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The map label for this gene is lpxK

Identifier: 162149013

GI number: 162149013

Start: 3333446

End: 3334429

Strand: Direct

Name: lpxK

Synonym: GDI_3243

Alternate gene names: 162149013

Gene position: 3333446-3334429 (Clockwise)

Preceding gene: 162149012

Following gene: 162149014

Centisome position: 84.52

GC content: 75.51

Gene sequence:

>984_bases
ATGCACGCGCCCCGCTTCTGGTCCGGGGGCGATGGCGGCTGGCCCGCGCGCCTGCTGGCGCCGGCCGCAGCACTCTACAC
GCTGGCCACGGCGCGGCGCATGCGCGGGACAGGCTGGCGCGCGCCGGTTCCCGTCCTGTGCTGCGGCAATCTGACGGCGG
GCGGCGCGGGCAAGACGACCGTGGCGCTGGACCTGGCGGCGCGCCTGGTCGCGCGCGGGCGCCATGTGCATATCCTGACC
CGCGGCTATGGCGGTCGCGCGCGCGGCCCCCTGCTGGTGGACCCCGCCCGCCATAGCGCCGCCGAGGTCGGGGACGAGGC
CCTGCTGCTGGCCCGGGTCGCCCCCTGCCATGTATCGGCCGACCGCGCGGCCGGCGCGCGCGCGGCGGTGGCCGCCGGGG
CGGATTGCCTGGTGATGGATGACGGGTTCCAGAATCCCGGCCTGCGCCAGGATATGGGCCTGCTGGTCATCGACGGCGGC
AGCGGCTTCGGCAACGGGCATGTCCTGCCCGCCGGGCCGCTGCGCGAACCGGTGGCGCAGGGCTGCCGGCGCGCACGCGC
CGCCATCCTGATCGGCGGGGACCGGACCGGGGCGCTGGCGCACCTGCCCCCCGCCCTGCCGGTCCTGCGTGCCGACCTGG
CGATGCAGGAGGCTGCCCCGATGCTGGCCGGGCGGCCCGCCATCGCCTTCGCGGGGATCGGGCGGCCCGACAAGTTCTTC
GACGGGCTGCGCGCGCAGGGCATCCGGCTTGCGGCCTGCCTGCCCTTTCCCGACCATCATGCCTATCGCCCCCGGGACGT
GCGCCGCCTGTCAGCCATGGCCGCGGTACAGGGCGCCGTGCTGCTGACGACGCCCAAGGACGCGGTACGCCTGCCCCCCG
CCATCCGGGCGCAGGTCCGCAGCGTGGACGTCACGCTGGCATGGGCCGATCCCATGGCGCCGGAGCGGCTGCTGGATATG
TGGCTGGATAAAGCATCATCATGA

Upstream 100 bases:

>100_bases
GCGCCCGCGATGCCGGATGCCGCGCGGCCCAGGTCGCCAGCCAGGACCAGGGCCTGCCAGGCCGCATCGCCGCGCGTCTG
CTGGCGCTGATGGAGACGTG

Downstream 100 bases:

>100_bases
CGGACACGGACAAGACGCCACGCGTCACCCTGCTGATGCGCGCCGAGGCCCTGGCCGCGCGTGGCGCGCTGGCCCTGCTG
CGCCGGCTGGGACCGGTGCG

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MHAPRFWSGGDGGWPARLLAPAAALYTLATARRMRGTGWRAPVPVLCCGNLTAGGAGKTTVALDLAARLVARGRHVHILT
RGYGGRARGPLLVDPARHSAAEVGDEALLLARVAPCHVSADRAAGARAAVAAGADCLVMDDGFQNPGLRQDMGLLVIDGG
SGFGNGHVLPAGPLREPVAQGCRRARAAILIGGDRTGALAHLPPALPVLRADLAMQEAAPMLAGRPAIAFAGIGRPDKFF
DGLRAQGIRLAACLPFPDHHAYRPRDVRRLSAMAAVQGAVLLTTPKDAVRLPPAIRAQVRSVDVTLAWADPMAPERLLDM
WLDKASS

Sequences:

>Translated_327_residues
MHAPRFWSGGDGGWPARLLAPAAALYTLATARRMRGTGWRAPVPVLCCGNLTAGGAGKTTVALDLAARLVARGRHVHILT
RGYGGRARGPLLVDPARHSAAEVGDEALLLARVAPCHVSADRAAGARAAVAAGADCLVMDDGFQNPGLRQDMGLLVIDGG
SGFGNGHVLPAGPLREPVAQGCRRARAAILIGGDRTGALAHLPPALPVLRADLAMQEAAPMLAGRPAIAFAGIGRPDKFF
DGLRAQGIRLAACLPFPDHHAYRPRDVRRLSAMAAVQGAVLLTTPKDAVRLPPAIRAQVRSVDVTLAWADPMAPERLLDM
WLDKASS
>Mature_327_residues
MHAPRFWSGGDGGWPARLLAPAAALYTLATARRMRGTGWRAPVPVLCCGNLTAGGAGKTTVALDLAARLVARGRHVHILT
RGYGGRARGPLLVDPARHSAAEVGDEALLLARVAPCHVSADRAAGARAAVAAGADCLVMDDGFQNPGLRQDMGLLVIDGG
SGFGNGHVLPAGPLREPVAQGCRRARAAILIGGDRTGALAHLPPALPVLRADLAMQEAAPMLAGRPAIAFAGIGRPDKFF
DGLRAQGIRLAACLPFPDHHAYRPRDVRRLSAMAAVQGAVLLTTPKDAVRLPPAIRAQVRSVDVTLAWADPMAPERLLDM
WLDKASS

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=303, Percent_Identity=37.953795379538, Blast_Score=154, Evalue=9e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_GLUDA (A9H0Y0)

Other databases:

- EMBL:   CP001189
- EMBL:   AM889285
- RefSeq:   YP_001603474.1
- RefSeq:   YP_002277466.1
- GeneID:   5790664
- GeneID:   6976555
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_3121
- HOGENOM:   HBG663914
- OMA:   DEPVLIH
- ProtClustDB:   CLSK936577
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 34135; Mature: 34135

Theoretical pI: Translated: 10.97; Mature: 10.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAPRFWSGGDGGWPARLLAPAAALYTLATARRMRGTGWRAPVPVLCCGNLTAGGAGKTT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCEE
VALDLAARLVARGRHVHILTRGYGGRARGPLLVDPARHSAAEVGDEALLLARVAPCHVSA
HHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEECCCHHHHHHCCCCEEEEEEECCCCCCC
DRAAGARAAVAAGADCLVMDDGFQNPGLRQDMGLLVIDGGSGFGNGHVLPAGPLREPVAQ
CCCCCCHHHHHCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCCCCEECCCCCHHHHHHH
GCRRARAAILIGGDRTGALAHLPPALPVLRADLAMQEAAPMLAGRPAIAFAGIGRPDKFF
HHHHCCEEEEECCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHH
DGLRAQGIRLAACLPFPDHHAYRPRDVRRLSAMAAVQGAVLLTTPKDAVRLPPAIRAQVR
HHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCEEEEECCHHHHHCCHHHHHHEE
SVDVTLAWADPMAPERLLDMWLDKASS
EEEEEEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MHAPRFWSGGDGGWPARLLAPAAALYTLATARRMRGTGWRAPVPVLCCGNLTAGGAGKTT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCEE
VALDLAARLVARGRHVHILTRGYGGRARGPLLVDPARHSAAEVGDEALLLARVAPCHVSA
HHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEECCCHHHHHHCCCCEEEEEEECCCCCCC
DRAAGARAAVAAGADCLVMDDGFQNPGLRQDMGLLVIDGGSGFGNGHVLPAGPLREPVAQ
CCCCCCHHHHHCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCCCCEECCCCCHHHHHHH
GCRRARAAILIGGDRTGALAHLPPALPVLRADLAMQEAAPMLAGRPAIAFAGIGRPDKFF
HHHHCCEEEEECCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHH
DGLRAQGIRLAACLPFPDHHAYRPRDVRRLSAMAAVQGAVLLTTPKDAVRLPPAIRAQVR
HHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCEEEEECCHHHHHCCHHHHHHEE
SVDVTLAWADPMAPERLLDMWLDKASS
EEEEEEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA