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The map label for this gene is emrY [H]

Identifier: 162148622

GI number: 162148622

Start: 2939187

End: 2940740

Strand: Direct

Name: emrY [H]

Synonym: GDI_2849

Alternate gene names: 162148622

Gene position: 2939187-2940740 (Clockwise)

Preceding gene: 162148621

Following gene: 162148623

Centisome position: 74.52

GC content: 65.44

Gene sequence:

>1554_bases
ATGACGTCCGAGATGCGAGGACAGCTTCTCACGGGCAGCTGCGGTGTCTGCGCGGCCTGGATGGTCATGATGTCGACGCG
GTTCTTCGCGCTGTCGCTGGCGGATATCGAAGGCGCGCTGGGGATCGGCCCGGATGAAGGGTCATGGCTGACCGCAGGGT
ATCTGGCCTTCGAGCCGGTCGGTGTCGGCCTGGGATGCTGGCTCGCCGTGATCTTCTCCCTGCGCCGGATCATGCTCCCC
GCGATCACGCTATTCGCGACCTCGTCCGCCATCGCGGCCATGACGCATGACCTGACAGTGATGATCCTGGCGCGATCGGG
CATGGGGCTCGCCGCCGGAATCATCATTCCGCTCGCCATCATCACCGAGTTGCGGACCTTCCCGCCGACATGGCGCGCGC
TGGCGATCGGGCTCTACGCCTCGGCGGCGACTATGGCGCCGCAGGCCGCCGCATCGCTGGATGTCTGGCTCGTCGAACAC
TGGGGAACGCCGGCGATCTTCTGGATTGCGATCCCGCTGGGAATGATCGCGTTCGTCTGCGGATATCTCGGGCTATGGCG
GGAGCGGATTCGCTGGCTGTTGTTTGCGCGTGCCGACCTGCGCGTGGTCACGCTGTTTTCAATGGGGGCCATTCTCCTTG
GCGGTGGCCTTACTCAGGGGAACCGGCTGCACTGGTCGGAGACGCCGCTGACCCTGTTCGCCGTCATCATGGGTGCAGCA
CTCCTGCTCGGAGCATTCTGGCTCGGGGGACGCCGGGTCGTTCACCCTATCCTGATGACGCGATTGCTGACCCGCCGCAA
TGCCCTGCTCGGCGCGCTGATCGCCATTCCCTATCAGTTCGCATCGGTCCTTTCCGGTGGTCTGGTACCGGCATTCCTCG
TCGATATCCCCGGTTACCGGCCAGAGCAGATCGCGCCGGTGCTGGATGCGGCGTTCTGGCCACAGGCCGTTGCGTACCCG
GCCTGCATCGTGACGCTGCGCTACGGATGGTTGGAAGCCCGGACCTTTCTCGTGTTGGGCTTCGGACTGAATGCACTGGC
CTGCCTGCTCGACCTCAACGTCACCAGTGACTGGATTCCCGACAATTTCGTCGTGGGGCAGATCCTCCAGGGGATCGGCC
TGCCGTGGATTCTCCTACCTTTGCTGATGCTGTTCGTGGGCGACGTGGTGCCGAGTGAGGGGCTTTATGCCGCCGCCATC
TTTAACGTGGCGCGCAGCCTTGCCGGCACCGTCGCGACCGCGTGGGCGGCAACCGGGCTGCGGCTGCGGGCCGAGGGACG
CTATGGCGAACTGCTCACCAGCACCGGCCTCCAGCCACACCATCGCACGCTCGCAGCGTGGGATGGCGTGAATGCCCTGC
CCTGGACGACGCCAGATCGGGTCCTGCTGGACCACCGTGCGCGATCGGTGGTCGGCGCACTCGTACGACACCAATCGATC
GTCATCGGCTTTTCGACGCTGCTGGCCGACCTCGCGCTGATGCTGGCCGCAACCTGTGTCATTGCTGCCTGCATGCCCCC
GGCCGGAGCCGATCGGCCGGAGGTGCGATCGTGA

Upstream 100 bases:

>100_bases
TCGTCATCGAGCCGGATCAGGCGGGCACCGACCTCCTGCGACCCGGTATGTCCTCACACGTCTCTGTGCGGACTCTCGTC
GCCATACGGAGAGACGCGCC

Downstream 100 bases:

>100_bases
ACATGACGCGCACGGCCTCCATTCTTGCACTCATCGTCATCGCCGGCTGCACCGTCGGGCCGGATTATGTCGCGCCCCAT
GCGGAGGCTCCACCCCAATG

Product: multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MTSEMRGQLLTGSCGVCAAWMVMMSTRFFALSLADIEGALGIGPDEGSWLTAGYLAFEPVGVGLGCWLAVIFSLRRIMLP
AITLFATSSAIAAMTHDLTVMILARSGMGLAAGIIIPLAIITELRTFPPTWRALAIGLYASAATMAPQAAASLDVWLVEH
WGTPAIFWIAIPLGMIAFVCGYLGLWRERIRWLLFARADLRVVTLFSMGAILLGGGLTQGNRLHWSETPLTLFAVIMGAA
LLLGAFWLGGRRVVHPILMTRLLTRRNALLGALIAIPYQFASVLSGGLVPAFLVDIPGYRPEQIAPVLDAAFWPQAVAYP
ACIVTLRYGWLEARTFLVLGFGLNALACLLDLNVTSDWIPDNFVVGQILQGIGLPWILLPLLMLFVGDVVPSEGLYAAAI
FNVARSLAGTVATAWAATGLRLRAEGRYGELLTSTGLQPHHRTLAAWDGVNALPWTTPDRVLLDHRARSVVGALVRHQSI
VIGFSTLLADLALMLAATCVIAACMPPAGADRPEVRS

Sequences:

>Translated_517_residues
MTSEMRGQLLTGSCGVCAAWMVMMSTRFFALSLADIEGALGIGPDEGSWLTAGYLAFEPVGVGLGCWLAVIFSLRRIMLP
AITLFATSSAIAAMTHDLTVMILARSGMGLAAGIIIPLAIITELRTFPPTWRALAIGLYASAATMAPQAAASLDVWLVEH
WGTPAIFWIAIPLGMIAFVCGYLGLWRERIRWLLFARADLRVVTLFSMGAILLGGGLTQGNRLHWSETPLTLFAVIMGAA
LLLGAFWLGGRRVVHPILMTRLLTRRNALLGALIAIPYQFASVLSGGLVPAFLVDIPGYRPEQIAPVLDAAFWPQAVAYP
ACIVTLRYGWLEARTFLVLGFGLNALACLLDLNVTSDWIPDNFVVGQILQGIGLPWILLPLLMLFVGDVVPSEGLYAAAI
FNVARSLAGTVATAWAATGLRLRAEGRYGELLTSTGLQPHHRTLAAWDGVNALPWTTPDRVLLDHRARSVVGALVRHQSI
VIGFSTLLADLALMLAATCVIAACMPPAGADRPEVRS
>Mature_516_residues
TSEMRGQLLTGSCGVCAAWMVMMSTRFFALSLADIEGALGIGPDEGSWLTAGYLAFEPVGVGLGCWLAVIFSLRRIMLPA
ITLFATSSAIAAMTHDLTVMILARSGMGLAAGIIIPLAIITELRTFPPTWRALAIGLYASAATMAPQAAASLDVWLVEHW
GTPAIFWIAIPLGMIAFVCGYLGLWRERIRWLLFARADLRVVTLFSMGAILLGGGLTQGNRLHWSETPLTLFAVIMGAAL
LLGAFWLGGRRVVHPILMTRLLTRRNALLGALIAIPYQFASVLSGGLVPAFLVDIPGYRPEQIAPVLDAAFWPQAVAYPA
CIVTLRYGWLEARTFLVLGFGLNALACLLDLNVTSDWIPDNFVVGQILQGIGLPWILLPLLMLFVGDVVPSEGLYAAAIF
NVARSLAGTVATAWAATGLRLRAEGRYGELLTSTGLQPHHRTLAAWDGVNALPWTTPDRVLLDHRARSVVGALVRHQSIV
IGFSTLLADLALMLAATCVIAACMPPAGADRPEVRS

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=435, Percent_Identity=26.2068965517241, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1789042, Length=451, Percent_Identity=23.5033259423503, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55432; Mature: 55301

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSEMRGQLLTGSCGVCAAWMVMMSTRFFALSLADIEGALGIGPDEGSWLTAGYLAFEPV
CCCCCCCCEECCCCHHHHHHHHHHHHHHHHEEHHHCCCCCCCCCCCCCEEEECEEEECCC
GVGLGCWLAVIFSLRRIMLPAITLFATSSAIAAMTHDLTVMILARSGMGLAAGIIIPLAI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHH
ITELRTFPPTWRALAIGLYASAATMAPQAAASLDVWLVEHWGTPAIFWIAIPLGMIAFVC
HHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHH
GYLGLWRERIRWLLFARADLRVVTLFSMGAILLGGGLTQGNRLHWSETPLTLFAVIMGAA
HHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHH
LLLGAFWLGGRRVVHPILMTRLLTRRNALLGALIAIPYQFASVLSGGLVPAFLVDIPGYR
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCC
PEQIAPVLDAAFWPQAVAYPACIVTLRYGWLEARTFLVLGFGLNALACLLDLNVTSDWIP
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHEEHEEECCCHHHHHHHHCCCCCCCCCC
DNFVVGQILQGIGLPWILLPLLMLFVGDVVPSEGLYAAAIFNVARSLAGTVATAWAATGL
CCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCE
RLRAEGRYGELLTSTGLQPHHRTLAAWDGVNALPWTTPDRVLLDHRARSVVGALVRHQSI
EEEECCCCHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VIGFSTLLADLALMLAATCVIAACMPPAGADRPEVRS
EEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSEMRGQLLTGSCGVCAAWMVMMSTRFFALSLADIEGALGIGPDEGSWLTAGYLAFEPV
CCCCCCCEECCCCHHHHHHHHHHHHHHHHEEHHHCCCCCCCCCCCCCEEEECEEEECCC
GVGLGCWLAVIFSLRRIMLPAITLFATSSAIAAMTHDLTVMILARSGMGLAAGIIIPLAI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHH
ITELRTFPPTWRALAIGLYASAATMAPQAAASLDVWLVEHWGTPAIFWIAIPLGMIAFVC
HHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHH
GYLGLWRERIRWLLFARADLRVVTLFSMGAILLGGGLTQGNRLHWSETPLTLFAVIMGAA
HHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHH
LLLGAFWLGGRRVVHPILMTRLLTRRNALLGALIAIPYQFASVLSGGLVPAFLVDIPGYR
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCC
PEQIAPVLDAAFWPQAVAYPACIVTLRYGWLEARTFLVLGFGLNALACLLDLNVTSDWIP
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHEEHEEECCCHHHHHHHHCCCCCCCCCC
DNFVVGQILQGIGLPWILLPLLMLFVGDVVPSEGLYAAAIFNVARSLAGTVATAWAATGL
CCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCE
RLRAEGRYGELLTSTGLQPHHRTLAAWDGVNALPWTTPDRVLLDHRARSVVGALVRHQSI
EEEECCCCHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VIGFSTLLADLALMLAATCVIAACMPPAGADRPEVRS
EEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]