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The map label for this gene is lpxC [H]

Identifier: 162148967

GI number: 162148967

Start: 3287726

End: 3288751

Strand: Direct

Name: lpxC [H]

Synonym: GDI_3197

Alternate gene names: 162148967

Gene position: 3287726-3288751 (Clockwise)

Preceding gene: 162148966

Following gene: 162148968

Centisome position: 83.36

GC content: 69.1

Gene sequence:

>1026_bases
ATGGACGGTATGCTGGCAATTCCGGGGCATGATACTGTGTCCTCTGTCGGTGTATCTTCTGGCAGCGCCCCCTCGGGTGC
CACCTCGTCCGGCAGCCCCGCCCCCGCGCGCGCGGCGGTACGCACGGCGCGGCAGCATACGCTGGGCAATTCCATTTCCT
CCATCGGCGTCGGGCTGCATACCGGGCGGCGCATTCGCCTGACGCTGCATCCGGCGGCGGAAAATACCGGCATCGTCTTC
CGGCGCACCGACCTGGACGACCGCACCATTCCGGCCCGGTTCGACCATGTCGTCGATACGCGGCTGAGCACCGTCATCGG
CGATGCCACGGACCCCGCGCTGCGCATCGCCACCATCGAACATCTGATGTCCGCCCTGTCGGGAAGCGGCGTCGACAATG
TGCTGATCGATGTCGACGGGCCGGAAATCCCGGTCTTCGACGGCTCGGCGGCCGATTTCATCTTCCTGCTGGATTGCGCG
GGCCTGGCGGAACAGGCCGCCCCGCGCACCGCGATCGACGTCCTGCGCCCCGTTCGCGTGACCGAGGGTGACGCCTTCGC
CGAACTGCGCCCGGGCCGCGAGGGCGGGTTGTCGCTGACCCTGTCCATCGACTTCCCCGCCGCCGCGATCGGCGAGCAGA
CGTTTGCGACCCGTCTGGACCGTCAGGGCTACCGTGCCGAAATCGCCAATTGTCGGACCTTCACCCTGCGCCAGGAAATC
GAAGCCCTGCACCGGGCGGGCCTGGCGCGCGGCGGCTCGCTGGACAATGCGATCGTGGTGGACGGCGCCAGCGTTCTGAA
CCCGTCCGGCCTGCGCCGGCCCGACGAATTCGTCCGTCACAAGATGATCGACGCGGTGGGTGACCTGTACCTGGCCGGCG
GCGCGATCAACGGCCTGTTCACCGGCCACAAATCCGGCCACGCGCTGAACAACCGGCTGCTGCGCGCGCTGTTCGCCGAC
CGTGCGGCCTGGCGCATGCACACCCGCGCGCAGCGTGCCCAGGCCGCACTGCGTGCGGCGGCCTAG

Upstream 100 bases:

>100_bases
TCGGCAACAAACATTGACTCGCCTGTCCACCACCCCGACGCTACAAATTAGGCTGTCGTTCTTTTAGCGACTGAATAAAG
AACAACGCGAGGGACACGCG

Downstream 100 bases:

>100_bases
AGTCGGCCTGTAAACGCGCGCTGGTGGCGACCCGACGCGCATCCGCTGTGCTTCGATGCTCACGGCCGACACGGCCGCTT
CGCTGCTCGCAGACACACGC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine; Acetate. [C]

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MDGMLAIPGHDTVSSVGVSSGSAPSGATSSGSPAPARAAVRTARQHTLGNSISSIGVGLHTGRRIRLTLHPAAENTGIVF
RRTDLDDRTIPARFDHVVDTRLSTVIGDATDPALRIATIEHLMSALSGSGVDNVLIDVDGPEIPVFDGSAADFIFLLDCA
GLAEQAAPRTAIDVLRPVRVTEGDAFAELRPGREGGLSLTLSIDFPAAAIGEQTFATRLDRQGYRAEIANCRTFTLRQEI
EALHRAGLARGGSLDNAIVVDGASVLNPSGLRRPDEFVRHKMIDAVGDLYLAGGAINGLFTGHKSGHALNNRLLRALFAD
RAAWRMHTRAQRAQAALRAAA

Sequences:

>Translated_341_residues
MDGMLAIPGHDTVSSVGVSSGSAPSGATSSGSPAPARAAVRTARQHTLGNSISSIGVGLHTGRRIRLTLHPAAENTGIVF
RRTDLDDRTIPARFDHVVDTRLSTVIGDATDPALRIATIEHLMSALSGSGVDNVLIDVDGPEIPVFDGSAADFIFLLDCA
GLAEQAAPRTAIDVLRPVRVTEGDAFAELRPGREGGLSLTLSIDFPAAAIGEQTFATRLDRQGYRAEIANCRTFTLRQEI
EALHRAGLARGGSLDNAIVVDGASVLNPSGLRRPDEFVRHKMIDAVGDLYLAGGAINGLFTGHKSGHALNNRLLRALFAD
RAAWRMHTRAQRAQAALRAAA
>Mature_341_residues
MDGMLAIPGHDTVSSVGVSSGSAPSGATSSGSPAPARAAVRTARQHTLGNSISSIGVGLHTGRRIRLTLHPAAENTGIVF
RRTDLDDRTIPARFDHVVDTRLSTVIGDATDPALRIATIEHLMSALSGSGVDNVLIDVDGPEIPVFDGSAADFIFLLDCA
GLAEQAAPRTAIDVLRPVRVTEGDAFAELRPGREGGLSLTLSIDFPAAAIGEQTFATRLDRQGYRAEIANCRTFTLRQEI
EALHRAGLARGGSLDNAIVVDGASVLNPSGLRRPDEFVRHKMIDAVGDLYLAGGAINGLFTGHKSGHALNNRLLRALFAD
RAAWRMHTRAQRAQAALRAAA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=297, Percent_Identity=46.1279461279461, Blast_Score=257, Evalue=6e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 35955; Mature: 35955

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGMLAIPGHDTVSSVGVSSGSAPSGATSSGSPAPARAAVRTARQHTLGNSISSIGVGLH
CCCEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCEEC
TGRRIRLTLHPAAENTGIVFRRTDLDDRTIPARFDHVVDTRLSTVIGDATDPALRIATIE
CCCEEEEEEECCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
HLMSALSGSGVDNVLIDVDGPEIPVFDGSAADFIFLLDCAGLAEQAAPRTAIDVLRPVRV
HHHHHHCCCCCCEEEEECCCCCCEEECCCCCCEEEEEEHHHHHHHCCCHHHHHHHCCCEE
TEGDAFAELRPGREGGLSLTLSIDFPAAAIGEQTFATRLDRQGYRAEIANCRTFTLRQEI
CCCCCHHHCCCCCCCCEEEEEEECCCHHHHCHHHHHHHHHCCCCHHHHCCCEEHHHHHHH
EALHRAGLARGGSLDNAIVVDGASVLNPSGLRRPDEFVRHKMIDAVGDLYLAGGAINGLF
HHHHHHCCCCCCCCCCEEEECCHHHCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCEE
TGHKSGHALNNRLLRALFADRAAWRMHTRAQRAQAALRAAA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDGMLAIPGHDTVSSVGVSSGSAPSGATSSGSPAPARAAVRTARQHTLGNSISSIGVGLH
CCCEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCEEC
TGRRIRLTLHPAAENTGIVFRRTDLDDRTIPARFDHVVDTRLSTVIGDATDPALRIATIE
CCCEEEEEEECCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
HLMSALSGSGVDNVLIDVDGPEIPVFDGSAADFIFLLDCAGLAEQAAPRTAIDVLRPVRV
HHHHHHCCCCCCEEEEECCCCCCEEECCCCCCEEEEEEHHHHHHHCCCHHHHHHHCCCEE
TEGDAFAELRPGREGGLSLTLSIDFPAAAIGEQTFATRLDRQGYRAEIANCRTFTLRQEI
CCCCCHHHCCCCCCCCEEEEEEECCCHHHHCHHHHHHHHHCCCCHHHHCCCEEHHHHHHH
EALHRAGLARGGSLDNAIVVDGASVLNPSGLRRPDEFVRHKMIDAVGDLYLAGGAINGLF
HHHHHHCCCCCCCCCCEEEECCHHHCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCEE
TGHKSGHALNNRLLRALFADRAAWRMHTRAQRAQAALRAAA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine; H2O [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine + H2O = UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine + Acetate. [C]

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA