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The map label for this gene is pdhB [H]

Identifier: 162148288

GI number: 162148288

Start: 2599204

End: 2600193

Strand: Direct

Name: pdhB [H]

Synonym: GDI_2505

Alternate gene names: 162148288

Gene position: 2599204-2600193 (Clockwise)

Preceding gene: 162148287

Following gene: 162148289

Centisome position: 65.9

GC content: 68.48

Gene sequence:

>990_bases
ATGTTGGATAGCCATGGCCTGACAACCACCCGGATGTTCTTTCGCGAGGGCGTCGCGCGCGCCGTCCGCGAGGAAATGAC
GCGTGATCCCCGTATCCTGATCATGGGGCAGGACGTCGGGGCCTTCGGCGGTTCCTACCGGGAATTCGATGGGCTGTACC
CGATCTTCGGGCCCGGGCGCATTCGCGACACGCCGGTGGCGGAAGCCGCCACCATCGGAATTGCCGCCGGCGCCGCCGCC
GCCGGGTATCGCCCGCTGGTCAGCATCACCTACATGGATTTCCTGATGCTGGGTTTCGACGCGCTGATCAATTACGCGGC
CAAGCTGCGCTATAAATCGGCCGGGACCCTGACGGCGCCGCTGGTGGTGAAGACGACGGCCGGCGCGCACGGCCAGGGCG
TGGCCCATTCGCAATGCATCGAGGCCTGGCTGATGAGCGTCCCGGGCCTGACGGTCGTGGCGCCGGCCACCCCGGCCGAC
GCCTACGGGCTGATGAAGACGGCCCTGCGGCATGACGGGCCCGTCGTCTATATCGACCACAAGCGGCTGTTCCCCGCCCC
GGGCGAGGTGCCGGTGATCGAGGAACCGGTTCCCTTCGGGCAGGCCTGCGTCCGGCGCACGGGGCGGGACGTGACGCTGG
TCACCCATGGCTACATGGTCCAGGTGGCCCTGGAGGCGGCGCGCGCGCTCGAATACCAGGACATATCCTGCGAAGTCATC
GACCTGCGCAGCCTGGCGCCGCTGGACATCGGAACCGTGACGGCGTCCGTCGCGCGGACGGGGCGATTGCTGACCCTGGA
GGAAGGCCAGACCGTCTGCGGCGTCGGCGCCGAGGTGGCCAGCCAGATGTTCGAACGGATCGGCCCCAGGCCGTGGATCC
GCATCGGCGCCCTTCCCGCGCCCGTTTCATCGAATCCGGTTCTGGAGACGGCGTGCGTCCCCGATGCGGCACGCGTTGCC
CGAACCGTGTGCGCGCTTATGGCGCAATAG

Upstream 100 bases:

>100_bases
GATCTGGAGCGGATGCAGCAGCAGGCGACCAGCCGCGCGGCACAGGCCCTGGCCTATGCCGACGCCTCACCCTACCCGGA
CGCAGAGGAGGTCCTGCATC

Downstream 100 bases:

>100_bases
AGCAGATCGTGGTCGGGTGAAATCACCTCCACGTGAAGATGCTCGGAAAACAAAAGACTGGAGCAATTCAGCTGGTTCTA
TCCGATGACTGATTGCTCTA

Product: 2-oxoglutarate dehydrogenase E1 component beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MLDSHGLTTTRMFFREGVARAVREEMTRDPRILIMGQDVGAFGGSYREFDGLYPIFGPGRIRDTPVAEAATIGIAAGAAA
AGYRPLVSITYMDFLMLGFDALINYAAKLRYKSAGTLTAPLVVKTTAGAHGQGVAHSQCIEAWLMSVPGLTVVAPATPAD
AYGLMKTALRHDGPVVYIDHKRLFPAPGEVPVIEEPVPFGQACVRRTGRDVTLVTHGYMVQVALEAARALEYQDISCEVI
DLRSLAPLDIGTVTASVARTGRLLTLEEGQTVCGVGAEVASQMFERIGPRPWIRIGALPAPVSSNPVLETACVPDAARVA
RTVCALMAQ

Sequences:

>Translated_329_residues
MLDSHGLTTTRMFFREGVARAVREEMTRDPRILIMGQDVGAFGGSYREFDGLYPIFGPGRIRDTPVAEAATIGIAAGAAA
AGYRPLVSITYMDFLMLGFDALINYAAKLRYKSAGTLTAPLVVKTTAGAHGQGVAHSQCIEAWLMSVPGLTVVAPATPAD
AYGLMKTALRHDGPVVYIDHKRLFPAPGEVPVIEEPVPFGQACVRRTGRDVTLVTHGYMVQVALEAARALEYQDISCEVI
DLRSLAPLDIGTVTASVARTGRLLTLEEGQTVCGVGAEVASQMFERIGPRPWIRIGALPAPVSSNPVLETACVPDAARVA
RTVCALMAQ
>Mature_329_residues
MLDSHGLTTTRMFFREGVARAVREEMTRDPRILIMGQDVGAFGGSYREFDGLYPIFGPGRIRDTPVAEAATIGIAAGAAA
AGYRPLVSITYMDFLMLGFDALINYAAKLRYKSAGTLTAPLVVKTTAGAHGQGVAHSQCIEAWLMSVPGLTVVAPATPAD
AYGLMKTALRHDGPVVYIDHKRLFPAPGEVPVIEEPVPFGQACVRRTGRDVTLVTHGYMVQVALEAARALEYQDISCEVI
DLRSLAPLDIGTVTASVARTGRLLTLEEGQTVCGVGAEVASQMFERIGPRPWIRIGALPAPVSSNPVLETACVPDAARVA
RTVCALMAQ

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=316, Percent_Identity=35.7594936708861, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI291084858, Length=315, Percent_Identity=34.2857142857143, Blast_Score=195, Evalue=4e-50,
Organism=Homo sapiens, GI4557353, Length=282, Percent_Identity=36.1702127659575, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI34101272, Length=282, Percent_Identity=36.1702127659575, Blast_Score=171, Evalue=8e-43,
Organism=Escherichia coli, GI1786622, Length=241, Percent_Identity=25.3112033195021, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538422, Length=330, Percent_Identity=38.1818181818182, Blast_Score=218, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI17506935, Length=285, Percent_Identity=38.9473684210526, Blast_Score=162, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6319698, Length=334, Percent_Identity=34.4311377245509, Blast_Score=189, Evalue=4e-49,
Organism=Drosophila melanogaster, GI21358145, Length=284, Percent_Identity=40.1408450704225, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24650940, Length=284, Percent_Identity=40.1408450704225, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI160714828, Length=318, Percent_Identity=34.2767295597484, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI160714832, Length=318, Percent_Identity=34.2767295597484, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24650943, Length=97, Percent_Identity=35.0515463917526, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24650945, Length=97, Percent_Identity=35.0515463917526, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35067; Mature: 35067

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSHGLTTTRMFFREGVARAVREEMTRDPRILIMGQDVGAFGGSYREFDGLYPIFGPGR
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCCCCCCCCCCC
IRDTPVAEAATIGIAAGAAAAGYRPLVSITYMDFLMLGFDALINYAAKLRYKSAGTLTAP
CCCCCCHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEC
LVVKTTAGAHGQGVAHSQCIEAWLMSVPGLTVVAPATPADAYGLMKTALRHDGPVVYIDH
EEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEEEC
KRLFPAPGEVPVIEEPVPFGQACVRRTGRDVTLVTHGYMVQVALEAARALEYQDISCEVI
CEECCCCCCCCEECCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEE
DLRSLAPLDIGTVTASVARTGRLLTLEEGQTVCGVGAEVASQMFERIGPRPWIRIGALPA
ECCCCCCCCHHHHHHHHHHCCCEEEECCCCEEECCCHHHHHHHHHHHCCCCEEEECCCCC
PVSSNPVLETACVPDAARVARTVCALMAQ
CCCCCCCEEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLDSHGLTTTRMFFREGVARAVREEMTRDPRILIMGQDVGAFGGSYREFDGLYPIFGPGR
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCCCCCCCCCCC
IRDTPVAEAATIGIAAGAAAAGYRPLVSITYMDFLMLGFDALINYAAKLRYKSAGTLTAP
CCCCCCHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEC
LVVKTTAGAHGQGVAHSQCIEAWLMSVPGLTVVAPATPADAYGLMKTALRHDGPVVYIDH
EEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEEEC
KRLFPAPGEVPVIEEPVPFGQACVRRTGRDVTLVTHGYMVQVALEAARALEYQDISCEVI
CEECCCCCCCCEECCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEE
DLRSLAPLDIGTVTASVARTGRLLTLEEGQTVCGVGAEVASQMFERIGPRPWIRIGALPA
ECCCCCCCCHHHHHHHHHHCCCEEEECCCCEEECCCHHHHHHHHHHHCCCCEEEECCCCC
PVSSNPVLETACVPDAARVARTVCALMAQ
CCCCCCCEEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]