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The map label for this gene is parE [H]

Identifier: 162447245

GI number: 162447245

Start: 396636

End: 398591

Strand: Direct

Name: parE [H]

Synonym: ACL_0379

Alternate gene names: 162447245

Gene position: 396636-398591 (Clockwise)

Preceding gene: 162447244

Following gene: 162447246

Centisome position: 26.5

GC content: 35.07

Gene sequence:

>1956_bases
GTGGCAAAAACAAATTATGACGAGACGAGTATTCAAATATTAGAAGGACTAGAGGCTGTACGAAAAAGACCGGGTATGTA
TATTGGTTCAACTGACCATAGGGGATTACATCATTTGGTTTGGGAAATCGTAGATAACGCGATGGATGAAGTATTAGCTG
GTTTTGGTAGTGAAATTACAGTAACAATCAAACCTGACAATGCAATCGAAGTACTAGATGATGGACGCGGTATGCCATAT
AAAAAACATACATCTGGGGTTCCAACTACCCAGGTTATTTTTACTGTTTTACATGCAGGAGGTAAATTTGGTGGCGATGG
TGCATATAAAGTAGCTGGTGGTTTACACGGTGTTGGTTCATCTGTAGTAAATGCATTATCCTCTGTCTTGGAAGTTACTG
TATATAAAGACGGCGGTATTTTCAGACAACGTTTTGAAAATGGTGGTAAAAAGATATTTAACCAAGAAAAAATAGGAGAT
ACTAAAAAAACTGGTACACAAGTATACTTTAAACCAGATCCGTCTATTTTTTCTACAACGCTTTATAACTACGATACGAT
TAAAGAACGATTAAAAGAATCTGCTTACTTAATTAAGGGTCTAAAAATTAATCTTATTGATGAAAGAAATAATAAAAAAG
AAACCTTTAAATTTGATGAAGGTATTAAAGCCTACGTGGAGTTTATGAACACTGGTAAAAATGCACTACACGATGTAACG
GATGTGGAGGGCACTTTTAATACTGCTAAAGATAGTGCAATTGAAGTCGAAGTTGCCTTACAGTATACAGATAGTTATAG
TGAAAATATTATTTCGTTTGTAAATAACGTACGTACCAAAGATGGTGGTACCCATGAAATTGGGTTTAAATCTGCACTTA
CTAAAGTTATTAATGACTACGCTAGAAAATATAATCACATAAAAGAAAAAGATAGTAATATTGATGGCGTAGACATTAGA
GAAGGGCTAACCGCTATTGTATCATTACGTATACCTGAAACAGTCCTAGAGTTTGAAGGGCAAACTAAAGGTAAGCTAGG
AACACCAGAGGCAAGAAATGCACTAGAGACAGTATTTTATGAAAAGTTTAACACCTTTTTAGAAGAAAATTCGGATGCTG
CTTTATCTATTATTACGAAAGCTGTTGCTGCAGCTAATGCTAGAGAGGCTGCAAGAAAAGCACGTGAAGAAGCTAGAGCT
GGTAAGAAAAGAAGTAAAAAAGAAGTTATTCTTTCAGGTAAATTAACTCCTGCTCAAGGTAAAGATAAATCAATTAATGA
ACTCTTCTTAGTTGAAGGTGATTCTGCTGGTGGTTCTGCTAAACAAGGTAGAAATAGACGCTTCCAAGCGATTTTACCGC
TACGTGGTAAGGTGATTAACACAGAACGCACCAACACAGAAACCATCTTAAAAAACGAAGAAATTTCGACCATGATCTAC
ACCATTGGTGCTGATTTTGGTGAGGATTTTGATATTAAAAAGTGTAACTATAATAAAGTGATTATTATGACTGATGCCGA
TGATGATGGTGCGCATATTCAAACACTTCTTTTAACATTCTTCTTTAGATACATGAGACCATTAATTGAAGCGGGTAGAT
TATATATTGCACAGCCTCCATTTTATAAAGTAACTTACAAGAAAAACAAAAAAGAAGAAACTGTTTATGCTTGGAGTGAT
GAAGATTTAAAAGAAACACTTGAATCCATTGGACAAAACTACATGATTACACGTTTTAAAGGGTTAGGCGAAATGAACTT
TTATCAGTTATGGGAAACTACAATGAATCCTGAGTCACGTACACTGATTCAAGTTACAATCGATGATTTAAACGTTAGTG
ATAAGCACATTAGTGTATTAATGGGTGACCAGGTTGCACCAAGACGTGAATGGATTGAAGCAAACGTTGATTTTGAAGTA
ACTGATGAATTTGACATAGAAGGTAAGGTAAGATGA

Upstream 100 bases:

>100_bases
TAATACAGCAAGAAAATACTTTTAAAGATAATCATTCTTGTTATAATGATTATCTTTTAATGTATAATAGAGATATAATT
TCAATGATTGGAGTACAACT

Downstream 100 bases:

>100_bases
GTAAAATTGACAAAAAACTAGACAAATTCATAGAAGAAAAAATTGAAAAAGTTCTCTTAGAAGATATTATGTCTTCTAGA
TTTGGACGATACTCTAAATA

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 651; Mature: 650

Protein sequence:

>651_residues
MAKTNYDETSIQILEGLEAVRKRPGMYIGSTDHRGLHHLVWEIVDNAMDEVLAGFGSEITVTIKPDNAIEVLDDGRGMPY
KKHTSGVPTTQVIFTVLHAGGKFGGDGAYKVAGGLHGVGSSVVNALSSVLEVTVYKDGGIFRQRFENGGKKIFNQEKIGD
TKKTGTQVYFKPDPSIFSTTLYNYDTIKERLKESAYLIKGLKINLIDERNNKKETFKFDEGIKAYVEFMNTGKNALHDVT
DVEGTFNTAKDSAIEVEVALQYTDSYSENIISFVNNVRTKDGGTHEIGFKSALTKVINDYARKYNHIKEKDSNIDGVDIR
EGLTAIVSLRIPETVLEFEGQTKGKLGTPEARNALETVFYEKFNTFLEENSDAALSIITKAVAAANAREAARKAREEARA
GKKRSKKEVILSGKLTPAQGKDKSINELFLVEGDSAGGSAKQGRNRRFQAILPLRGKVINTERTNTETILKNEEISTMIY
TIGADFGEDFDIKKCNYNKVIIMTDADDDGAHIQTLLLTFFFRYMRPLIEAGRLYIAQPPFYKVTYKKNKKEETVYAWSD
EDLKETLESIGQNYMITRFKGLGEMNFYQLWETTMNPESRTLIQVTIDDLNVSDKHISVLMGDQVAPRREWIEANVDFEV
TDEFDIEGKVR

Sequences:

>Translated_651_residues
MAKTNYDETSIQILEGLEAVRKRPGMYIGSTDHRGLHHLVWEIVDNAMDEVLAGFGSEITVTIKPDNAIEVLDDGRGMPY
KKHTSGVPTTQVIFTVLHAGGKFGGDGAYKVAGGLHGVGSSVVNALSSVLEVTVYKDGGIFRQRFENGGKKIFNQEKIGD
TKKTGTQVYFKPDPSIFSTTLYNYDTIKERLKESAYLIKGLKINLIDERNNKKETFKFDEGIKAYVEFMNTGKNALHDVT
DVEGTFNTAKDSAIEVEVALQYTDSYSENIISFVNNVRTKDGGTHEIGFKSALTKVINDYARKYNHIKEKDSNIDGVDIR
EGLTAIVSLRIPETVLEFEGQTKGKLGTPEARNALETVFYEKFNTFLEENSDAALSIITKAVAAANAREAARKAREEARA
GKKRSKKEVILSGKLTPAQGKDKSINELFLVEGDSAGGSAKQGRNRRFQAILPLRGKVINTERTNTETILKNEEISTMIY
TIGADFGEDFDIKKCNYNKVIIMTDADDDGAHIQTLLLTFFFRYMRPLIEAGRLYIAQPPFYKVTYKKNKKEETVYAWSD
EDLKETLESIGQNYMITRFKGLGEMNFYQLWETTMNPESRTLIQVTIDDLNVSDKHISVLMGDQVAPRREWIEANVDFEV
TDEFDIEGKVR
>Mature_650_residues
AKTNYDETSIQILEGLEAVRKRPGMYIGSTDHRGLHHLVWEIVDNAMDEVLAGFGSEITVTIKPDNAIEVLDDGRGMPYK
KHTSGVPTTQVIFTVLHAGGKFGGDGAYKVAGGLHGVGSSVVNALSSVLEVTVYKDGGIFRQRFENGGKKIFNQEKIGDT
KKTGTQVYFKPDPSIFSTTLYNYDTIKERLKESAYLIKGLKINLIDERNNKKETFKFDEGIKAYVEFMNTGKNALHDVTD
VEGTFNTAKDSAIEVEVALQYTDSYSENIISFVNNVRTKDGGTHEIGFKSALTKVINDYARKYNHIKEKDSNIDGVDIRE
GLTAIVSLRIPETVLEFEGQTKGKLGTPEARNALETVFYEKFNTFLEENSDAALSIITKAVAAANAREAARKAREEARAG
KKRSKKEVILSGKLTPAQGKDKSINELFLVEGDSAGGSAKQGRNRRFQAILPLRGKVINTERTNTETILKNEEISTMIYT
IGADFGEDFDIKKCNYNKVIIMTDADDDGAHIQTLLLTFFFRYMRPLIEAGRLYIAQPPFYKVTYKKNKKEETVYAWSDE
DLKETLESIGQNYMITRFKGLGEMNFYQLWETTMNPESRTLIQVTIDDLNVSDKHISVLMGDQVAPRREWIEANVDFEVT
DEFDIEGKVR

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=612, Percent_Identity=25.4901960784314, Blast_Score=109, Evalue=1e-23,
Organism=Homo sapiens, GI19913408, Length=613, Percent_Identity=24.6329526916803, Blast_Score=104, Evalue=3e-22,
Organism=Escherichia coli, GI48994957, Length=571, Percent_Identity=47.9859894921191, Blast_Score=472, Evalue=1e-134,
Organism=Escherichia coli, GI1789408, Length=643, Percent_Identity=36.0808709175739, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17535065, Length=610, Percent_Identity=25.9016393442623, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI212645845, Length=538, Percent_Identity=24.1635687732342, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324241, Length=626, Percent_Identity=26.8370607028754, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17136538, Length=616, Percent_Identity=26.7857142857143, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005740 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 73014; Mature: 72883

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTNYDETSIQILEGLEAVRKRPGMYIGSTDHRGLHHLVWEIVDNAMDEVLAGFGSEIT
CCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
VTIKPDNAIEVLDDGRGMPYKKHTSGVPTTQVIFTVLHAGGKFGGDGAYKVAGGLHGVGS
EEECCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEECCCCCCCHH
SVVNALSSVLEVTVYKDGGIFRQRFENGGKKIFNQEKIGDTKKTGTQVYFKPDPSIFSTT
HHHHHHHHHHEEEEECCCCHHHHHHHCCCHHHCCHHHCCCCCCCCCEEEECCCCCHHHHH
LYNYDTIKERLKESAYLIKGLKINLIDERNNKKETFKFDEGIKAYVEFMNTGKNALHDVT
HCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEHHHHHHHHHHHHHCCHHHHHHHH
DVEGTFNTAKDSAIEVEVALQYTDSYSENIISFVNNVRTKDGGTHEIGFKSALTKVINDY
CCCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
ARKYNHIKEKDSNIDGVDIREGLTAIVSLRIPETVLEFEGQTKGKLGTPEARNALETVFY
HHHHHHHHHCCCCCCCCCHHHHHHHHEEECCCHHHHHCCCCCCCCCCCCHHHHHHHHHHH
EKFNTFLEENSDAALSIITKAVAAANAREAARKAREEARAGKKRSKKEVILSGKLTPAQG
HHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
KDKSINELFLVEGDSAGGSAKQGRNRRFQAILPLRGKVINTERTNTETILKNEEISTMIY
CCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCHHEEECCCCEEEEE
TIGADFGEDFDIKKCNYNKVIIMTDADDDGAHIQTLLLTFFFRYMRPLIEAGRLYIAQPP
EECCCCCCCCCCEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
FYKVTYKKNKKEETVYAWSDEDLKETLESIGQNYMITRFKGLGEMNFYQLWETTMNPESR
CEEEEECCCCCCCEEEEECCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCC
TLIQVTIDDLNVSDKHISVLMGDQVAPRREWIEANVDFEVTDEFDIEGKVR
EEEEEEEECCCCCCCEEEEEECCCCCCCHHHHCCCCCEEECCCCCCCCCCC
>Mature Secondary Structure 
AKTNYDETSIQILEGLEAVRKRPGMYIGSTDHRGLHHLVWEIVDNAMDEVLAGFGSEIT
CCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
VTIKPDNAIEVLDDGRGMPYKKHTSGVPTTQVIFTVLHAGGKFGGDGAYKVAGGLHGVGS
EEECCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEECCCCCCCHH
SVVNALSSVLEVTVYKDGGIFRQRFENGGKKIFNQEKIGDTKKTGTQVYFKPDPSIFSTT
HHHHHHHHHHEEEEECCCCHHHHHHHCCCHHHCCHHHCCCCCCCCCEEEECCCCCHHHHH
LYNYDTIKERLKESAYLIKGLKINLIDERNNKKETFKFDEGIKAYVEFMNTGKNALHDVT
HCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEHHHHHHHHHHHHHCCHHHHHHHH
DVEGTFNTAKDSAIEVEVALQYTDSYSENIISFVNNVRTKDGGTHEIGFKSALTKVINDY
CCCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
ARKYNHIKEKDSNIDGVDIREGLTAIVSLRIPETVLEFEGQTKGKLGTPEARNALETVFY
HHHHHHHHHCCCCCCCCCHHHHHHHHEEECCCHHHHHCCCCCCCCCCCCHHHHHHHHHHH
EKFNTFLEENSDAALSIITKAVAAANAREAARKAREEARAGKKRSKKEVILSGKLTPAQG
HHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
KDKSINELFLVEGDSAGGSAKQGRNRRFQAILPLRGKVINTERTNTETILKNEEISTMIY
CCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCHHEEECCCCEEEEE
TIGADFGEDFDIKKCNYNKVIIMTDADDDGAHIQTLLLTFFFRYMRPLIEAGRLYIAQPP
EECCCCCCCCCCEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
FYKVTYKKNKKEETVYAWSDEDLKETLESIGQNYMITRFKGLGEMNFYQLWETTMNPESR
CEEEEECCCCCCCEEEEECCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCC
TLIQVTIDDLNVSDKHISVLMGDQVAPRREWIEANVDFEVTDEFDIEGKVR
EEEEEEEECCCCCCCEEEEEECCCCCCCHHHHCCCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377 [H]