTATTTTAGTAGATCGTATTAAAAC
ATCTCCTCATTTCATAATCTCAGCATCTAGAGTATCCAAAACACAAATCAAAGAAGATGTAAAGGTACGTATTTTATCCA
CTAAAGAAGCGCTGATTACTACAGTATCTGACTTAAAATATGTTGCGAATAAATATGGAAAGAAAATGGTAGAGGACGGT
TACTATTTAGAAATATACCCAGCAGAAACTGAAGAAAAAGATACGCCAGTACAACCAAAAAAAGAAGTAAAAAAAGATGA
TACATTACAAGCTAAAGTCATTGAAGAAACAATACAAACAAAACAAAATCAAAAGTTAAGACTATCAAGGCTTGATTTAT
TTGATGAAGAATAG

Upstream 100 bases:

>100_bases
GTGTATTAATGGGTGACCAGGTTGCACCAAGACGTGAATGGATTGAAGCAAACGTTGATTTTGAAGTAACTGATGAATTT
GACATAGAAGGTAAGGTAAG

Downstream 100 bases:

>100_bases
AGGAAAAAGTATGAAACTAAAGATTAACAATGAAGTACTTGAGTTAAAAGAACCATTAACACTGGAAAAACTTGCTCAAA
AATTAAATATTTCTAATGCA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 857; Mature: 856

Protein sequence:

>857_residues
MSKIDKKLDKFIEEKIEKVLLEDIMSSRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMGQMGLAFNKSYKKSARIAGE
VMGKYHPHGDSSIYEAMVRMSQDFKMRVPLVDMHGNNGSIDGDSAAAMRYTEARLSKEAEFLLKDIDKRTVNFVPNFDDE
EQEPTVLPARFPNLLVNGAMGISAGYATKIPPHNLNEVIDATIALIDNPNITNDEILKYIKGPDFPTGGIVQGKAGIKEA
LTTGSGKIIIRAKMNVEEMSKSQDRIVITEIPYEVNKADLVRQIDNLRINNNIEDILEIRDETDQEGLRIAIDLKKGADA
QFIQNYLLKSSDLQVNYNYNMVAILKHRPVLSGAFELLKVYLEHQKEVVTNRSNYELERATKRNHIVDGLIQMTSVVSEV
IEEIRKSKNKADSKENIQKRFGFSELQAEAIVMLQLYRLSTTDIQALLDEKDTLYKEITRLEQILSNERILLKTIKSELQ
EVQTLLPSPRRTELEAEIETIKIDEKDLISDEQTYVAITKDGYVKRASLRSVVASKEVGLKENDAMLYEEELNTLDTLLL
FTNLGQYIYLPVYKIEEQKWRDLGVYINNIVPTSKGETIIRVLKVSDFSIDQKILLTTKQGQMKQVNLADFEVSRYNRPL
RAMKLSKDDELVSVDYNQLDNIVAISKHGYVLRFDTEELPVYGLTAGGVKSMALAEGDEVAVAFYAKESDDFYFLTSRGH
IIKDTVLELPKYARNRRGIILVDRIKTSPHFIISASRVSKTQIKEDVKVRILSTKEALITTVSDLKYVANKYGKKMVEDG
YYLEIYPAETEEKDTPVQPKKEVKKDDTLQAKVIEETIQTKQNQKLRLSRLDLFDEE

Sequences:

>Translated_857_residues
MSKIDKKLDKFIEEKIEKVLLEDIMSSRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMGQMGLAFNKSYKKSARIAGE
VMGKYHPHGDSSIYEAMVRMSQDFKMRVPLVDMHGNNGSIDGDSAAAMRYTEARLSKEAEFLLKDIDKRTVNFVPNFDDE
EQEPTVLPARFPNLLVNGAMGISAGYATKIPPHNLNEVIDATIALIDNPNITNDEILKYIKGPDFPTGGIVQGKAGIKEA
LTTGSGKIIIRAKMNVEEMSKSQDRIVITEIPYEVNKADLVRQIDNLRINNNIEDILEIRDETDQEGLRIAIDLKKGADA
QFIQNYLLKSSDLQVNYNYNMVAILKHRPVLSGAFELLKVYLEHQKEVVTNRSNYELERATKRNHIVDGLIQMTSVVSEV
IEEIRKSKNKADSKENIQKRFGFSELQAEAIVMLQLYRLSTTDIQALLDEKDTLYKEITRLEQILSNERILLKTIKSELQ
EVQTLLPSPRRTELEAEIETIKIDEKDLISDEQTYVAITKDGYVKRASLRSVVASKEVGLKENDAMLYEEELNTLDTLLL
FTNLGQYIYLPVYKIEEQKWRDLGVYINNIVPTSKGETIIRVLKVSDFSIDQKILLTTKQGQMKQVNLADFEVSRYNRPL
RAMKLSKDDELVSVDYNQLDNIVAISKHGYVLRFDTEELPVYGLTAGGVKSMALAEGDEVAVAFYAKESDDFYFLTSRGH
IIKDTVLELPKYARNRRGIILVDRIKTSPHFIISASRVSKTQIKEDVKVRILSTKEALITTVSDLKYVANKYGKKMVEDG
YYLEIYPAETEEKDTPVQPKKEVKKDDTLQAKVIEETIQTKQNQKLRLSRLDLFDEE
>Mature_856_residues
SKIDKKLDKFIEEKIEKVLLEDIMSSRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMGQMGLAFNKSYKKSARIAGEV
MGKYHPHGDSSIYEAMVRMSQDFKMRVPLVDMHGNNGSIDGDSAAAMRYTEARLSKEAEFLLKDIDKRTVNFVPNFDDEE
QEPTVLPARFPNLLVNGAMGISAGYATKIPPHNLNEVIDATIALIDNPNITNDEILKYIKGPDFPTGGIVQGKAGIKEAL
TTGSGKIIIRAKMNVEEMSKSQDRIVITEIPYEVNKADLVRQIDNLRINNNIEDILEIRDETDQEGLRIAIDLKKGADAQ
FIQNYLLKSSDLQVNYNYNMVAILKHRPVLSGAFELLKVYLEHQKEVVTNRSNYELERATKRNHIVDGLIQMTSVVSEVI
EEIRKSKNKADSKENIQKRFGFSELQAEAIVMLQLYRLSTTDIQALLDEKDTLYKEITRLEQILSNERILLKTIKSELQE
VQTLLPSPRRTELEAEIETIKIDEKDLISDEQTYVAITKDGYVKRASLRSVVASKEVGLKENDAMLYEEELNTLDTLLLF
TNLGQYIYLPVYKIEEQKWRDLGVYINNIVPTSKGETIIRVLKVSDFSIDQKILLTTKQGQMKQVNLADFEVSRYNRPLR
AMKLSKDDELVSVDYNQLDNIVAISKHGYVLRFDTEELPVYGLTAGGVKSMALAEGDEVAVAFYAKESDDFYFLTSRGHI
IKDTVLELPKYARNRRGIILVDRIKTSPHFIISASRVSKTQIKEDVKVRILSTKEALITTVSDLKYVANKYGKKMVEDGY
YLEIYPAETEEKDTPVQPKKEVKKDDTLQAKVIEETIQTKQNQKLRLSRLDLFDEE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:
GO:0003677: DNA topoisomerase IV, subunit A
GO:0003916: DNA topoisomerase IV, subunit A
GO:0003918: DNA topoisomerase IV, subunit A
GO:0005524: DNA topoisomerase IV, subunit A
GO:0005694: DNA topoisomerase IV, subunit A
GO:0006259: DNA topoisomerase IV, subunit A
GO:0006265: DNA topoisomerase IV, subunit A
GO:0006355: DNA topoisomerase IV, subunit A
GO:0016853: DNA topoisomerase IV, subunit A

Cell location: Cytoplasm. Note=Bipolarly localized [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=176, Percent_Identity=31.8181818181818, Blast_Score=81, Evalue=5e-15,
Organism=Homo sapiens, GI19913408, Length=176, Percent_Identity=30.6818181818182, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1788562, Length=769, Percent_Identity=37.7113133940182, Blast_Score=501, Evalue=1e-143,
Organism=Escherichia coli, GI1789396, Length=751, Percent_Identity=35.1531291611185, Blast_Score=382, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI212645845, Length=184, Percent_Identity=31.5217391304348, Blast_Score=73, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI212645657, Length=165, Percent_Identity=31.5151515151515, Blast_Score=73, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17535065, Length=167, Percent_Identity=31.1377245508982, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115534553, Length=173, Percent_Identity=30.635838150289, Blast_Score=70, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=170, Percent_Identity=33.5294117647059, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136538, Length=170, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 97767; Mature: 97636

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIDKKLDKFIEEKIEKVLLEDIMSSRFGRYSKYIIQDRALPDARDGLKPVQRRILYAM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHCCHHHHHHHHHHHH
GQMGLAFNKSYKKSARIAGEVMGKYHPHGDSSIYEAMVRMSQDFKMRVPLVDMHGNNGSI
HHCCCHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEECCEEEECCCCCCC
DGDSAAAMRYTEARLSKEAEFLLKDIDKRTVNFVPNFDDEEQEPTVLPARFPNLLVNGAM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCHHHHCCCC
GISAGYATKIPPHNLNEVIDATIALIDNPNITNDEILKYIKGPDFPTGGIVQGKAGIKEA
CCCCCCCCCCCCCCHHHHHHHHEEEECCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHH
LTTGSGKIIIRAKMNVEEMSKSQDRIVITEIPYEVNKADLVRQIDNLRINNNIEDILEIR
HHCCCCEEEEEEECCHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCEECCCHHHHHHHH
DETDQEGLRIAIDLKKGADAQFIQNYLLKSSDLQVNYNYNMVAILKHRPVLSGAFELLKV
CCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCEEEEEECCCHHHHHHHHHHH
YLEHQKEVVTNRSNYELERATKRNHIVDGLIQMTSVVSEVIEEIRKSKNKADSKENIQKR
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
FGFSELQAEAIVMLQLYRLSTTDIQALLDEKDTLYKEITRLEQILSNERILLKTIKSELQ
CCHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EVQTLLPSPRRTELEAEIETIKIDEKDLISDEQTYVAITKDGYVKRASLRSVVASKEVGL
HHHHHCCCCCCCCEEEEEEEEEECHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHHCCC
KENDAMLYEEELNTLDTLLLFTNLGQYIYLPVYKIEEQKWRDLGVYINNIVPTSKGETII
CCCCCEEEHHHHHHHHHHHHHHCCCCEEEEEEEEECHHHHHHHCEEEECCCCCCCCCEEE
RVLKVSDFSIDQKILLTTKQGQMKQVNLADFEVSRYNRPLRAMKLSKDDELVSVDYNQLD
EEEEECCCCCCCEEEEEECCCCCEECCCCCEEHHHCCCCHHHHCCCCCCCEEEECHHHCC
NIVAISKHGYVLRFDTEELPVYGLTAGGVKSMALAEGDEVAVAFYAKESDDFYFLTSRGH
CEEEEECCCEEEEECCCCCCEEEECCCCCHHHHCCCCCCEEEEEEEECCCCEEEEECCCC
IIKDTVLELPKYARNRRGIILVDRIKTSPHFIISASRVSKTQIKEDVKVRILSTKEALIT
CHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECHHHHHHHHCCCEEEEEECHHHHHH
TVSDLKYVANKYGKKMVEDGYYLEIYPAETEEKDTPVQPKKEVKKDDTLQAKVIEETIQT
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHH
KQNQKLRLSRLDLFDEE
CCCCCEEHHHCCCCCCC
>Mature Secondary Structure 
SKIDKKLDKFIEEKIEKVLLEDIMSSRFGRYSKYIIQDRALPDARDGLKPVQRRILYAM
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHCCHHHHHHHHHHHH
GQMGLAFNKSYKKSARIAGEVMGKYHPHGDSSIYEAMVRMSQDFKMRVPLVDMHGNNGSI
HHCCCHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEECCEEEECCCCCCC
DGDSAAAMRYTEARLSKEAEFLLKDIDKRTVNFVPNFDDEEQEPTVLPARFPNLLVNGAM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCHHHHCCCC
GISAGYATKIPPHNLNEVIDATIALIDNPNITNDEILKYIKGPDFPTGGIVQGKAGIKEA
CCCCCCCCCCCCCCHHHHHHHHEEEECCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHH
LTTGSGKIIIRAKMNVEEMSKSQDRIVITEIPYEVNKADLVRQIDNLRINNNIEDILEIR
HHCCCCEEEEEEECCHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCEECCCHHHHHHHH
DETDQEGLRIAIDLKKGADAQFIQNYLLKSSDLQVNYNYNMVAILKHRPVLSGAFELLKV
CCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCEEEEEECCCHHHHHHHHHHH
YLEHQKEVVTNRSNYELERATKRNHIVDGLIQMTSVVSEVIEEIRKSKNKADSKENIQKR
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
FGFSELQAEAIVMLQLYRLSTTDIQALLDEKDTLYKEITRLEQILSNERILLKTIKSELQ
CCHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EVQTLLPSPRRTELEAEIETIKIDEKDLISDEQTYVAITKDGYVKRASLRSVVASKEVGL
HHHHHCCCCCCCCEEEEEEEEEECHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHHCCC
KENDAMLYEEELNTLDTLLLFTNLGQYIYLPVYKIEEQKWRDLGVYINNIVPTSKGETII
CCCCCEEEHHHHHHHHHHHHHHCCCCEEEEEEEEECHHHHHHHCEEEECCCCCCCCCEEE
RVLKVSDFSIDQKILLTTKQGQMKQVNLADFEVSRYNRPLRAMKLSKDDELVSVDYNQLD
EEEEECCCCCCCEEEEEECCCCCEECCCCCEEHHHCCCCHHHHCCCCCCCEEEECHHHCC
NIVAISKHGYVLRFDTEELPVYGLTAGGVKSMALAEGDEVAVAFYAKESDDFYFLTSRGH
CEEEEECCCEEEEECCCCCCEEEECCCCCHHHHCCCCCCEEEEEEEECCCCEEEEECCCC
IIKDTVLELPKYARNRRGIILVDRIKTSPHFIISASRVSKTQIKEDVKVRILSTKEALIT
CHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECHHHHHHHHCCCEEEEEECHHHHHH
TVSDLKYVANKYGKKMVEDGYYLEIYPAETEEKDTPVQPKKEVKKDDTLQAKVIEETIQT
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHH
KQNQKLRLSRLDLFDEE
CCCCCEEHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377 [H]