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The map label for this gene is pdhA [H]

Identifier: 162148287

GI number: 162148287

Start: 2598279

End: 2599214

Strand: Direct

Name: pdhA [H]

Synonym: GDI_2504

Alternate gene names: 162148287

Gene position: 2598279-2599214 (Clockwise)

Preceding gene: 162148286

Following gene: 162148288

Centisome position: 65.88

GC content: 70.83

Gene sequence:

>936_bases
ATGAGCCATATCGATCGTATCGAGGCCCTGCGCGACATGATGCTGATCCGGGCCTTCGAGGAGGCGCTGTCGGCGCGCAA
GGACCATGGCTTCCAGCTTCTGTCGTCGGGCGAGGAAGCGGTTGCCGTCGGCCTGGCCTCGGCGCTGGAGGCGGGCGATC
AGTTGCTGACCGGTGGACGGTCGATCGGCCCCATCCTGGCACGCGGCGTGGCGCCCGAGCGGGTCATGGCCGAACTGCTG
GGCCGGACCGGCGGCATGAATCGCGGGCGCGCCGGCCGTGGCCACATGTCGGCGCCCGATGACGGCTTTTTCGGCGCGCA
CGCGGTGGTGGGCGGCAATATCAGCATCGCGGCCGGGGTGGCGCTGGCCCGGCAGATGGACGGGACCGGCGGCATTGTCG
TCATCCTGTTCGGCGACGGTGCCTGCGGCGCCGGGGCGCTGCACGAAACGCTGAACATGGCGGCCCTGTGGAAGCTGCCG
CTGCTGTTCGTGTGCAACAACAACCAGCTTTCGGTTTCGACCGCGCGCGAGGCTGCGCTGGCCGTCCCGCGCCTGTCGGA
CCTGGGGGCCACGTTCGGATTGTGGGCCCGGACGATCGACGGGCTGGATGTCGGCCTGGTCGCCGCCACCGCCGCCGAGG
CCGTCCGCCATGTCCGCGACGGACGGGGGCCGGCCTTCCTGGAATGCACGTCCATCCGCCTGCGCTCGCACTCCACCACG
GCGCGGGAGACCCGCAGCCGGCCCGAACTGACCGCGCTGCGGACGCATTGCCCGATCGAGCGCACGATCACGGCCCTGCG
GGCCGAAGGCATCCTGGGTGCGGCGGATCTGGAGCGGATGCAGCAGCAGGCGACCAGCCGCGCGGCACAGGCCCTGGCCT
ATGCCGACGCCTCACCCTACCCGGACGCAGAGGAGGTCCTGCATCATGTTGGATAG

Upstream 100 bases:

>100_bases
CCATGGAAAAACTAGTCCATGCCGTGCGCAAGCGCGGCGTGCAGGAAAGCCTGGGCCTGCTGACCACCGGCGTCATCCGC
GCATTCGGCGCGAGGTAGAC

Downstream 100 bases:

>100_bases
CCATGGCCTGACAACCACCCGGATGTTCTTTCGCGAGGGCGTCGCGCGCGCCGTCCGCGAGGAAATGACGCGTGATCCCC
GTATCCTGATCATGGGGCAG

Product: 2-oxoglutarate dehydrogenase E1 component beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSHIDRIEALRDMMLIRAFEEALSARKDHGFQLLSSGEEAVAVGLASALEAGDQLLTGGRSIGPILARGVAPERVMAELL
GRTGGMNRGRAGRGHMSAPDDGFFGAHAVVGGNISIAAGVALARQMDGTGGIVVILFGDGACGAGALHETLNMAALWKLP
LLFVCNNNQLSVSTAREAALAVPRLSDLGATFGLWARTIDGLDVGLVAATAAEAVRHVRDGRGPAFLECTSIRLRSHSTT
ARETRSRPELTALRTHCPIERTITALRAEGILGAADLERMQQQATSRAAQALAYADASPYPDAEEVLHHVG

Sequences:

>Translated_311_residues
MSHIDRIEALRDMMLIRAFEEALSARKDHGFQLLSSGEEAVAVGLASALEAGDQLLTGGRSIGPILARGVAPERVMAELL
GRTGGMNRGRAGRGHMSAPDDGFFGAHAVVGGNISIAAGVALARQMDGTGGIVVILFGDGACGAGALHETLNMAALWKLP
LLFVCNNNQLSVSTAREAALAVPRLSDLGATFGLWARTIDGLDVGLVAATAAEAVRHVRDGRGPAFLECTSIRLRSHSTT
ARETRSRPELTALRTHCPIERTITALRAEGILGAADLERMQQQATSRAAQALAYADASPYPDAEEVLHHVG
>Mature_310_residues
SHIDRIEALRDMMLIRAFEEALSARKDHGFQLLSSGEEAVAVGLASALEAGDQLLTGGRSIGPILARGVAPERVMAELLG
RTGGMNRGRAGRGHMSAPDDGFFGAHAVVGGNISIAAGVALARQMDGTGGIVVILFGDGACGAGALHETLNMAALWKLPL
LFVCNNNQLSVSTAREAALAVPRLSDLGATFGLWARTIDGLDVGLVAATAAEAVRHVRDGRGPAFLECTSIRLRSHSTTA
RETRSRPELTALRTHCPIERTITALRAEGILGAADLERMQQQATSRAAQALAYADASPYPDAEEVLHHVG

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=312, Percent_Identity=31.4102564102564, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI4505685, Length=314, Percent_Identity=31.2101910828025, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI291084742, Length=314, Percent_Identity=31.2101910828025, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI291084744, Length=314, Percent_Identity=30.8917197452229, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI291084757, Length=314, Percent_Identity=27.7070063694268, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI11386135, Length=302, Percent_Identity=25.1655629139073, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI258645172, Length=305, Percent_Identity=25.2459016393443, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17536047, Length=287, Percent_Identity=36.2369337979094, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI32564172, Length=287, Percent_Identity=36.2369337979094, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI86563357, Length=271, Percent_Identity=29.1512915129151, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI86563355, Length=271, Percent_Identity=29.1512915129151, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321026, Length=306, Percent_Identity=33.0065359477124, Blast_Score=158, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24639744, Length=255, Percent_Identity=36.4705882352941, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI28571106, Length=255, Percent_Identity=36.4705882352941, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24639740, Length=312, Percent_Identity=33.0128205128205, Blast_Score=151, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24639746, Length=306, Percent_Identity=33.6601307189542, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24639748, Length=289, Percent_Identity=34.6020761245675, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21355903, Length=263, Percent_Identity=26.2357414448669, Blast_Score=91, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 32613; Mature: 32481

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHIDRIEALRDMMLIRAFEEALSARKDHGFQLLSSGEEAVAVGLASALEAGDQLLTGGR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHCHHHHHCCC
SIGPILARGVAPERVMAELLGRTGGMNRGRAGRGHMSAPDDGFFGAHAVVGGNISIAAGV
HHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHH
ALARQMDGTGGIVVILFGDGACGAGALHETLNMAALWKLPLLFVCNNNQLSVSTAREAAL
HHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCEEEEECCCEEEHHHHHHHHH
AVPRLSDLGATFGLWARTIDGLDVGLVAATAAEAVRHVRDGRGPAFLECTSIRLRSHSTT
HCCCHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCH
ARETRSRPELTALRTHCPIERTITALRAEGILGAADLERMQQQATSRAAQALAYADASPY
HHHHCCCCCHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
PDAEEVLHHVG
CCHHHHHHHCC
>Mature Secondary Structure 
SHIDRIEALRDMMLIRAFEEALSARKDHGFQLLSSGEEAVAVGLASALEAGDQLLTGGR
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHCHHHHHCCC
SIGPILARGVAPERVMAELLGRTGGMNRGRAGRGHMSAPDDGFFGAHAVVGGNISIAAGV
HHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHH
ALARQMDGTGGIVVILFGDGACGAGALHETLNMAALWKLPLLFVCNNNQLSVSTAREAAL
HHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCEEEEECCCEEEHHHHHHHHH
AVPRLSDLGATFGLWARTIDGLDVGLVAATAAEAVRHVRDGRGPAFLECTSIRLRSHSTT
HCCCHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCH
ARETRSRPELTALRTHCPIERTITALRAEGILGAADLERMQQQATSRAAQALAYADASPY
HHHHCCCCCHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
PDAEEVLHHVG
CCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]