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The map label for this gene is zwf [H]

Identifier: 162148947

GI number: 162148947

Start: 3263535

End: 3265013

Strand: Direct

Name: zwf [H]

Synonym: GDI_3177

Alternate gene names: 162148947

Gene position: 3263535-3265013 (Clockwise)

Preceding gene: 162148944

Following gene: 162148948

Centisome position: 82.74

GC content: 67.0

Gene sequence:

>1479_bases
ATGGCTCAGCTCCCCCCCGTGGATATCTTCGACTACATCGTTTTCGGAGCCACCGGCGACCTGACGATGCGCAAGCTGCT
GCCGGCGCTGTATTACCGCTATCGCGACGGGCAGATCCCCGACGAGGCCCGGATCATCGGCACCGCGCGTTCGCCGCTGT
CGCGGGCGGATTTCCAGGGCCGTGCCGAAAAGGCGCTGCATAACTTCGTCAAGCCCGCCGACCTGGACCCGGACACCGCG
CGCCGCTTCCTGGACCTGGTCCATTACGTCAGCCTGAACGGCGCCGAGGCCGACAGCACCTGGCCGGCGCTGAAGAGCCT
GCTGGCCGAAGCCCCCGCCGACCGCATCCGCGTCTACTACCTGGCGACGGCGCCGGGCCTGTATGGCCAGATCTGCGAGA
ACCTGAGCAACCAGGGCCTGGTGACCGAGCAGTCGCGCGTCGTGCTGGAAAAGCCGATCGGCACGGATCTGCAGAGCGCC
AATGCCATCAATGACGGGGTGGGCCGGCACTTCCCGGAAAACCACATCTTCCGCATCGACCACTACCTGGGCAAGGAAAC
CGTCCAGAACCTGATCGCGCTGCGCTTCGCCAATCCGGTGTTCGAGCGGCTGTGGTCCAGCGACGCGATCGAATACGTCC
AGATCACGGCGGCCGAGACCGTGGGCGTCGAGGGCCGCGGCCCGTATTATGACAAGTCCGGTGCCCTGCGCGACATGATC
CAGAACCATCTGCTGCAGGTGCTGTGCCTGGTGGCAATGGACCCGCCCGGCTCGCTGGAAGCCGACAGCCTGCGCAACGA
GAAGCTGAAGGTGCTGCACGCGCTGCGCCCCATCACGCCCGACGATGTCGCGACCTACACCGTGCGCGGCCAGTACACGT
GCGGCAAGGAAGGCGACAAGACGCTGGCGGGCTATCTGGAGGACCTGGGCGAAGATGCGACCAGCAGCACCGAGACCTTC
GTCGCCATCCGGGCCGAGGTGCATTCCTGGCGCTGGGGCGCCGTGCCGTTCTATCTGCGCTCGGGCAAGCGCATGGCCGA
GAAATGCAGCGAGATCGTCATCCAGTTCAAGGCCGCGCCCTGGTCGATCTTCGCCACCAAGCCTCCGGCGAACCGCCTGG
TCATCCGCATCCAGCCCGATGAAGGCGTGACGCTGTCGGTATCCACCAAGGACCCGACGCCCACCGACAGCCTGGCCCTG
CGGCAGGCGGATATCGACATCGCCTTCGAAAAAGCCTTCGGTACCCGCTATCCGGATTCGTACGAGCGCCTGCTGCTGGA
CGTCGTGCGCGGCGACCCGGTGCTGTTCATCCGCCGCGACGAGGTCGAGGCCGCGTGGCGCTGGGCCGACCCGATCCTGC
AGGGCTGGGCCGAGGACAAGGTGAAGCTGGAGCCCTACCCGGCCGGAAGCTGGGGCCCCGAGGCGGCCCGCGCCCTGCTG
GCACGCAGCGGCCACCAGTGGCACGAGGACATGGCGTAA

Upstream 100 bases:

>100_bases
CCACGGCAACGGGGCCGGCTTCTGCACGTCCGTGTGATACCCCCGATACCAAGCGCGACAACAAGTACAACAATCAAACA
CTTGCAGGAGGCCGCACCCG

Downstream 100 bases:

>100_bases
AAGAGCACGAACCTGATGGCTTCCCTGAACCCCAAGCCGGCGATGCGCCGCCCGCGCCTGACGATGCGCCAGCGCATTGT
CAGGCGCCTGTTGATGGTGG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MAQLPPVDIFDYIVFGATGDLTMRKLLPALYYRYRDGQIPDEARIIGTARSPLSRADFQGRAEKALHNFVKPADLDPDTA
RRFLDLVHYVSLNGAEADSTWPALKSLLAEAPADRIRVYYLATAPGLYGQICENLSNQGLVTEQSRVVLEKPIGTDLQSA
NAINDGVGRHFPENHIFRIDHYLGKETVQNLIALRFANPVFERLWSSDAIEYVQITAAETVGVEGRGPYYDKSGALRDMI
QNHLLQVLCLVAMDPPGSLEADSLRNEKLKVLHALRPITPDDVATYTVRGQYTCGKEGDKTLAGYLEDLGEDATSSTETF
VAIRAEVHSWRWGAVPFYLRSGKRMAEKCSEIVIQFKAAPWSIFATKPPANRLVIRIQPDEGVTLSVSTKDPTPTDSLAL
RQADIDIAFEKAFGTRYPDSYERLLLDVVRGDPVLFIRRDEVEAAWRWADPILQGWAEDKVKLEPYPAGSWGPEAARALL
ARSGHQWHEDMA

Sequences:

>Translated_492_residues
MAQLPPVDIFDYIVFGATGDLTMRKLLPALYYRYRDGQIPDEARIIGTARSPLSRADFQGRAEKALHNFVKPADLDPDTA
RRFLDLVHYVSLNGAEADSTWPALKSLLAEAPADRIRVYYLATAPGLYGQICENLSNQGLVTEQSRVVLEKPIGTDLQSA
NAINDGVGRHFPENHIFRIDHYLGKETVQNLIALRFANPVFERLWSSDAIEYVQITAAETVGVEGRGPYYDKSGALRDMI
QNHLLQVLCLVAMDPPGSLEADSLRNEKLKVLHALRPITPDDVATYTVRGQYTCGKEGDKTLAGYLEDLGEDATSSTETF
VAIRAEVHSWRWGAVPFYLRSGKRMAEKCSEIVIQFKAAPWSIFATKPPANRLVIRIQPDEGVTLSVSTKDPTPTDSLAL
RQADIDIAFEKAFGTRYPDSYERLLLDVVRGDPVLFIRRDEVEAAWRWADPILQGWAEDKVKLEPYPAGSWGPEAARALL
ARSGHQWHEDMA
>Mature_491_residues
AQLPPVDIFDYIVFGATGDLTMRKLLPALYYRYRDGQIPDEARIIGTARSPLSRADFQGRAEKALHNFVKPADLDPDTAR
RFLDLVHYVSLNGAEADSTWPALKSLLAEAPADRIRVYYLATAPGLYGQICENLSNQGLVTEQSRVVLEKPIGTDLQSAN
AINDGVGRHFPENHIFRIDHYLGKETVQNLIALRFANPVFERLWSSDAIEYVQITAAETVGVEGRGPYYDKSGALRDMIQ
NHLLQVLCLVAMDPPGSLEADSLRNEKLKVLHALRPITPDDVATYTVRGQYTCGKEGDKTLAGYLEDLGEDATSSTETFV
AIRAEVHSWRWGAVPFYLRSGKRMAEKCSEIVIQFKAAPWSIFATKPPANRLVIRIQPDEGVTLSVSTKDPTPTDSLALR
QADIDIAFEKAFGTRYPDSYERLLLDVVRGDPVLFIRRDEVEAAWRWADPILQGWAEDKVKLEPYPAGSWGPEAARALLA
RSGHQWHEDMA

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=486, Percent_Identity=37.4485596707819, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI108773793, Length=486, Percent_Identity=37.4485596707819, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI52145310, Length=493, Percent_Identity=29.8174442190669, Blast_Score=156, Evalue=4e-38,
Organism=Escherichia coli, GI1788158, Length=496, Percent_Identity=46.1693548387097, Blast_Score=444, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17538218, Length=486, Percent_Identity=35.1851851851852, Blast_Score=297, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6324088, Length=482, Percent_Identity=36.3070539419087, Blast_Score=283, Evalue=4e-77,
Organism=Drosophila melanogaster, GI24643350, Length=471, Percent_Identity=36.5180467091295, Blast_Score=298, Evalue=7e-81,
Organism=Drosophila melanogaster, GI24643352, Length=471, Percent_Identity=36.5180467091295, Blast_Score=298, Evalue=8e-81,
Organism=Drosophila melanogaster, GI221513548, Length=502, Percent_Identity=29.8804780876494, Blast_Score=201, Evalue=8e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54925; Mature: 54794

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLPPVDIFDYIVFGATGDLTMRKLLPALYYRYRDGQIPDEARIIGTARSPLSRADFQG
CCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHEEEECCCCCCHHHCCCC
RAEKALHNFVKPADLDPDTARRFLDLVHYVSLNGAEADSTWPALKSLLAEAPADRIRVYY
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEE
LATAPGLYGQICENLSNQGLVTEQSRVVLEKPIGTDLQSANAINDGVGRHFPENHIFRID
EEECCCHHHHHHHCCCCCCEEECCCCEEEECCCCCCCHHCCCHHCCCCCCCCCCCEEEEH
HYLGKETVQNLIALRFANPVFERLWSSDAIEYVQITAAETVGVEGRGPYYDKSGALRDMI
HHHCHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEEEEHHHCCCCCCCCCCCCCCHHHHHH
QNHLLQVLCLVAMDPPGSLEADSLRNEKLKVLHALRPITPDDVATYTVRGQYTCGKEGDK
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECEECCCCCCH
TLAGYLEDLGEDATSSTETFVAIRAEVHSWRWGAVPFYLRSGKRMAEKCSEIVIQFKAAP
HHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHCCHHHHHHHHHHHEEEECCC
WSIFATKPPANRLVIRIQPDEGVTLSVSTKDPTPTDSLALRQADIDIAFEKAFGTRYPDS
EEEEECCCCCCEEEEEEECCCCEEEEEECCCCCCCHHHEEEECCCCEEEEHHCCCCCCHH
YERLLLDVVRGDPVLFIRRDEVEAAWRWADPILQGWAEDKVKLEPYPAGSWGPEAARALL
HHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHH
ARSGHQWHEDMA
HHCCCCHHHCCC
>Mature Secondary Structure 
AQLPPVDIFDYIVFGATGDLTMRKLLPALYYRYRDGQIPDEARIIGTARSPLSRADFQG
CCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHEEEECCCCCCHHHCCCC
RAEKALHNFVKPADLDPDTARRFLDLVHYVSLNGAEADSTWPALKSLLAEAPADRIRVYY
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEE
LATAPGLYGQICENLSNQGLVTEQSRVVLEKPIGTDLQSANAINDGVGRHFPENHIFRID
EEECCCHHHHHHHCCCCCCEEECCCCEEEECCCCCCCHHCCCHHCCCCCCCCCCCEEEEH
HYLGKETVQNLIALRFANPVFERLWSSDAIEYVQITAAETVGVEGRGPYYDKSGALRDMI
HHHCHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEEEEHHHCCCCCCCCCCCCCCHHHHHH
QNHLLQVLCLVAMDPPGSLEADSLRNEKLKVLHALRPITPDDVATYTVRGQYTCGKEGDK
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECEECCCCCCH
TLAGYLEDLGEDATSSTETFVAIRAEVHSWRWGAVPFYLRSGKRMAEKCSEIVIQFKAAP
HHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHCCHHHHHHHHHHHEEEECCC
WSIFATKPPANRLVIRIQPDEGVTLSVSTKDPTPTDSLALRQADIDIAFEKAFGTRYPDS
EEEEECCCCCCEEEEEEECCCCEEEEEECCCCCCCHHHEEEECCCCEEEEHHCCCCCCHH
YERLLLDVVRGDPVLFIRRDEVEAAWRWADPILQGWAEDKVKLEPYPAGSWGPEAARALL
HHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHH
ARSGHQWHEDMA
HHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]