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The map label for this gene is obgE [H]

Identifier: 162148943

GI number: 162148943

Start: 3259895

End: 3261055

Strand: Direct

Name: obgE [H]

Synonym: GDI_3173

Alternate gene names: 162148943

Gene position: 3259895-3261055 (Clockwise)

Preceding gene: 162148942

Following gene: 162148944

Centisome position: 82.65

GC content: 70.46

Gene sequence:

>1161_bases
TTGCGTCATGGCGCGGCGTTGCACCCGCGCCGTGGCCGCACGATTTCACGGCATGCCCCACCGGCATGCCTGCACAGGGC
GCGCCTTCGCCCCGACCGGACCAGTACGATGAAATTTCTCGACCAGGCCAAGATCTACGTGAAGTCCGGTGACGGCGGCG
ACGGCGTCGTCGCCTTCCGGCGCGAGAAATACATCGAATTCGGCGGTCCGGACGGCGGCAATGGCGGGCGCGGCGGCGAC
ATCGTGTTCGAGGCCGCGGGCAACCTGAACACGCTGATCGATTTCCGCTACACCCAGCATTTCCGCGCCCGCAAGGGCGG
CAACGGGGCCGGGTCCGACCGGACGGGCGCGGCGGCCGCCCCGGTGCTGATCCAGGTCCCGGTGGGCACGCAGATCTTCG
ACGAGGACCGCGAGACGATGCTGGCGGACCTGGACCAGCCCGGCAAGCGCATCGTGCTGTGCCACGGCGGCGACGGCGGC
CGGGGCAACGCCCATTTCAAGACCAGCACCAACCGCGCCCCCCGCCGCGCGGACAAGGGCTGGCCGGGCGAGGAGCGCTG
GATCTGGCTGCGGCTGAAGCTGATCGCCGATGTCGGACTGGTCGGCCTGCCCAATGCCGGCAAGTCCACCTTCCTGTCGG
TCGTCTCGGCCGCGCGGCCCAAGATCGCGGATTATCCGTTCACCACCCTGCATCCGCAACTGGGCGTCGTGCGCCTGTCG
GTGGCCGAGGAATTCGTGATCGCGGACATTCCCGGCCTGATCGAGGGCGCGCACGAGGGCGCGGGGCTGGGCGACCGCTT
CCTGGGCCATGTCGAACGCTGCGCCGTGCTGCTGCACCTGGTCGACGGGGCGGCGGGCGACGTCGTGAAGGCGTGGCGCA
CCATCCGGCACGAACTGGAAGCCTATGATGGCGGGCTGGCCGCCAAGCCGGAAATCATCGCCCTGAACAAGATCGACGCC
ATGACGCCGCAGCAGATTTCCAGCCGCCGCCGCGCGCTGGAAAAGGCCAGCGGCATGCCGGTCGTCACCCTATCCGGCGT
CACGCGGCAGAATCTGGACGACGTGCTGCGCCTGCTGCAGGACCGCGTGACCGCGACCCGCGAGGCCGCGCGCGACGCGG
CCCCGCCGCAGGCCGCGGCCGGGCGGGAGGAAACGGCGTGA

Upstream 100 bases:

>100_bases
GTGTCGGTCGAGGCGTTGCCGGTCGCCGCCGAGTAAGCTTTCCCGCTTCTCGGGACCGTTTTCGACCCCGCAAAGGGCCG
GTCCTCGGGACCGGCCCTTT

Downstream 100 bases:

>100_bases
CCGCCCCCGAATCCACCGGCCTGCCCGACCTGGGCGCCGCCCGCCGCGTCGTCGTGAAGATCGGCAGCGCGCTGGTCGTG
GATTCGGGGACCGAGCCCGG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MRHGAALHPRRGRTISRHAPPACLHRARLRPDRTSTMKFLDQAKIYVKSGDGGDGVVAFRREKYIEFGGPDGGNGGRGGD
IVFEAAGNLNTLIDFRYTQHFRARKGGNGAGSDRTGAAAAPVLIQVPVGTQIFDEDRETMLADLDQPGKRIVLCHGGDGG
RGNAHFKTSTNRAPRRADKGWPGEERWIWLRLKLIADVGLVGLPNAGKSTFLSVVSAARPKIADYPFTTLHPQLGVVRLS
VAEEFVIADIPGLIEGAHEGAGLGDRFLGHVERCAVLLHLVDGAAGDVVKAWRTIRHELEAYDGGLAAKPEIIALNKIDA
MTPQQISSRRRALEKASGMPVVTLSGVTRQNLDDVLRLLQDRVTATREAARDAAPPQAAAGREETA

Sequences:

>Translated_386_residues
MRHGAALHPRRGRTISRHAPPACLHRARLRPDRTSTMKFLDQAKIYVKSGDGGDGVVAFRREKYIEFGGPDGGNGGRGGD
IVFEAAGNLNTLIDFRYTQHFRARKGGNGAGSDRTGAAAAPVLIQVPVGTQIFDEDRETMLADLDQPGKRIVLCHGGDGG
RGNAHFKTSTNRAPRRADKGWPGEERWIWLRLKLIADVGLVGLPNAGKSTFLSVVSAARPKIADYPFTTLHPQLGVVRLS
VAEEFVIADIPGLIEGAHEGAGLGDRFLGHVERCAVLLHLVDGAAGDVVKAWRTIRHELEAYDGGLAAKPEIIALNKIDA
MTPQQISSRRRALEKASGMPVVTLSGVTRQNLDDVLRLLQDRVTATREAARDAAPPQAAAGREETA
>Mature_386_residues
MRHGAALHPRRGRTISRHAPPACLHRARLRPDRTSTMKFLDQAKIYVKSGDGGDGVVAFRREKYIEFGGPDGGNGGRGGD
IVFEAAGNLNTLIDFRYTQHFRARKGGNGAGSDRTGAAAAPVLIQVPVGTQIFDEDRETMLADLDQPGKRIVLCHGGDGG
RGNAHFKTSTNRAPRRADKGWPGEERWIWLRLKLIADVGLVGLPNAGKSTFLSVVSAARPKIADYPFTTLHPQLGVVRLS
VAEEFVIADIPGLIEGAHEGAGLGDRFLGHVERCAVLLHLVDGAAGDVVKAWRTIRHELEAYDGGLAAKPEIIALNKIDA
MTPQQISSRRRALEKASGMPVVTLSGVTRQNLDDVLRLLQDRVTATREAARDAAPPQAAAGREETA

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=333, Percent_Identity=40.5405405405405, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI111955139, Length=293, Percent_Identity=39.2491467576792, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI111955063, Length=139, Percent_Identity=45.3237410071942, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI58761500, Length=150, Percent_Identity=31.3333333333333, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4758796, Length=127, Percent_Identity=36.2204724409449, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI4557537, Length=106, Percent_Identity=35.8490566037736, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1789574, Length=305, Percent_Identity=53.7704918032787, Blast_Score=282, Evalue=2e-77,
Organism=Escherichia coli, GI1787454, Length=102, Percent_Identity=39.2156862745098, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=328, Percent_Identity=38.109756097561, Blast_Score=177, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17552324, Length=343, Percent_Identity=30.9037900874636, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17509631, Length=134, Percent_Identity=34.3283582089552, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17555344, Length=115, Percent_Identity=33.0434782608696, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321962, Length=192, Percent_Identity=39.0625, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319281, Length=123, Percent_Identity=34.1463414634146, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI20129375, Length=365, Percent_Identity=36.1643835616438, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24585318, Length=330, Percent_Identity=36.3636363636364, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24640873, Length=100, Percent_Identity=35, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24640877, Length=100, Percent_Identity=35, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24640875, Length=100, Percent_Identity=35, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17981711, Length=136, Percent_Identity=31.6176470588235, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 41560; Mature: 41560

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHGAALHPRRGRTISRHAPPACLHRARLRPDRTSTMKFLDQAKIYVKSGDGGDGVVAFR
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCEEEEEECCCCCCEEEEE
REKYIEFGGPDGGNGGRGGDIVFEAAGNLNTLIDFRYTQHFRARKGGNGAGSDRTGAAAA
EECEEECCCCCCCCCCCCCCEEEEECCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCCC
PVLIQVPVGTQIFDEDRETMLADLDQPGKRIVLCHGGDGGRGNAHFKTSTNRAPRRADKG
CEEEEECCCCHHHHCHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCC
WPGEERWIWLRLKLIADVGLVGLPNAGKSTFLSVVSAARPKIADYPFTTLHPQLGVVRLS
CCCCCCEEEEEEEEHHCCCCEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEE
VAEEFVIADIPGLIEGAHEGAGLGDRFLGHVERCAVLLHLVDGAAGDVVKAWRTIRHELE
HHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AYDGGLAAKPEIIALNKIDAMTPQQISSRRRALEKASGMPVVTLSGVTRQNLDDVLRLLQ
HHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHH
DRVTATREAARDAAPPQAAAGREETA
HHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRHGAALHPRRGRTISRHAPPACLHRARLRPDRTSTMKFLDQAKIYVKSGDGGDGVVAFR
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCEEEEEECCCCCCEEEEE
REKYIEFGGPDGGNGGRGGDIVFEAAGNLNTLIDFRYTQHFRARKGGNGAGSDRTGAAAA
EECEEECCCCCCCCCCCCCCEEEEECCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCCC
PVLIQVPVGTQIFDEDRETMLADLDQPGKRIVLCHGGDGGRGNAHFKTSTNRAPRRADKG
CEEEEECCCCHHHHCHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCC
WPGEERWIWLRLKLIADVGLVGLPNAGKSTFLSVVSAARPKIADYPFTTLHPQLGVVRLS
CCCCCCEEEEEEEEHHCCCCEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEE
VAEEFVIADIPGLIEGAHEGAGLGDRFLGHVERCAVLLHLVDGAAGDVVKAWRTIRHELE
HHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AYDGGLAAKPEIIALNKIDAMTPQQISSRRRALEKASGMPVVTLSGVTRQNLDDVLRLLQ
HHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHH
DRVTATREAARDAAPPQAAAGREETA
HHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA