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The map label for this gene is manB [H]

Identifier: 162148911

GI number: 162148911

Start: 3229895

End: 3231367

Strand: Direct

Name: manB [H]

Synonym: GDI_3141

Alternate gene names: 162148911

Gene position: 3229895-3231367 (Clockwise)

Preceding gene: 162148910

Following gene: 162148912

Centisome position: 81.89

GC content: 69.99

Gene sequence:

>1473_bases
ATGAAAATAGCCCAGTGGATGACGCAGTCGGGCGTCGCGTTCGGCACCAGCGGCGCGCGCGGCCTCGTCACCGCCATGAC
GGATGCGGTCTGCTTCGCCTACACCGTGGGTTATCTGAAGCATCTGGCGACCCTGGGCGAATTTTCCCCCGGCACCCCGG
TCGCCGTCGCGGGCGACCTGCGTCCCAGCACGCCCCGCATCGTCCGCGCCTGCGTCGCCGCGATCCGCTCCATGCGGGGC
GAGCCGGTATTCTGCGGCTTCGTTCCCACGCCCGCGCTGTGCGTGCATGCCTTTGCGCGCGGCATTCCCTCGCTGATGGT
CACGGGCAGCCATATCCCGGCCGACCGCAACGGCATCAAGTTCAACCGCGCGCATGGCGAATTCCTCAAGACCGACGAGG
CCGCGATGCGGGAACAGGATGTCGAACTGCCCGAAGGCTGGTTCGATGCCGACGGCGCGCTCGCGATTGCCGCCGACCTG
CCCGCGATCACCGACGTGGTTCCCCCCTTCGTCGCCCGCTACCGCGATTTCTTCGGCCCGGACGCCCTGTCGGGCCTGAC
GCTGGGCGTGTACCAGCATTCCGCCGTCGGCCGCGACGTGCTGGTGGACATCGTCGAGGCGCTGGGCGGCAAGGCCGTGC
CGCTGGGGCGGATGGACAGTTTCATCCCCGTCGATACCGAGGCCGTGCGCCCCGAGGATGCCGCCCTGGCCCGCGACTGG
GCCGCCGCCGGCACGCTGGACGCCATCCTGACCACCGATGGCGATTCCGACCGGCCGCTGCTGGCCGACCGCGCCGGGAA
CTGGCTGCGCGGCGACGTGCTGGGCATCCTGGCCGCACGCTTCCTGAACGCGGCCGCCGTGACCACGCCCGTCAGCAGCA
ACACGGCGCTGGAACTGTCCGGCTTCGCGAAAGAGGTCCGCCGCACCCGTATCGGTTCCCCCTTCGTCGTGGCCGCGATG
ACCGAGGCCGCCGAGGCCGGGCTCGTGCCCTCGGTGGGCTACGAAGCCAATGGCGGGTTCCTGCTGGCCAGCGACGTGAC
GCGCTACGGCCGTACGCTTGCCGCCCTGCCGACGCGCGATTCCGTCCTGCCCATGATCTGCGCGCTGGTCGCCGCCCGCG
AGCAGGGCCGCGATCTCGATGCCCTGGTCGCCACCCTGCCCCCGCGCTTCACCCTCAGCGACCGCCTGGTCGAAATGCCG
ACGGCGCAGAGCCAGGCGCAGATAGCGAAACTCGGCGAGGACCCCGAAGGCGGCGCGGCGGCGCTGGGCTTCACCGAAGC
ATGCGGCCCCCTCCATCACGTGGACAAGACCGACGGCCTGCGGATGATTTTCGCCAATGGCGAGATCATCCACCTCCGCC
CTTCTGGCAATGCACCGGAACTGCGCGTCTACGTCGAAGCCGACAGCCCCGAACGGGCCGATGAACTGCTGAAGACCGGA
CTGGCCGCCGTCAGCACGTGGCGGCAAGGCTGA

Upstream 100 bases:

>100_bases
AGTTCACGCTTGCGCCCGGGATGGAAGTCCTGCTGATTTAGCGCACGAAAAACGGAACGGACGCCCGTTCGAACGGCGTC
GCAACGGCGGGAAAGACCTC

Downstream 100 bases:

>100_bases
AGCCCCCACCAGCGATCCGGACGGCATATCCGGTCCGGATCACGACTTCAGGAGCGCGCAAAAGAGTATCAGCGGCCAGA
GGAAAACGACCTAGACGCCC

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MKIAQWMTQSGVAFGTSGARGLVTAMTDAVCFAYTVGYLKHLATLGEFSPGTPVAVAGDLRPSTPRIVRACVAAIRSMRG
EPVFCGFVPTPALCVHAFARGIPSLMVTGSHIPADRNGIKFNRAHGEFLKTDEAAMREQDVELPEGWFDADGALAIAADL
PAITDVVPPFVARYRDFFGPDALSGLTLGVYQHSAVGRDVLVDIVEALGGKAVPLGRMDSFIPVDTEAVRPEDAALARDW
AAAGTLDAILTTDGDSDRPLLADRAGNWLRGDVLGILAARFLNAAAVTTPVSSNTALELSGFAKEVRRTRIGSPFVVAAM
TEAAEAGLVPSVGYEANGGFLLASDVTRYGRTLAALPTRDSVLPMICALVAAREQGRDLDALVATLPPRFTLSDRLVEMP
TAQSQAQIAKLGEDPEGGAAALGFTEACGPLHHVDKTDGLRMIFANGEIIHLRPSGNAPELRVYVEADSPERADELLKTG
LAAVSTWRQG

Sequences:

>Translated_490_residues
MKIAQWMTQSGVAFGTSGARGLVTAMTDAVCFAYTVGYLKHLATLGEFSPGTPVAVAGDLRPSTPRIVRACVAAIRSMRG
EPVFCGFVPTPALCVHAFARGIPSLMVTGSHIPADRNGIKFNRAHGEFLKTDEAAMREQDVELPEGWFDADGALAIAADL
PAITDVVPPFVARYRDFFGPDALSGLTLGVYQHSAVGRDVLVDIVEALGGKAVPLGRMDSFIPVDTEAVRPEDAALARDW
AAAGTLDAILTTDGDSDRPLLADRAGNWLRGDVLGILAARFLNAAAVTTPVSSNTALELSGFAKEVRRTRIGSPFVVAAM
TEAAEAGLVPSVGYEANGGFLLASDVTRYGRTLAALPTRDSVLPMICALVAAREQGRDLDALVATLPPRFTLSDRLVEMP
TAQSQAQIAKLGEDPEGGAAALGFTEACGPLHHVDKTDGLRMIFANGEIIHLRPSGNAPELRVYVEADSPERADELLKTG
LAAVSTWRQG
>Mature_490_residues
MKIAQWMTQSGVAFGTSGARGLVTAMTDAVCFAYTVGYLKHLATLGEFSPGTPVAVAGDLRPSTPRIVRACVAAIRSMRG
EPVFCGFVPTPALCVHAFARGIPSLMVTGSHIPADRNGIKFNRAHGEFLKTDEAAMREQDVELPEGWFDADGALAIAADL
PAITDVVPPFVARYRDFFGPDALSGLTLGVYQHSAVGRDVLVDIVEALGGKAVPLGRMDSFIPVDTEAVRPEDAALARDW
AAAGTLDAILTTDGDSDRPLLADRAGNWLRGDVLGILAARFLNAAAVTTPVSSNTALELSGFAKEVRRTRIGSPFVVAAM
TEAAEAGLVPSVGYEANGGFLLASDVTRYGRTLAALPTRDSVLPMICALVAAREQGRDLDALVATLPPRFTLSDRLVEMP
TAQSQAQIAKLGEDPEGGAAALGFTEACGPLHHVDKTDGLRMIFANGEIIHLRPSGNAPELRVYVEADSPERADELLKTG
LAAVSTWRQG

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS group C2 O antigen [H]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.8 [H]

Molecular weight: Translated: 51685; Mature: 51685

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAQWMTQSGVAFGTSGARGLVTAMTDAVCFAYTVGYLKHLATLGEFSPGTPVAVAGDL
CCHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCC
RPSTPRIVRACVAAIRSMRGEPVFCGFVPTPALCVHAFARGIPSLMVTGSHIPADRNGIK
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCE
FNRAHGEFLKTDEAAMREQDVELPEGWFDADGALAIAADLPAITDVVPPFVARYRDFFGP
EECCCCCHHCCCHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCC
DALSGLTLGVYQHSAVGRDVLVDIVEALGGKAVPLGRMDSFIPVDTEAVRPEDAALARDW
CHHCCCEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHH
AAAGTLDAILTTDGDSDRPLLADRAGNWLRGDVLGILAARFLNAAAVTTPVSSNTALELS
HHCCCEEEEEECCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCEEEHH
GFAKEVRRTRIGSPFVVAAMTEAAEAGLVPSVGYEANGGFLLASDVTRYGRTLAALPTRD
HHHHHHHHHHCCCCEEEEEHHHHHHCCCCCCCCCCCCCCEEEECCHHHHCCEEEECCCCC
SVLPMICALVAAREQGRDLDALVATLPPRFTLSDRLVEMPTAQSQAQIAKLGEDPEGGAA
CHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCEE
ALGFTEACGPLHHVDKTDGLRMIFANGEIIHLRPSGNAPELRVYVEADSPERADELLKTG
ECCHHHHCCCHHCCCCCCCEEEEEECCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHH
LAAVSTWRQG
HHHHHHHCCC
>Mature Secondary Structure
MKIAQWMTQSGVAFGTSGARGLVTAMTDAVCFAYTVGYLKHLATLGEFSPGTPVAVAGDL
CCHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCC
RPSTPRIVRACVAAIRSMRGEPVFCGFVPTPALCVHAFARGIPSLMVTGSHIPADRNGIK
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCE
FNRAHGEFLKTDEAAMREQDVELPEGWFDADGALAIAADLPAITDVVPPFVARYRDFFGP
EECCCCCHHCCCHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCC
DALSGLTLGVYQHSAVGRDVLVDIVEALGGKAVPLGRMDSFIPVDTEAVRPEDAALARDW
CHHCCCEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHH
AAAGTLDAILTTDGDSDRPLLADRAGNWLRGDVLGILAARFLNAAAVTTPVSSNTALELS
HHCCCEEEEEECCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCEEEHH
GFAKEVRRTRIGSPFVVAAMTEAAEAGLVPSVGYEANGGFLLASDVTRYGRTLAALPTRD
HHHHHHHHHHCCCCEEEEEHHHHHHCCCCCCCCCCCCCCEEEECCHHHHCCEEEECCCCC
SVLPMICALVAAREQGRDLDALVATLPPRFTLSDRLVEMPTAQSQAQIAKLGEDPEGGAA
CHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCEE
ALGFTEACGPLHHVDKTDGLRMIFANGEIIHLRPSGNAPELRVYVEADSPERADELLKTG
ECCHHHHCCCHHCCCCCCCEEEEEECCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHH
LAAVSTWRQG
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1379320 [H]