Click here to switch to the map view.

The map label for this gene is kefC [H]

Identifier: 162148363

GI number: 162148363

Start: 2673859

End: 2675592

Strand: Direct

Name: kefC [H]

Synonym: GDI_2580

Alternate gene names: 162148363

Gene position: 2673859-2675592 (Clockwise)

Preceding gene: 162148361

Following gene: 162148366

Centisome position: 67.79

GC content: 68.74

Gene sequence:

>1734_bases
ATGTCCCACGCCAGCCCCCTGATCACCATCCTGGTCGTCGGCCTGACATTGGCCTTCGTGCTGGGAATGCTGGCCAACCG
GCTGAAGATTTCGGTTCTGGTCGGCTACCTGCTGGCCGGTGTCGCGGTGGGGCCGTTCACGCCCGGTTTCGTCGCGGACC
AGGAACTGGCCCTGCAACTGGCCGATATCGGCGTCATCCTGCTGATGTTCGGGGTCGGGCTGCATTTTTCGGTCAAGGAC
CTGCTGGCCGTGCGCGCCATCGCCCTGCCCGGCACCCTGCTGCAGGTGGCGCTGTCCAGCCTGGCCGGCATGGGACTGGC
GCTGCTGATGGGCTGGACGGTACGGGCAGGGCTGGTCTTCGGCCTGGCGTTGAGCGTCGCCAGCACGGTCGTGCTGATGC
GCGCGCTGGACGAACAGCGGCTGATGGAAACCGAGCGCGGGCACCTGGCCATCGGGTGGCTGGTGATCCAGGACCTGGTG
ACCGTGCTGGTGCTGGTCATGCTGCCCGCGCTGGCCCCGGTGCTGAAGGACGGGGCCGCCCATGCGCCCACCCTGTGGGC
GCTGGCACTGACCCTGGCGCTGACCCTGGGCAAGGTCGCGGCGTTCATCGCGCTGATGCTGCTGGTCGGGCGCCGCGTCA
TTCCGGCGGCGCTGCATTACGTGGCGCGGATCGGATCGCGCGAACTGTTCCGCCTGGCGCTGCTGGCCGTGGCGCTGGGC
GTCGCCTTCATGGCGTCGGAACTGTTCGGCGTCTCCTTCGCGCTGGGGGCCTTCGTCGCGGGCATGGTGCTGAGCGAATC
CGCGCTCAGCCAGCACGCGGCGGAGGAAACCCTGCCGCTGCGCGACGCCTTCGCCGTGCTGTTCTTCATTTCCGTGGGCA
TGCTGTTCGAACCCACGACCCTGCTGCGTCACCCCGCCAGCCTGCTGGCCCCCCTGGCCGTCGTCTTCATCGTGACGCCG
GCCATCGTGTTCGTCACCCTCTGCATTCTGCGCCAGAGCCTGCGCACCGCGCTGACCATTGCCGCCGGATTGTCGCAGAT
CGGGGAATTCTCATTCATCCTGGCGACGCTGGGGGTCGATCTGGGATTGCTGGACGAATCGGCGCGCAGCCTGATCCTGG
CCGTCTCGATCCTGTCGATCCTGCTCAATCCCCTGGCCTTCCTGGCGGTCACCCTGCTGGCCCCGTGGGCGGAGAGGATC
GACGCCCTGCGCGCGGGACCACCCGGCGAAGCCGCGACGGTAGCCCATCCCAGCACCCTGCGCGGGCACGCCGTGGTCGT
GGGCTATGGCCGGGTGGGCGCGCTGGTGGTGGACGGGCTGCTGCACCAGGGCTGGCCGCTGCTGGTGATCGAAACCGGGG
ACATGGCGATGCAGCCCCTGCGCGATCGCGGGATCGAGACCATTCTGGGCAATGCCGCCGATCCCGCGGTCCTGGCCGCC
GCGAACATTCCCGAGGCCCGGCTGCTGGTCGTGGCAATCCCCGAGGCGTTCGAGGCCGGACAGGTGGTCGCGCAGGGCCG
CGCCGCCAATCCGTCCATCACCATCATCGCCCGCGCGCATTTCGACAGCGCGGTCGATCACCTGCACCATCTGGGCGCGG
ACGTCGTCATCATGGGCGAACGCGAAATTGCCCGGGCGATGCTGGACCATGCCGAACACGACATATCCCCTATCTCTCCG
GTACACGCCATGACGCGCGCCCTGCCGGAAATGGGCGGCGGCGCGGTGGCATAG

Upstream 100 bases:

>100_bases
TTTCGCATGCATCATGCCGGTTGTACAGTAAATAACGGTCCCGCCCCACAACCCCGGCCGACGTTCCGCCGTTGTTCCGG
TACCGCCAGGAGTACCGGCC

Downstream 100 bases:

>100_bases
CGCGGATCGGGATCAGGCTGCGAAAAACGCCGCCGTCGCCTGGGACAGCGCATGAAGGCCCGCGCCGCCGTTCCACACCA
TGCAGGCCGCCCAGGCGACG

Product: glutathione-regulated potassium-efflux system protein kefC (K(+)/H(+ antiporter)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 577; Mature: 576

Protein sequence:

>577_residues
MSHASPLITILVVGLTLAFVLGMLANRLKISVLVGYLLAGVAVGPFTPGFVADQELALQLADIGVILLMFGVGLHFSVKD
LLAVRAIALPGTLLQVALSSLAGMGLALLMGWTVRAGLVFGLALSVASTVVLMRALDEQRLMETERGHLAIGWLVIQDLV
TVLVLVMLPALAPVLKDGAAHAPTLWALALTLALTLGKVAAFIALMLLVGRRVIPAALHYVARIGSRELFRLALLAVALG
VAFMASELFGVSFALGAFVAGMVLSESALSQHAAEETLPLRDAFAVLFFISVGMLFEPTTLLRHPASLLAPLAVVFIVTP
AIVFVTLCILRQSLRTALTIAAGLSQIGEFSFILATLGVDLGLLDESARSLILAVSILSILLNPLAFLAVTLLAPWAERI
DALRAGPPGEAATVAHPSTLRGHAVVVGYGRVGALVVDGLLHQGWPLLVIETGDMAMQPLRDRGIETILGNAADPAVLAA
ANIPEARLLVVAIPEAFEAGQVVAQGRAANPSITIIARAHFDSAVDHLHHLGADVVIMGEREIARAMLDHAEHDISPISP
VHAMTRALPEMGGGAVA

Sequences:

>Translated_577_residues
MSHASPLITILVVGLTLAFVLGMLANRLKISVLVGYLLAGVAVGPFTPGFVADQELALQLADIGVILLMFGVGLHFSVKD
LLAVRAIALPGTLLQVALSSLAGMGLALLMGWTVRAGLVFGLALSVASTVVLMRALDEQRLMETERGHLAIGWLVIQDLV
TVLVLVMLPALAPVLKDGAAHAPTLWALALTLALTLGKVAAFIALMLLVGRRVIPAALHYVARIGSRELFRLALLAVALG
VAFMASELFGVSFALGAFVAGMVLSESALSQHAAEETLPLRDAFAVLFFISVGMLFEPTTLLRHPASLLAPLAVVFIVTP
AIVFVTLCILRQSLRTALTIAAGLSQIGEFSFILATLGVDLGLLDESARSLILAVSILSILLNPLAFLAVTLLAPWAERI
DALRAGPPGEAATVAHPSTLRGHAVVVGYGRVGALVVDGLLHQGWPLLVIETGDMAMQPLRDRGIETILGNAADPAVLAA
ANIPEARLLVVAIPEAFEAGQVVAQGRAANPSITIIARAHFDSAVDHLHHLGADVVIMGEREIARAMLDHAEHDISPISP
VHAMTRALPEMGGGAVA
>Mature_576_residues
SHASPLITILVVGLTLAFVLGMLANRLKISVLVGYLLAGVAVGPFTPGFVADQELALQLADIGVILLMFGVGLHFSVKDL
LAVRAIALPGTLLQVALSSLAGMGLALLMGWTVRAGLVFGLALSVASTVVLMRALDEQRLMETERGHLAIGWLVIQDLVT
VLVLVMLPALAPVLKDGAAHAPTLWALALTLALTLGKVAAFIALMLLVGRRVIPAALHYVARIGSRELFRLALLAVALGV
AFMASELFGVSFALGAFVAGMVLSESALSQHAAEETLPLRDAFAVLFFISVGMLFEPTTLLRHPASLLAPLAVVFIVTPA
IVFVTLCILRQSLRTALTIAAGLSQIGEFSFILATLGVDLGLLDESARSLILAVSILSILLNPLAFLAVTLLAPWAERID
ALRAGPPGEAATVAHPSTLRGHAVVVGYGRVGALVVDGLLHQGWPLLVIETGDMAMQPLRDRGIETILGNAADPAVLAAA
NIPEARLLVVAIPEAFEAGQVVAQGRAANPSITIIARAHFDSAVDHLHHLGADVVIMGEREIARAMLDHAEHDISPISPV
HAMTRALPEMGGGAVA

Specific function: Unknown

COG id: COG4651

COG function: function code P; Kef-type K+ transport system, predicted NAD-binding component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=411, Percent_Identity=27.2506082725061, Blast_Score=91, Evalue=4e-18,
Organism=Escherichia coli, GI1786685, Length=553, Percent_Identity=54.6112115732369, Blast_Score=542, Evalue=1e-155,
Organism=Escherichia coli, GI1786232, Length=549, Percent_Identity=30.0546448087432, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1789749, Length=500, Percent_Identity=29.8, Blast_Score=156, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 60288; Mature: 60157

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHASPLITILVVGLTLAFVLGMLANRLKISVLVGYLLAGVAVGPFTPGFVADQELALQL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
ADIGVILLMFGVGLHFSVKDLLAVRAIALPGTLLQVALSSLAGMGLALLMGWTVRAGLVF
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLALSVASTVVLMRALDEQRLMETERGHLAIGWLVIQDLVTVLVLVMLPALAPVLKDGAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HAPTLWALALTLALTLGKVAAFIALMLLVGRRVIPAALHYVARIGSRELFRLALLAVALG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
VAFMASELFGVSFALGAFVAGMVLSESALSQHAAEETLPLRDAFAVLFFISVGMLFEPTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHH
LLRHPASLLAPLAVVFIVTPAIVFVTLCILRQSLRTALTIAAGLSQIGEFSFILATLGVD
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LGLLDESARSLILAVSILSILLNPLAFLAVTLLAPWAERIDALRAGPPGEAATVAHPSTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
RGHAVVVGYGRVGALVVDGLLHQGWPLLVIETGDMAMQPLRDRGIETILGNAADPAVLAA
CCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCHHHHHCCCCCCCEEEE
ANIPEARLLVVAIPEAFEAGQVVAQGRAANPSITIIARAHFDSAVDHLHHLGADVVIMGE
CCCCCCEEEEEECCCHHCCCHHHHCCCCCCCCEEEEEECHHHHHHHHHHHCCCCEEEECC
REIARAMLDHAEHDISPISPVHAMTRALPEMGGGAVA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SHASPLITILVVGLTLAFVLGMLANRLKISVLVGYLLAGVAVGPFTPGFVADQELALQL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
ADIGVILLMFGVGLHFSVKDLLAVRAIALPGTLLQVALSSLAGMGLALLMGWTVRAGLVF
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLALSVASTVVLMRALDEQRLMETERGHLAIGWLVIQDLVTVLVLVMLPALAPVLKDGAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HAPTLWALALTLALTLGKVAAFIALMLLVGRRVIPAALHYVARIGSRELFRLALLAVALG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
VAFMASELFGVSFALGAFVAGMVLSESALSQHAAEETLPLRDAFAVLFFISVGMLFEPTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHH
LLRHPASLLAPLAVVFIVTPAIVFVTLCILRQSLRTALTIAAGLSQIGEFSFILATLGVD
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LGLLDESARSLILAVSILSILLNPLAFLAVTLLAPWAERIDALRAGPPGEAATVAHPSTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
RGHAVVVGYGRVGALVVDGLLHQGWPLLVIETGDMAMQPLRDRGIETILGNAADPAVLAA
CCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCHHHHHCCCCCCCEEEE
ANIPEARLLVVAIPEAFEAGQVVAQGRAANPSITIIARAHFDSAVDHLHHLGADVVIMGE
CCCCCCEEEEEECCCHHCCCHHHHCCCCCCCCEEEEEECHHHHHHHHHHHCCCCEEEECC
REIARAMLDHAEHDISPISPVHAMTRALPEMGGGAVA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 7721718 [H]