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The map label for this gene is guaA [H]

Identifier: 162148917

GI number: 162148917

Start: 3236403

End: 3238091

Strand: Reverse

Name: guaA [H]

Synonym: GDI_3147

Alternate gene names: 162148917

Gene position: 3238091-3236403 (Counterclockwise)

Preceding gene: 162148922

Following gene: 162148916

Centisome position: 82.1

GC content: 67.26

Gene sequence:

>1689_bases
TTGCATGGCCCGCCCGGCCCGTGCAGCACGCCCCGTGACCGTAATGCCGCGACCGAAAGAACGATGATGAGCGATAAAGT
GAAGAGTGCCGGACCCGCCCAGACCGCCCCCCAGGACGTCGCCGCCCTGGAAGGTGCCCTGCATCAGGACCGGGTCCTGA
TCCTGGATTTCGGCAGCCAGGTCACGCAGCTGATCGCCCGTCGCGTGCGCGAAAGCGGCGTGTATTGCGAAATCTGGCCG
TTTTCGACGGACGAGGCCAAAATTCGCGCCTTCGCCCCGCGCGGCATCATCCTGTCCGGCGGTCCGGCCAGCGTGCTGGA
CGAGAAGGCGCCGCGCATCCCCGACGTGGTGTTCGCGCTCGGCGTGCCGGTGCTGGGCATCTGCTACGGGCAGCAGGCGC
TGTGTCATCAGTTGGGCGGCGCGGTGGAAACGCATGAACATCGCGAATTCGGGCGGGCGCATATCGACATCATCGAGGAT
TGCGCCCTGTTCCGCGGCACCTGGGCGCGTGGCGGGCGTGAACAGGTGTGGATGAGCCACGGCGACCGGGTCACGAAGCT
GCCGCCCGGATTTCGCTCGGTCGCGGTCAGCGAGGGCGCGCCCTTCGCCATCATCGCGGACGAGGGGCGGCGCCTGTACG
GCGTGCAGTTCCATCCCGAGGTGGTGCATACGCCCCATGGGGCGGCGCTGCTGCGCAACTTCACCCATGACGTGGTGGGC
TGCCGGGGCATCTGGACCATGGCCGGCTTCCGCGACATGGAAATCGCCCGCATCCGCGAACAGGTCGGTTCGGGCCACGT
GATCTGCGGCCTGTCGGGCGGTGTCGATTCCTCGGTCGCCGCAGTGCTGATTCACGAGGCGATCGGCGACCAGTTGACCT
GCATCTTCGTCGATCCGGGCATCCTGCGTGCCGGAGAGGCCGAGGAGGTGGTCAAGACCTTCCGCGGCCGCTTCAACATC
AAGCTGGTCCATCGCGATGCGTCGGACCTGTTCCTGTCGGCCCTGGAGGGCGTCACGGACCCGGAAATCAAGCGCAAGAC
GATCGGCCGCCTGTTCGTCGAGGTGTTCGAGGAACAGGCCGCGAAGCTGGGCGGCGCGGACTTCCTGGCCCAGGGCACGC
TGTATCCGGACGTGATCGAAAGCGTCAGCTTCACCGGCGGCCCGTCGGTGACGATCAAGTCGCATCACAATGTCGGCGGC
CTGCCCGATCGGATGAAGATGCAGTTGGTCGAGCCGCTGCGCGAACTGTTCAAGGACGAGGTCCGCGAACTGGGGCGTGA
ACTGGGCATCCCCGAGGCCATAGTCGGCCGCCACCCGTTCCCCGGCCCGGGCCTGGCCATCCGCATCCCGGGCGCGGTGG
ATCGCGACAAGCTGGCGCTGCTGCGCCGGGTGGACACGATCTTCCTGGAGGAAATCCGCGGTGCCGGCCTGTATGACGCG
ATCTGGCAGGCCTTCGCGGTGCTGCTGCCGGTCCGCACCGTCGGCGTGATGGGCGATGGCCGCACCTACGACTATGCCTG
CGCGCTGCGCGCCGTCACCAGCACCGACGGCATGACGGCCGACGTCTTTCCCTTCGACATCGGCTTCCTGAACCGCGTCG
CCAGCCGCATCGTCAACGAGGTCCAGGGCGTGAACCGCGTGACCTACGACATCACCTCGAAGCCGCCTGGCACGATCGAG
TGGGAGTGA

Upstream 100 bases:

>100_bases
GGGGAACGGCCCCCAATATGGGCCCGGGCGGCGCGGCGGGCCATAGGGTCCCGGCCGGCGCGGTCTTGCGCTATACTCGG
CATCGACGCATATCCCGCGC

Downstream 100 bases:

>100_bases
ACTAGGGTGGTTTCAGACCATCCCGCGCCGTGTCTGACATCGCGCGAACTCTCTGACTGACAAGGATTATTTTTCCCACC
CCGTATCACTGCATGTCACC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MHGPPGPCSTPRDRNAATERTMMSDKVKSAGPAQTAPQDVAALEGALHQDRVLILDFGSQVTQLIARRVRESGVYCEIWP
FSTDEAKIRAFAPRGIILSGGPASVLDEKAPRIPDVVFALGVPVLGICYGQQALCHQLGGAVETHEHREFGRAHIDIIED
CALFRGTWARGGREQVWMSHGDRVTKLPPGFRSVAVSEGAPFAIIADEGRRLYGVQFHPEVVHTPHGAALLRNFTHDVVG
CRGIWTMAGFRDMEIARIREQVGSGHVICGLSGGVDSSVAAVLIHEAIGDQLTCIFVDPGILRAGEAEEVVKTFRGRFNI
KLVHRDASDLFLSALEGVTDPEIKRKTIGRLFVEVFEEQAAKLGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGG
LPDRMKMQLVEPLRELFKDEVRELGRELGIPEAIVGRHPFPGPGLAIRIPGAVDRDKLALLRRVDTIFLEEIRGAGLYDA
IWQAFAVLLPVRTVGVMGDGRTYDYACALRAVTSTDGMTADVFPFDIGFLNRVASRIVNEVQGVNRVTYDITSKPPGTIE
WE

Sequences:

>Translated_562_residues
MHGPPGPCSTPRDRNAATERTMMSDKVKSAGPAQTAPQDVAALEGALHQDRVLILDFGSQVTQLIARRVRESGVYCEIWP
FSTDEAKIRAFAPRGIILSGGPASVLDEKAPRIPDVVFALGVPVLGICYGQQALCHQLGGAVETHEHREFGRAHIDIIED
CALFRGTWARGGREQVWMSHGDRVTKLPPGFRSVAVSEGAPFAIIADEGRRLYGVQFHPEVVHTPHGAALLRNFTHDVVG
CRGIWTMAGFRDMEIARIREQVGSGHVICGLSGGVDSSVAAVLIHEAIGDQLTCIFVDPGILRAGEAEEVVKTFRGRFNI
KLVHRDASDLFLSALEGVTDPEIKRKTIGRLFVEVFEEQAAKLGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGG
LPDRMKMQLVEPLRELFKDEVRELGRELGIPEAIVGRHPFPGPGLAIRIPGAVDRDKLALLRRVDTIFLEEIRGAGLYDA
IWQAFAVLLPVRTVGVMGDGRTYDYACALRAVTSTDGMTADVFPFDIGFLNRVASRIVNEVQGVNRVTYDITSKPPGTIE
WE
>Mature_562_residues
MHGPPGPCSTPRDRNAATERTMMSDKVKSAGPAQTAPQDVAALEGALHQDRVLILDFGSQVTQLIARRVRESGVYCEIWP
FSTDEAKIRAFAPRGIILSGGPASVLDEKAPRIPDVVFALGVPVLGICYGQQALCHQLGGAVETHEHREFGRAHIDIIED
CALFRGTWARGGREQVWMSHGDRVTKLPPGFRSVAVSEGAPFAIIADEGRRLYGVQFHPEVVHTPHGAALLRNFTHDVVG
CRGIWTMAGFRDMEIARIREQVGSGHVICGLSGGVDSSVAAVLIHEAIGDQLTCIFVDPGILRAGEAEEVVKTFRGRFNI
KLVHRDASDLFLSALEGVTDPEIKRKTIGRLFVEVFEEQAAKLGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGG
LPDRMKMQLVEPLRELFKDEVRELGRELGIPEAIVGRHPFPGPGLAIRIPGAVDRDKLALLRRVDTIFLEEIRGAGLYDA
IWQAFAVLLPVRTVGVMGDGRTYDYACALRAVTSTDGMTADVFPFDIGFLNRVASRIVNEVQGVNRVTYDITSKPPGTIE
WE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=555, Percent_Identity=37.4774774774775, Blast_Score=316, Evalue=5e-86,
Organism=Escherichia coli, GI1788854, Length=521, Percent_Identity=57.9654510556622, Blast_Score=613, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI71992717, Length=616, Percent_Identity=36.8506493506493, Blast_Score=311, Evalue=6e-85,
Organism=Caenorhabditis elegans, GI71992710, Length=571, Percent_Identity=38.1786339754816, Blast_Score=310, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI133901714, Length=571, Percent_Identity=38.1786339754816, Blast_Score=308, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6323873, Length=520, Percent_Identity=54.2307692307692, Blast_Score=553, Evalue=1e-158,
Organism=Drosophila melanogaster, GI281365319, Length=556, Percent_Identity=37.410071942446, Blast_Score=295, Evalue=4e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 61182; Mature: 61182

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGPPGPCSTPRDRNAATERTMMSDKVKSAGPAQTAPQDVAALEGALHQDRVLILDFGSQ
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEECCHH
VTQLIARRVRESGVYCEIWPFSTDEAKIRAFAPRGIILSGGPASVLDEKAPRIPDVVFAL
HHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCEEECCCCHHHHHCCCCCCCHHHHHH
GVPVLGICYGQQALCHQLGGAVETHEHREFGRAHIDIIEDCALFRGTWARGGREQVWMSH
HHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHCHHCCCCCCHHHHCC
GDRVTKLPPGFRSVAVSEGAPFAIIADEGRRLYGVQFHPEVVHTPHGAALLRNFTHDVVG
CCEEEECCCCHHHEEECCCCCEEEEECCCCEEEEEEECCCCEECCCHHHHHHHHHHHHHC
CRGIWTMAGFRDMEIARIREQVGSGHVICGLSGGVDSSVAAVLIHEAIGDQLTCIFVDPG
CCHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCC
ILRAGEAEEVVKTFRGRFNIKLVHRDASDLFLSALEGVTDPEIKRKTIGRLFVEVFEEQA
CCCCCCHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
AKLGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPDRMKMQLVEPLRELFKDE
HHCCCCHHHHCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
VRELGRELGIPEAIVGRHPFPGPGLAIRIPGAVDRDKLALLRRVDTIFLEEIRGAGLYDA
HHHHHHHCCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHH
IWQAFAVLLPVRTVGVMGDGRTYDYACALRAVTSTDGMTADVFPFDIGFLNRVASRIVNE
HHHHHHHHHHHHHHEECCCCCCCHHHHHEEEECCCCCCEEECCCCHHHHHHHHHHHHHHH
VQGVNRVTYDITSKPPGTIEWE
HHCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MHGPPGPCSTPRDRNAATERTMMSDKVKSAGPAQTAPQDVAALEGALHQDRVLILDFGSQ
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEECCHH
VTQLIARRVRESGVYCEIWPFSTDEAKIRAFAPRGIILSGGPASVLDEKAPRIPDVVFAL
HHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCEEECCCCHHHHHCCCCCCCHHHHHH
GVPVLGICYGQQALCHQLGGAVETHEHREFGRAHIDIIEDCALFRGTWARGGREQVWMSH
HHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHCHHCCCCCCHHHHCC
GDRVTKLPPGFRSVAVSEGAPFAIIADEGRRLYGVQFHPEVVHTPHGAALLRNFTHDVVG
CCEEEECCCCHHHEEECCCCCEEEEECCCCEEEEEEECCCCEECCCHHHHHHHHHHHHHC
CRGIWTMAGFRDMEIARIREQVGSGHVICGLSGGVDSSVAAVLIHEAIGDQLTCIFVDPG
CCHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCC
ILRAGEAEEVVKTFRGRFNIKLVHRDASDLFLSALEGVTDPEIKRKTIGRLFVEVFEEQA
CCCCCCHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
AKLGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPDRMKMQLVEPLRELFKDE
HHCCCCHHHHCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
VRELGRELGIPEAIVGRHPFPGPGLAIRIPGAVDRDKLALLRRVDTIFLEEIRGAGLYDA
HHHHHHHCCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHH
IWQAFAVLLPVRTVGVMGDGRTYDYACALRAVTSTDGMTADVFPFDIGFLNRVASRIVNE
HHHHHHHHHHHHHHEECCCCCCCHHHHHEEEECCCCCCEEECCCCHHHHHHHHHHHHHHH
VQGVNRVTYDITSKPPGTIEWE
HHCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA